MetaADEDB 2.0 @ LMMD
Promethazine
(PWWVAXIEGOYWEE-UHFFFAOYSA-N)
Structure
SMILES
CN(C(CN1c2ccccc2Sc2c1cccc2)C)C
Type(s)
Approved; Investigational
ATC code(s)
D04AA10; R06AD02; R06AD52; V03AB05
Molecular Formula:
C17H20N2S
Molecular Weight:
284.419
Log P:
4.3044
Hydrogen Bond Acceptor:
2
Hydrogen Bond Donor:
0
TPSA:
31.78
CAS Number(s):
60-87-7; 38878-40-9
Synonym(s)
1.
Promethazine
2.
Proazamine
3.
Atosil
4.
Diphergan
5.
Diprazin
6.
Isopromethazine
7.
Phenargan
8.
Phenergan
9.
Phensedyl
10.
Pipolfen
11.
Pipolphen
12.
Promet
13.
Prometazin
14.
Promethazine Hydrochloride
15.
Prothazin
16.
Pyrethia
17.
Remsed
18.
Rumergan
19.
Hydrochloride, Promethazine
External Link(s)
MeSHD011398
PubChem Compound4927
BindingDB50017696
ChEBI8461
CHEMBLCHEMBL643
DrugBankDB01069
DrugCentral2286
IUPHAR/BPS Guide to PHARMACOLOGY7282
KEGGcpd:C07404
dr:D00494
Therapeutic Target DatabaseD0T2XU
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1AgitationFAERS: 21SIDER
US FAERS
2AnxietyFAERS: 18OFFSIDES
SIDER
US FAERS
3DizzinessFAERS: 15OFFSIDES
SIDER
US FAERS
4TremorFAERS: 15SIDER
US FAERS
5PainFAERS: 14OFFSIDES
SIDER
US FAERS
6DystoniaFAERS: 13

View details

3615241
7111060
12602712
16401869
17713320
18603743
 		CTD
US FAERS
7NauseaFAERS: 12OFFSIDES
US FAERS
8SomnolenceFAERS: 11SIDER
US FAERS
9Injection site painFAERS: 10US FAERS
10Mental status changesFAERS: 10OFFSIDES
US FAERS
11RestlessnessFAERS: 10US FAERS
12ErythemaFAERS: 9OFFSIDES
SIDER
US FAERS
13VomitingFAERS: 9US FAERS
14Drug ineffectiveFAERS: 8US FAERS
15DysarthriaFAERS: 8US FAERS
16Medication ErrorFAERS: 8US FAERS
17Unresponsive to stimuliFAERS: 8OFFSIDES
US FAERS
18AkathisiaFAERS: 7US FAERS
19Infusion site painFAERS: 7US FAERS
20NecrosisFAERS: 7SIDER
US FAERS
21Burning sensationFAERS: 6OFFSIDES
US FAERS
22Drug administration errorFAERS: 6US FAERS
23ExtravasationFAERS: 6SIDER
US FAERS
24Infusion site erythemaFAERS: 6US FAERS
25Neuroleptic Malignant SyndromeFAERS: 61485575
10548178		CTD
SIDER
US FAERS
26Accidental overdoseFAERS: 5US FAERS
27CyanosisFAERS: 5US FAERS
28GangreneFAERS: 5SIDER
US FAERS
29HeadacheFAERS: 55354796CTD
SIDER
US FAERS
30Infusion Site ExtravasationFAERS: 5US FAERS
31Pharmaceutical product complaintFAERS: 5OFFSIDES
US FAERS
32Poor feeding infantFAERS: 5US FAERS
33PruritusFAERS: 5SIDER
US FAERS
34SwellingFAERS: 5SIDER
US FAERS
35UrticariaFAERS: 5US FAERS
36Expired product administeredFAERS: 4US FAERS
37HypersensitivityFAERS: 416536907CTD
US FAERS
38HypotensionFAERS: 4SIDER
US FAERS
39Incorrect route of drug administrationFAERS: 4US FAERS
40Infusion site swellingFAERS: 4US FAERS
41Injection site extravasationFAERS: 4US FAERS
42Respiratory arrestFAERS: 4US FAERS
43Restless Legs SyndromeFAERS: 4US FAERS
44SyncopeFAERS: 4SIDER
US FAERS
45TachycardiaFAERS: 4SIDER
US FAERS
46Activities of daily living impairedFAERS: 3US FAERS
47AtaxiaFAERS: 3US FAERS
48DeliriumFAERS: 310548178CTD
SIDER
US FAERS
49Drug DependenceFAERS: 3US FAERS
50Feeling abnormalFAERS: 3OFFSIDES
SIDER
US FAERS
51Infusion site burningFAERS: 3US FAERS
52Infusion site reactionFAERS: 3US FAERS
53Injection Site ReactionFAERS: 3SIDER
US FAERS
54Injection site erythemaFAERS: 3US FAERS
55Injection site massFAERS: 3US FAERS
56Intentional product misuseFAERS: 3US FAERS
57Intentional self-injuryFAERS: 3US FAERS
58MalaiseFAERS: 3US FAERS
59Memory impairmentFAERS: 3US FAERS
60NervousnessFAERS: 3SIDER
US FAERS
61NystagmusFAERS: 3US FAERS
62OverdoseFAERS: 3OFFSIDES
US FAERS
63PhlebitisFAERS: 3SIDER
US FAERS
64PresyncopeFAERS: 3US FAERS
65Product substitution issueFAERS: 3US FAERS
66Skin necrosisFAERS: 3US FAERS
67ThrombosisFAERS: 3US FAERS
68Toxicity to various agentsFAERS: 3US FAERS
69Wrong patient received productFAERS: 3US FAERS
70Wrong technique in drug usage processFAERS: 3OFFSIDES
US FAERS
71Abdominal discomfortFAERS: 2OFFSIDES
US FAERS
72AstheniaFAERS: 2OFFSIDES
SIDER
US FAERS
73Blood creatine phosphokinase increasedFAERS: 2US FAERS
74Blood pressure immeasurableFAERS: 2US FAERS
75Cardiac ArrestFAERS: 2US FAERS
76CellulitisFAERS: 29921085CTD
OFFSIDES
US FAERS
77DehydrationFAERS: 2OFFSIDES
US FAERS
78Depressed moodFAERS: 2US FAERS
79Drug abuseFAERS: 2US FAERS
80Drug dispensing errorFAERS: 2US FAERS
81Drug exposure during pregnancyFAERS: 2US FAERS
82Drug screen positiveFAERS: 2OFFSIDES
US FAERS
83EcchymosisFAERS: 2US FAERS
84EncephalitisFAERS: 25018406CTD
US FAERS
85Feeling jitteryFAERS: 2US FAERS
86IncoherentFAERS: 2US FAERS
87Incorrect drug administration rateFAERS: 2US FAERS
88InflammationFAERS: 2US FAERS
89Infusion site phlebitisFAERS: 2US FAERS
90Injection site necrosisFAERS: 2US FAERS
91Injection site noduleFAERS: 2US FAERS
92Injury associated with deviceFAERS: 2US FAERS
93PallorFAERS: 2US FAERS
94Peripheral swellingFAERS: 2US FAERS
95PneumonitisFAERS: 2US FAERS
96Product storage errorFAERS: 2US FAERS
97Rash erythematousFAERS: 2US FAERS
98Respiratory distressFAERS: 2US FAERS
99Tardive DyskinesiaFAERS: 2SIDER
US FAERS
100Vascular Access ComplicationFAERS: 2US FAERS
101VasospasmFAERS: 2US FAERS
102Ventricular FibrillationFAERS: 2US FAERS
103AbasiaFAERS: 1US FAERS
104Abdominal PainFAERS: 1OFFSIDES
US FAERS
105Abnormal sleep-related eventFAERS: 1US FAERS
106Abnormal weight gainFAERS: 1US FAERS
107AbscessFAERS: 19921085CTD
SIDER
US FAERS
108Accidental drug intake by childFAERS: 1US FAERS
109Acute myocardial infarctionFAERS: 1US FAERS
110AkinesiaFAERS: 1US FAERS
111AmnesiaFAERS: 1US FAERS
112AngioedemaFAERS: 1US FAERS
113Anorectal discomfortFAERS: 1US FAERS
114Anoxic EncephalopathyFAERS: 1OFFSIDES
US FAERS
115AphasiaFAERS: 1US FAERS
116AphoniaFAERS: 1US FAERS
117Arterial thrombosisFAERS: 1US FAERS
118AsthenopiaFAERS: 1US FAERS
119Blood folate decreasedFAERS: 1US FAERS
120Blunted affectFAERS: 1US FAERS
121BradycardiaFAERS: 12028629
6963160		CTD
OFFSIDES
SIDER
US FAERS
122Brain DeathFAERS: 1OFFSIDES
US FAERS
123Brain stem syndromeFAERS: 1US FAERS
124Cardiac FlutterFAERS: 1US FAERS
125Cerebrovascular accidentFAERS: 1US FAERS
126Chemical injuryFAERS: 1US FAERS
127ChillsFAERS: 1US FAERS
128ChoreoathetosisFAERS: 1US FAERS
129Circumstance or information capable of leading to medication errorFAERS: 1US FAERS
130Cogwheel RigidityFAERS: 1US FAERS
131Coma scale abnormalFAERS: 1US FAERS
132Complications of maternal exposure to therapeutic drugsFAERS: 1US FAERS
133Concomitant disease aggravatedFAERS: 1US FAERS
134ConstipationFAERS: 1SIDER
US FAERS
135Conversion disorderFAERS: 1OFFSIDES
SIDER
US FAERS
136CryingFAERS: 1US FAERS
137Deep Vein ThrombosisFAERS: 1US FAERS
138DementiaFAERS: 1US FAERS
139DependenceFAERS: 1US FAERS
140DermatitisFAERS: 1SIDER
US FAERS
141Device breakageFAERS: 1US FAERS
142Device difficult to useFAERS: 1US FAERS
143DiscomfortFAERS: 1US FAERS
144DisorientationFAERS: 1SIDER
US FAERS
145Drug ToleranceFAERS: 1US FAERS
146Drug prescribing errorFAERS: 1US FAERS
147Drug screen false positiveFAERS: 1US FAERS
148Drug withdrawal syndromeFAERS: 1US FAERS
149Dry gangreneFAERS: 1US FAERS
150DysgeusiaFAERS: 1US FAERS
151DyspepsiaFAERS: 1OFFSIDES
SIDER
US FAERS
152DysuriaFAERS: 1OFFSIDES
US FAERS
153Electrocardiogram ST segment abnormalFAERS: 1OFFSIDES
US FAERS
154Electroencephalogram abnormalFAERS: 1US FAERS
155Electromechanical dissociationFAERS: 1US FAERS
156Emotional disorderFAERS: 1US FAERS
157Erythema MultiformeFAERS: 1US FAERS
158FatigueFAERS: 1OFFSIDES
SIDER
US FAERS
159Flat affectFAERS: 1US FAERS
160FlushingFAERS: 1US FAERS
161Grip strength decreasedFAERS: 1US FAERS
162Hallucinations, mixedFAERS: 1US FAERS
163HemiparesisFAERS: 1US FAERS
164Iatrogenic injuryFAERS: 1US FAERS
165Incorrect dose administeredFAERS: 1US FAERS
166Increased upper airway secretionFAERS: 1US FAERS
167InfarctionFAERS: 1US FAERS
168InfectionFAERS: 1US FAERS
169InfertilityFAERS: 1US FAERS
170Infusion site bruisingFAERS: 1US FAERS
171Infusion site inflammationFAERS: 1US FAERS
172Infusion site massFAERS: 1US FAERS
173Infusion site necrosisFAERS: 1US FAERS
174Initial insomniaFAERS: 1OFFSIDES
US FAERS
175Injected limb mobility decreasedFAERS: 1US FAERS
176Injection site abscessFAERS: 1US FAERS
177Injection site infectionFAERS: 1OFFSIDES
US FAERS
178Injection site injuryFAERS: 1OFFSIDES
US FAERS
179Injection site scarFAERS: 1US FAERS
180Injection site urticariaFAERS: 1US FAERS
181Intellectual DisabilityFAERS: 1US FAERS
182LacerationFAERS: 1US FAERS
183LeukocytosisFAERS: 110548178CTD
US FAERS
184Local reactionFAERS: 1US FAERS
185MacrocephalyFAERS: 1US FAERS
186Mixed liver injuryFAERS: 1US FAERS
187MonoplegiaFAERS: 1US FAERS
188Muscle RigidityFAERS: 1US FAERS
189Muscle necrosisFAERS: 1US FAERS
190Musculoskeletal stiffnessFAERS: 1US FAERS
191MutismFAERS: 1US FAERS
192MyalgiaFAERS: 1US FAERS
193MydriasisFAERS: 1US FAERS
194MyositisFAERS: 1US FAERS
195Neck PainFAERS: 1US FAERS
196NeuralgiaFAERS: 1US FAERS
197NeuropathyFAERS: 1US FAERS
198Nuchal RigidityFAERS: 1US FAERS
199Oculogyric crisisFAERS: 1SIDER
US FAERS
200Oxygen consumption decreasedFAERS: 1US FAERS
201PalpitationsFAERS: 1SIDER
US FAERS
202PneumoniaFAERS: 1US FAERS
203PosturingFAERS: 1US FAERS
204Product administered to patient of inappropriate ageFAERS: 1US FAERS
205Product administration errorFAERS: 1US FAERS
206Product dose omissionFAERS: 1US FAERS
207Product quality issueFAERS: 1US FAERS
208ProsopagnosiaFAERS: 1US FAERS
209Pulmonary EmbolismFAERS: 1US FAERS
210PurpuraFAERS: 1US FAERS
211PyelocaliectasisFAERS: 1US FAERS
212Respiratory DepressionFAERS: 1SIDER
US FAERS
213Senile dementiaFAERS: 1US FAERS
214SepsisFAERS: 1US FAERS
215Sinus TachycardiaFAERS: 1US FAERS
216Skin dystrophyFAERS: 1US FAERS
217StridorFAERS: 1US FAERS
218StuporFAERS: 12860211CTD
US FAERS
219Suicide attemptFAERS: 1US FAERS
220TensionFAERS: 1SIDER
US FAERS
221Therapy non-responderFAERS: 1US FAERS
222ThrombophlebitisFAERS: 1SIDER
US FAERS
223Tongue bitingFAERS: 1US FAERS
224Toxic Epidermal NecrolysisFAERS: 1US FAERS
225TrismusFAERS: 1US FAERS
226UlcerFAERS: 1US FAERS
227Unevaluable eventFAERS: 1OFFSIDES
US FAERS
228VasculitisFAERS: 1US FAERS
229Venous InjuryFAERS: 1US FAERS
230Venous ThrombosisFAERS: 1SIDER
US FAERS
231Venous occlusionFAERS: 1US FAERS
232Visual ImpairmentFAERS: 1US FAERS
233Weight decreasedFAERS: 1US FAERS
234WheezingFAERS: 1US FAERS
235Wrong product administeredFAERS: 1US FAERS
236Wrong technique in product usage processFAERS: 1US FAERS
237jaundiceFAERS: 1SIDER
US FAERS
238nervous system disorderFAERS: 1US FAERS
239Abdominal sepsisOFFSIDES
240AbuseOFFSIDES
241Acidosis10548178CTD
242Acute bronchitisOFFSIDES
243Acute kidney injury1485575
19814645		CTD
244Acute sinusitisOFFSIDES
245AgranulocytosisSIDER
246Alcohol abuseOFFSIDES
247AlveolitisOFFSIDES
248Amyotrophic Lateral Sclerosis17686041CTD
249Anaphylactic shockSIDER
250AngerOFFSIDES
251AnisocoriaOFFSIDES
252AnorexiaOFFSIDES
253Anticholinergic SyndromeOFFSIDES
254Anticonvulsant drug level below therapeuticOFFSIDES
255Apnea2028629CTD
OFFSIDES
256Arteriovenous fistula thrombosisOFFSIDES
257AsphyxiaOFFSIDES
258Aspiration PneumoniaOFFSIDES
259AsthmaOFFSIDES
SIDER
260Atrial tachycardiaOFFSIDES
261Autoimmune thrombocytopeniaOFFSIDES
262Azotemia10548178CTD
263Band neutrophil percentage increasedOFFSIDES
264Basal cell carcinomaOFFSIDES
265Biliary DyskinesiaOFFSIDES
266Bipolar Disorder2732745CTD
267Blood GlucoseOFFSIDES
268Blood chloride decreasedOFFSIDES
269Blood cholesterolOFFSIDES
270Blood creatinine increasedOFFSIDES
271Blood glucose decreasedOFFSIDES
272Blood prolactin increasedOFFSIDES
273Blood sodiumOFFSIDES
274Blurred visionOFFSIDES
275Body TemperatureOFFSIDES
276Bone lesionOFFSIDES
277Breast discomfortOFFSIDES
278BronchitisOFFSIDES
279BronchoscopyOFFSIDES
280Bullous lung diseaseOFFSIDES
281BunionOFFSIDES
282Cardiac asthmaOFFSIDES
283Cardioactive drug level increasedOFFSIDES
284Catalepsy1033567
7200248		CTD
285CatatoniaSIDER
286Catheter related complicationOFFSIDES
287Catheter related infectionOFFSIDES
288Caustic injuryOFFSIDES
289Cerebral AtherosclerosisOFFSIDES
290Cerebral artery stenosisOFFSIDES
291Cerebral atrophyOFFSIDES
292Chemical and Drug Induced Liver Injury26011634CTD
293Chest PainOFFSIDES
294Choking sensationOFFSIDES
295Cholecystitis infectiveOFFSIDES
296Chronic Obstructive Airway DiseaseOFFSIDES
297Chronic sinusitisOFFSIDES
298Clostridium difficile colitisOFFSIDES
299Cognition Disorders15451046CTD
300Contact DermatitisOFFSIDES
301Cubital Tunnel SyndromeOFFSIDES
302CystoceleOFFSIDES
303DeafnessOFFSIDES
304DemyelinationOFFSIDES
305DiabetesOFFSIDES
306Diabetes mellitus inadequate controlOFFSIDES
307Diabetic RetinopathyOFFSIDES
308DiarrheaOFFSIDES
309DiplopiaSIDER
310Disorders of Excessive Somnolence8839521CTD
311DrowsinessSIDER
312Drug dose omissionOFFSIDES
313Drug withdrawal convulsionsOFFSIDES
314Drug withdrawal headacheOFFSIDES
315DysgraphiaOFFSIDES
316Dyskinesia, Drug-Induced15999955CTD
317Economic problemOFFSIDES
318Edema19703484
27474066		CTD
319Ejection Fraction DecreasedOFFSIDES
320Emotional distressOFFSIDES
321EnterocolitisOFFSIDES
322Epigastric distressSIDER
323Euphoric moodSIDER
324Extremity necrosisOFFSIDES
325Eye painOFFSIDES
326Fatty LiverOFFSIDES
327Febrile NeutropeniaOFFSIDES
328Feeling ColdOFFSIDES
329Fetal Distress6963160CTD
330Fever2919514
10548178		CTD
331FibromyalgiaOFFSIDES
332FlatulenceOFFSIDES
333Fluid overloadOFFSIDES
334Gastric DilatationOFFSIDES
335GastroenteritisOFFSIDES
336GranulocytosisOFFSIDES
337GranulomaOFFSIDES
338Hallucinations2919514
3343203
14709767		CTD
339Heparin-induced thrombocytopeniaOFFSIDES
340Hepatobiliary scanOFFSIDES
341Hepatomegaly26011634
26558467
28108177		CTD
342Hyperalgesia12727271
15265675
30261224		CTD
343Hyperkalemia10548178CTD
344Hypernatremia10548178CTD
345Hypertrophy26558467CTD
346Hypocalcemia10548178CTD
347HypoxiaOFFSIDES
348HysteriaSIDER
349Impaired gastric emptyingOFFSIDES
350Injection site phlebitisSIDER
351Intervertebral Disc DegenerationOFFSIDES
352Joint sprainOFFSIDES
353Kidney FailureOFFSIDES
354LassitudeSIDER
355LeukoencephalopathyOFFSIDES
356LeukopeniaSIDER
357Lip erosionOFFSIDES
358LipaseOFFSIDES
359Long QT SyndromeOFFSIDES
360Maxillofacial operationOFFSIDES
361Metabolic acidosisOFFSIDES
362Motion Sickness1613127
18770049		CTD
363Mucosal erosionOFFSIDES
364Multiple drug overdose intentionalOFFSIDES
365Muscle Hypertonia6963160CTD
366Muscle WeaknessOFFSIDES
367Musculoskeletal PainOFFSIDES
368Musculoskeletal chest painOFFSIDES
369Myoclonus2860211CTD
370Myoglobinuria10548178CTD
371NasopharyngitisOFFSIDES
372Nephritic syndromeOFFSIDES
373Nephritis, Interstitial19814645CTD
374Nerve injurySIDER
375Nervous tensionOFFSIDES
376NocturiaOFFSIDES
377Non-cardiac chest painOFFSIDES
378Oral fungal infectionOFFSIDES
379OsteosclerosisOFFSIDES
380Otitis Media12602712CTD
381PancreaticoduodenectomyOFFSIDES
382PancreatitisOFFSIDES
383Paresis9921085CTD
384Pelvic prolapseOFFSIDES
385Pericardial effusionOFFSIDES
386Peripheral embolismOFFSIDES
387Pharyngitis12602712CTD
388PiloerectionOFFSIDES
389Pleural decorticationOFFSIDES
390PolyneuropathyOFFSIDES
391Post procedural infectionOFFSIDES
392Postoperative Complications717770CTD
393Postoperative Nausea and Vomiting15721732CTD
394Procedural complicationOFFSIDES
395Progesterone increasedOFFSIDES
396Psychoses, Substance-Induced14709767CTD
397Pulmonary HypertensionOFFSIDES
398Pulmonary congestionOFFSIDES
399Pulmonary function test decreasedSIDER
400Pustular psoriasisOFFSIDES
401Renal lipomatosisOFFSIDES
402Renal tubular acidosisOFFSIDES
403Renal tubular necrosisOFFSIDES
404Respiratory FailureOFFSIDES
405Respiratory Insufficiency283080CTD
406Rheumatic FeverOFFSIDES
407RhonchiOFFSIDES
408Schizophrenia1485575CTD
409Seizures6020981
11526976		CTD
410Septic ShockOFFSIDES
411ShockSIDER
412SinusitisOFFSIDES
413Sleep Apnea Syndromes89428
11422220		CTD
414Sleep Apnea, Central3991270CTD
415Sleep Apnea, Obstructive3991270CTD
416SpondylolisthesisOFFSIDES
417Stevens-Johnson SyndromeOFFSIDES
418Substance Abuse, Intravenous12432208CTD
419Substance Withdrawal Syndrome11526976CTD
420Sudden Cardiac DeathOFFSIDES
421Tachycardia, Ventricular8256055CTD
422ThrombocytopeniaSIDER
423Thrombocytopenic purpuraSIDER
424TinnitusSIDER
425TonsillitisOFFSIDES
426Torsades de Pointes8256055CTD
427TorticollisSIDER
428Tracheal fistulaOFFSIDES
429Urinary RetentionSIDER
430Urinary hesitationSIDER
431Urinary tract infection enterococcalOFFSIDES
432Vaginal ProlapseOFFSIDES
433Venous InsufficiencyOFFSIDES
434Visual disturbanceOFFSIDES
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