MetaADEDB 2.0 @ LMMD
zafirlukast
(YEEZWCHGZNKEEK-UHFFFAOYSA-N)
Structure
SMILES
COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C
Type(s)
Approved; Investigational
ATC code(s)
R03DC01
Molecular Formula:
C31H33N3O6S
Molecular Weight:
575.675
Log P:
7.2406
Hydrogen Bond Acceptor:
9
Hydrogen Bond Donor:
2
TPSA:
124.11
CAS Number(s):
107753-78-6
Synonym(s)
1.
zafirlukast
2.
4-(5-cyclopentyloxycarbonylamino-2-methylindol-3-yl-methyl)-3-methoxy-N-O-tolylsulfonylbenzamide
3.
Accolate
4.
Aeronix
5.
ICI 204,219
6.
ICI 204219
7.
ICI-204219
8.
Olmoran
External Link(s)
MeSHC062735
PubChem Compound5717
BindingDB50009073
ChEBI10100
CHEMBLCHEMBL603
DrugBankDB00549
DrugCentral2855
IUPHAR/BPS Guide to PHARMACOLOGY3322
KEGGcpd:C07206
dr:D00411
Therapeutic Target DatabaseD05DVP
ZINC896717
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug dose omissionFAERS: 30US FAERS
2AsthmaFAERS: 28

View details

1673495
8087328
8162986
8222486
9027267
9196086
9377612
9412547
9620945
9620946
9690572
9701106
9825082
9847434
9949315
10027429
10064661
10359889
10386485
10439636
10780761
10817796
10852428
10929920
10934090
10967152
11061985
11070746
11393122
11570617
11596838
11694805
11885876
11991558
12095178
12113382
12114351
12189465
12583521
12604023
12742009
14609035
15136378
15170009
15572850
18489783
19667530
19681236
20332717
 		CTD
OFFSIDES
US FAERS
3MalaiseFAERS: 23SIDER
US FAERS
4PneumoniaFAERS: 11US FAERS
5Drug ineffectiveFAERS: 9US FAERS
6HeadacheFAERS: 69377612
10386485		CTD
SIDER
US FAERS
7NauseaFAERS: 610386485CTD
OFFSIDES
SIDER
US FAERS
8Alanine Aminotransferase IncreasedFAERS: 5OFFSIDES
US FAERS
9Incorrect dose administeredFAERS: 5US FAERS
10Multiple allergiesFAERS: 5US FAERS
11Product substitution issueFAERS: 5US FAERS
12AnxietyFAERS: 4OFFSIDES
US FAERS
13Aspartate Aminotransferase IncreasedFAERS: 4US FAERS
14FatigueFAERS: 4OFFSIDES
SIDER
US FAERS
15Feeling abnormalFAERS: 4OFFSIDES
SIDER
US FAERS
16Intentional drug misuseFAERS: 4US FAERS
17Myocardial InfarctionFAERS: 4US FAERS
18Acute respiratory failureFAERS: 3OFFSIDES
US FAERS
19BlindnessFAERS: 3US FAERS
20BronchitisFAERS: 3OFFSIDES
US FAERS
21Diabetes MellitusFAERS: 3US FAERS
22DysuriaFAERS: 3US FAERS
23FibromyalgiaFAERS: 3OFFSIDES
US FAERS
24NasopharyngitisFAERS: 3US FAERS
25PainFAERS: 311438310
15935457		CTD
OFFSIDES
SIDER
US FAERS
26Product quality issueFAERS: 3US FAERS
27Septic ShockFAERS: 3OFFSIDES
US FAERS
28ShockFAERS: 3US FAERS
29Urinary tract infectionFAERS: 3US FAERS
30Abdominal discomfortFAERS: 2OFFSIDES
SIDER
US FAERS
31AstheniaFAERS: 2OFFSIDES
SIDER
US FAERS
32Chest PainFAERS: 2OFFSIDES
US FAERS
33Chest discomfortFAERS: 2US FAERS
34DementiaFAERS: 2US FAERS
35Dermatitis HerpetiformisFAERS: 2US FAERS
36DizzinessFAERS: 2OFFSIDES
SIDER
US FAERS
37DyspepsiaFAERS: 2OFFSIDES
SIDER
US FAERS
38DysphoniaFAERS: 2US FAERS
39HypersensitivityFAERS: 2SIDER
US FAERS
40Joint injuryFAERS: 2OFFSIDES
US FAERS
41Joint swellingFAERS: 2US FAERS
42OverdoseFAERS: 2US FAERS
43PeritonitisFAERS: 2OFFSIDES
US FAERS
44Respiratory FailureFAERS: 2OFFSIDES
US FAERS
45SomnolenceFAERS: 2US FAERS
46SplenomegalyFAERS: 2US FAERS
47Suicide attemptFAERS: 2US FAERS
48ThrombosisFAERS: 2US FAERS
49jaundiceFAERS: 211682043CTD
SIDER
US FAERS
50AbasiaFAERS: 1OFFSIDES
US FAERS
51Abdominal PainFAERS: 1OFFSIDES
SIDER
US FAERS
52Acute myocardial infarctionFAERS: 1US FAERS
53Adverse eventFAERS: 1US FAERS
54AlopeciaFAERS: 1OFFSIDES
US FAERS
55AphoniaFAERS: 1OFFSIDES
US FAERS
56Apparent deathFAERS: 1US FAERS
57AscitesFAERS: 1US FAERS
58Atrial FibrillationFAERS: 1US FAERS
59Blood cholesterol increasedFAERS: 1US FAERS
60Blood glucose increasedFAERS: 1US FAERS
61Burning sensationFAERS: 1US FAERS
62Cardiac ArrestFAERS: 1US FAERS
63Central Nervous System InfectionFAERS: 1US FAERS
64Cerebrovascular accidentFAERS: 1US FAERS
65ChillsFAERS: 1US FAERS
66CryingFAERS: 1OFFSIDES
US FAERS
67Dark circles under eyesFAERS: 1US FAERS
68Depressed Level of ConsciousnessFAERS: 1OFFSIDES
US FAERS
69Depressed moodFAERS: 1US FAERS
70Disseminated Intravascular CoagulationFAERS: 1US FAERS
71Drug dispensing errorFAERS: 1US FAERS
72Emotional disorderFAERS: 1US FAERS
73Eosinophilic PneumoniaFAERS: 1SIDER
US FAERS
74Eosinophilic granulomatosis with polyangiitisFAERS: 1US FAERS
75Epigastric discomfortFAERS: 1US FAERS
76ErythemaFAERS: 1OFFSIDES
US FAERS
77FlatulenceFAERS: 1OFFSIDES
US FAERS
78Food PoisoningFAERS: 1US FAERS
79GoutFAERS: 1OFFSIDES
US FAERS
80Hepatitis BFAERS: 1US FAERS
81Hepatitis CFAERS: 1US FAERS
82HepatitisFAERS: 112189465CTD
OFFSIDES
SIDER
US FAERS
83HepatomegalyFAERS: 1US FAERS
84HepatotoxicityFAERS: 1SIDER
US FAERS
85HerniaFAERS: 1US FAERS
86HypermetabolismFAERS: 1US FAERS
87ImmobileFAERS: 1US FAERS
88Inappropriate schedule of drug administrationFAERS: 1US FAERS
89Increased tendency to bruiseFAERS: 1SIDER
US FAERS
90Injury associated with deviceFAERS: 1US FAERS
91Intentional product misuseFAERS: 1US FAERS
92Leukocytoclastic vasculitisFAERS: 1SIDER
US FAERS
93Malignant hypertensive heart diseaseFAERS: 1US FAERS
94Medication ErrorFAERS: 1US FAERS
95Memory impairmentFAERS: 1US FAERS
96Mental status changesFAERS: 1US FAERS
97Metastatic NeoplasmFAERS: 1OFFSIDES
US FAERS
98Multiple SclerosisFAERS: 1US FAERS
99MyalgiaFAERS: 1SIDER
US FAERS
100NervousnessFAERS: 1US FAERS
101Oropharyngeal painFAERS: 1SIDER
US FAERS
102PallorFAERS: 1US FAERS
103PalpitationsFAERS: 1US FAERS
104Pancreatic carcinomaFAERS: 1US FAERS
105Peptic UlcerFAERS: 1US FAERS
106Platelet count abnormalFAERS: 1US FAERS
107PleurisyFAERS: 1OFFSIDES
US FAERS
108Post procedural complicationFAERS: 1OFFSIDES
US FAERS
109Rheumatoid ArthritisFAERS: 1US FAERS
110SepsisFAERS: 1US FAERS
111Skin UlcerFAERS: 1US FAERS
112Sudden deathFAERS: 1US FAERS
113SwellingFAERS: 1SIDER
US FAERS
114Thrombocytopenic purpuraFAERS: 1US FAERS
115TremorFAERS: 1US FAERS
116Urinary IncontinenceFAERS: 1US FAERS
117Vertebrobasilar InsufficiencyFAERS: 1US FAERS
118Weight decreasedFAERS: 1US FAERS
119WheezingFAERS: 1US FAERS
120Abdominal tendernessOFFSIDES
121Abnormal visionOFFSIDES
122AbscessOFFSIDES
123Accidental exposureOFFSIDES
124Acid refluxOFFSIDES
125AcidosisOFFSIDES
126Actinic keratosisOFFSIDES
127Acute bronchitisOFFSIDES
128Acute sinusitisOFFSIDES
129AgranulocytosisSIDER
130AmnesiaOFFSIDES
131Anal FissureOFFSIDES
132Anal discomfortOFFSIDES
133AnalgesiaOFFSIDES
134Analgesic drug levelOFFSIDES
135AngerOFFSIDES
136AngioedemaSIDER
137AngiomyolipomaOFFSIDES
138AnhedoniaOFFSIDES
139AnhidrosisOFFSIDES
140Anorectal discomfortOFFSIDES
141AnorexiaOFFSIDES
142Anoxic EncephalopathyOFFSIDES
143Antiphospholipid antibodies positiveOFFSIDES
144ApathyOFFSIDES
145ApneaOFFSIDES
146ArthralgiaSIDER
147ArthritisOFFSIDES
148Aseptic MeningitisOFFSIDES
149AspergillosisOFFSIDES
150AsphyxiaOFFSIDES
151Asthma, Aspirin-Induced19667532CTD
152Asthma, Exercise-Induced

View details

1554195
8389103
10984370
11953129
19667531
 		CTD
153AtelectasisOFFSIDES
154Atrial thrombosisOFFSIDES
155Avascular necrosisOFFSIDES
156Back PainSIDER
157Bacteria sputum identifiedOFFSIDES
158BlepharoptosisOFFSIDES
159BlepharospasmOFFSIDES
160Blood GlucoseOFFSIDES
161Blood alkaline phosphatase increasedOFFSIDES
162Blood creatine phosphokinase increasedOFFSIDES
163Blood immunoglobulin A decreasedOFFSIDES
164Blood immunoglobulin G decreasedOFFSIDES
165Blood immunoglobulin MOFFSIDES
166Blood immunoglobulin M decreasedOFFSIDES
167Blood iron decreasedOFFSIDES
168Blood lactate dehydrogenase increasedOFFSIDES
169Blood pH increasedOFFSIDES
170Blood potassium decreasedOFFSIDES
171Blood triglycerides increasedOFFSIDES
172Blood urea increasedOFFSIDES
173Bone lesionOFFSIDES
174Bone trimmingOFFSIDES
175Bronchial Diseases11994701CTD
176BronchiectasisOFFSIDES
177BronchopneumoniaOFFSIDES
178BursitisOFFSIDES
179Candidiasis, Vulvovaginal15170009CTD
180Carotid bruitOFFSIDES
181CellulitisOFFSIDES
182Chemical and Drug Induced Liver Injury

View details

11119397
12583521
23956101
28437613
 		CTD
183Choking sensationOFFSIDES
184ChokingOFFSIDES
185CholangiolitisOFFSIDES
186CholecystitisOFFSIDES
187Chronic Obstructive Airway DiseaseOFFSIDES
188Chronic sinusitisOFFSIDES
189Chronic ulcerative colitisOFFSIDES
190CirrhosisOFFSIDES
191ColectomyOFFSIDES
192ColitisOFFSIDES
193Colonic StenosisOFFSIDES
194Completed SuicideOFFSIDES
195Cor pulmonaleOFFSIDES
196CyanosisOFFSIDES
197Cystic Fibrosis15463842CTD
198CystoceleOFFSIDES
199DeafnessOFFSIDES
200Decompression Sickness18309904CTD
201DemyelinationOFFSIDES
202Dental cariesOFFSIDES
203Dental prosthesis placementOFFSIDES
204Dermatitis, Atopic11901593CTD
205DermatitisSIDER
206DermatomyositisOFFSIDES
207DiabetesOFFSIDES
208Diabetes mellitus inadequate controlOFFSIDES
209Diabetic FootOFFSIDES
210Diabetic NephropathyOFFSIDES
211DiarrheaOFFSIDES
212Diastolic dysfunctionOFFSIDES
213DiscomfortSIDER
214DiverticulosisOFFSIDES
215DrowsinessOFFSIDES
216Drug specific antibody presentOFFSIDES
217Drug toxicityOFFSIDES
218Drug withdrawal headacheOFFSIDES
219Dyspnoea exacerbatedOFFSIDES
220Economic problemOFFSIDES
221Edema15351322CTD
222Electromechanical dissociationOFFSIDES
223Endodontic procedureOFFSIDES
224Endometriosis15019815CTD
225Eosinophilia

View details

12189465
12689652
12742009
15351322
15696079
 		CTD
SIDER
226EscharOFFSIDES
227Extremity necrosisOFFSIDES
228Fatty LiverOFFSIDES
229Fear of fallingOFFSIDES
230Flank PainOFFSIDES
231Fluid overloadOFFSIDES
232FolliculitisOFFSIDES
233FormicationOFFSIDES
234Gamma-Glutamyltransferase IncreasedOFFSIDES
235GangreneOFFSIDES
236Gastric ulcerOFFSIDES
237GastroenteritisOFFSIDES
238Gastrointestinal PainSIDER
239Gingival erythemaOFFSIDES
240Hepatic Encephalopathy11682043CTD
241HydronephrosisOFFSIDES
242HypoxiaOFFSIDES
243HysterectomyOFFSIDES
244Iatrogenic injuryOFFSIDES
245Idiopathic urticariaOFFSIDES
246Immunosuppressant drug levelOFFSIDES
247Impaired work abilityOFFSIDES
248IncontinenceOFFSIDES
249Infected varicose veinOFFSIDES
250InfectionSIDER
251Infectious MononucleosisOFFSIDES
252Inflammation11438310
18309904		CTD
253Initial insomniaOFFSIDES
254Injection site pruritusOFFSIDES
255Intestinal PerforationOFFSIDES
256Intestinal resectionOFFSIDES
257Joint InstabilityOFFSIDES
258Joint sprainOFFSIDES
259Jugular vein distensionOFFSIDES
260Kidney FailureOFFSIDES
261Labile blood pressureOFFSIDES
262LentigoOFFSIDES
263Leukocytosis18489783CTD
264LeukoencephalopathyOFFSIDES
265Limb injuryOFFSIDES
266Lung Diseases, Obstructive9847434CTD
267Lung consolidationOFFSIDES
268Lung hyperinflationOFFSIDES
269Massive Hepatic Necrosis11682043CTD
270MegacolonOFFSIDES
271Migraine Disorders10759916CTD
272Motor retardationOFFSIDES
273Muscle WeaknessOFFSIDES
274Muscle abscessOFFSIDES
275Musculoskeletal PainOFFSIDES
276Musculoskeletal chest painOFFSIDES
277Musculoskeletal discomfortSIDER
278Nail InfectionOFFSIDES
279Nasal Polyps10665187
12053594		CTD
280Necrosis15028970CTD
281NephrolithiasisOFFSIDES
282Nervous tensionOFFSIDES
283NeuralgiaOFFSIDES
284NeuropathySIDER
285NeutropeniaSIDER
286NocturiaOFFSIDES
287NoduleOFFSIDES
288NumbnessSIDER
289Optic Disc EdemaOFFSIDES
290Oral infectionOFFSIDES
291Oropharyngeal discomfortSIDER
292OsteolysisOFFSIDES
293OsteomyelitisOFFSIDES
294Pancreatitis15028970CTD
OFFSIDES
295PeriodontitisOFFSIDES
296Perivascular dermatitisOFFSIDES
297Pharmaceutical product complaintOFFSIDES
298Pharyngitis9377612
10386485		CTD
299Pharyngolaryngeal PainOFFSIDES
300Pilonidal CystOFFSIDES
301Poor dental conditionOFFSIDES
302Poor quality sleepOFFSIDES
303Postoperative infectionOFFSIDES
304Primary sequestrumOFFSIDES
305Procedural complicationOFFSIDES
306ProctitisOFFSIDES
307Productive CoughOFFSIDES
308PruritusSIDER
309Pulmonary Edema18309904CTD
310Pulmonary congestionOFFSIDES
311Pulmonary function test decreasedOFFSIDES
312PyelonephritisOFFSIDES
313Rectal polypOFFSIDES
314Reperfusion Injury12967936CTD
315Respiratory tract congestionOFFSIDES
316Retinal DegenerationOFFSIDES
317Rhinitis7767514
12742009
20332717		CTD
OFFSIDES
318RhinorrheaOFFSIDES
319SclerodermaOFFSIDES
320Scrotal cystOFFSIDES
321Seminal vesiculitisOFFSIDES
322Sensory level abnormalOFFSIDES
323Sinusitis10386485
10665187		CTD
OFFSIDES
SIDER
324Skin necrosisOFFSIDES
325Sleep TalkingOFFSIDES
326SnoringOFFSIDES
327Status EpilepticusOFFSIDES
328StridorOFFSIDES
329TendinitisOFFSIDES
330Tension HeadacheOFFSIDES
331Therapy non-responderOFFSIDES
332ThrombocytopeniaSIDER
333Tinea PedisOFFSIDES
334Tooth ExtractionOFFSIDES
335Traumatic liver injurySIDER
336Ultrasound scan abnormalOFFSIDES
337Umbilical hernia perforationOFFSIDES
338Unresponsive to stimuliOFFSIDES
339Upper airway resistance syndromeOFFSIDES
340Upset stomachSIDER
341Urticaria14512923
14713918		CTD
SIDER
342Vaginal mycosisOFFSIDES
343Vasculitic rashSIDER
344Vasculitis12189465CTD
SIDER
345Venous stasisOFFSIDES
346Visual disturbanceOFFSIDES
347VomitingSIDER
348Wheelchair userOFFSIDES
349Wound InfectionOFFSIDES
350effusionOFFSIDES
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