MetaADEDB 2.0 @ LMMD
candesartan
(HTQMVQVXFRQIKW-UHFFFAOYSA-N)
Structure
SMILES
CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O
Type(s)
Experimental
ATC code(s)
C09CA06; C09DA06; C09DB07; C09DX06
Molecular Formula:
C24H20N6O3
Molecular Weight:
440.454
Log P:
4.0286
Hydrogen Bond Acceptor:
8
Hydrogen Bond Donor:
2
TPSA:
118.81
CAS Number(s):
139481-59-7
Synonym(s)
1.
candesartan
2.
2-ethoxy-7-carboxy-1-(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methylbenzimidazole
3.
CV 11974
4.
CV-11974
5.
CV11974
External Link(s)
MeSHC081643
PubChem Compound2541
BindingDB50240609
ChEBI3347
CHEMBLCHEMBL1016
DrugBankDB13919
IUPHAR/BPS Guide to PHARMACOLOGY587
6907
KEGGcpd:C07468
dr:D00522
Therapeutic Target DatabaseD0D5SQ
D0A0QL
ZINC3782818
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1OligohydramniosFAERS: 2020132879CTD
OFFSIDES
US FAERS
2Drug exposure during pregnancyFAERS: 19US FAERS
3RhabdomyolysisFAERS: 17SIDER
US FAERS
4Acute kidney injuryFAERS: 8
Canada Vigilance: 7		18259965CTD
Canada Vigilance
US FAERS
5Cerebral InfarctionFAERS: 7US FAERS
6HeadacheFAERS: 6
Canada Vigilance: 3		Canada Vigilance
SIDER
US FAERS
7HypotensionFAERS: 621287150CTD
SIDER
US FAERS
8MyalgiaFAERS: 6SIDER
US FAERS
9ArthralgiaFAERS: 5SIDER
US FAERS
10NasopharyngitisFAERS: 5SIDER
US FAERS
11StillbirthFAERS: 5US FAERS
12CholestasisFAERS: 4US FAERS
13Depressed Level of ConsciousnessFAERS: 4OFFSIDES
US FAERS
14DizzinessFAERS: 4
Canada Vigilance: 4		Canada Vigilance
OFFSIDES
SIDER
US FAERS
15MalaiseFAERS: 4
Canada Vigilance: 4		Canada Vigilance
US FAERS
16NauseaFAERS: 4
Canada Vigilance: 3		Canada Vigilance
SIDER
US FAERS
17Neonatal hypotensionFAERS: 4US FAERS
18Nephrogenic Diabetes InsipidusFAERS: 4US FAERS
19Respiratory FailureFAERS: 4US FAERS
20TremorFAERS: 4US FAERS
21VasculitisFAERS: 4SIDER
US FAERS
22AnuriaFAERS: 3US FAERS
23Drug ineffectiveFAERS: 3
Canada Vigilance: 9		Canada Vigilance
US FAERS
24Failure to ThriveFAERS: 3OFFSIDES
US FAERS
25InfectionFAERS: 3SIDER
US FAERS
26PemphigusFAERS: 3US FAERS
27Retinal DetachmentFAERS: 3US FAERS
28UrticariaFAERS: 3SIDER
US FAERS
29Ventricular FibrillationFAERS: 3OFFSIDES
US FAERS
30Alanine Aminotransferase IncreasedFAERS: 2US FAERS
31AnxietyFAERS: 2
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
32Aspartate Aminotransferase IncreasedFAERS: 2US FAERS
33AstheniaFAERS: 2OFFSIDES
SIDER
US FAERS
34Atrial FibrillationFAERS: 2US FAERS
35Cardiac HypertrophyFAERS: 2US FAERS
36Chest PainFAERS: 2SIDER
US FAERS
37Chest discomfortFAERS: 2US FAERS
38ChillsFAERS: 2US FAERS
39Dry skinFAERS: 2US FAERS
40DysmorphismFAERS: 2US FAERS
41Erythema MultiformeFAERS: 2US FAERS
42ErythemaFAERS: 2US FAERS
43Head discomfortFAERS: 2US FAERS
44Hepatitis BFAERS: 2US FAERS
45HepatotoxicityFAERS: 2US FAERS
46HypersensitivityFAERS: 2SIDER
US FAERS
47Hypertensive crisisFAERS: 2US FAERS
48HypospadiasFAERS: 2US FAERS
49Insulin autoimmune syndromeFAERS: 2US FAERS
50Oropharyngeal discomfortFAERS: 2US FAERS
51PalpitationsFAERS: 2SIDER
US FAERS
52PancytopeniaFAERS: 2SIDER
US FAERS
53PneumoniaFAERS: 2SIDER
US FAERS
54Poor peripheral circulationFAERS: 2US FAERS
55Product substitution issueFAERS: 2
Canada Vigilance: 13		Canada Vigilance
US FAERS
56PruritusFAERS: 2SIDER
US FAERS
57Renal failure neonatalFAERS: 2US FAERS
58Renal impairment neonatalFAERS: 2US FAERS
59TalipesFAERS: 2US FAERS
60Urinary RetentionFAERS: 2US FAERS
61insulinomaFAERS: 2US FAERS
62Accidental drug intake by childFAERS: 1US FAERS
63Accidental overdoseFAERS: 1US FAERS
64AcidosisFAERS: 1US FAERS
65Activities of daily living impairedFAERS: 1US FAERS
66Acute respiratory failureFAERS: 1US FAERS
67Anal sphincter atonyFAERS: 1US FAERS
68Anaphylactic shockFAERS: 1SIDER
US FAERS
69Anti-HBc IgM antibody positiveFAERS: 1US FAERS
70ApathyFAERS: 1OFFSIDES
US FAERS
71AscitesFAERS: 1US FAERS
72BlindnessFAERS: 1US FAERS
73Blood alkaline phosphatase increasedFAERS: 1US FAERS
74Blood chloride decreasedFAERS: 1US FAERS
75Blood creatine phosphokinase increasedFAERS: 1SIDER
US FAERS
76Blood creatinine increasedFAERS: 1OFFSIDES
SIDER
US FAERS
77Blood potassium decreasedFAERS: 1US FAERS
78Blood pressure inadequately controlledFAERS: 1
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
79BradyphreniaFAERS: 1US FAERS
80Burning Mouth SyndromeFAERS: 115185557CTD
US FAERS
81Burning sensationFAERS: 1US FAERS
82Cardiac ArrestFAERS: 1SIDER
US FAERS
83Cerebrovascular accidentFAERS: 1US FAERS
84CholecystitisFAERS: 1US FAERS
85Cold sweatFAERS: 1US FAERS
86Complications of maternal exposure to therapeutic drugsFAERS: 1US FAERS
87Congenital cystic kidney diseaseFAERS: 1US FAERS
88Congenital hydronephrosisFAERS: 1US FAERS
89Congenital renal disorderFAERS: 1US FAERS
90DeafnessFAERS: 1US FAERS
91Deep Vein ThrombosisFAERS: 1US FAERS
92DermatitisFAERS: 1SIDER
US FAERS
93Drug effect incompleteFAERS: 1US FAERS
94Duodenal UlcerFAERS: 1US FAERS
95DysgeusiaFAERS: 1US FAERS
96DysuriaFAERS: 1OFFSIDES
US FAERS
97Electrocardiogram T wave amplitude increasedFAERS: 1US FAERS
98Erectile dysfunctionFAERS: 1SIDER
US FAERS
99Exposure during breast feedingFAERS: 1US FAERS
100Extremity contractureFAERS: 1US FAERS
101Eye inflammationFAERS: 1US FAERS
102Facial paralysisFAERS: 1US FAERS
103FatigueFAERS: 1
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
104Feeling ColdFAERS: 1US FAERS
105Feeling abnormalFAERS: 1US FAERS
106Fulminant type 1 diabetes mellitusFAERS: 1US FAERS
107GlioblastomaFAERS: 1US FAERS
108HemiparesisFAERS: 1US FAERS
109HepatitisFAERS: 1SIDER
US FAERS
110HepatomegalyFAERS: 1US FAERS
111HypercapniaFAERS: 1US FAERS
112IleusFAERS: 1US FAERS
113ImmobileFAERS: 1US FAERS
114IncontinenceFAERS: 1US FAERS
115Intentional misuseFAERS: 1US FAERS
116Joint stiffnessFAERS: 1US FAERS
117Joint swellingFAERS: 1US FAERS
118Left atrial dilatationFAERS: 1US FAERS
119Lower respiratory tract infectionFAERS: 1US FAERS
120Lymphocyte stimulation test positiveFAERS: 1US FAERS
121Macular degenerationFAERS: 1US FAERS
122Metabolic acidosisFAERS: 1US FAERS
123MicrocephalyFAERS: 1US FAERS
124Monocyte count decreasedFAERS: 1US FAERS
125Mouth swellingFAERS: 1US FAERS
126Multi-organ disorderFAERS: 1US FAERS
127Musculoskeletal chest painFAERS: 1OFFSIDES
US FAERS
128Neonatal disorderFAERS: 1US FAERS
129Neonatal hepatomegalyFAERS: 1US FAERS
130Neonatal respiratory acidosisFAERS: 1US FAERS
131NephritisFAERS: 1US FAERS
132Nephrotic SyndromeFAERS: 1US FAERS
133NeutropeniaFAERS: 1SIDER
US FAERS
134Night sweatsFAERS: 1US FAERS
135OliguriaFAERS: 1OFFSIDES
US FAERS
136OsteoporosisFAERS: 1US FAERS
137Pain of skinFAERS: 1US FAERS
138PainFAERS: 1SIDER
US FAERS
139PallorFAERS: 1US FAERS
140PancreatitisFAERS: 1SIDER
US FAERS
141Patent ductus arteriosusFAERS: 1US FAERS
142Pharyngeal swellingFAERS: 1US FAERS
143PneumothoraxFAERS: 1OFFSIDES
US FAERS
144Post procedural complicationFAERS: 1US FAERS
145Pre-EclampsiaFAERS: 1US FAERS
146Prescribed overdoseFAERS: 1US FAERS
147PriapismFAERS: 1US FAERS
148ProteinuriaFAERS: 1

View details

9407466
11910311
11917051
16687628
19887503
 		CTD
US FAERS
149Pulmonary FibrosisFAERS: 1US FAERS
150PyelonephritisFAERS: 1US FAERS
151Renal painFAERS: 1US FAERS
152Respiratory tract inflammationFAERS: 1US FAERS
153RetchingFAERS: 1US FAERS
154SepsisFAERS: 1US FAERS
155Sexual DysfunctionFAERS: 1US FAERS
156Skin lesionFAERS: 1US FAERS
157Specific gravity urine abnormalFAERS: 1US FAERS
158Spinal Muscular AtrophyFAERS: 1US FAERS
159Sprue-like enteropathyFAERS: 1US FAERS
160Stevens-Johnson SyndromeFAERS: 1US FAERS
161StressFAERS: 1OFFSIDES
US FAERS
162Sudden deathFAERS: 1OFFSIDES
US FAERS
163Suicide attemptFAERS: 1US FAERS
164SyncopeFAERS: 1SIDER
US FAERS
165ThrombocytopeniaFAERS: 1SIDER
US FAERS
166Tongue pruritusFAERS: 1US FAERS
167Toxicity to various agentsFAERS: 1US FAERS
168Transaminases increasedFAERS: 1OFFSIDES
SIDER
US FAERS
169Urinary IncontinenceFAERS: 1US FAERS
170Urinary occult blood positiveFAERS: 1US FAERS
171Urinary sediment presentFAERS: 1US FAERS
172Urinary tract infectionFAERS: 1SIDER
US FAERS
173Urine ketone bodyFAERS: 1US FAERS
174Vasculitic rashFAERS: 1US FAERS
175Ventricular arrhythmiaFAERS: 1US FAERS
176Visual ImpairmentFAERS: 1US FAERS
177VomitingFAERS: 1SIDER
US FAERS
178Weight decreasedFAERS: 1US FAERS
179White blood cell count decreasedFAERS: 1US FAERS
180pH urine decreasedFAERS: 1US FAERS
181Abdominal PainCanada Vigilance: 1Canada Vigilance
SIDER
182Abdominal discomfortCanada Vigilance: 3Canada Vigilance
183Acute Coronary SyndromeSIDER
184Acute angle-closure glaucomaSIDER
185Acute myocardial infarctionOFFSIDES
186Ageusia15185557CTD
187AgitationSIDER
188AgranulocytosisSIDER
189Albuminuria18679781CTD
SIDER
190Altered state of consciousnessOFFSIDES
191Amaurosis FugaxOFFSIDES
192AmnesiaOFFSIDES
193Amnestic DisorderOFFSIDES
194Angina PectorisSIDER
195Angioedema12566029
19709832		CTD
SIDER
196Angle Closure GlaucomaSIDER
197AnorexiaOFFSIDES
SIDER
198Anti-insulin antibody positiveOFFSIDES
199Anticholinergic SyndromeOFFSIDES
200Antigliadin antibody positiveOFFSIDES
201Application site urticariaOFFSIDES
202Arteriosclerosis ObliteransOFFSIDES
203Arteriovenous fistula site complicationOFFSIDES
204ArthritisSIDER
205ArthropathySIDER
206AtaxiaOFFSIDES
207Atrioventricular BlockSIDER
208AuraOFFSIDES
209Back PainSIDER
210Bacteria stool identifiedOFFSIDES
211BedriddenOFFSIDES
212Bile duct cancer stage IIIOFFSIDES
213Bladder painSIDER
214Blood GlucoseOFFSIDES
215Blood and lymphatic system disordersSIDER
216Blood glucose decreasedOFFSIDES
217Blood potassium increasedOFFSIDES
218Blood sodiumOFFSIDES
219Blood triglycerides increasedSIDER
220Blood urea increasedOFFSIDES
SIDER
221Blood uric acidOFFSIDES
222Body TemperatureOFFSIDES
223Bone marrow depressionSIDER
224Bone painSIDER
225BradycardiaOFFSIDES
226Brain Ischemia18551021CTD
227Brain Stem Infarctions18769283CTD
228BronchitisSIDER
229Brown urineSIDER
230Buccal mucosal rougheningOFFSIDES
231BulimiaOFFSIDES
232Cardiomegaly17082731
20562518		CTD
233Cardiomyopathies16324756
20132879		CTD
234Cataract operationOFFSIDES
235CataractOFFSIDES
236Chemical and Drug Induced Liver Injury11141435CTD
237Cholecystitis infectiveOFFSIDES
238CholelithiasisSIDER
239ChromaturiaOFFSIDES
SIDER
240Cold symptomsSIDER
241Concomitant disease progressionOFFSIDES
242Congenital vaginal cystOFFSIDES
243ConjunctivitisSIDER
244ConstipationSIDER
245Coronary Artery DiseaseSIDER
246Creatine Phosphokinase IncreasedSIDER
247Creatinine increasedSIDER
248CystitisSIDER
249DehydrationSIDER
250Diabetes MellitusSIDER
251Diabetic Retinopathy18823656CTD
252DiarrheaOFFSIDES
253Disseminated Intravascular CoagulationOFFSIDES
254DiverticulumOFFSIDES
255DrowsinessOFFSIDES
256DyspepsiaCanada Vigilance: 1Canada Vigilance
SIDER
257EczemaOFFSIDES
SIDER
258Electrocardiogram QRS complexOFFSIDES
259Electrolyte imbalanceSIDER
260EndocarditisOFFSIDES
261Endomyocardial Fibrosis14871019
18829990
19487956		CTD
262Enteritis17763956CTD
263EnterocolitisOFFSIDES
264Epigastric discomfortSIDER
265EpistaxisOFFSIDES
SIDER
266Erosive gastritisOFFSIDES
267Fetal Growth Retardation20132879CTD
268Flank PainOFFSIDES
269FlushingSIDER
270FrustrationOFFSIDES
271GangreneOFFSIDES
272Gastric irritationSIDER
273Gastric ulcerOFFSIDES
274GastroenteritisSIDER
275Gastrointestinal PainCanada Vigilance: 1Canada Vigilance
SIDER
276Gastrointestinal motility disorderOFFSIDES
277Gastrointestinal perforationOFFSIDES
278Glasgow coma scaleOFFSIDES
279Glaucoma12566029CTD
280Glomerulonephritis9407466CTD
281GlycosuriaSIDER
282GoutOFFSIDES
283Heart failure

View details

15849448
16028461
16285075
16891293
 		CTD
284Hepatitis ASIDER
285HydronephrosisOFFSIDES
286Hyperkalemia16285075CTD
287Hypertensive heart diseaseOFFSIDES
288Hypertrophy19047581CTD
289Hypoglossal nerve paresisOFFSIDES
290Hypokalemia11332259CTD
291HypophagiaOFFSIDES
292ImpatienceOFFSIDES
293Incorrect drug administration durationOFFSIDES
294Infarction, Middle Cerebral Artery16824557CTD
295Infection in an immunocompromised hostOFFSIDES
296InfestationSIDER
297Inflammation14620923CTD
SIDER
298Inflicted injurySIDER
299Influenza-like symptomsSIDER
300Injection site cellulitisOFFSIDES
301Injection site warmthOFFSIDES
302Insulin Resistance22253423CTD
303Intention tremorOFFSIDES
304Kidney Diseases12954793
30368989		CTD
305LaryngitisSIDER
306LethargyOFFSIDES
307LeukoencephalopathyOFFSIDES
308LeukopeniaSIDER
309Ligament injuryOFFSIDES
310LightheadednessSIDER
311Long QT SyndromeOFFSIDES
312Lyme DiseaseOFFSIDES
313MalnutritionSIDER
314MetatarsalgiaOFFSIDES
315Migraine Disorders18759728CTD
316MonoplegiaOFFSIDES
317Muscle tightnessCanada Vigilance: 1Canada Vigilance
318Musculoskeletal discomfortSIDER
319Myelitis18769283CTD
320Myocardial InfarctionSIDER
321Myoglobin blood increasedOFFSIDES
322MyopathySIDER
323MyopiaSIDER
324MyositisSIDER
325NervousnessSIDER
326Occult blood positiveOFFSIDES
327Optic Neuropathy, Ischemic18769283CTD
328Oral Ulcer15185557CTD
329Oropharyngeal blisteringOFFSIDES
330Ovarian Hyperstimulation SyndromeOFFSIDES
331Patellofemoral Pain SyndromeOFFSIDES
332PeritonitisOFFSIDES
333PharyngitisSIDER
334Portal Vein ThrombosisOFFSIDES
335Potentiating drug interactionOFFSIDES
336Psychiatric symptomOFFSIDES
337Pulmonary HypertensionOFFSIDES
338Rectal ProlapseOFFSIDES
339Rectal StenosisOFFSIDES
340Renal Insufficiency

View details

9890305
16285075
16543688
20132879
 		CTD
341Renal cystOFFSIDES
342Renal tubular necrosisOFFSIDES
343Respiratory distressSIDER
344RhinitisSIDER
345Secretion dischargeCanada Vigilance: 1Canada Vigilance
346Septic ShockOFFSIDES
347Septic arthritis staphylococcalOFFSIDES
348Serum SicknessOFFSIDES
349ShockSIDER
350SinusitisSIDER
351Sleep-related eating disorderOFFSIDES
352SomnolenceSIDER
353Spinal Cord Ischemia18769283CTD
354Staphylococcal osteomyelitisOFFSIDES
355Stomatitis15185557CTD
356StridorOFFSIDES
357SweatingSIDER
358SwellingSIDER
359TachycardiaSIDER
360TendinitisOFFSIDES
361TensionSIDER
362TetanyOFFSIDES
363Therapeutic product ineffectiveCanada Vigilance: 2Canada Vigilance
364Therapeutic response changedCanada Vigilance: 1Canada Vigilance
365Throat irritationCanada Vigilance: 1Canada Vigilance
366ThrombophlebitisSIDER
367TinnitusCanada Vigilance: 1Canada Vigilance
OFFSIDES
SIDER
368Tongue bitingOFFSIDES
369Tongue blisteringOFFSIDES
370ToothacheSIDER
371Toxic Epidermal NecrolysisSIDER
372Troponin increasedOFFSIDES
373Tympanic Membrane PerforationOFFSIDES
374Upper respiratory tract inflammationOFFSIDES
375UremiaSIDER
376VIIth nerve paralysisOFFSIDES
377Vascular Diseases19047581CTD
378Ventricular Dysfunction, Left14737854CTD
379VertigoSIDER
380Weight Gain22253423CTD
381jaundiceSIDER
382nervous system disorderSIDER
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