MetaADEDB 2.0 @ LMMD
Meropenem
(DMJNNHOOLUXYBV-PQTSNVLCSA-N)
Structure
SMILES
C[C@H]([C@H]1C(=O)N2[C@@H]1[C@@H](C)C(=C2C(=O)O)S[C@@H]1CN[C@@H](C1)C(=O)N(C)C)O
Type(s)
Approved; Investigational
ATC code(s)
J01DH02; J01DH52
Molecular Formula:
C17H25N3O5S
Molecular Weight:
383.462
Log P:
-0.0413
Hydrogen Bond Acceptor:
9
Hydrogen Bond Donor:
3
TPSA:
135.48
CAS Number(s):
96036-03-2; 119478-56-7
Synonym(s)
1.
Meropenem
2.
3-(5-Dimethylcarbamoylpyrrolidin-3-ylthio)-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid
3.
Merrem
4.
Penem
5.
Ronem
6.
SM 7338
7.
SM-7338
8.
SM7338
External Link(s)
MeSHD000077731
PubChem Compound40466974
441130
BindingDB50129062
ChEBI43968
CHEMBLCHEMBL127
DrugBankDB00760
DrugCentral1709
KEGGdr:D02222
dr:D08185
Therapeutic Target DatabaseD0O5FY
ZINC3808779
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1PancytopeniaFAERS: 26US FAERS
2Toxic Epidermal NecrolysisFAERS: 18SIDER
US FAERS
3Drug ineffectiveFAERS: 17
Canada Vigilance: 1		Canada Vigilance
US FAERS
4Alanine Aminotransferase IncreasedFAERS: 16OFFSIDES
SIDER
US FAERS
5Aspartate Aminotransferase IncreasedFAERS: 16SIDER
US FAERS
6Anaphylactic shockFAERS: 14SIDER
US FAERS
7Drug resistanceFAERS: 14US FAERS
8Cardiac ArrestFAERS: 13SIDER
US FAERS
9EpilepsyFAERS: 13US FAERS
10Septic ShockFAERS: 10OFFSIDES
US FAERS
11Depressed Level of ConsciousnessFAERS: 9OFFSIDES
US FAERS
12HypersensitivityFAERS: 9SIDER
US FAERS
13Blood creatine phosphokinase increasedFAERS: 8US FAERS
14CholestasisFAERS: 8SIDER
US FAERS
15ErythemaFAERS: 8SIDER
US FAERS
16SepsisFAERS: 8SIDER
US FAERS
17ThrombocytopeniaFAERS: 8SIDER
US FAERS
18UrticariaFAERS: 8SIDER
US FAERS
19EosinophiliaFAERS: 7SIDER
US FAERS
20NeutropeniaFAERS: 7
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
21White blood cell count decreasedFAERS: 7SIDER
US FAERS
22Blood alkaline phosphatase increasedFAERS: 6OFFSIDES
SIDER
US FAERS
23Blood lactate dehydrogenase increasedFAERS: 6OFFSIDES
SIDER
US FAERS
24BronchospasmFAERS: 6US FAERS
25HypotensionFAERS: 6SIDER
US FAERS
26MalaiseFAERS: 6SIDER
US FAERS
27Pathogen resistanceFAERS: 6OFFSIDES
US FAERS
28PneumoniaFAERS: 615221158
16882111		CTD
SIDER
US FAERS
29PruritusFAERS: 6SIDER
US FAERS
30Status EpilepticusFAERS: 6US FAERS
31TremorFAERS: 6US FAERS
32Amylase increasedFAERS: 5US FAERS
33Chest discomfortFAERS: 5US FAERS
34Disseminated Intravascular CoagulationFAERS: 5OFFSIDES
US FAERS
35HepatitisFAERS: 5SIDER
US FAERS
36InfectionFAERS: 5SIDER
US FAERS
37Metabolic alkalosisFAERS: 5US FAERS
38NauseaFAERS: 510381210CTD
SIDER
US FAERS
39Oculomucocutaneous syndromeFAERS: 5US FAERS
40VomitingFAERS: 510381210CTD
SIDER
US FAERS
41jaundiceFAERS: 5SIDER
US FAERS
42pseudomembranous colitisFAERS: 5SIDER
US FAERS
43AgranulocytosisFAERS: 4SIDER
US FAERS
44AngioedemaFAERS: 4SIDER
US FAERS
45Blood potassium increasedFAERS: 4US FAERS
46Eosinophilic PneumoniaFAERS: 4US FAERS
47Myasthenia GravisFAERS: 4US FAERS
48OverdoseFAERS: 4US FAERS
49PneumonitisFAERS: 4US FAERS
50Polyarteritis NodosaFAERS: 4US FAERS
51Poor quality drug administeredFAERS: 4US FAERS
52Respiratory FailureFAERS: 4OFFSIDES
SIDER
US FAERS
53Acute kidney injuryFAERS: 3US FAERS
54ChillsFAERS: 3SIDER
US FAERS
55Feeling abnormalFAERS: 3SIDER
US FAERS
56Gamma-Glutamyltransferase IncreasedFAERS: 3OFFSIDES
SIDER
US FAERS
57HyperpyrexiaFAERS: 3US FAERS
58Incorrect dose administeredFAERS: 3US FAERS
59Incorrect drug administration rateFAERS: 3US FAERS
60Injection site extravasationFAERS: 3US FAERS
61LaryngospasmFAERS: 3US FAERS
62LeukopeniaFAERS: 3SIDER
US FAERS
63Medication ErrorFAERS: 3US FAERS
64PancreatitisFAERS: 3OFFSIDES
US FAERS
65Pulmonary EosinophiliaFAERS: 3US FAERS
66Respiratory distressFAERS: 3US FAERS
67RhabdomyolysisFAERS: 3OFFSIDES
US FAERS
68ShockFAERS: 3SIDER
US FAERS
69Skin reactionFAERS: 3US FAERS
70Subcorneal pustular dermatosisFAERS: 3US FAERS
71TachycardiaFAERS: 3SIDER
US FAERS
72ThrombocytosisFAERS: 310381210CTD
SIDER
US FAERS
73ThrombosisFAERS: 3US FAERS
74Vanishing bile duct syndromeFAERS: 3OFFSIDES
US FAERS
75Accidental overdoseFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
76Altered state of consciousnessFAERS: 2OFFSIDES
US FAERS
77AnosmiaFAERS: 2OFFSIDES
US FAERS
78Atrial FibrillationFAERS: 2US FAERS
79Back PainFAERS: 2SIDER
US FAERS
80BedriddenFAERS: 2US FAERS
81Blood sodium increasedFAERS: 2US FAERS
82Blood urea increasedFAERS: 2OFFSIDES
SIDER
US FAERS
83Burning sensationFAERS: 2US FAERS
84Candida sepsisFAERS: 2OFFSIDES
US FAERS
85CellulitisFAERS: 2US FAERS
86Cheyne-Stokes RespirationFAERS: 2US FAERS
87Clostridium difficile colitisFAERS: 2US FAERS
88CyanosisFAERS: 2US FAERS
89DiscomfortFAERS: 2US FAERS
90DizzinessFAERS: 2OFFSIDES
SIDER
US FAERS
91Drug dose omissionFAERS: 2US FAERS
92Drug ineffective for unapproved indicationFAERS: 2US FAERS
93DysgeusiaFAERS: 2SIDER
US FAERS
94EpidermolysisFAERS: 2US FAERS
95Febrile NeutropeniaFAERS: 2OFFSIDES
US FAERS
96FlushingFAERS: 2US FAERS
97General physical health deteriorationFAERS: 2OFFSIDES
US FAERS
98Histiocytosis haematophagicFAERS: 2US FAERS
99Incorrect route of drug administrationFAERS: 2US FAERS
100Injection site necrosisFAERS: 2US FAERS
101Intestinal PerforationFAERS: 2OFFSIDES
US FAERS
102LacerationFAERS: 2OFFSIDES
US FAERS
103LeukoencephalopathyFAERS: 2US FAERS
104LymphadenopathyFAERS: 2US FAERS
105MegacolonFAERS: 2US FAERS
106Neutrophil count decreasedFAERS: 2OFFSIDES
US FAERS
107PainFAERS: 2SIDER
US FAERS
108PalpitationsFAERS: 2US FAERS
109PericarditisFAERS: 2US FAERS
110Product use in unapproved indicationFAERS: 2US FAERS
111Product use issueFAERS: 2US FAERS
112Prothrombin level decreasedFAERS: 2US FAERS
113PurpuraFAERS: 2US FAERS
114Rash erythematousFAERS: 2US FAERS
115Superinfection fungalFAERS: 2US FAERS
116Transaminases increasedFAERS: 2OFFSIDES
US FAERS
117Urinary tract infectionFAERS: 2US FAERS
118VertigoFAERS: 2US FAERS
119Vital functions abnormalFAERS: 2US FAERS
120Vitamin K DeficiencyFAERS: 2US FAERS
121Weight decreasedFAERS: 2US FAERS
122Abdominal PainFAERS: 1SIDER
US FAERS
123Acinetobacter test positiveFAERS: 1US FAERS
124Activities of daily living impairedFAERS: 1US FAERS
125Acute respiratory failureFAERS: 1OFFSIDES
US FAERS
126Administration site extravasationFAERS: 1US FAERS
127AgeusiaFAERS: 1US FAERS
128AgitationFAERS: 1SIDER
US FAERS
129Antibiotic resistant Staphylococcus test positiveFAERS: 1US FAERS
130Anticonvulsant drug level decreasedFAERS: 1US FAERS
131AnuriaFAERS: 1OFFSIDES
US FAERS
132AnxietyFAERS: 1SIDER
US FAERS
133ArthralgiaFAERS: 1US FAERS
134ArthritisFAERS: 1US FAERS
135AsthmaFAERS: 1SIDER
US FAERS
136Autonomic nervous system imbalanceFAERS: 1US FAERS
137Beta 2 microglobulin urine increasedFAERS: 1US FAERS
138Blood albumin increasedFAERS: 1US FAERS
139Blood amylase increasedFAERS: 1OFFSIDES
US FAERS
140Blood bilirubin abnormalFAERS: 1US FAERS
141Blood chloride increasedFAERS: 1US FAERS
142Blood creatinine abnormalFAERS: 1US FAERS
143Blood creatinine increasedFAERS: 1OFFSIDES
SIDER
US FAERS
144Blood glucose increasedFAERS: 1US FAERS
145Brain DeathFAERS: 1OFFSIDES
US FAERS
146BronchiectasisFAERS: 1US FAERS
147C-reactive protein abnormalFAERS: 1US FAERS
148CataractFAERS: 1US FAERS
149Central nervous system lesionFAERS: 1OFFSIDES
US FAERS
150Chest PainFAERS: 1SIDER
US FAERS
151Choking sensationFAERS: 1US FAERS
152ChokingFAERS: 1US FAERS
153CholecystitisFAERS: 1OFFSIDES
US FAERS
154Clostridium test positiveFAERS: 1US FAERS
155ColitisFAERS: 1SIDER
US FAERS
156ConstipationFAERS: 1SIDER
US FAERS
157Coombs test positiveFAERS: 1US FAERS
158Counterfeit drug administeredFAERS: 1US FAERS
159Cystic FibrosisFAERS: 1US FAERS
160Cytokine stormFAERS: 1US FAERS
161CytopeniaFAERS: 1US FAERS
162Deafness NeurosensoryFAERS: 1US FAERS
163DeliriumFAERS: 1
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
164Device related infectionFAERS: 1US FAERS
165Disease ProgressionFAERS: 1US FAERS
166DisorientationFAERS: 1US FAERS
167Documented hypersensitivity to administered productFAERS: 1US FAERS
168Drug level below therapeuticFAERS: 1US FAERS
169Drug level decreasedFAERS: 1US FAERS
170Drug level increasedFAERS: 1US FAERS
171DysuriaFAERS: 1SIDER
US FAERS
172EczemaFAERS: 1US FAERS
173EnteritisFAERS: 1US FAERS
174Enterococcal infectionFAERS: 1OFFSIDES
US FAERS
175Erythema marginatumFAERS: 1US FAERS
176Escherichia infectionFAERS: 1OFFSIDES
US FAERS
177Exfoliative rashFAERS: 1OFFSIDES
US FAERS
178Expired drug administeredFAERS: 1US FAERS
179Febrile bone marrow aplasiaFAERS: 1US FAERS
180Fixed eruptionFAERS: 1US FAERS
181Gastric ulcerFAERS: 1US FAERS
182Haptoglobin DecreasedFAERS: 1US FAERS
183HeadacheFAERS: 1SIDER
US FAERS
184HepatotoxicityFAERS: 1US FAERS
185HypertransaminasaemiaFAERS: 1US FAERS
186HyperventilationFAERS: 1US FAERS
187HypoxiaFAERS: 1OFFSIDES
US FAERS
188ImmunosuppressionFAERS: 1US FAERS
189Impaired work abilityFAERS: 1US FAERS
190Incorrect product storageFAERS: 1US FAERS
191InflammationFAERS: 110381210CTD
SIDER
US FAERS
192Inflammatory marker increasedFAERS: 1US FAERS
193Infusion Site ExtravasationFAERS: 1US FAERS
194Joint swellingFAERS: 1US FAERS
195Large intestinal stenosisFAERS: 1US FAERS
196LethargyFAERS: 1US FAERS
197Limb injuryFAERS: 1US FAERS
198Lip swellingFAERS: 1US FAERS
199MaculeFAERS: 1US FAERS
200Maternal exposure during pregnancyFAERS: 1US FAERS
201Mechanical ventilationFAERS: 1US FAERS
202Medication tamperingFAERS: 1US FAERS
203Memory impairmentFAERS: 1US FAERS
204Multiple MyelomaFAERS: 1US FAERS
205Muscle RigidityFAERS: 1US FAERS
206MyalgiaFAERS: 1US FAERS
207MyoclonusFAERS: 1US FAERS
208Nerve injuryFAERS: 1US FAERS
209Neutropenic colitisFAERS: 1US FAERS
210Night sweatsFAERS: 1US FAERS
211NoduleFAERS: 1US FAERS
212NystagmusFAERS: 1US FAERS
213Ocular icterusFAERS: 1US FAERS
214Oral painFAERS: 1US FAERS
215Oro-pharyngeal aspergillosisFAERS: 1US FAERS
216OsteomyelitisFAERS: 1US FAERS
217Ovarian vein thrombosisFAERS: 1US FAERS
218Pancreatic CystFAERS: 1US FAERS
219Peptic UlcerFAERS: 1US FAERS
220Pericardial effusionFAERS: 1OFFSIDES
US FAERS
221PlasmacytosisFAERS: 1US FAERS
222Platelet function test abnormalFAERS: 1US FAERS
223Pneumatosis intestinalisFAERS: 1US FAERS
224Post procedural complicationFAERS: 1US FAERS
225Postural Orthostatic Tachycardia SyndromeFAERS: 1US FAERS
226Protein total increasedFAERS: 1US FAERS
227Protein-losing gastroenteropathyFAERS: 1US FAERS
228Pseudomonal sepsisFAERS: 1US FAERS
229Psychiatric symptomFAERS: 1US FAERS
230Pulmonary arterial pressure increasedFAERS: 1US FAERS
231Pulmonary sepsisFAERS: 1US FAERS
232Raoultella ornithinolytica infectionFAERS: 1US FAERS
233Respiratory arrestFAERS: 1US FAERS
234RestlessnessFAERS: 1US FAERS
235Serum SicknessFAERS: 1US FAERS
236Skin lesionFAERS: 1US FAERS
237Skin necrosisFAERS: 1US FAERS
238Soft tissue necrosisFAERS: 1US FAERS
239SoliloquyFAERS: 1US FAERS
240SomnolenceFAERS: 1SIDER
US FAERS
241Staphylococcus test positiveFAERS: 1US FAERS
242Stevens-Johnson SyndromeFAERS: 125811541CTD
OFFSIDES
SIDER
US FAERS
243StuporFAERS: 1US FAERS
244Subgaleal haematomaFAERS: 1US FAERS
245SuperinfectionFAERS: 1US FAERS
246SwellingFAERS: 1US FAERS
247Systemic Inflammatory Response SyndromeFAERS: 1US FAERS
248Therapy changeFAERS: 1US FAERS
249Thrombosis in deviceFAERS: 1OFFSIDES
US FAERS
250ToxoplasmosisFAERS: 1US FAERS
251Trigeminal NeuralgiaFAERS: 1US FAERS
252Type III immune complex mediated reactionFAERS: 1US FAERS
253Unresponsive to stimuliFAERS: 1US FAERS
254Urine output increasedFAERS: 1US FAERS
255Uterine inflammationFAERS: 1US FAERS
256WheezingFAERS: 1US FAERS
257White blood cell count abnormalFAERS: 1US FAERS
258Wound sepsisFAERS: 1US FAERS
259Wrong technique in drug usage processFAERS: 1US FAERS
260Abdominal AbscessOFFSIDES
261Abdominal InfectionOFFSIDES
262Abdominal sepsisOFFSIDES
263Abnormal visionOFFSIDES
264AcidosisOFFSIDES
265ActinomycosisOFFSIDES
266Acute Coronary SyndromeSIDER
267AdenomaOFFSIDES
268AnorexiaSIDER
269Anticonvulsant drug level below therapeuticOFFSIDES
270ApneaOFFSIDES
271Application site painSIDER
272Ascites infectionOFFSIDES
273AscitesOFFSIDES
274AspergillosisOFFSIDES
275Aspiration PneumoniaOFFSIDES
276AstheniaSIDER
277AtelectasisOFFSIDES
278Bacterial disease carrierOFFSIDES
279Band neutrophil percentage increasedOFFSIDES
280Biopsy liver abnormalOFFSIDES
281Blast cell count increasedOFFSIDES
282Blood albumin decreasedOFFSIDES
283Blood and lymphatic system disordersSIDER
284Blood beta-D-glucan increasedOFFSIDES
285Blood chloride decreasedOFFSIDES
286Blood cholinesterase decreasedOFFSIDES
287Blood osmolarity decreasedOFFSIDES
288Blood phosphorus increasedOFFSIDES
289Blood potassium decreasedOFFSIDES
290Blood sodium abnormalOFFSIDES
291Blood sodiumOFFSIDES
292Blood urea abnormalOFFSIDES
293Blood urine presentOFFSIDES
294Bone swellingOFFSIDES
295BradycardiaSIDER
296Bronchoalveolar LavageOFFSIDES
297BronchopneumoniaOFFSIDES
298Candidiasis12623318CTD
299Central Nervous System InfectionSIDER
300Cerebellar infarctionOFFSIDES
301CholangiolitisOFFSIDES
302Chronic left ventricular failureOFFSIDES
303Citrobacter infectionOFFSIDES
304Creatinine increasedSIDER
305Cross Infection15221158CTD
306CystOFFSIDES
307Depressed moodOFFSIDES
308DermatitisSIDER
309Diarrhea10381210CTD
OFFSIDES
310Diffuse Large B-Cell LymphomaOFFSIDES
311DyspepsiaSIDER
312Dyspnoea exacerbatedOFFSIDES
313Enlargement abdomenSIDER
314EnterocolitisOFFSIDES
315EpistaxisSIDER
316Erythema MultiformeSIDER
317Escherichia coli Infections20805395CTD
318Exanthema10381210CTD
319Eyelid margin crustingOFFSIDES
320Fibrin increasedOFFSIDES
321Fistula dischargeOFFSIDES
322FlatulenceSIDER
323Fluid overloadOFFSIDES
SIDER
324Fungus serology test positiveOFFSIDES
325Gastrointestinal PainSIDER
326Gastrointestinal hypomotilityOFFSIDES
327GlossitisSIDER
328Gram-Positive Bacterial Infections16584310CTD
329Granulocyte count decreasedOFFSIDES
330HiccoughOFFSIDES
331HypercapniaOFFSIDES
332HypokinesiaOFFSIDES
333IleusSIDER
334Infection in an immunocompromised hostOFFSIDES
335InfestationSIDER
336Injection Site ReactionCanada Vigilance: 1Canada Vigilance
SIDER
337Injection site inflammationSIDER
338Injection site painSIDER
339Instillation site painSIDER
340Intestinal ObstructionSIDER
341Kidney FailureOFFSIDES
342LeukocytosisSIDER
343Leukopenia neonatalOFFSIDES
344LipaseOFFSIDES
345Lung hyperinflationOFFSIDES
346Lung infection pseudomonalOFFSIDES
347Lymphangiosis carcinomatosaOFFSIDES
348Lymphocyte percentage decreasedOFFSIDES
349LymphomaOFFSIDES
350Lymphoplasmacytoid lymphoma/immunocytomaOFFSIDES
351Malignant neoplasm progressionOFFSIDES
352Meningitis, Bacterial7625802CTD
353Meningitis10381210CTD
354Metastatic NeoplasmOFFSIDES
355Monocyte percentage decreasedOFFSIDES
356Monocyte percentage increasedOFFSIDES
357Multiple sclerosis relapseOFFSIDES
358Muscle necrosisOFFSIDES
359Myocardial InfarctionSIDER
360NervousnessSIDER
361NeuropathySIDER
362Neutropenic sepsisOFFSIDES
363Nocardia Infections18498026CTD
364ObstructionOFFSIDES
365OligohydramniosOFFSIDES
366OliguriaOFFSIDES
367Oral candidiasisSIDER
368PCO2 decreasedOFFSIDES
369Pelvic PainSIDER
370Perirectal abscessOFFSIDES
371PeritonitisOFFSIDES
372PharyngitisSIDER
373Pharyngolaryngeal PainOFFSIDES
374PhlebitisCanada Vigilance: 1Canada Vigilance
OFFSIDES
SIDER
375PneumothoraxOFFSIDES
376PolyneuropathyOFFSIDES
377PolyuriaOFFSIDES
378Postoperative infectionOFFSIDES
379Protein total decreasedOFFSIDES
380Prothrombin time abnormalSIDER
381Pulmonary EmbolismSIDER
382Pulmonary congestionOFFSIDES
383Pulmonary function test decreasedOFFSIDES
384Pus in stoolOFFSIDES
385Renal abscessOFFSIDES
386Right atrial dilatationOFFSIDES
387Seizures

View details

1490893
7791026
7797443
10576583
15701769
16882111
 		CTD
388Skin UlcerSIDER
389Sputum culture positiveOFFSIDES
390Staphylococcal Infections20160048CTD
391Stem cell transplantOFFSIDES
392Stenotrophomonas sepsisOFFSIDES
393Sudden Cardiac DeathOFFSIDES
394SweatingSIDER
395SyncopeSIDER
396TensionSIDER
397ThrombophlebitisSIDER
398Tooth ExtractionOFFSIDES
399TracheobronchitisOFFSIDES
400Urinary IncontinenceSIDER
401Urinary tract infection fungalOFFSIDES
402Vulvovaginal mycotic infectionSIDER
403nervous system disorderSIDER
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