5-(4-ethylpiperazin-1-ylmethyl)pyridin-2-yl)-(5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-3H-benzimidazol-5-yl)pyrimidin-2-yl)amine
(UZWDCWONPYILKI-UHFFFAOYSA-N)
Structure
- SMILES
- CCN1CCN(CC1)Cc1ccc(nc1)Nc1ncc(c(n1)c1cc(F)c2c(c1)n(C(C)C)c(n2)C)F
- Type(s)
- Approved; Investigational
- ATC code(s)
- L01XE50
- Molecular Formula:
- C27H32F2N8
- Molecular Weight:
- 506.593
- Log P:
- 4.8857
- Hydrogen Bond Acceptor:
- 7
- Hydrogen Bond Donor:
- 1
- TPSA:
- 75
- CAS Number(s):
- 1231929-97-7
Synonym(s)
1.
5-(4-ethylpiperazin-1-ylmethyl)pyridin-2-yl)-(5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-3H-benzimidazol-5-yl)pyrimidin-2-yl)amine
2.
5-(4-ethylpiperazin-1-ylmethyl)pyridin-2-yl)-(5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-3H-benzoimidazol-5-yl)pyrimidin-2-yl)amine
3.
LY2385219
4.
LY2835210
5.
LY2835219
6.
abemaciclib
External Link(s)
| MeSH | C000590451 |
| PubChem Compound | 46220502 |
| BindingDB | 50110183 |
| CHEMBL | CHEMBL3301610 |
| DrugBank | DB12001 |
| DrugCentral | 5259 |
| IUPHAR/BPS Guide to PHARMACOLOGY | 7382 |
| KEGG | dr:D10688 |
| Therapeutic Target Database | D05SBO |
| ZINC | 72318121 |
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Nausea | FAERS: 115 | US FAERS | |
| 2 | Fatigue | FAERS: 102 | US FAERS | |
| 3 | Vomiting | FAERS: 75 | US FAERS | |
| 4 | Dehydration | FAERS: 43 | US FAERS | |
| 5 | White blood cell count decreased | FAERS: 42 | US FAERS | |
| 6 | Drug ineffective | FAERS: 35 | US FAERS | |
| 7 | Malignant neoplasm progression | FAERS: 34 | US FAERS | |
| 8 | Therapy cessation | FAERS: 27 | US FAERS | |
| 9 | Constipation | FAERS: 25 | US FAERS | |
| 10 | Asthenia | FAERS: 24 | US FAERS | |
| 11 | Abdominal Pain | FAERS: 22 | US FAERS | |
| 12 | Dizziness | FAERS: 21 | US FAERS | |
| 13 | Weight decreased | FAERS: 21 | US FAERS | |
| 14 | Blood creatinine increased | FAERS: 19 | US FAERS | |
| 15 | Alopecia | FAERS: 18 | US FAERS | |
| 16 | Disease Progression | FAERS: 18 | US FAERS | |
| 17 | Malaise | FAERS: 16 | US FAERS | |
| 18 | Headache | FAERS: 14 | US FAERS | |
| 19 | Abdominal discomfort | FAERS: 12 | US FAERS | |
| 20 | Dysgeusia | FAERS: 11 | US FAERS | |
| 21 | Peripheral swelling | FAERS: 11 | US FAERS | |
| 22 | Pneumonia | FAERS: 10 | US FAERS | |
| 23 | Therapy change | FAERS: 10 | US FAERS | |
| 24 | Urinary tract infection | FAERS: 10 | US FAERS | |
| 25 | Acute kidney injury | FAERS: 8 | US FAERS | |
| 26 | Arthralgia | FAERS: 8 | US FAERS | |
| 27 | Neutropenia | FAERS: 8 | US FAERS | |
| 28 | Drug dose omission | FAERS: 7 | US FAERS | |
| 29 | Neutrophil count decreased | FAERS: 7 | US FAERS | |
| 30 | Product dose omission | FAERS: 7 | US FAERS | |
| 31 | Pruritus | FAERS: 7 | US FAERS | |
| 32 | Thrombosis | FAERS: 7 | US FAERS | |
| 33 | Back Pain | FAERS: 6 | US FAERS | |
| 34 | Cytopenia | FAERS: 6 | US FAERS | |
| 35 | Feeling abnormal | FAERS: 6 | US FAERS | |
| 36 | Retching | FAERS: 6 | US FAERS | |
| 37 | Blood count abnormal | FAERS: 5 | US FAERS | |
| 38 | Full blood count decreased | FAERS: 5 | US FAERS | |
| 39 | Hypotension | FAERS: 5 | US FAERS | |
| 40 | Pain | FAERS: 5 | US FAERS | |
| 41 | Pulmonary Embolism | FAERS: 5 | US FAERS | |
| 42 | Tachycardia | FAERS: 5 | US FAERS | |
| 43 | Atrial Fibrillation | FAERS: 4 | US FAERS | |
| 44 | Cystitis | FAERS: 4 | US FAERS | |
| 45 | Flatulence | FAERS: 4 | US FAERS | |
| 46 | Gait inability | FAERS: 4 | US FAERS | |
| 47 | Hypophagia | FAERS: 4 | US FAERS | |
| 48 | Joint swelling | FAERS: 4 | US FAERS | |
| 49 | Memory impairment | FAERS: 4 | US FAERS | |
| 50 | Nasopharyngitis | FAERS: 4 | US FAERS | |
| 51 | Syncope | FAERS: 4 | US FAERS | |
| 52 | Thrombocytopenia | FAERS: 4 | US FAERS | |
| 53 | Tremor | FAERS: 4 | US FAERS | |
| 54 | Unevaluable event | FAERS: 4 | US FAERS | |
| 55 | treatment failure | FAERS: 4 | US FAERS | |
| 56 | Blindness | FAERS: 3 | US FAERS | |
| 57 | Blood glucose decreased | FAERS: 3 | US FAERS | |
| 58 | Blood magnesium decreased | FAERS: 3 | US FAERS | |
| 59 | Cerebrovascular accident | FAERS: 3 | US FAERS | |
| 60 | Chest Pain | FAERS: 3 | US FAERS | |
| 61 | Colitis | FAERS: 3 | US FAERS | |
| 62 | Feeling Cold | FAERS: 3 | US FAERS | |
| 63 | Myalgia | FAERS: 3 | US FAERS | |
| 64 | Pneumothorax | FAERS: 3 | US FAERS | |
| 65 | Sinusitis | FAERS: 3 | US FAERS | |
| 66 | Somnolence | FAERS: 3 | US FAERS | |
| 67 | Stomatitis | FAERS: 3 | US FAERS | |
| 68 | Swelling | FAERS: 3 | US FAERS | |
| 69 | Alanine Aminotransferase Increased | FAERS: 2 | US FAERS | |
| 70 | Ascites | FAERS: 2 | US FAERS | |
| 71 | Aspartate Aminotransferase Increased | FAERS: 2 | US FAERS | |
| 72 | Asthma | FAERS: 2 | US FAERS | |
| 73 | Blood alkaline phosphatase increased | FAERS: 2 | US FAERS | |
| 74 | Burning sensation | FAERS: 2 | US FAERS | |
| 75 | Cerebral disorder | FAERS: 2 | US FAERS | |
| 76 | Deep Vein Thrombosis | FAERS: 2 | US FAERS | |
| 77 | Delirium | FAERS: 2 | US FAERS | |
| 78 | Dysphonia | FAERS: 2 | US FAERS | |
| 79 | Electrolyte imbalance | FAERS: 2 | US FAERS | |
| 80 | Erythema | FAERS: 2 | US FAERS | |
| 81 | Feeling jittery | FAERS: 2 | US FAERS | |
| 82 | Fracture | FAERS: 2 | US FAERS | |
| 83 | Full blood count abnormal | FAERS: 2 | US FAERS | |
| 84 | Hospice Care | FAERS: 2 | US FAERS | |
| 85 | Hypersensitivity | FAERS: 2 | US FAERS | |
| 86 | Influenza | FAERS: 2 | US FAERS | |
| 87 | Intentional product misuse | FAERS: 2 | US FAERS | |
| 88 | Ligament rupture | FAERS: 2 | US FAERS | |
| 89 | Limb discomfort | FAERS: 2 | US FAERS | |
| 90 | Lip swelling | FAERS: 2 | US FAERS | |
| 91 | Mouth swelling | FAERS: 2 | US FAERS | |
| 92 | Musculoskeletal stiffness | FAERS: 2 | US FAERS | |
| 93 | Myocardial Infarction | FAERS: 2 | US FAERS | |
| 94 | Onychoclasis | FAERS: 2 | US FAERS | |
| 95 | Onycholysis | FAERS: 2 | US FAERS | |
| 96 | Oral pain | FAERS: 2 | US FAERS | |
| 97 | Oropharyngeal pain | FAERS: 2 | US FAERS | |
| 98 | Overdose | FAERS: 2 | US FAERS | |
| 99 | Pain of skin | FAERS: 2 | US FAERS | |
| 100 | Pallor | FAERS: 2 | US FAERS | |
| 101 | Platelet count abnormal | FAERS: 2 | US FAERS | |
| 102 | Pneumonitis | FAERS: 2 | US FAERS | |
| 103 | Product dispensing error | FAERS: 2 | US FAERS | |
| 104 | Product outer packaging issue | FAERS: 2 | US FAERS | |
| 105 | Product use issue | FAERS: 2 | US FAERS | |
| 106 | Restlessness | FAERS: 2 | US FAERS | |
| 107 | Scab | FAERS: 2 | US FAERS | |
| 108 | Skin irritation | FAERS: 2 | US FAERS | |
| 109 | Somnambulism | FAERS: 2 | US FAERS | |
| 110 | Therapy non-responder | FAERS: 2 | US FAERS | |
| 111 | Throat irritation | FAERS: 2 | US FAERS | |
| 112 | Visual Impairment | FAERS: 2 | US FAERS | |
| 113 | White blood cell count abnormal | FAERS: 2 | US FAERS | |
| 114 | Wrong technique in product usage process | FAERS: 2 | US FAERS | |
| 115 | Abdominal Infection | FAERS: 1 | US FAERS | |
| 116 | Abscess | FAERS: 1 | US FAERS | |
| 117 | Adverse event | FAERS: 1 | US FAERS | |
| 118 | Ageusia | FAERS: 1 | US FAERS | |
| 119 | Altered state of consciousness | FAERS: 1 | US FAERS | |
| 120 | Amnesia | FAERS: 1 | US FAERS | |
| 121 | Anxiety | FAERS: 1 | US FAERS | |
| 122 | Aortic occlusion | FAERS: 1 | US FAERS | |
| 123 | Aphonia | FAERS: 1 | US FAERS | |
| 124 | Arthritis | FAERS: 1 | US FAERS | |
| 125 | Arthropathy | FAERS: 1 | US FAERS | |
| 126 | Blister rupture | FAERS: 1 | US FAERS | |
| 127 | Blood glucose increased | FAERS: 1 | US FAERS | |
| 128 | Blood potassium decreased | FAERS: 1 | US FAERS | |
| 129 | Blood sodium increased | FAERS: 1 | US FAERS | |
| 130 | Bone pain | FAERS: 1 | US FAERS | |
| 131 | Bronchitis | FAERS: 1 | US FAERS | |
| 132 | Chills | FAERS: 1 | US FAERS | |
| 133 | Cholelithiasis | FAERS: 1 | US FAERS | |
| 134 | Clostridium difficile infection | FAERS: 1 | US FAERS | |
| 135 | Coronary artery embolism | FAERS: 1 | US FAERS | |
| 136 | Creatinine renal clearance decreased | FAERS: 1 | US FAERS | |
| 137 | Diplopia | FAERS: 1 | US FAERS | |
| 138 | Discontinued product administered | FAERS: 1 | US FAERS | |
| 139 | Drug level increased | FAERS: 1 | US FAERS | |
| 140 | Dry skin | FAERS: 1 | US FAERS | |
| 141 | Dysarthria | FAERS: 1 | US FAERS | |
| 142 | Dyspepsia | FAERS: 1 | US FAERS | |
| 143 | Dystonia | FAERS: 1 | US FAERS | |
| 144 | Dysuria | FAERS: 1 | US FAERS | |
| 145 | Emergency Care | FAERS: 1 | US FAERS | |
| 146 | Epistaxis | FAERS: 1 | US FAERS | |
| 147 | Eructation | FAERS: 1 | US FAERS | |
| 148 | Essential Tremor | FAERS: 1 | US FAERS | |
| 149 | Eyelids pruritus | FAERS: 1 | US FAERS | |
| 150 | Female Orgasmic Disorder | FAERS: 1 | US FAERS | |
| 151 | Fibrosis | FAERS: 1 | US FAERS | |
| 152 | Flushing | FAERS: 1 | US FAERS | |
| 153 | Gastroenteritis norovirus | FAERS: 1 | US FAERS | |
| 154 | Gastroenteritis | FAERS: 1 | US FAERS | |
| 155 | Gastrointestinal toxicity | FAERS: 1 | US FAERS | |
| 156 | Genital rash | FAERS: 1 | US FAERS | |
| 157 | Hip surgery | FAERS: 1 | US FAERS | |
| 158 | Impaired quality of life | FAERS: 1 | US FAERS | |
| 159 | Inappropriate schedule of drug administration | FAERS: 1 | US FAERS | |
| 160 | Inappropriate schedule of product administration | FAERS: 1 | US FAERS | |
| 161 | Incorrect dose administered | FAERS: 1 | US FAERS | |
| 162 | Infection | FAERS: 1 | US FAERS | |
| 163 | Inflammation | FAERS: 1 | US FAERS | |
| 164 | Intestinal Obstruction | FAERS: 1 | US FAERS | |
| 165 | Lethargy | FAERS: 1 | US FAERS | |
| 166 | Leukoencephalopathy | FAERS: 1 | US FAERS | |
| 167 | Leukopenia | FAERS: 1 | US FAERS | |
| 168 | Loss of personal independence in daily activities | FAERS: 1 | US FAERS | |
| 169 | Lymphangiosis carcinomatosa | FAERS: 1 | US FAERS | |
| 170 | Lymphopenia | FAERS: 1 | US FAERS | |
| 171 | Mastitis | FAERS: 1 | US FAERS | |
| 172 | Mental status changes | FAERS: 1 | US FAERS | |
| 173 | Metastatic Neoplasm | FAERS: 1 | US FAERS | |
| 174 | Multiple Sclerosis | FAERS: 1 | US FAERS | |
| 175 | Muscle tightness | FAERS: 1 | US FAERS | |
| 176 | Musculoskeletal Pain | FAERS: 1 | US FAERS | |
| 177 | Neck Pain | FAERS: 1 | US FAERS | |
| 178 | Necrosis | FAERS: 1 | US FAERS | |
| 179 | Neuralgia | FAERS: 1 | US FAERS | |
| 180 | Oral mucosal eruption | FAERS: 1 | US FAERS | |
| 181 | Osteonecrosis of Jaw | FAERS: 1 | US FAERS | |
| 182 | Palpitations | FAERS: 1 | US FAERS | |
| 183 | Pancreatitis | FAERS: 1 | US FAERS | |
| 184 | Paranasal sinus discomfort | FAERS: 1 | US FAERS | |
| 185 | Pericardial effusion | FAERS: 1 | US FAERS | |
| 186 | Peripheral artery thrombosis | FAERS: 1 | US FAERS | |
| 187 | Peripheral embolism | FAERS: 1 | US FAERS | |
| 188 | Pleurisy | FAERS: 1 | US FAERS | |
| 189 | Post procedural infection | FAERS: 1 | US FAERS | |
| 190 | Presyncope | FAERS: 1 | US FAERS | |
| 191 | Product dispensing issue | FAERS: 1 | US FAERS | |
| 192 | Product use complaint | FAERS: 1 | US FAERS | |
| 193 | Pulmonary thrombosis | FAERS: 1 | US FAERS | |
| 194 | Quality of life decreased | FAERS: 1 | US FAERS | |
| 195 | Radiation Pneumonitis | FAERS: 1 | US FAERS | |
| 196 | Respiratory Failure | FAERS: 1 | US FAERS | |
| 197 | Respiratory arrest | FAERS: 1 | US FAERS | |
| 198 | Respiratory distress | FAERS: 1 | US FAERS | |
| 199 | Rosacea | FAERS: 1 | US FAERS | |
| 200 | Sepsis | FAERS: 1 | US FAERS | |
| 201 | Skin Ulcer | FAERS: 1 | US FAERS | |
| 202 | Thirst | FAERS: 1 | US FAERS | |
| 203 | Toxicity to various agents | FAERS: 1 | US FAERS | |
| 204 | Transaminases increased | FAERS: 1 | US FAERS | |
| 205 | Upper-airway cough syndrome | FAERS: 1 | US FAERS | |
| 206 | Vertigo | FAERS: 1 | US FAERS | |
| 207 | Vocal Cord Paralysis | FAERS: 1 | US FAERS | |
| 208 | Vulvovaginal pruritus | FAERS: 1 | US FAERS | |
| 209 | furuncle | FAERS: 1 | US FAERS |
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