MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

amprenavir

(YMARZQAQMVYCKC-OEMFJLHTSA-N)

Structure

SMILES: CC(CN(S(=O)(=O)c1ccc(cc1)N)C[C@H]([C@H](Cc1ccccc1)NC(=O)O[C@H]1CCOC1)O)C
Type(s): Approved; Investigational
ATC code(s): J05AE05
Molecular Formula:: C25H35N3O6S
Molecular Weight:: 505.627
Log P:: 4.4557
Hydrogen Bond Acceptor:: 9
Hydrogen Bond Donor:: 3
TPSA:: 139.57
CAS Number(s):: 161814-49-9

Synonym(s)

amprenavir

141W94

Agenerase

VX 478

VX-478

Vertex VX478

tetrahydro-3-furyl N-(3-(4-amino-N-isobutylbenzenesulfonamido)-1-benzyl-2-hydroxypropyl)carbamate

External Link(s)

MeSH	C095108
PubChem Compound	65016
BindingDB	50215393 577
ChEBI	40050
CHEMBL	CHEMBL116
DrugBank	DB00701
DrugCentral	200
KEGG	cpd:C08086 dr:D00894
Therapeutic Target Database	D0A0OO
ZINC	3809192

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Blood cholesterol increased	FAERS: 1		US FAERS
2	Blood triglycerides increased	FAERS: 1		OFFSIDES SIDER US FAERS
3	Pharmaceutical product complaint	FAERS: 1		US FAERS
4	Abdominal Pain			SIDER
5	Abdominal discomfort			OFFSIDES SIDER
6	Abdominal symptom			SIDER
7	Acanthosis			OFFSIDES
8	Acidosis			OFFSIDES
9	Acquired Protein S Deficiency			OFFSIDES
10	Acute Coronary Syndrome			SIDER
11	Acute myocardial infarction			OFFSIDES
12	Adenitis			OFFSIDES
13	Alanine Aminotransferase Increased			SIDER
14	Amylase increased			SIDER
15	Angioedema			SIDER
16	Anogenital dysplasia			OFFSIDES
17	Anorexia			SIDER
18	Anxiety			OFFSIDES
19	Apathy			OFFSIDES
20	Arteriogram coronary abnormal			OFFSIDES
21	Arthropathy			OFFSIDES
22	Aspartate Aminotransferase Increased			SIDER
23	Aspiration Pneumonia			OFFSIDES
24	Asthenia			SIDER
25	Atrial tachycardia			OFFSIDES
26	Bacteria stool identified			OFFSIDES
27	Bipolar I disorder			OFFSIDES
28	Blepharoptosis			OFFSIDES
29	Blood Glucose			OFFSIDES
30	Blood HIV RNA			OFFSIDES
31	Blood alkaline phosphatase increased			OFFSIDES
32	Blood amylase increased			OFFSIDES
33	Blood cholesterol			OFFSIDES
34	Blood creatine phosphokinase increased			OFFSIDES SIDER
35	Blood parathyroid hormone increased			OFFSIDES
36	Brain natriuretic peptide increased			OFFSIDES
37	Bronchiectasis			OFFSIDES
38	Buffalo hump			SIDER
39	CD4 lymphocytes increased			OFFSIDES
40	Cardiac Tamponade			OFFSIDES
41	Chest Pain			OFFSIDES
42	Circumstance or information capable of leading to medication error			OFFSIDES
43	Coagulation factor VII level increased			OFFSIDES
44	Coagulation factor VIII level increased			OFFSIDES
45	Creatine Phosphokinase Increased			SIDER
46	Cyst			OFFSIDES
47	Demyelination			OFFSIDES
48	Depressive disorder			SIDER
49	Dermatitis			SIDER
50	Diabetes			OFFSIDES
51	Diabetes Mellitus			SIDER
52	Diarrhea			OFFSIDES
53	Discomfort			SIDER
54	Disease recurrence			OFFSIDES
55	Drug administration error			OFFSIDES
56	Drug ineffective			OFFSIDES
57	Drug resistance			OFFSIDES
58	Drug withdrawal headache			OFFSIDES
59	Dry skin			OFFSIDES
60	Dyspeptic signs and symptoms			SIDER
61	Dysthymic Disorder			SIDER
62	Epistaxis			OFFSIDES
63	Erythema Multiforme			SIDER
64	Eye pain			OFFSIDES
65	Facial wasting			OFFSIDES
66	Fat redistribution			OFFSIDES SIDER
67	Fatigue			OFFSIDES SIDER
68	Fatty Liver			OFFSIDES
69	Flatulence			SIDER
70	Gamma-Glutamyltransferase Increased			OFFSIDES
71	Gastrointestinal Pain			SIDER
72	HIV Infections		11365545 16639341 20660842	CTD
73	HIV Wasting Syndrome			OFFSIDES
74	Headache			SIDER
75	Hepatitis B			SIDER
76	Hydronephrosis		18771058	CTD
77	Hypercapnia			OFFSIDES
78	Hypertrophy of Breast			SIDER
79	Hypoxia			OFFSIDES
80	Immunosuppression			OFFSIDES
81	Impetigo			OFFSIDES
82	Incontinence			OFFSIDES
83	Inflammation			SIDER
84	Injection site burning			OFFSIDES
85	Injection site erythema			OFFSIDES
86	Injection site irritation			OFFSIDES
87	Injection site mass			OFFSIDES
88	Injection site pruritus			OFFSIDES
89	Insulin Resistance			SIDER
90	Intraocular inflammation			OFFSIDES
91	Kidney Calculi		18771058	CTD
92	Leukoencephalopathy			OFFSIDES
93	Leukopenia neonatal			OFFSIDES
94	Lip erosion			OFFSIDES
95	Lipase			OFFSIDES
96	Lipodystrophy acquired			OFFSIDES SIDER
97	Lipodystrophy			SIDER
98	Lipohypertrophy			OFFSIDES SIDER
99	Lymphoma			OFFSIDES
100	Macrocytosis			OFFSIDES
101	Malabsorption from injection site			OFFSIDES
102	Malnutrition			SIDER
103	Mastoiditis			OFFSIDES
104	Mental status changes			OFFSIDES
105	Metastases to adrenals			OFFSIDES
106	Mononeuritis			OFFSIDES
107	Multiple allergies			OFFSIDES
108	Muscle Weakness			OFFSIDES
109	Muscle necrosis			OFFSIDES
110	Musculoskeletal discomfort			SIDER
111	Myalgia			SIDER
112	Myocardial Infarction		20660842	CTD SIDER
113	Myositis			SIDER
114	Nasopharyngitis			OFFSIDES
115	Nausea			OFFSIDES SIDER
116	Nephrolithiasis			SIDER
117	Neutropenia			SIDER
118	No adverse effect			OFFSIDES
119	Nodule			OFFSIDES
120	Nystagmus			OFFSIDES
121	Obstruction			OFFSIDES
122	Ophthalmoplegia			OFFSIDES
123	Overweight			OFFSIDES
124	Performance status decreased			OFFSIDES
125	Perioral paraesthesia			SIDER
126	Polyuria			OFFSIDES
127	Portal Vein Thrombosis			OFFSIDES
128	Protein total decreased			OFFSIDES
129	Pruritus			SIDER
130	Pseudomonal sepsis			OFFSIDES
131	Quadriparesis			OFFSIDES
132	Renal tubular disorder			OFFSIDES
133	Renal tubular necrosis			OFFSIDES
134	Rhabdomyolysis			SIDER
135	Rhinitis			OFFSIDES
136	Scleroderma			OFFSIDES
137	Sense of oppression			OFFSIDES
138	Sick Sinus Syndrome			OFFSIDES
139	Sinusitis			OFFSIDES
140	Stevens-Johnson Syndrome		25811541	CTD SIDER
141	Taste Disorders			SIDER
142	Transaminases increased			SIDER
143	Tremor			SIDER
144	Viral load decreased			OFFSIDES
145	Viral mutation identified			OFFSIDES
146	Visual tracking test abnormal			OFFSIDES
147	Vomiting			SIDER
148	Von Willebrand's factor multimers abnormal			OFFSIDES
149	nervous system disorder			SIDER

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120239