MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

abacavir

(MCGSCOLBFJQGHM-SCZZXKLOSA-N)

Structure

SMILES: OC[C@@H]1C=C[C@@H](C1)n1cnc2c1nc(N)nc2NC1CC1
Type(s): Approved; Investigational
ATC code(s): J05AF06; J05AR02; J05AR04; J05AR13
Molecular Formula:: C14H18N6O
Molecular Weight:: 286.332
Log P:: 1.7465
Hydrogen Bond Acceptor:: 7
Hydrogen Bond Donor:: 3
TPSA:: 101.88
CAS Number(s):: 136470-78-5; 188062-50-2

Synonym(s)

abacavir

(1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-2-cyclopentene-1-methanol

1592U89

Ziagen

abacavir succinate

abacavir sulfate

External Link(s)

MeSH	C106538
PubChem Compound	441300
BindingDB	50366816
ChEBI	421707
CHEMBL	CHEMBL1380
DrugBank	DB01048
DrugCentral	34
KEGG	cpd:C07624 dr:D07057
Therapeutic Target Database	D0A4IJ
ZINC	2015928

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Hypersensitivity	FAERS: 34 Canada Vigilance: 15	23541086	CTD SIDER Canada Vigilance US FAERS
2	Myocardial Infarction	FAERS: 22 Canada Vigilance: 3	View details 18387667 18434947 18753925 20660842	CTD SIDER Canada Vigilance US FAERS
3	Acute Coronary Syndrome	FAERS: 20		SIDER US FAERS
4	Vomiting	FAERS: 14 Canada Vigilance: 8		Canada Vigilance SIDER US FAERS
5	Nausea	FAERS: 13 Canada Vigilance: 7		Canada Vigilance OFFSIDES SIDER US FAERS
6	Malaise	FAERS: 11 Canada Vigilance: 7		Canada Vigilance SIDER US FAERS
7	Pruritus	FAERS: 11 Canada Vigilance: 4		Canada Vigilance SIDER US FAERS
8	Abdominal Pain	FAERS: 9 Canada Vigilance: 3		Canada Vigilance OFFSIDES SIDER US FAERS
9	Myalgia	FAERS: 9 Canada Vigilance: 3		Canada Vigilance SIDER US FAERS
10	Hypotension	FAERS: 7		SIDER US FAERS
11	Dizziness	FAERS: 6 Canada Vigilance: 2		Canada Vigilance SIDER US FAERS
12	Fatigue	FAERS: 5 Canada Vigilance: 7		Canada Vigilance OFFSIDES SIDER US FAERS
13	Skin lesion	FAERS: 5		OFFSIDES US FAERS
14	Asthenia	FAERS: 4		OFFSIDES SIDER US FAERS
15	Blood creatine phosphokinase increased	FAERS: 4		OFFSIDES SIDER US FAERS
16	Chills	FAERS: 4 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
17	Headache	FAERS: 4 Canada Vigilance: 7		Canada Vigilance SIDER US FAERS
18	Rhabdomyolysis	FAERS: 4		SIDER US FAERS
19	Stillbirth	FAERS: 4		US FAERS
20	Urticaria	FAERS: 4		SIDER US FAERS
21	jaundice	FAERS: 4		US FAERS
22	Abdominal discomfort	FAERS: 3		SIDER US FAERS
23	Arthralgia	FAERS: 3 Canada Vigilance: 2		Canada Vigilance SIDER US FAERS
24	Asthma	FAERS: 3		US FAERS
25	Blood creatinine increased	FAERS: 3		SIDER US FAERS
26	Chest Pain	FAERS: 3 Canada Vigilance: 2		Canada Vigilance OFFSIDES US FAERS
27	Cholestasis	FAERS: 3 Canada Vigilance: 1		Canada Vigilance US FAERS
28	Drug ineffective	FAERS: 3		US FAERS
29	Dyspepsia	FAERS: 3 Canada Vigilance: 1		Canada Vigilance US FAERS
30	Hepatitis	FAERS: 3		OFFSIDES SIDER US FAERS
31	Hepatomegaly	FAERS: 3 Canada Vigilance: 2		Canada Vigilance SIDER US FAERS
32	Infarction	FAERS: 3		US FAERS
33	Respiratory distress	FAERS: 3		US FAERS
34	Blood triglycerides increased	FAERS: 2		OFFSIDES SIDER US FAERS
35	Cerebrovascular accident	FAERS: 2		US FAERS
36	Coronary Artery Disease	FAERS: 2		US FAERS
37	Feeling abnormal	FAERS: 2		SIDER US FAERS
38	Lipase increased	FAERS: 2		US FAERS
39	Product substitution issue	FAERS: 2		US FAERS
40	Stevens-Johnson Syndrome	FAERS: 2	25811541	CTD SIDER US FAERS
41	Stool analysis abnormal	FAERS: 2		OFFSIDES US FAERS
42	Toxic Shock Syndrome	FAERS: 2		US FAERS
43	Abscess	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
44	Acute myocardial infarction	FAERS: 1		US FAERS
45	Adverse event	FAERS: 1		US FAERS
46	Agranulocytosis	FAERS: 1		US FAERS
47	Angina Pectoris	FAERS: 1		US FAERS
48	Angioedema	FAERS: 1		US FAERS
49	Ascites	FAERS: 1		OFFSIDES US FAERS
50	Auricular swelling	FAERS: 1		US FAERS
51	Blood alkaline phosphatase increased	FAERS: 1		OFFSIDES US FAERS
52	Blood amylase increased	FAERS: 1		OFFSIDES US FAERS
53	Bone marrow depression	FAERS: 1		OFFSIDES US FAERS
54	Bradycardia	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
55	Bronchitis	FAERS: 1		SIDER US FAERS
56	CD4 Lymphocytes Decreased	FAERS: 1		OFFSIDES US FAERS
57	Cardiac stress test abnormal	FAERS: 1		US FAERS
58	Cerebral Infarction	FAERS: 1		US FAERS
59	Chest discomfort	FAERS: 1		US FAERS
60	Disease Progression	FAERS: 1		US FAERS
61	Emotional distress	FAERS: 1		US FAERS
62	Eosinophilia	FAERS: 1		US FAERS
63	Erectile dysfunction	FAERS: 1		US FAERS
64	Erythema	FAERS: 1 Canada Vigilance: 4		Canada Vigilance US FAERS
65	Extremity necrosis	FAERS: 1		US FAERS
66	Facial Pain	FAERS: 1		US FAERS
67	Hepatotoxicity	FAERS: 1		OFFSIDES US FAERS
68	Impaired work ability	FAERS: 1		US FAERS
69	Inappropriate schedule of drug administration	FAERS: 1		US FAERS
70	Mental status changes	FAERS: 1		US FAERS
71	Musculoskeletal Pain	FAERS: 1		SIDER US FAERS
72	Myocarditis	FAERS: 1		US FAERS
73	Nasopharyngitis	FAERS: 1		US FAERS
74	Nonspecific reaction	FAERS: 1		US FAERS
75	Ocular icterus	FAERS: 1		OFFSIDES US FAERS
76	Oral candidiasis	FAERS: 1		US FAERS
77	Pain	FAERS: 1 Canada Vigilance: 4		Canada Vigilance SIDER US FAERS
78	Pancreatitis	FAERS: 1		OFFSIDES SIDER US FAERS
79	Pancytopenia	FAERS: 1		US FAERS
80	Pharyngitis	FAERS: 1		SIDER US FAERS
81	Photophobia	FAERS: 1		US FAERS
82	Pneumonia	FAERS: 1		SIDER US FAERS
83	Polymyalgia Rheumatica	FAERS: 1		US FAERS
84	Polyneuropathy	FAERS: 1		US FAERS
85	Product used for unknown indication	FAERS: 1		US FAERS
86	Pulmonary Embolism	FAERS: 1		US FAERS
87	Pulmonary Fibrosis	FAERS: 1		US FAERS
88	Rehabilitation therapy	FAERS: 1		US FAERS
89	Respiratory Failure	FAERS: 1		SIDER US FAERS
90	Sinusitis	FAERS: 1		US FAERS
91	Skin Ulcer	FAERS: 1		US FAERS
92	Smoker	FAERS: 1		US FAERS
93	Syncope	FAERS: 1		US FAERS
94	Tachycardia	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
95	Thrombocytopenia	FAERS: 1		SIDER US FAERS
96	Toxicity to various agents	FAERS: 1		US FAERS
97	Transaminases increased	FAERS: 1		OFFSIDES US FAERS
98	Ventricular arrhythmia	FAERS: 1		US FAERS
99	West Nile viral infection	FAERS: 1		US FAERS
100	Wheezing	FAERS: 1		SIDER US FAERS
101	nervous system disorder	FAERS: 1		SIDER US FAERS
102	5'nucleotidase increased			OFFSIDES
103	AIDS Dementia Complex			SIDER
104	AIDS related complication			OFFSIDES
105	Abdominal sepsis			OFFSIDES
106	Abdominal tenderness			OFFSIDES
107	Abuse			OFFSIDES
108	Acidosis			OFFSIDES
109	Acquired Protein S Deficiency			OFFSIDES
110	Acute psychosis			OFFSIDES
111	Adenocarcinoma			OFFSIDES
112	Adrenal cortex necrosis			OFFSIDES
113	Adrenalitis			OFFSIDES
114	Alanine Aminotransferase Increased			OFFSIDES SIDER
115	Alopecia			SIDER
116	Aminoaciduria			OFFSIDES
117	Anaphylactic shock			SIDER
118	Angioplasty			OFFSIDES
119	Anisocytosis			OFFSIDES
120	Anorexia			SIDER
121	Antiviral drug level below therapeutic			OFFSIDES
122	Anxiety			SIDER
123	Apathy			OFFSIDES
124	Aphthous Stomatitis			OFFSIDES
125	Appendectomy			OFFSIDES
126	Appendicitis			OFFSIDES
127	Arteritis			OFFSIDES
128	Arthropod bite			OFFSIDES
129	Aspartate Aminotransferase Increased			SIDER
130	Beta 2 microglobulin urine increased			OFFSIDES
131	Biopsy bone marrow abnormal			OFFSIDES
132	Bipolar I disorder			OFFSIDES
133	Blepharoptosis			OFFSIDES
134	Blood HIV RNA			OFFSIDES
135	Blood albumin abnormal			OFFSIDES
136	Blood bicarbonate abnormal			OFFSIDES
137	Blood bilirubin unconjugated increased			OFFSIDES
138	Blood cholesterol			OFFSIDES
139	Blood cortisol decreased			OFFSIDES
140	Blood creatine increased			OFFSIDES
141	Blood electrolytes abnormal			OFFSIDES
142	Blood fibrinogen			OFFSIDES
143	Blood glucose abnormal			OFFSIDES
144	Blood immunoglobulin E			OFFSIDES
145	Blood lactate dehydrogenase decreased			OFFSIDES
146	Blood lactate dehydrogenase increased			OFFSIDES
147	Blood parathyroid hormone increased			OFFSIDES
148	Blood phosphorus decreased			OFFSIDES
149	Blood phosphorus increased			OFFSIDES
150	Blood uric acid			OFFSIDES
151	Blood zinc decreased			OFFSIDES
152	Body fat disorder			OFFSIDES
153	Bone marrow necrosis			OFFSIDES
154	Bronchopneumonia			OFFSIDES
155	Buffalo hump			SIDER
156	C-reactive protein decreased			OFFSIDES
157	CD4 lymphocytes increased			OFFSIDES
158	Calcinosis			OFFSIDES
159	Cardiac Tamponade			OFFSIDES
160	Cardiovascular Diseases		18753925	CTD
161	Cell Death			OFFSIDES
162	Central nervous system lesion			OFFSIDES
163	Cervical dysplasia			OFFSIDES
164	Chemical and Drug Induced Liver Injury		28437613	CTD
165	Cholangiolitis			OFFSIDES
166	Cirrhosis			OFFSIDES
167	Clonus			OFFSIDES
168	Clumsiness			OFFSIDES
169	Coagulation factor VIII level increased			OFFSIDES
170	Congenital hepatobiliary anomaly			OFFSIDES
171	Congenital hypertrichosis			OFFSIDES
172	Congenital mitochondrial cytopathy			OFFSIDES
173	Conjunctival deposit			OFFSIDES
174	Conjunctivitis			SIDER
175	Constipation	Canada Vigilance: 1		Canada Vigilance
176	Cortisol free urine decreased			OFFSIDES
177	Creatine Phosphokinase Increased			SIDER
178	Creatinine increased			SIDER
179	Creatinine renal clearance decreased			OFFSIDES
180	Cytolytic hepatitis			OFFSIDES
181	Cytomegalovirus chorioretinitis			OFFSIDES
182	Cytomegalovirus test			OFFSIDES
183	Demyelination			OFFSIDES
184	Depressed mood			SIDER
185	Depressive disorder			SIDER
186	Dermatitis			SIDER
187	Diabetes			OFFSIDES
188	Diabetes Insipidus			OFFSIDES
189	Diabetes mellitus inadequate control			OFFSIDES
190	Diarrhea			OFFSIDES
191	Diplopia			OFFSIDES
192	Discomfort			SIDER
193	Disease recurrence			OFFSIDES
194	Drug Tolerance			OFFSIDES
195	Drug resistance			OFFSIDES
196	Drug toxicity			OFFSIDES
197	Drug withdrawal headache			OFFSIDES
198	Duodenal Ulcer			OFFSIDES
199	Dysphasia			OFFSIDES
200	Dysthymic Disorder			SIDER
201	Electrocardiogram ST-T change			OFFSIDES
202	Encephalitis			OFFSIDES
203	Eosinophilic myocarditis			OFFSIDES
204	Ependymoma			OFFSIDES
205	Epididymitis			OFFSIDES
206	Epidural lipomatosis			OFFSIDES
207	Erythema Infectiosum			OFFSIDES
208	Erythema Multiforme			SIDER
209	Euphoric mood			OFFSIDES
210	Excoriation			OFFSIDES
211	Facial wasting			OFFSIDES
212	Factor VIII Deficiency			OFFSIDES
213	Factor VIII inhibition			OFFSIDES
214	Fanconi Syndrome		17102551	CTD OFFSIDES
215	Fat redistribution			OFFSIDES SIDER
216	Fatty Liver			OFFSIDES
217	Feeling Cold	Canada Vigilance: 1		Canada Vigilance
218	Femoral artery occlusion			OFFSIDES
219	Fibrosarcoma			OFFSIDES
220	Focal glomerulosclerosis			OFFSIDES
221	Folliculitis			OFFSIDES
222	Gallop rhythm present			OFFSIDES
223	Gamma-Glutamyltransferase Increased			OFFSIDES SIDER
224	Gastric ulcer			OFFSIDES
225	Gastritis			SIDER
226	Gastroenteritis			SIDER
227	Gastrointestinal Pain			SIDER
228	Gastrointestinal toxicity			OFFSIDES
229	Gastroschisis			OFFSIDES
230	General physical condition			OFFSIDES
231	General physical health deterioration			OFFSIDES
232	Gestational Diabetes			OFFSIDES
233	Giardiasis			OFFSIDES
234	Glioma			OFFSIDES
235	Globulinuria			OFFSIDES
236	Glomerulonephritis			OFFSIDES
237	Graft dysfunction			OFFSIDES
238	HIV Infections		View details 10465092 11141242 11365545 11943262 12891065 16288408 17457083 20660842 23541086	CTD
239	HIV Wasting Syndrome			OFFSIDES
240	Haematotoxicity			OFFSIDES
241	Haemoconcentration			OFFSIDES
242	Haptoglobin Decreased			OFFSIDES
243	Head circumference abnormal			OFFSIDES
244	Heart Diseases		18348343	CTD
245	Hemiparesis			OFFSIDES
246	Hepatic displacement			OFFSIDES
247	Hepatic necrosis			OFFSIDES
248	Hepatitis B Virus			OFFSIDES
249	Hepatitis B positive			OFFSIDES
250	Hepatitis B		12760870	CTD OFFSIDES SIDER
251	Hepatitis C RNA			OFFSIDES
252	Hepatitis C			OFFSIDES
253	Hepatosplenomegaly			OFFSIDES
254	Hyperpigmentation			OFFSIDES
255	Hypertrophy of Breast			SIDER
256	Hypogonadism			OFFSIDES
257	Hyporeflexia			OFFSIDES
258	Ileal ulcer			OFFSIDES
259	Iliac artery stenosis			OFFSIDES
260	Immune reconstitution syndrome			OFFSIDES
261	Immunosuppressant drug level			OFFSIDES
262	Impetigo			OFFSIDES
263	Incontinence			OFFSIDES
264	Infection in an immunocompromised host			OFFSIDES
265	Infection			SIDER
266	Inflammation			SIDER
267	Infusion site mobility decreased			OFFSIDES
268	Injection site inflammation			OFFSIDES
269	Insulin Resistance			OFFSIDES SIDER
270	Intercepted drug administration error			OFFSIDES
271	Intermittent Claudication			OFFSIDES
272	Intervertebral disc disorder			OFFSIDES
273	Keratitis sicca			OFFSIDES
274	Kidney Failure			OFFSIDES
275	Klebsiella sepsis			OFFSIDES
276	Lack of spontaneous speech			OFFSIDES
277	Late developer			OFFSIDES
278	Left Ventricular Hypertrophy			OFFSIDES
279	Lethargy			SIDER
280	Leukoencephalomyelitis			OFFSIDES
281	Leukoencephalopathy			OFFSIDES
282	Leukopenia neonatal			OFFSIDES
283	Leukopenia			SIDER
284	Lip erosion			OFFSIDES
285	Lipase			OFFSIDES
286	Lipids abnormal			OFFSIDES
287	Lipodystrophy acquired			OFFSIDES SIDER
288	Lipodystrophy			SIDER
289	Lipohypertrophy			OFFSIDES SIDER
290	Live Birth			OFFSIDES
291	Liver transplant rejection			OFFSIDES
292	Lymphadenopathy			SIDER
293	Lymphoma			OFFSIDES
294	Lymphopenia			SIDER
295	Malaria			OFFSIDES
296	Malignant Hypertension			OFFSIDES
297	Malnutrition			SIDER
298	Medical observation			OFFSIDES
299	Mental retardation severity unspecified			OFFSIDES
300	Mesenteric artery stenosis			OFFSIDES
301	Metabolic acidosis			OFFSIDES
302	Microcephaly			OFFSIDES
303	Microcytosis			OFFSIDES
304	Mitochondrial DNA deletion			OFFSIDES
305	Mitochondrial toxicity			OFFSIDES
306	Mucocutaneous rash			OFFSIDES
307	Multi-organ disorder			OFFSIDES
308	Muscle necrosis			OFFSIDES
309	Musculoskeletal discomfort			SIDER
310	Mutism			OFFSIDES
311	Neonatal respiratory arrest			OFFSIDES
312	Nephritic syndrome			OFFSIDES
313	Nephritis allergic			OFFSIDES
314	Nephrolithiasis			OFFSIDES
315	Nephrotic Syndrome			OFFSIDES
316	Neurologic Manifestations		10465092	CTD
317	Neuropathy			SIDER
318	Neurosyphilis			OFFSIDES
319	Neutropenia			SIDER
320	Nodular regenerative hyperplasia			OFFSIDES
321	Nodule			OFFSIDES
322	Ophthalmoplegia			OFFSIDES
323	Opioid-Related Disorders		12855129	CTD
324	Oropharyngeal candidiasis			OFFSIDES
325	Oropharyngeal discomfort			SIDER
326	Oropharyngeal pain	Canada Vigilance: 1		Canada Vigilance SIDER
327	Osteolysis			OFFSIDES
328	Osteopenia			OFFSIDES
329	Osteoporosis			OFFSIDES
330	Pallor			OFFSIDES
331	Pancreatic enzymes increased			OFFSIDES
332	Pathogen resistance			OFFSIDES
333	Percutaneous Coronary Intervention			OFFSIDES
334	Perianal abscess			OFFSIDES
335	Pericardial effusion			OFFSIDES
336	Peripheral nerve palsy			OFFSIDES
337	Persistent left superior vena cava			OFFSIDES
338	Pharyngolaryngeal Pain			OFFSIDES
339	Plagiocephaly			OFFSIDES
340	Pneumococcal sepsis			OFFSIDES
341	Pneumocystis jiroveci pneumonia			OFFSIDES
342	Polydactyly			OFFSIDES
343	Polysubstance abuse			OFFSIDES
344	Polyuria			OFFSIDES
345	Porphyrins urine increased			OFFSIDES
346	Portal Hypertension			OFFSIDES
347	Portal Vein Thrombosis			OFFSIDES
348	Post lumbar puncture syndrome			OFFSIDES
349	Pre-Eclampsia			OFFSIDES
350	Pregnancy with advanced maternal age			OFFSIDES
351	Proctitis			OFFSIDES
352	Productive Cough			OFFSIDES
353	Prothrombin level decreased			OFFSIDES
354	Pseudomonal sepsis			OFFSIDES
355	Psoas Abscess			OFFSIDES
356	Pulmonary Hypertension			OFFSIDES
357	Pyelonephritis			OFFSIDES
358	Pyonephrosis			OFFSIDES
359	Radial nerve palsy			OFFSIDES
360	Rash erythematous	Canada Vigilance: 2		Canada Vigilance
361	Red blood cell schistocytes present			OFFSIDES
362	Renal Colic			OFFSIDES
363	Renal interstitial fibrosis			OFFSIDES
364	Renal tubular acidosis			OFFSIDES
365	Renal tubular disorder			OFFSIDES
366	Renal tubular necrosis			OFFSIDES
367	Retinal Vein Occlusion			OFFSIDES
368	Retinitis			OFFSIDES
369	Rhinorrhea			OFFSIDES
370	Scab			OFFSIDES
371	Schistosomiasis			OFFSIDES
372	Schizophrenia			OFFSIDES
373	Severe Acute Respiratory Syndrome			OFFSIDES
374	Sex hormone binding globulin decreased			OFFSIDES
375	Sick Sinus Syndrome			OFFSIDES
376	Sinoatrial Block			OFFSIDES
377	Skeletal injury			OFFSIDES
378	Spinal cord herniation			OFFSIDES
379	Splenomegaly			SIDER
380	Status Epilepticus		20851280	CTD
381	Stomatitis			SIDER
382	Substance Withdrawal Syndrome		12855129	CTD
383	Syndactyly			OFFSIDES
384	Syphilis			OFFSIDES
385	Tenosynovitis			OFFSIDES
386	Therapy non-responder			OFFSIDES
387	Thromboangiitis Obliterans			OFFSIDES
388	Tinea Capitis			OFFSIDES
389	Tonsillitis			OFFSIDES
390	Toxic Epidermal Necrolysis			SIDER
391	Toxoplasmosis			OFFSIDES
392	Transfusion Reaction			OFFSIDES
393	Trisomy 21			OFFSIDES
394	Tuberculoid leprosy			OFFSIDES
395	Ultrasound abdomen abnormal			OFFSIDES
396	Ultrasound scan abnormal			OFFSIDES
397	Ventricular hypoplasia			OFFSIDES
398	Vertigo			SIDER
399	Vestibular Neuronitis			OFFSIDES
400	Viral load decreased			OFFSIDES
401	Viral mutation identified			OFFSIDES
402	Visual Impairment	Canada Vigilance: 1		Canada Vigilance
403	Visual disturbance			OFFSIDES
404	Xerosis			OFFSIDES
405	treatment failure			OFFSIDES

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120239