MetaADEDB 2.0 @ LMMD
Tigecycline
(SOVUOXKZCCAWOJ-HJYUBDRYSA-N)
Structure
SMILES
O=C(Nc1cc(N(C)C)c2c(c1O)C(=C1[C@@H](C2)C[C@@H]2[C@@](C1=O)(O)C(=C(C(=O)[C@H]2N(C)C)C(=O)N)O)O)CNC(C)(C)C
Type(s)
Approved
ATC code(s)
J01AA12; J01AA20
Molecular Formula:
C29H39N5O8
Molecular Weight:
585.649
Log P:
1.5208
Hydrogen Bond Acceptor:
13
Hydrogen Bond Donor:
7
TPSA:
205.76
CAS Number(s):
220620-09-7; 1229002-07-6
Synonym(s)
1.
Tigecycline
2.
9-(tert-Butylglycylamido)minocycline
3.
GAR 936
4.
GAR-936
5.
TBG-MINO
6.
Tygacil
7.
GAR936
External Link(s)
MeSHD000078304
PubChem Compound54686904
BindingDB50247905
ChEBI149836
CHEMBLCHEMBL376140
DrugBankDB00560
DrugCentral2661
KEGGcpd:C12012
dr:D01079
Therapeutic Target DatabaseD0G4OD
ZINC14879972
102200515
100022633
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1PancreatitisFAERS: 67OFFSIDES
SIDER
US FAERS
2Drug ineffectiveFAERS: 60
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
3NauseaFAERS: 52OFFSIDES
SIDER
US FAERS
4VomitingFAERS: 23SIDER
US FAERS
5Pathogen resistanceFAERS: 22OFFSIDES
US FAERS
6SepsisFAERS: 22SIDER
US FAERS
7ThrombocytopeniaFAERS: 19SIDER
US FAERS
8Septic ShockFAERS: 16OFFSIDES
SIDER
US FAERS
9InfectionFAERS: 14SIDER
US FAERS
10Blood alkaline phosphatase increasedFAERS: 12OFFSIDES
SIDER
US FAERS
11CholestasisFAERS: 12SIDER
US FAERS
12HypersensitivityFAERS: 12
Canada Vigilance: 2		Canada Vigilance
SIDER
US FAERS
13jaundiceFAERS: 12SIDER
US FAERS
14Aspartate Aminotransferase IncreasedFAERS: 10
Canada Vigilance: 2		Canada Vigilance
SIDER
US FAERS
15HepatotoxicityFAERS: 10OFFSIDES
US FAERS
16Transaminases increasedFAERS: 10OFFSIDES
US FAERS
17Alanine Aminotransferase IncreasedFAERS: 9
Canada Vigilance: 2		Canada Vigilance
OFFSIDES
SIDER
US FAERS
18Blood urea increasedFAERS: 9SIDER
US FAERS
19Stevens-Johnson SyndromeFAERS: 825811541CTD
SIDER
US FAERS
20treatment failureFAERS: 8US FAERS
21Abdominal PainFAERS: 7SIDER
US FAERS
22AstheniaFAERS: 7SIDER
US FAERS
23Drug resistanceFAERS: 7US FAERS
24Enterococcal infectionFAERS: 7OFFSIDES
US FAERS
25FatigueFAERS: 7US FAERS
26HeadacheFAERS: 7SIDER
US FAERS
27LeukocytosisFAERS: 7SIDER
US FAERS
28Lipase increasedFAERS: 7US FAERS
29PruritusFAERS: 7SIDER
US FAERS
30Blood creatinine increasedFAERS: 6SIDER
US FAERS
31HypotensionFAERS: 6SIDER
US FAERS
32LeukopeniaFAERS: 6SIDER
US FAERS
33SuperinfectionFAERS: 6US FAERS
34White blood cell count decreasedFAERS: 6US FAERS
35Abdominal InfectionFAERS: 5US FAERS
36Abdominal discomfortFAERS: 5US FAERS
37Blood fibrinogen decreasedFAERS: 5US FAERS
38Chest PainFAERS: 5OFFSIDES
SIDER
US FAERS
39ErythemaFAERS: 5US FAERS
40Escherichia infectionFAERS: 5US FAERS
41Gamma-Glutamyltransferase IncreasedFAERS: 5OFFSIDES
US FAERS
42BronchospasmFAERS: 4US FAERS
43Cerebrovascular accidentFAERS: 4US FAERS
44Disseminated Intravascular CoagulationFAERS: 4US FAERS
45Drug ineffective for unapproved indicationFAERS: 4US FAERS
46ExtravasationFAERS: 4US FAERS
47Feeling abnormalFAERS: 4OFFSIDES
SIDER
US FAERS
48HepatitisFAERS: 4US FAERS
49Impaired work abilityFAERS: 4US FAERS
50Infusion Site ExtravasationFAERS: 4US FAERS
51MalaiseFAERS: 4SIDER
US FAERS
52NephrolithiasisFAERS: 4OFFSIDES
US FAERS
53NeutropeniaFAERS: 4SIDER
US FAERS
54PeritonitisFAERS: 4SIDER
US FAERS
55Respiratory FailureFAERS: 4OFFSIDES
US FAERS
56TachycardiaFAERS: 4SIDER
US FAERS
57Unresponsive to stimuliFAERS: 4US FAERS
58UrticariaFAERS: 4
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
59Anaphylactic shockFAERS: 3SIDER
US FAERS
60Blood amylase increasedFAERS: 3US FAERS
61Blood glucose decreasedFAERS: 3OFFSIDES
US FAERS
62Cardiac ArrestFAERS: 3US FAERS
63Carotid aneurysm ruptureFAERS: 3US FAERS
64Disease ProgressionFAERS: 3OFFSIDES
US FAERS
65DysgeusiaFAERS: 3SIDER
US FAERS
66Metabolic acidosisFAERS: 3OFFSIDES
US FAERS
67No adverse eventFAERS: 3US FAERS
68PancytopeniaFAERS: 3US FAERS
69Product use in unapproved indicationFAERS: 3US FAERS
70Product use issueFAERS: 3US FAERS
71Pulmonary EmbolismFAERS: 3US FAERS
72Weight decreasedFAERS: 3US FAERS
73Blood albumin decreasedFAERS: 2US FAERS
74Blood glucose increasedFAERS: 2US FAERS
75BradycardiaFAERS: 2SIDER
US FAERS
76Chest discomfortFAERS: 2US FAERS
77Clostridium difficile colitisFAERS: 2OFFSIDES
US FAERS
78Clostridium difficile infectionFAERS: 2US FAERS
79Coagulation factor XII level decreasedFAERS: 2US FAERS
80Creatinine renal clearance decreasedFAERS: 2SIDER
US FAERS
81DeafnessFAERS: 2US FAERS
82Device related infectionFAERS: 2OFFSIDES
US FAERS
83Diabetes InsipidusFAERS: 2US FAERS
84DizzinessFAERS: 2SIDER
US FAERS
85Drug prescribing errorFAERS: 2US FAERS
86Escherichia urinary tract infectionFAERS: 2US FAERS
87Feeling jitteryFAERS: 2US FAERS
88Guillain-Barre SyndromeFAERS: 2US FAERS
89HypoxiaFAERS: 2US FAERS
90IleusFAERS: 2US FAERS
91Incorrect dose administeredFAERS: 2US FAERS
92Injection site erythemaFAERS: 2US FAERS
93Intestinal PerforationFAERS: 2US FAERS
94Klebsiella sepsisFAERS: 2US FAERS
95Mental status changesFAERS: 2US FAERS
96Middle insomniaFAERS: 2US FAERS
97Mycobacterium abscessus InfectionFAERS: 2US FAERS
98Neutrophil count decreasedFAERS: 2US FAERS
99OverdoseFAERS: 2US FAERS
100Pharyngolaryngeal PainFAERS: 2US FAERS
101PneumoniaFAERS: 2SIDER
US FAERS
102QuadriparesisFAERS: 2US FAERS
103Rash erythematousFAERS: 2US FAERS
104Refusal of treatment by relativeFAERS: 2OFFSIDES
US FAERS
105RetchingFAERS: 2US FAERS
106RhabdomyolysisFAERS: 2US FAERS
107Skin lesionFAERS: 2US FAERS
108Skin reactionFAERS: 2US FAERS
109SomnolenceFAERS: 2SIDER
US FAERS
110Therapy non-responderFAERS: 2US FAERS
111ThrombosisFAERS: 2US FAERS
112TinnitusFAERS: 2US FAERS
113VasculitisFAERS: 2US FAERS
114Wound InfectionFAERS: 2OFFSIDES
SIDER
US FAERS
115Wound dehiscenceFAERS: 2US FAERS
116AbasiaFAERS: 1US FAERS
117Abdominal tendernessFAERS: 1US FAERS
118AbscessFAERS: 1SIDER
US FAERS
119Acquired porphyriaFAERS: 1OFFSIDES
US FAERS
120Activated partial thromboplastin time abnormalFAERS: 1US FAERS
121Activities of daily living impairedFAERS: 1US FAERS
122Alanine aminotransferase abnormalFAERS: 1US FAERS
123AlopeciaFAERS: 1US FAERS
124AmnesiaFAERS: 1US FAERS
125Amylase abnormalFAERS: 1US FAERS
126AngioedemaFAERS: 1US FAERS
127AngiokeratomaFAERS: 1US FAERS
128AnorexiaFAERS: 1SIDER
US FAERS
129Aspartate aminotransferase abnormalFAERS: 1US FAERS
130AtelectasisFAERS: 1OFFSIDES
US FAERS
131Atrial FibrillationFAERS: 1SIDER
US FAERS
132Back PainFAERS: 1SIDER
US FAERS
133Bacterial pericarditisFAERS: 1US FAERS
134Blood albumin abnormalFAERS: 1US FAERS
135Blood creatine phosphokinase abnormalFAERS: 1US FAERS
136Blood creatinine abnormalFAERS: 1US FAERS
137Blood electrolytes abnormalFAERS: 1US FAERS
138Blood lactate dehydrogenase increasedFAERS: 1
Canada Vigilance: 2		Canada Vigilance
SIDER
US FAERS
139Blood potassium increasedFAERS: 1US FAERS
140Blood sodium increasedFAERS: 1US FAERS
141Blood triglycerides decreasedFAERS: 1US FAERS
142Burning sensationFAERS: 1US FAERS
143CellulitisFAERS: 1OFFSIDES
US FAERS
144Cerebral disorderFAERS: 1US FAERS
145ChillsFAERS: 1SIDER
US FAERS
146CholecystitisFAERS: 1OFFSIDES
US FAERS
147CholelithiasisFAERS: 1US FAERS
148ChromaturiaFAERS: 1US FAERS
149Circumstance or information capable of leading to medication errorFAERS: 1US FAERS
150ColitisFAERS: 1US FAERS
151Concomitant disease aggravatedFAERS: 1US FAERS
152ConjunctivitisFAERS: 1US FAERS
153ConstipationFAERS: 1SIDER
US FAERS
154Creatinine renal clearance increasedFAERS: 1US FAERS
155Culture positiveFAERS: 1OFFSIDES
US FAERS
156DehydrationFAERS: 1OFFSIDES
US FAERS
157DeliriumFAERS: 1US FAERS
158Depressed Level of ConsciousnessFAERS: 1US FAERS
159DermatitisFAERS: 1SIDER
US FAERS
160DiplopiaFAERS: 1OFFSIDES
US FAERS
161Disease recurrenceFAERS: 1US FAERS
162DisorientationFAERS: 1US FAERS
163Drug dose omissionFAERS: 1US FAERS
164DysuriaFAERS: 1US FAERS
165EosinophiliaFAERS: 1SIDER
US FAERS
166Erythema MultiformeFAERS: 1SIDER
US FAERS
167ExsanguinationFAERS: 1US FAERS
168Extra dose administeredFAERS: 1US FAERS
169Eye irritationFAERS: 1US FAERS
170Febrile NeutropeniaFAERS: 1US FAERS
171Fibrin D dimer increasedFAERS: 1US FAERS
172Fluid overloadFAERS: 1US FAERS
173FlushingFAERS: 1US FAERS
174FolliculitisFAERS: 1US FAERS
175Gas GangreneFAERS: 1US FAERS
176Gastrointestinal PainFAERS: 1SIDER
US FAERS
177Gastrointestinal stoma complicationFAERS: 1US FAERS
178Gastrointestinal toxicityFAERS: 1US FAERS
179Haemorrhagic Necrotic PancreatitisFAERS: 1US FAERS
180Heparin-induced thrombocytopeniaFAERS: 1US FAERS
181Hepatic InfarctionFAERS: 1US FAERS
182Hepatorenal SyndromeFAERS: 1US FAERS
183HungerFAERS: 1US FAERS
184HyperpyrexiaFAERS: 1US FAERS
185HyperventilationFAERS: 1US FAERS
186Hypocoagulable stateFAERS: 1US FAERS
187Idiosyncratic drug reactionFAERS: 1US FAERS
188Incision site infectionFAERS: 1US FAERS
189Incorrect drug administration durationFAERS: 1US FAERS
190Infusion site painFAERS: 1US FAERS
191Infusion site rashFAERS: 1US FAERS
192Injection site extravasationFAERS: 1US FAERS
193Joint swellingFAERS: 1US FAERS
194LethargyFAERS: 1US FAERS
195Leukocytoclastic vasculitisFAERS: 1US FAERS
196Liver AbscessFAERS: 118495793CTD
US FAERS
197Lung AbscessFAERS: 1US FAERS
198MalabsorptionFAERS: 1US FAERS
199Medical device site joint erythemaFAERS: 1US FAERS
200Medication ErrorFAERS: 1US FAERS
201MetastasisFAERS: 1US FAERS
202Morganella infectionFAERS: 1US FAERS
203Multi-organ disorderFAERS: 1US FAERS
204Musculoskeletal PainFAERS: 1US FAERS
205Myocardial InfarctionFAERS: 1US FAERS
206MyoclonusFAERS: 1US FAERS
207MyoglobinaemiaFAERS: 1US FAERS
208MyopathyFAERS: 1US FAERS
209NasopharyngitisFAERS: 1US FAERS
210NeuralgiaFAERS: 1US FAERS
211Neurological decompensationFAERS: 1US FAERS
212Night sweatsFAERS: 1US FAERS
213Ocular icterusFAERS: 1US FAERS
214PainFAERS: 1SIDER
US FAERS
215PallorFAERS: 1US FAERS
216PalpitationsFAERS: 1SIDER
US FAERS
217Pancreatic enzymes increasedFAERS: 1US FAERS
218Pancreatic toxicityFAERS: 1US FAERS
219Panic DisorderFAERS: 1US FAERS
220ParanoiaFAERS: 1US FAERS
221Pharmaceutical product complaintFAERS: 1US FAERS
222PhotophobiaFAERS: 1US FAERS
223Physical product label issueFAERS: 1US FAERS
224Product barcode issueFAERS: 1US FAERS
225Product quality issueFAERS: 1US FAERS
226Protein total decreasedFAERS: 1OFFSIDES
US FAERS
227Prothrombin time abnormalFAERS: 1US FAERS
228PurulenceFAERS: 1US FAERS
229Renal tubular acidosisFAERS: 1OFFSIDES
US FAERS
230Renal tubular disorderFAERS: 1OFFSIDES
US FAERS
231RestlessnessFAERS: 1US FAERS
232ScreamingFAERS: 1US FAERS
233Sense of oppressionFAERS: 1US FAERS
234Skin graft detachmentFAERS: 1US FAERS
235Subacute hepatic failureFAERS: 1US FAERS
236Supraventricular tachycardiaFAERS: 1OFFSIDES
US FAERS
237SwellingFAERS: 1US FAERS
238Therapeutic response delayedFAERS: 1US FAERS
239Therapy cessationFAERS: 1US FAERS
240Thrombin-antithrombin III complex abnormalFAERS: 1US FAERS
241ThrombocytosisFAERS: 1SIDER
US FAERS
242Toxic Epidermal NecrolysisFAERS: 1US FAERS
243Toxicity to various agentsFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
244TremorFAERS: 1SIDER
US FAERS
245TrismusFAERS: 1US FAERS
246UlcerFAERS: 1US FAERS
247Urinary tract infection pseudomonalFAERS: 1US FAERS
248Urticarial vasculitisFAERS: 1US FAERS
249Uterine abscessFAERS: 1US FAERS
250Venous InjuryFAERS: 1US FAERS
251VertigoFAERS: 1SIDER
US FAERS
252WheezingFAERS: 1US FAERS
253White blood cell count abnormalFAERS: 1US FAERS
254Wound ComplicationFAERS: 1US FAERS
255Wound infection staphylococcalFAERS: 1US FAERS
256Wrong technique in drug usage processFAERS: 1US FAERS
257Abdominal AbscessOFFSIDES
258Abnormal visionSIDER
259AcidosisOFFSIDES
SIDER
260Acute graft versus host disease in intestineOFFSIDES
261AdenomaOFFSIDES
262AlveolitisOFFSIDES
263Amylase increasedSIDER
264Anaphylactoid ReactionSIDER
265AnhedoniaOFFSIDES
266Antibiotic level below therapeuticOFFSIDES
267Aortic RuptureOFFSIDES
268ArteriosclerosisOFFSIDES
269Basal cell carcinomaOFFSIDES
270Biliary dilatationOFFSIDES
271Blood and lymphatic system disordersSIDER
272Blood chloride decreasedOFFSIDES
273Blood creatine increasedOFFSIDES
274Blood creatine phosphokinase increasedSIDER
275Blurred visionOFFSIDES
276Brain natriuretic peptide increasedOFFSIDES
277BronchitisOFFSIDES
278Bronchoalveolar LavageOFFSIDES
279Catheter related infectionOFFSIDES
280Chemotherapeutic drug level increasedOFFSIDES
281CholangiolitisOFFSIDES
282Choroidal DetachmentOFFSIDES
283Chronic Obstructive Airway DiseaseOFFSIDES
284Compression fractureOFFSIDES
285Cor pulmonaleOFFSIDES
286Creatine Phosphokinase IncreasedSIDER
287Creatinine increasedSIDER
288DemyelinationOFFSIDES
289Dental prosthesis placementOFFSIDES
290Device malfunctionSIDER
291Diabetes MellitusSIDER
292Diabetic foot infectionSIDER
293DiarrheaOFFSIDES
294DiscomfortSIDER
295DyspepsiaSIDER
296EcchymosisSIDER
297EctropionOFFSIDES
298Ejection Fraction DecreasedOFFSIDES
299Electrocardiogram abnormalSIDER
300Endodontic procedureOFFSIDES
301Enterococcal sepsisOFFSIDES
302Eosinophilic myocarditisOFFSIDES
303Escherichia coli Infections20805395CTD
304Esophageal StenosisOFFSIDES
305FlatulenceSIDER
306GastrinomaOFFSIDES
307General physical health deteriorationOFFSIDES
308GlaucomaOFFSIDES
309GlobulinuriaOFFSIDES
310GlossitisSIDER
311GranulocytosisOFFSIDES
312Heart-lung transplant rejectionOFFSIDES
313HepatosplenomegalyOFFSIDES
314Histiocytosis haematophagicOFFSIDES
315Immunosuppressant drug levelOFFSIDES
316Increased bronchial secretionSIDER
317InfestationSIDER
318Infusion site irritationOFFSIDES
319Injection Site ReactionSIDER
320Injection site inflammationSIDER
321Injection site painSIDER
322Injection site phlebitisSIDER
323Keratitis siccaOFFSIDES
324Kidney FailureOFFSIDES
325Lactic dehydrogenase activity increasedSIDER
326LeukoencephalopathyOFFSIDES
327LeukorrheaSIDER
328Local reactionSIDER
329MalnutritionSIDER
330Musculoskeletal discomfortSIDER
331MyalgiaSIDER
332MyopiaOFFSIDES
333Nephritis allergicOFFSIDES
334Nerve Degeneration23200736CTD
335NervousnessSIDER
336Open reduction of fractureOFFSIDES
337Oral candidiasisSIDER
338Oral mucosal hypertrophyOFFSIDES
339OsteomyelitisOFFSIDES
SIDER
340OsteopeniaOFFSIDES
341OsteoporosisOFFSIDES
342PeriarthritisOFFSIDES
343PharyngitisSIDER
344PhlebitisSIDER
345PolyuriaSIDER
346Prolapse repairOFFSIDES
347Prothrombin level decreasedSIDER
348PrurigoSIDER
349Pseudomonal sepsisOFFSIDES
350Rectal ProlapseOFFSIDES
351Renal tubular necrosisOFFSIDES
352Right Ventricular DysfunctionOFFSIDES
353Serum urea increasedSIDER
354ShockSIDER
355Sinus TachycardiaSIDER
356Sinus bradycardiaSIDER
357Skin neoplasm excisionOFFSIDES
358Staphylococcal Infections18495793
18819981
20805395		CTD
359Stenotrophomonas infectionOFFSIDES
360SweatingSIDER
361SyncopeSIDER
362TendinitisOFFSIDES
363TensionSIDER
364ThrombophlebitisOFFSIDES
SIDER
365Tooth ExtractionOFFSIDES
366Tracheal StenosisOFFSIDES
367Traumatic liver injurySIDER
368Urinary tract infectionSIDER
369Urine output increasedSIDER
370Vaginal DischargeSIDER
371Vaginal cellulitisOFFSIDES
372Ventricular arrhythmiaSIDER
373Visual ImpairmentSIDER
374Vitreous DetachmentOFFSIDES
375Vulvovaginal mycotic infectionSIDER
376VulvovaginitisSIDER
377Wound infection fungalOFFSIDES
378nervous system disorderSIDER
379pseudomembranous colitisSIDER
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