MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Fludrocortisone

(AAXVEMMRQDVLJB-BULBTXNYSA-N)

Structure

SMILES: OCC(=O)[C@@]1(O)CC[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2CCC2=CC(=O)CC[C@]12C)F
Type(s): Approved; Investigational
ATC code(s): H02AA02; S01CA06; S02CA07; S03CA05
Molecular Formula:: C21H29FO5
Molecular Weight:: 380.450
Log P:: 1.8737
Hydrogen Bond Acceptor:: 5
Hydrogen Bond Donor:: 3
TPSA:: 94.83
CAS Number(s):: 127-31-1

Synonym(s)

Fludrocortisone

9-Fluorocortisol

9 alpha Fludrohydrocortisone

9 alpha-Fluoro-17-Hydroxycorticosterone

9 alpha-Fluorohydrocortisone

9-Fluoro-17-Hydroxycortisone

9-Fluorohydrocortisone

Astonin

Astonin Merck

10.

Astonin-H

11.

FCOL

12.

9 Fluoro 17 Hydroxycortisone

13.

9 Fluorocortisol

14.

9 Fluorohydrocortisone

15.

9 alpha Fluoro 17 Hydroxycorticosterone

16.

9 alpha Fluorohydrocortisone

17.

Astonin H

18.

Merck, Astonin

External Link(s)

MeSH	D005438
PubChem Compound	31378
ChEBI	50885
CHEMBL	CHEMBL1201388
DrugBank	DB00687
IUPHAR/BPS Guide to PHARMACOLOGY	2873
KEGG	dr:D07967 cpd:C07004
Therapeutic Target Database	D00EKN D0R7JT
ZINC	4097304

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Drug ineffective	FAERS: 4 Canada Vigilance: 1		Canada Vigilance US FAERS
2	Dizziness	FAERS: 3 Canada Vigilance: 1	8444823	CTD OFFSIDES Canada Vigilance US FAERS
3	Intestinal Obstruction	FAERS: 2		US FAERS
4	Pharmaceutical product complaint	FAERS: 2		OFFSIDES US FAERS
5	Adverse event	FAERS: 1		US FAERS
6	Asthenia	FAERS: 1		OFFSIDES SIDER US FAERS
7	Blindness	FAERS: 1		US FAERS
8	Blood potassium increased	FAERS: 1		OFFSIDES US FAERS
9	Blood sodium decreased	FAERS: 1		US FAERS
10	Breast tenderness	FAERS: 1		US FAERS
11	Circumstance or information capable of leading to medication error	FAERS: 1		US FAERS
12	Dark circles under eyes	FAERS: 1		US FAERS
13	Diplopia	FAERS: 1		US FAERS
14	Drug prescribing error	FAERS: 1		US FAERS
15	Dry skin	FAERS: 1		US FAERS
16	Hypersensitivity	FAERS: 1		SIDER US FAERS
17	Intentional product use issue	FAERS: 1		US FAERS
18	Malaise	FAERS: 1		US FAERS
19	Medication Error	FAERS: 1		US FAERS
20	Musculoskeletal Pain	FAERS: 1		US FAERS
21	Nausea	FAERS: 1 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
22	Overdose	FAERS: 1		US FAERS
23	Peripheral swelling	FAERS: 1		US FAERS
24	Pneumonia	FAERS: 1		US FAERS
25	Product use in unapproved indication	FAERS: 1		US FAERS
26	Pruritus	FAERS: 1		US FAERS
27	Unevaluable event	FAERS: 1		US FAERS
28	Vomiting	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
29	17-hydroxyprogesterone increased			OFFSIDES
30	Abasia			OFFSIDES
31	Abdominal Pain			OFFSIDES
32	Abdominal discomfort			OFFSIDES
33	Abscess			OFFSIDES
34	Abuse			OFFSIDES
35	Accidental overdose			OFFSIDES
36	Acid reflux			OFFSIDES
37	Actinomycosis			OFFSIDES
38	Activities of daily living impaired			OFFSIDES
39	Acute bronchitis			OFFSIDES
40	Acute respiratory failure			OFFSIDES
41	Addison Disease		9816363	CTD
42	Adrenocortical insufficiency chronic			OFFSIDES
43	Agnosia			OFFSIDES
44	Agraphia			OFFSIDES
45	Alcoholic Intoxication			OFFSIDES
46	Alkalosis		6622340	CTD
47	Alopecia Areata		4422330	CTD
48	Alveolitis			OFFSIDES
49	Amnesia, Transient Global		18349207	CTD
50	Amnesia			OFFSIDES
51	Amphetamines			OFFSIDES
52	Anal sphincter atony			OFFSIDES
53	Anaphylactic shock			SIDER
54	Anaphylactoid Reaction			SIDER
55	Aneurysm	Canada Vigilance: 1		Canada Vigilance
56	Angioplasty			OFFSIDES
57	Anhedonia			OFFSIDES
58	Anhidrosis			OFFSIDES
59	Animal bite			OFFSIDES
60	Ankle Fracture			OFFSIDES
61	Anorexia			OFFSIDES SIDER
62	Anosmia			OFFSIDES
63	Anti-thyroid antibody positive			OFFSIDES
64	Anxiety			OFFSIDES
65	Apathy			OFFSIDES
66	Apnea			OFFSIDES
67	Appendicitis			OFFSIDES
68	Arthralgia	Canada Vigilance: 1		Canada Vigilance
69	Arthropathy			OFFSIDES
70	Ascites			OFFSIDES
71	Aseptic Meningitis			OFFSIDES
72	Aseptic necrosis			SIDER
73	Aspiration Pneumonia			OFFSIDES
74	Asthma			OFFSIDES
75	Atelectasis			OFFSIDES
76	Athetosis			OFFSIDES
77	Atrial Flutter			OFFSIDES
78	Aura			OFFSIDES
79	Autoimmune hepatitis			OFFSIDES
80	Automatism			OFFSIDES
81	Autonomic neuropathy			OFFSIDES
82	Back disorder			OFFSIDES
83	Bacterial sepsis			OFFSIDES
84	Bacterial test positive			OFFSIDES
85	Benign Prostatic Hyperplasia			OFFSIDES
86	Beta 2 microglobulin increased			OFFSIDES
87	Biliary dilatation			OFFSIDES
88	Biopsy bone abnormal			OFFSIDES
89	Blastomycosis			OFFSIDES
90	Blepharospasm			OFFSIDES
91	Blood Glucose			OFFSIDES
92	Blood HIV RNA			OFFSIDES
93	Blood albumin decreased			OFFSIDES
94	Blood albumin increased			OFFSIDES
95	Blood alkaline phosphatase increased			OFFSIDES
96	Blood chloride increased			OFFSIDES
97	Blood cholesterol			OFFSIDES
98	Blood corticotrophin increased			OFFSIDES
99	Blood creatinine increased			OFFSIDES
100	Blood glucose decreased			OFFSIDES
101	Blood glucose fluctuation			OFFSIDES
102	Blood iron decreased			OFFSIDES
103	Blood magnesium decreased			OFFSIDES
104	Blood parathyroid hormone			OFFSIDES
105	Blood potassium decreased			OFFSIDES
106	Blood pressure fluctuation			OFFSIDES
107	Blood sodium			OFFSIDES
108	Blood testosterone decreased			OFFSIDES
109	Blood urea increased			OFFSIDES
110	Bone marrow depression			OFFSIDES
111	Bone pain			OFFSIDES
112	Bone scan abnormal			OFFSIDES
113	Brain natriuretic peptide increased			OFFSIDES
114	Bronchial secretion retention			OFFSIDES
115	Bronchitis			OFFSIDES
116	Brucellosis			OFFSIDES
117	Bursitis			OFFSIDES
118	Calciphylaxis			OFFSIDES
119	Carbohydrate tolerance decreased			SIDER
120	Cardiac Hypertrophy			OFFSIDES
121	Cardiac Tamponade			OFFSIDES
122	Cardiomegaly		449947	CTD SIDER
123	Cartilage injury			OFFSIDES
124	Cataract operation			OFFSIDES
125	Cataract			OFFSIDES SIDER
126	Catheter related infection			OFFSIDES
127	Catheter site infection			OFFSIDES
128	Cellulitis			OFFSIDES
129	Cerebral artery stenosis			OFFSIDES
130	Chest Pain			OFFSIDES
131	Chest discomfort	Canada Vigilance: 1		Canada Vigilance
132	Choking sensation			OFFSIDES
133	Chronic Fatigue Syndrome			OFFSIDES
134	Chronic Obstructive Airway Disease			OFFSIDES
135	Chronic sinusitis			OFFSIDES
136	Cirrhosis			OFFSIDES
137	Clostridium difficile colitis			OFFSIDES
138	Colon adenoma			OFFSIDES
139	Complications of bone marrow transplant			OFFSIDES
140	Concomitant disease progression			OFFSIDES
141	Confabulation			OFFSIDES
142	Congenital tracheomalacia			OFFSIDES
143	Congenital tricuspid valve incompetence			OFFSIDES
144	Contact Dermatitis			OFFSIDES
145	Creatinine renal clearance increased			OFFSIDES
146	Cutaneous hypersensitivity			SIDER
147	Cystocele			OFFSIDES
148	Cyst			OFFSIDES
149	Deafness			OFFSIDES
150	Debridement			OFFSIDES
151	Dehydration			OFFSIDES
152	Demyelination			OFFSIDES
153	Dental abscess			OFFSIDES
154	Dental alveolar anomaly			OFFSIDES
155	Dental caries			OFFSIDES
156	Dental examination			OFFSIDES
157	Dental prosthesis placement			OFFSIDES
158	Denture wearer			OFFSIDES
159	Depressive disorder		9014799	CTD
160	Dermatitis acneiform			SIDER
161	Device dislocation			OFFSIDES
162	Device related infection			OFFSIDES
163	Diabetes Insipidus			OFFSIDES
164	Diabetes Mellitus			SIDER
165	Diabetic Autonomic Neuropathy			OFFSIDES
166	Diabetic			SIDER
167	Diarrhea			OFFSIDES
168	Disease Progression			OFFSIDES
169	Disease recurrence			OFFSIDES
170	Disseminated Intravascular Coagulation			OFFSIDES
171	Distal intestinal obstruction syndrome			OFFSIDES
172	Diverticulum			OFFSIDES
173	Drowsiness			OFFSIDES
174	Drug withdrawal headache			OFFSIDES
175	Dysgeusia			SIDER
176	Dyspepsia			OFFSIDES
177	Dysthymic Disorder			OFFSIDES
178	Dysuria			OFFSIDES
179	Ecchymosis			SIDER
180	Economic problem			OFFSIDES
181	Edema		9014799	CTD
182	Ejection Fraction Decreased			OFFSIDES
183	Ejection fraction abnormal			OFFSIDES
184	Electrocardiogram poor R-wave progression			OFFSIDES
185	Endodontic procedure			OFFSIDES
186	Enteritis			OFFSIDES
187	Enterococcal infection			OFFSIDES
188	Erectile dysfunction			OFFSIDES
189	Erythema			OFFSIDES SIDER
190	Exophthalmos			SIDER
191	Extremity contracture			OFFSIDES
192	Extremity necrosis			OFFSIDES
193	Eye Infection			OFFSIDES
194	Failure to Thrive			OFFSIDES
195	Fanconi Syndrome			OFFSIDES
196	Fat necrosis			OFFSIDES
197	Fatigue			OFFSIDES
198	Fatty Liver			OFFSIDES
199	Femoral artery occlusion			OFFSIDES
200	Fistula repair			OFFSIDES
201	Fluid overload			OFFSIDES
202	Focal glomerulosclerosis			OFFSIDES
203	Food Poisoning			OFFSIDES
204	Formication			OFFSIDES
205	Fracture			SIDER
206	Gastric pH decreased			SIDER
207	Gastric ulcer			OFFSIDES
208	General physical health deterioration			OFFSIDES
209	Glaucoma			SIDER
210	Glycosuria			SIDER
211	Goiter			OFFSIDES
212	Granulocytosis			OFFSIDES
213	Headache			SIDER
214	Heart failure		8074919 9014799 9816363	CTD
215	Heparin-induced thrombocytopenia			OFFSIDES
216	Hepatitis C			OFFSIDES
217	Hepatitis			OFFSIDES
218	Hidradenitis			OFFSIDES
219	Hirsutism			SIDER
220	Hydropneumothorax			OFFSIDES
221	Hyperchlorhydria			SIDER
222	Hyperkalemia		3375885	CTD
223	Hyperosmolar state			OFFSIDES
224	Hyperparathyroidism			OFFSIDES
225	Hyperpigmentation			OFFSIDES
226	Hypertensive Retinopathy		449947	CTD
227	Hypokalemia		View details 496411 668870 4740571 9014799	CTD
228	Hyponatremia		19834406	CTD
229	Hypopituitarism			OFFSIDES
230	Hypotension, Orthostatic		View details 221881 321175 4740571 7989286 10369619 17901021	CTD
231	Hypotension		593126	CTD
232	Hypoxia			OFFSIDES
233	Iliac artery stenosis			OFFSIDES
234	Impetigo			OFFSIDES
235	Implantable defibrillator insertion			OFFSIDES
236	Incoherent			OFFSIDES
237	Increased bronchial secretion			OFFSIDES
238	Increased insulin requirement			SIDER
239	Induration			OFFSIDES
240	Infection			OFFSIDES SIDER
241	Infusion site mobility decreased			OFFSIDES
242	Intentional drug misuse			OFFSIDES
243	Intermittent Claudication			OFFSIDES
244	Intervertebral Disc Degeneration			OFFSIDES
245	Intraocular pressure test			OFFSIDES
246	Intussusception			OFFSIDES
247	Joint Range of Motion Decreased			OFFSIDES
248	Joint stiffness			OFFSIDES
249	Kidney Failure			OFFSIDES
250	Kidney Neoplasm			OFFSIDES
251	Left Ventricular Hypertrophy			OFFSIDES
252	Left atrial dilatation			OFFSIDES
253	Lethargy			OFFSIDES
254	Leukoaraiosis			OFFSIDES
255	Leukoencephalopathy			OFFSIDES
256	Limb discomfort			OFFSIDES
257	Limb injury			OFFSIDES
258	Limb operation			OFFSIDES
259	Lipoatrophy			SIDER
260	Livedo Reticularis			OFFSIDES
261	Liver transplant rejection			OFFSIDES
262	Locked-In Syndrome			OFFSIDES
263	Lung consolidation			OFFSIDES
264	Lupus Nephritis			OFFSIDES
265	Lymphocele			OFFSIDES
266	Lymphocyte count decreased			OFFSIDES
267	Macrocytosis			OFFSIDES
268	Malabsorption			OFFSIDES
269	Malignant Hypertension			OFFSIDES
270	Malocclusion			OFFSIDES
271	Maxillofacial operation			OFFSIDES
272	Measles			SIDER
273	Mechanical ventilation			OFFSIDES
274	Mental status changes			OFFSIDES
275	Metabolic acidosis			OFFSIDES
276	Metaplasia			OFFSIDES
277	Metastases to adrenals			OFFSIDES
278	Metastatic Renal Cell Carcinoma			OFFSIDES
279	Middle insomnia			OFFSIDES
280	Mitral valve sclerosis			OFFSIDES
281	Mood swings			SIDER
282	Multiple Myeloma			OFFSIDES
283	Multiple Sclerosis			OFFSIDES
284	Multiple sclerosis relapse			OFFSIDES
285	Muscle Weakness			OFFSIDES
286	Muscle tightness			OFFSIDES
287	Musculoskeletal chest pain			OFFSIDES
288	Musculoskeletal discomfort			SIDER
289	Musculoskeletal stiffness			OFFSIDES
290	Myalgia	Canada Vigilance: 1		Canada Vigilance SIDER
291	Myasthenia Gravis			OFFSIDES
292	Myelodysplasia			OFFSIDES
293	Myeloma recurrence			OFFSIDES
294	Myocardial Infarction	Canada Vigilance: 1		Canada Vigilance
295	Myopathy			SIDER
296	Myosclerosis			OFFSIDES
297	Nasal mucosal disorder			OFFSIDES
298	Nephrogenic Fibrosing Dermopathy			OFFSIDES
299	Nephrolithiasis			OFFSIDES
300	Neuralgia			OFFSIDES
301	Neurodermatitis			OFFSIDES
302	Nitrogen balance negative			SIDER
303	Ocular icterus			OFFSIDES
304	Open reduction of fracture			OFFSIDES
305	Optic Neuritis			OFFSIDES SIDER
306	Oral infection			OFFSIDES
307	Oral mucosal exfoliation			OFFSIDES
308	Oropharyngeal swelling			OFFSIDES
309	Orthosis user			OFFSIDES
310	Osteolysis			OFFSIDES
311	Osteomyelitis			OFFSIDES
312	Osteopenia			OFFSIDES
313	Osteoporosis			OFFSIDES SIDER
314	Osteoradionecrosis			OFFSIDES
315	Osteosclerosis			OFFSIDES
316	Pain of skin			OFFSIDES
317	Pain			OFFSIDES
318	Pancreatic Insufficiency			OFFSIDES
319	Pancreatic Pseudocyst			OFFSIDES
320	Pancreatitis			SIDER
321	Parkinson Disease		6497767	CTD
322	Parotitis			OFFSIDES
323	Partner stress			OFFSIDES
324	Pelvic abscess			OFFSIDES
325	Peptic Ulcer			SIDER
326	Peptostreptococcus infection			OFFSIDES
327	Percutaneous Coronary Intervention			OFFSIDES
328	Pericardial effusion			OFFSIDES
329	Pericarditis			OFFSIDES
330	Periodontal operation			OFFSIDES
331	Periodontitis			OFFSIDES
332	Peripheral arterial occlusive disease			OFFSIDES
333	Perirectal abscess			OFFSIDES
334	Petechiae			SIDER
335	Pneumocystis jiroveci pneumonia			OFFSIDES
336	Poor dental condition			OFFSIDES
337	Postural Orthostatic Tachycardia Syndrome		11198485	CTD
338	Primary sequestrum			OFFSIDES
339	Procedural hypertension			OFFSIDES
340	Proctitis			OFFSIDES
341	Product dispensing error	Canada Vigilance: 1		Canada Vigilance
342	Prostate cancer recurrent			OFFSIDES
343	Pulmonary Hypertension			OFFSIDES
344	Pulmonary congestion			OFFSIDES
345	Pulmonary function test decreased			OFFSIDES
346	Purpura			SIDER
347	Purulent discharge			OFFSIDES
348	Quadriplegia			OFFSIDES
349	Renal cyst			OFFSIDES
350	Renal mass			OFFSIDES
351	Renal tubular acidosis			OFFSIDES
352	Renal tubular disorder			OFFSIDES
353	Renin decreased			OFFSIDES
354	Residual urine			OFFSIDES
355	Respiratory Failure			OFFSIDES
356	Respiratory syncytial virus test positive			OFFSIDES
357	Retroperitoneal lymphadenopathy			OFFSIDES
358	Rhabdomyolysis			OFFSIDES
359	Rhonchi			OFFSIDES
360	Right atrial dilatation			OFFSIDES
361	Septic Shock			OFFSIDES
362	Severe Acute Respiratory Syndrome			OFFSIDES
363	Shy-Drager Syndrome		4740571	CTD
364	Sigmoiditis			OFFSIDES
365	Sinus bradycardia			OFFSIDES
366	Sinusitis			OFFSIDES
367	Skeletal injury			OFFSIDES
368	Skin Erosion			OFFSIDES
369	Skin Induration			OFFSIDES
370	Skin hypertrophy			OFFSIDES
371	Skin laceration			OFFSIDES
372	Skin test positive			OFFSIDES
373	Skin tightness			OFFSIDES
374	Sleep Talking			OFFSIDES
375	Soft Tissue Infection			OFFSIDES
376	Spinal fusion surgery			OFFSIDES
377	Spondylolysis			OFFSIDES
378	Stem cell transplant			OFFSIDES
379	Subcutaneous Abscess			OFFSIDES
380	Subileus			OFFSIDES
381	Supraventricular tachycardia			OFFSIDES
382	Syncope		2000273	CTD
383	Tardive Dyskinesia			OFFSIDES
384	Temporal Arteritis			OFFSIDES
385	Tendinitis			OFFSIDES
386	Tension Headache			OFFSIDES
387	Thrombectomy			OFFSIDES
388	Thrombophlebitis			SIDER
389	Thrombosis in device			OFFSIDES
390	Tinea Capitis			OFFSIDES
391	Tinnitus			OFFSIDES
392	Tooth Extraction			OFFSIDES
393	Tooth Loss			OFFSIDES
394	Transaminases increased			OFFSIDES
395	Trauma			SIDER
396	Troponin increased			OFFSIDES
397	Ulcer			SIDER
398	Upper respiratory tract inflammation			OFFSIDES
399	Urge Incontinence			OFFSIDES
400	Urinary tract infection enterococcal			OFFSIDES
401	Urticaria			SIDER
402	Uterine Polyp			OFFSIDES
403	Vascular insufficiency			OFFSIDES
404	Vascular purpura			SIDER
405	Venous thrombosis limb			OFFSIDES
406	Ventricular hypokinesia			OFFSIDES
407	Ventriculoperitoneal shunt malfunction			OFFSIDES
408	Vertebroplasty			OFFSIDES
409	Vertigo			SIDER
410	Vitritis			OFFSIDES
411	Walking aid user			OFFSIDES
412	Wound dehiscence			OFFSIDES
413	angiogram			OFFSIDES
414	effusion			OFFSIDES
415	furuncle			OFFSIDES
416	kyphosis			OFFSIDES

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