MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Pancreatic Insufficiency

(UMLS:C0030293)

UMLS ID:: C0030293
MeSH ID:: D010188

Classification:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.689.276

Synonym(s)

Pancreatic Insufficiency

Insufficiency;pancreatic

PANCREAS INSUFFICIENCY

PANCREATIC INSUFFICIENCY

Pancreatic failure

Pancreatic insufficiency

Pancreatic insufficiency, NOS

insufficiency pancreatic

insufficiency; pancreas

10.

pancreas insufficiency

11.

pancreas; insufficiency

12.

pancreatic insufficiency

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Octreotide	FAERS: 10	US FAERS
2	Olmesartan Medoxomil	FAERS: 7	US FAERS
3	Rosiglitazone	FAERS: 6	US FAERS
4	Deferasirox	FAERS: 4	US FAERS
5	Exenatide	FAERS: 4	US FAERS
6	Atorvastatin	FAERS: 3	US FAERS
7	Insulin Glargine	FAERS: 3	US FAERS
8	Sitagliptin Phosphate	FAERS: 3	US FAERS
9	Sunitinib	FAERS: 3	US FAERS
10	Amoxicillin	FAERS: 2	US FAERS
11	Cabergoline	FAERS: 2	OFFSIDES US FAERS
12	Diovan Hct	FAERS: 2	US FAERS
13	Febuxostat	FAERS: 2	US FAERS
14	Gefitinib	FAERS: 2	OFFSIDES US FAERS
15	Imatinib Mesylate	FAERS: 2	US FAERS
16	Lamotrigine	FAERS: 2	US FAERS
17	Methylprednisolone Hemisuccinate	FAERS: 2	US FAERS
18	Nitrofurantoin	FAERS: 2	OFFSIDES US FAERS
19	Orlistat	FAERS: 2	US FAERS
20	Tacrolimus	FAERS: 2	US FAERS
21	Varenicline	FAERS: 2	US FAERS
22	aliskiren	FAERS: 2	US FAERS
23	ambrisentan	FAERS: 2	OFFSIDES US FAERS
24	2-[(E)-[1-(2-Amino-1,3-thiazol-4-yl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]amino]-2-oxoethylidene]amino]oxy-2-methylpropanoic acid;(2S)-2,6-diaminohexanoic acid	FAERS: 1	US FAERS
25	6-Chloro-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide;3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide;hydrochloride	FAERS: 1	US FAERS
26	Aripiprazole	FAERS: 1	US FAERS
27	Atomoxetine Hydrochloride	FAERS: 1	US FAERS
28	Benicar hct	FAERS: 1	US FAERS
29	Capecitabine	FAERS: 1	US FAERS
30	Carbidopa, levodopa, and entacapone	FAERS: 1	US FAERS
31	Citalopram	FAERS: 1	US FAERS
32	Clotrimazole	FAERS: 1	US FAERS
33	Clozapine	FAERS: 1	US FAERS
34	Didanosine	FAERS: 1	US FAERS
35	Emtricitabine, Rilpivirine, Tenofovir Drug Combination	FAERS: 1	US FAERS
36	Ezetimibe	FAERS: 1	US FAERS
37	Ibuprofen	FAERS: 1	US FAERS
38	Insulin Detemir	FAERS: 1	US FAERS
39	Octreotide	FAERS: 1	OFFSIDES US FAERS
40	Olanzapine	FAERS: 1	US FAERS
41	Pentostatin	FAERS: 1	US FAERS
42	Pregabalin	FAERS: 1	US FAERS
43	Quetiapine Fumarate	FAERS: 1	US FAERS
44	Risperidone	FAERS: 1	US FAERS
45	Terbinafine	FAERS: 1	OFFSIDES US FAERS
46	Thyroxine	FAERS: 1	US FAERS
47	Tobramycin	FAERS: 1	US FAERS
48	Tramadol	FAERS: 1	US FAERS
49	Voriconazole	FAERS: 1	US FAERS
50	Zoledronic Acid	FAERS: 1	US FAERS
51	eletriptan	FAERS: 1	US FAERS
52	eltrombopag	FAERS: 1	US FAERS
53	gemcitabine	FAERS: 1	US FAERS
54	ivacaftor	FAERS: 1	US FAERS
55	pazopanib	FAERS: 1	US FAERS
56	Acetylcysteine		OFFSIDES
57	Bisacodyl		OFFSIDES
58	Buspirone		OFFSIDES
59	Butylscopolammonium Bromide		OFFSIDES
60	Caffeine mixture with phenobarbital		OFFSIDES
61	Carbamazepine		OFFSIDES
62	Clemastine		OFFSIDES
63	Clonazepam		OFFSIDES
64	Darunavir		OFFSIDES
65	Dehydroepiandrosterone		OFFSIDES
66	Diosmin		OFFSIDES
67	Doxepin		OFFSIDES
68	Fluconazole		OFFSIDES
69	Fludrocortisone		OFFSIDES
70	Gabapentin		OFFSIDES
71	Galactose		OFFSIDES
72	Gatifloxacin		OFFSIDES
73	Haloperidol		OFFSIDES
74	Hydralazine		OFFSIDES
75	Imipenem		OFFSIDES
76	Indapamide		OFFSIDES
77	Lamivudine		OFFSIDES
78	Linezolid		OFFSIDES
79	Loperamide		OFFSIDES
80	Methyltestosterone		OFFSIDES
81	N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide		SIDER
82	Nicorandil		OFFSIDES
83	Pamidronate		OFFSIDES
84	Primidone		OFFSIDES
85	Quinapril		OFFSIDES
86	Saquinavir		OFFSIDES
87	Spironolactone		OFFSIDES
88	Stavudine		OFFSIDES
89	Varenicline		OFFSIDES
90	brinzolamide		OFFSIDES
91	butalbital		OFFSIDES
92	liposomal amphotericin B		OFFSIDES
93	magnesium citrate		OFFSIDES
94	reviparin		OFFSIDES
95	trospium chloride		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Pancreatitis	42.9%
2	Pancreatitis, Chronic	31%
3	Pancreatic Cyst	28.6%
4	Pancreatic Fistula	27.8%
5	Biliary Tract Diseases	23.1%
6	Gastrointestinal Diseases	23.1%
7	Liver diseases	23.1%
8	Pancreatic Pseudocyst	20.5%
9	Pancreatitis, Alcoholic	20.2%
10	Pancreatic Neoplasm	18.6%
11	Cystic Fibrosis	17.1%
12	Congenital Hyperinsulinism	16.4%
13	Digestive System Neoplasms	15%
14	Bile Duct Diseases	14.3%
15	Cholelithiasis	14.3%
16	Chylous Ascites	14.3%
17	Esophageal Diseases	14.3%
18	Fatty Liver	14.3%
19	Gastroenteritis	14.3%
20	Hepatitis	14.3%
21	Portal Hypertension	14.3%
22	Intestinal Diseases	14.3%
23	Liver Cirrhosis	14.3%
24	Pneumoperitoneum	14.3%
25	Stomach Diseases	14.3%
26	Focal Nodular Hyperplasia	14.3%
27	Hepatic Insufficiency	14.3%
28	Steatohepatitis	14.3%
29	Gastrointestinal Neoplasms	14%
30	Liver neoplasms	14%
31	Zollinger-Ellison syndrome	13.9%
32	Biliary cirrhosis	13.8%
33	Dysentery	13.6%
34	Enteritis	13.6%
35	Enterocolitis	13.6%
36	Esophageal and Gastric Varices	13.6%
37	Esophagitis	13.6%
38	Gastritis	13.6%
39	Inflammatory Bowel Diseases	13.6%
40	Cholecystolithiasis	13.6%
41	Proctocolitis	12.7%
42	Duodenitis	12.4%
43	Ileitis	12.4%
44	Erosive Duodenitis	12.4%
45	Colitis	12.4%
46	Duodenogastric Reflux	12.4%
47	Peptic Ulcer	12.4%
48	Proctitis	12.4%
49	Choledocholithiasis	12.4%
50	Mesenteric vascular insufficiency	12.3%
51	Bile Duct Neoplasms	12.1%
52	gallbladder neoplasm	12.1%
53	Intestinal Neoplasms	12.1%
54	Stomach Neoplasms	12.1%
55	Esophageal Atresia	12.1%
56	Intestinal Atresia	12.1%
57	Mesenteric Vascular Occlusion	12.1%
58	Intestinal Fistula	12%
59	Enterocutaneous Fistula	12%
60	Nesidioblastosis	11.9%
61	Colorectal Neoplasms	11.7%
62	Crohn Disease	11.1%
63	Duodenal Obstruction	11.1%
64	Peritoneal Neoplasms	11.1%
65	Enterocolitis, Neutropenic	11.1%
66	Necrotizing Enterocolitis	11.1%
67	Pouchitis	11%
68	Cecal Neoplasms	10.9%
69	Duodenal Neoplasms	10.9%
70	Rectal Fistula	10.6%
71	Anal Fistula	10.6%
72	Duodenal Ulcer	10.5%
73	Peptic Ulcer Perforation	10.5%
74	Gastric ulcer	10.5%
75	Cecal Diseases	10.3%
76	Cholangitis	10.3%
77	Cholecystitis	10.3%
78	Cholestasis	10.3%
79	Colonic Diseases	10.3%
80	Common Bile Duct Diseases	10.3%
81	Esophageal Stenosis	10.3%
82	Hepatitis, Chronic	10.3%
83	Ileal Diseases	10.3%
84	Intestinal Obstruction	10.3%
85	Intestinal Perforation	10.3%
86	Jejunal Diseases	10.3%
87	Pneumatosis Cystoides Intestinalis	10.3%
88	Rectal Diseases	10.3%
89	Gastric Dilatation	10.3%
90	Liver Failure	10.3%
91	Gastric outlet obstruction	10.3%
92	Cronkhite-Canada Syndrome	10.3%
93	Non-alcoholic Fatty Liver Disease	10.3%
94	Chronic active hepatitis	10.3%
95	Intestinal Polyposis	10.3%
96	Gastrointestinal Stromal Tumors	10.1%
97	Esophageal Neoplasms	10.1%
98	Fatty Liver, Alcoholic	10%
99	Hepatitis, Alcoholic	10%
100	Liver Cirrhosis, Alcoholic	10%
101	Liver Diseases, Parasitic	10%
102	Carcinoma, Pancreatic Ductal	9.9%
103	Anus Neoplasms	9.8%
104	Sigmoid Neoplasms	9.8%
105	Choledochal Cyst	9.7%
106	Appendiceal Neoplasms	9.7%
107	Colonic Neoplasms	9.7%
108	Rectal Neoplasms	9.7%
109	Colonic Pseudo-Obstruction	9.6%
110	Hepatic Veno-Occlusive Disease	9.5%
111	Peliosis Hepatis	9.5%
112	Hepatopulmonary Syndrome	9.5%
113	Anus, Imperforate	9.3%
114	Gastrointestinal Hemorrhage	9.3%
115	Hemoperitoneum	9.3%
116	Hepatomegaly	9.3%
117	Mesenteric Panniculitis	9.3%
118	Panniculitis, Peritoneal	9.3%
119	Peritonitis	9.3%
120	Peritoneal Fibrosis	9.3%
121	Encapsulating Peritoneal Sclerosis	9.3%
122	Anorectal Malformations	9.3%
123	insulinoma	9.3%
124	Gastrinoma	9.3%
125	Glucagonoma	9.3%
126	Appendicitis	9.2%
127	Biliary Fistula	9.2%
128	Gastric Fistula	9.2%
129	Hepatic Vein Thrombosis	9.1%
130	Liver Abscess	9.1%
131	Budd-Chiari Syndrome	9.1%
132	Tuberculosis, Gastrointestinal	9.1%
133	Cholestasis, Extrahepatic	8.5%
134	Biliary Dyskinesia	8.5%
135	Cholangitis, Sclerosing	8.5%
136	Colonic Diseases, Functional	8.5%
137	Esophageal motility disorders	8.5%
138	Fecal Incontinence	8.5%
139	Fecal Impaction	8.5%
140	Intussusception	8.5%
141	Mallory-Weiss Syndrome	8.5%
142	Megacolon	8.5%
143	Pyloric Stenosis	8.5%
144	Liver Failure, Acute	8.5%
145	Acalculous Cholecystitis	8.5%
146	End Stage Liver Disease	8.5%
147	Ileus	8.5%
148	Meconium ileus	8.5%
149	Enterocolitis, Pseudomembranous	8.3%
150	pseudomembranous colitis	8.3%
151	Dysentery, Bacillary	8.3%
152	Vipoma	8.1%
153	Colitis, Ischemic	8%
154	Hepatocellular Adenoma	8%
155	Massive Hepatic Necrosis	7.6%
156	Esophageal Achalasia	7.6%
157	Anal Fissure	7.6%
158	Intestinal Pseudo-Obstruction	7.6%
159	Irritable Bowel Syndrome	7.6%
160	Superior Mesenteric Artery Syndrome	7.6%
161	Emphysematous Cholecystitis	7.6%
162	Neurogenic Bowel	7.6%
163	Sphincter of Oddi Dysfunction	7.6%
164	Anal Ulcer	7.6%
165	Adenomatous Polyposis Coli	7.5%
166	Esophageal Perforation	7.3%
167	Hepatitis, Animal	7.3%
168	Hepatitis, Viral, Human	7.3%
169	Intestinal Diseases, Parasitic	7.3%
170	Chemical and Drug Induced Liver Injury	7.1%
171	Barrett Esophagus	7%
172	Deglutition Disorders	7%
173	Hepatorenal Syndrome	6.8%
174	Achlorhydria	6.8%
175	Liver Cirrhosis, Experimental	6.8%
176	Gastric Antral Vascular Ectasia	6.8%
177	Liver Abscess, Amebic	6.8%
178	Liver Neoplasms, Experimental	6.7%
179	Peptic Ulcer Hemorrhage	6.7%
180	Gastroparesis	6.7%
181	Hepatitis B, Chronic	6.3%
182	Hepatitis C, Chronic	6.3%
183	Hemorrhoids	5.7%
184	Autoimmune hepatitis	5.7%
185	Afferent Loop Syndrome	5.6%
186	Celiac Disease	5.6%
187	Short Bowel Syndrome	5.6%
188	Sprue, Tropical	5.6%
189	Steatorrhea	5.6%
190	Rectocele	5.6%
191	Sprue	5.6%
192	Diverticulitis	5.6%
193	Dumping Syndrome	5.6%
194	Rectal Prolapse	5.6%
195	Porphyrias, Hepatic	5.5%
196	Fascioliasis	5.2%
197	Echinococcosis, Hepatic	5.1%
198	Melena	5.1%
199	Chemical and Drug Induced Liver Injury, Chronic	5.1%
200	Reye Syndrome	5%
201	Pruritus Ani	5%
202	Hematemesis	5%
203	Laryngopharyngeal Reflux	4.8%
204	Hepatitis, Viral, Animal	4.5%
205	Giardiasis	4.3%
206	Hepatitis E	4.3%
207	Hepatitis B	4.3%
208	Hepatitis C	4.3%
209	Diverticulum	4.2%
210	Hepatitis A	4.2%
211	Diverticulosis	4.2%
212	Hepatic Encephalopathy	4.2%
213	Variegate Porphyria	4%
214	Acute intermittent porphyria	4%
215	Porphyria Cutanea Tarda	4%
216	Peutz-Jeghers Syndrome	3.4%
217	Lactose Intolerance	3.3%
218	Cryptosporidiosis	2.4%
219	Zellweger Syndrome	2.4%
220	Hepatolenticular Degeneration	2.2%
221	Rift Valley Fever	2.2%
222	CREST Syndrome	2.1%

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