MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Estramustine

(FRPJXPJMRWBBIH-RBRWEJTLSA-N)

Structure

SMILES: ClCCN(C(=O)Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C)CCCl
Type(s): Approved; Investigational
ATC code(s): L01XX11
Molecular Formula:: C23H31Cl2NO3
Molecular Weight:: 440.403
Log P:: 5.1820
Hydrogen Bond Acceptor:: 4
Hydrogen Bond Donor:: 1
TPSA:: 49.77
CAS Number(s):: 2998-57-4

Synonym(s)

Estramustine

Estramustinphosphate

Emcyt

Estracyt

Estramustin Phosphate

Estramustine Phosphate Sodium

Leo-275

NSC-89199

Leo 275

10.

Leo275

11.

NSC 89199

12.

NSC89199

13.

Phosphate Sodium, Estramustine

14.

Phosphate, Estramustin

External Link(s)

MeSH	D004961
PubChem Compound	259331
BindingDB	50333646
ChEBI	4868
CHEMBL	CHEMBL1575
DrugBank	DB01196
DrugCentral	1065
IUPHAR/BPS Guide to PHARMACOLOGY	9076
KEGG	cpd:C11228 dr:D04066
Therapeutic Target Database	D03SRY
ZINC	4099032

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Deep Vein Thrombosis	FAERS: 2		US FAERS
2	Blood glucose abnormal	FAERS: 1		US FAERS
3	Dehydration	FAERS: 1		US FAERS
4	Nausea	FAERS: 1	6377283 9949296 11844837	CTD OFFSIDES SIDER US FAERS
5	Vomiting	FAERS: 1	6377283 9949296 11844837	CTD SIDER US FAERS
6	Abdominal Infection			OFFSIDES
7	Abdominal Pain			OFFSIDES
8	Abdominal discomfort			OFFSIDES SIDER
9	Abscess			OFFSIDES
10	Acute Coronary Syndrome			SIDER
11	Acute respiratory failure			OFFSIDES
12	Agraphia			OFFSIDES
13	Alopecia		17846704	CTD OFFSIDES SIDER
14	Amnesia			OFFSIDES
15	Anemia		9256895 9949296 17846704	CTD
16	Angioedema		9218739	CTD SIDER
17	Anhedonia			OFFSIDES
18	Anorexia			OFFSIDES SIDER
19	Anxiety			OFFSIDES SIDER
20	Aphthous Stomatitis			OFFSIDES
21	Asthenia			OFFSIDES
22	Benign neoplasm of bladder			OFFSIDES
23	Biopsy site unspecified abnormal			OFFSIDES
24	Blood Glucose			OFFSIDES
25	Blood chloride decreased			OFFSIDES
26	Blood sodium			OFFSIDES
27	Bone Marrow Diseases		866798	CTD
28	Bone marrow depression			OFFSIDES
29	Bone pain			OFFSIDES
30	Bowel movement irregularity			OFFSIDES
31	Brain Ischemia		3529368	CTD
32	Bronchiectasis			OFFSIDES
33	Bronchitis			OFFSIDES
34	Calcinosis			OFFSIDES
35	Cardiac Arrest			SIDER
36	Cardiovascular Diseases		2935644 7317753	CTD
37	Cataract operation			OFFSIDES
38	Cataract			OFFSIDES
39	Cellulitis			OFFSIDES
40	Cerebral atrophy			OFFSIDES
41	Cerebrovascular accident			SIDER
42	Cervicobrachial syndrome			OFFSIDES
43	Chemical and Drug Induced Liver Injury		9949296 17846704	CTD
44	Chest Pain			OFFSIDES SIDER
45	Choking sensation			OFFSIDES
46	Clostridium difficile colitis			OFFSIDES
47	Colitis			OFFSIDES
48	Cor pulmonale			OFFSIDES
49	Cramps of lower extremities			SIDER
50	Culture positive			OFFSIDES
51	Cyst removal			OFFSIDES
52	Cyst			OFFSIDES
53	Dacryostenosis acquired			OFFSIDES
54	Debridement			OFFSIDES
55	Demyelination			OFFSIDES
56	Dental Fistula			OFFSIDES
57	Dental abscess			OFFSIDES
58	Dental caries			OFFSIDES
59	Dental prosthesis placement			OFFSIDES
60	Dermatitis			SIDER
61	Diarrhea			OFFSIDES
62	Disseminated Intravascular Coagulation			OFFSIDES
63	Disturbance in sexual arousal			SIDER
64	Diuresis			SIDER
65	Diverticulum			OFFSIDES
66	Drowsiness			OFFSIDES
67	Drug prescribing error			OFFSIDES
68	Dry skin			SIDER
69	Dyspepsia			SIDER
70	Dysphonia			SIDER
71	Dysuria			OFFSIDES
72	Edema		2935644	CTD
73	Embolism			SIDER
74	Encephalomalacia			OFFSIDES
75	Enterocolitis			OFFSIDES
76	Epistaxis			OFFSIDES
77	Erectile dysfunction		9949296	CTD OFFSIDES SIDER
78	Eye pain			SIDER
79	Failure to Thrive			OFFSIDES
80	Fatigue		11844837 17846704	CTD OFFSIDES
81	Febrile Neutropenia			OFFSIDES
82	Feeling abnormal			SIDER
83	Flatulence			SIDER
84	Fluid overload			OFFSIDES
85	Flushing			SIDER
86	Formication			OFFSIDES
87	Gastrointestinal Diseases		866798 3525866	CTD
88	General physical health deterioration			OFFSIDES
89	Gingival erythema			OFFSIDES
90	Gliosis			OFFSIDES
91	Headache			SIDER
92	Heart Diseases		6938012	CTD
93	Heart failure		3529368	CTD
94	Heat Exhaustion			OFFSIDES
95	Hemolytic-Uremic Syndrome		9949296	CTD
96	Hoarseness			SIDER
97	Hydronephrosis			OFFSIDES
98	Hypercalcemia		9949296	CTD
99	Hypertensive angiopathy			OFFSIDES
100	Hypocalcemia		17846704	CTD
101	Hypogeusia			OFFSIDES
102	Hypophagia			OFFSIDES
103	Hypotension		11844837	CTD
104	Increased tendency to bruise			SIDER
105	Infection			OFFSIDES
106	Lacrimation			SIDER
107	Lethargy			SIDER
108	Leukoencephalopathy			OFFSIDES
109	Leukopenia neonatal			OFFSIDES
110	Leukopenia		9218739	CTD SIDER
111	Limb injury			OFFSIDES
112	Liver diseases		866798 11844837	CTD
113	Loose tooth			OFFSIDES
114	Markedly reduced dietary intake			OFFSIDES
115	Mental impairment			OFFSIDES
116	Metabolic acidosis			OFFSIDES
117	Mood swings			SIDER
118	Muscle Weakness			OFFSIDES
119	Muscle strain			OFFSIDES
120	Musculoskeletal Pain			OFFSIDES
121	Myelodysplasia			OFFSIDES
122	Myelosuppression			SIDER
123	Myocardial Infarction			SIDER
124	Myocardial Ischemia		3529368	CTD
125	Nasopharyngitis			OFFSIDES
126	Nephrolithiasis			OFFSIDES
127	Neutropenia		9256895	CTD
128	Night sweats			SIDER
129	Nutritional condition abnormal			OFFSIDES
130	Onycholysis			OFFSIDES
131	Oral Cavity Fistula			OFFSIDES
132	Oral infection			OFFSIDES
133	Osteopenia			OFFSIDES
134	PCO2 decreased			OFFSIDES
135	Pain			OFFSIDES
136	Pancreatitis			OFFSIDES
137	Pancytopenia			SIDER
138	Pharyngolaryngeal Pain			OFFSIDES
139	Physical disability			OFFSIDES
140	Polyuria			OFFSIDES SIDER
141	Primary sequestrum			OFFSIDES
142	Proctitis			OFFSIDES
143	Prostate cancer recurrent			OFFSIDES
144	Prostatic Neoplasms		View details 866798 3525866 6377283 6938012 9218739 9256895 16685278 17153888 18824434	CTD
145	Pruritus			SIDER
146	Pulmonary Embolism		17846704	CTD
147	Pulmonary congestion			OFFSIDES
148	Pulmonary radiation injury			OFFSIDES
149	Purulent discharge			OFFSIDES
150	Renal cyst			OFFSIDES
151	Renal tubular acidosis			OFFSIDES
152	Risus sardonicus			OFFSIDES
153	Septic Shock			OFFSIDES
154	Sinusitis			OFFSIDES
155	Spinal column stenosis			OFFSIDES
156	Spinal haemangioma			OFFSIDES
157	Supraventricular tachycardia			OFFSIDES
158	Tendinitis			OFFSIDES
159	Thirst			SIDER
160	Thoracic vertebral fracture			OFFSIDES
161	Throat irritation			SIDER
162	Thrombocytopenia		9949296	CTD SIDER
163	Thromboembolism			SIDER
164	Thrombophlebitis		866798	CTD SIDER
165	Thrombosis		11844837	CTD
166	Tinnitus			SIDER
167	Tongue Diseases		17153888	CTD
168	Tooth Extraction			OFFSIDES
169	Tooth Infection			OFFSIDES
170	Tooth repair			OFFSIDES
171	Transaminases increased			SIDER
172	Urine flow decreased			OFFSIDES
173	Venous Thromboembolism		3529368 6938012	CTD
174	Venous Thrombosis		3529368 15536625 17846704	CTD
175	Ventricular Fibrillation			OFFSIDES
176	Vertebroplasty			OFFSIDES
177	Wrong drug administered			OFFSIDES
178	kyphosis			OFFSIDES
179	liposarcoma			OFFSIDES

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