MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Clorazepate Dipotassium

(XDDJGVMJFWAHJX-UHFFFAOYSA-N)

Structure

SMILES: OC(=O)C1N=C(c2ccccc2)c2c(NC1=O)ccc(c2)Cl
Type(s): Approved; Illicit
Molecular Formula:: C16H11ClN2O3
Molecular Weight:: 314.723
Log P:: 2.1563
Hydrogen Bond Acceptor:: 5
Hydrogen Bond Donor:: 2
TPSA:: 78.76
CAS Number(s):: 23887-31-2; 149128-44-9

Synonym(s)

Clorazepate Dipotassium

Chlorazepate

Dipotassium Chlorazepate

4306-CB

Clorazepate

Clorazepate Monopotassium

Clorazepic Acid

Tranxene

Tranxilium

External Link(s)

MeSH	D003009
PubChem Compound	2809
ChEBI	3761
CHEMBL	CHEMBL1213252
DrugBank	DB00628
DrugCentral	711
IUPHAR/BPS Guide to PHARMACOLOGY	7548
KEGG	cpd:C06921
Therapeutic Target Database	D0P3JU

Adverse Drug Event(s)

	Name	Number of Reports	Data Source
1	Drug ineffective	FAERS: 4 Canada Vigilance: 2	Canada Vigilance US FAERS
2	Product substitution issue	FAERS: 3	US FAERS
3	Agitation	FAERS: 1	US FAERS
4	Anxiety	FAERS: 1	OFFSIDES US FAERS
5	Aura	FAERS: 1	OFFSIDES US FAERS
6	Bradyphrenia	FAERS: 1	US FAERS
7	Delirium	FAERS: 1	US FAERS
8	Dermatitis	FAERS: 1	SIDER US FAERS
9	Drug Dependence	FAERS: 1 Canada Vigilance: 2	Canada Vigilance US FAERS
10	Drug effective for unapproved indication	FAERS: 1	US FAERS
11	Drug ineffective for unapproved indication	FAERS: 1	US FAERS
12	Drug withdrawal syndrome	FAERS: 1	US FAERS
13	Drug-disease interaction	FAERS: 1	US FAERS
14	Dysgeusia	FAERS: 1	US FAERS
15	Dyspepsia	FAERS: 1	US FAERS
16	Emotional disorder	FAERS: 1	US FAERS
17	Feeling abnormal	FAERS: 1	SIDER US FAERS
18	Fibromyalgia	FAERS: 1	US FAERS
19	General physical health deterioration	FAERS: 1	OFFSIDES US FAERS
20	Incorrect drug administration duration	FAERS: 1	US FAERS
21	Lethargy	FAERS: 1	OFFSIDES US FAERS
22	Malaise	FAERS: 1	US FAERS
23	Product formulation issue	FAERS: 1	US FAERS
24	Product quality issue	FAERS: 1	US FAERS
25	Reaction to preservatives	FAERS: 1	US FAERS
26	Somnolence	FAERS: 1 Canada Vigilance: 2	Canada Vigilance SIDER US FAERS
27	Stress	FAERS: 1	US FAERS
28	Therapeutic response unexpected with drug substitution	FAERS: 1	OFFSIDES US FAERS
29	Tremor	FAERS: 1	SIDER US FAERS
30	Visual disturbance	FAERS: 1	US FAERS
31	nervous system disorder	FAERS: 1	US FAERS
32	Abdominal Abscess		OFFSIDES
33	Abdominal discomfort		OFFSIDES
34	Abscess soft tissue		OFFSIDES
35	Abuse		OFFSIDES
36	Accidental overdose		OFFSIDES
37	Activities of daily living impaired		OFFSIDES
38	Acute Coronary Syndrome		OFFSIDES
39	Acute myocardial infarction		OFFSIDES
40	Adenoma		OFFSIDES
41	Agnosia		OFFSIDES
42	Agoraphobia		OFFSIDES
43	Alanine Aminotransferase Increased		OFFSIDES
44	Alcohol withdrawal syndrome		OFFSIDES
45	Alcoholic Intoxication		OFFSIDES
46	Alopecia		OFFSIDES
47	Alveolitis		OFFSIDES
48	Amenorrhea		OFFSIDES
49	Amimia		OFFSIDES
50	Amnesia		OFFSIDES
51	Anal abscess		OFFSIDES
52	Anhidrosis		OFFSIDES
53	Anorexia		OFFSIDES
54	Anticholinergic Syndrome		OFFSIDES
55	Anticonvulsant drug level below therapeutic		OFFSIDES
56	Antipsychotic drug level above therapeutic		OFFSIDES
57	Antiviral drug level above therapeutic		OFFSIDES
58	Anuria		OFFSIDES
59	Apparent death		OFFSIDES
60	Arthroscopy		OFFSIDES
61	Ascites		OFFSIDES
62	Aseptic Meningitis		OFFSIDES
63	Asphyxia		OFFSIDES
64	Aspiration Pneumonia		OFFSIDES
65	Asthenia		OFFSIDES SIDER
66	Asthma		OFFSIDES
67	Ataxia	Canada Vigilance: 1	Canada Vigilance SIDER
68	Atherosclerosis		OFFSIDES
69	Atrial Flutter		OFFSIDES
70	Autoimmune thyroiditis		OFFSIDES
71	Automatism		OFFSIDES
72	B-cell lymphoma stage I		OFFSIDES
73	Bacteria stool identified		OFFSIDES
74	Bacterial test positive		OFFSIDES
75	Biopsy breast abnormal		OFFSIDES
76	Biopsy		OFFSIDES
77	Bipolar II disorder		OFFSIDES
78	Blood Glucose		OFFSIDES
79	Blood alcohol increased		OFFSIDES
80	Blood alkaline phosphatase increased		OFFSIDES
81	Blood amylase increased		OFFSIDES
82	Blood blister		OFFSIDES
83	Blood cholesterol		OFFSIDES
84	Blood osmolarity decreased		OFFSIDES
85	Blood potassium decreased		OFFSIDES
86	Blood sodium increased		OFFSIDES
87	Blood sodium		OFFSIDES
88	Blood thyroid stimulating hormone		OFFSIDES
89	Body Temperature		OFFSIDES
90	Bronchitis		OFFSIDES
91	Bulimia		OFFSIDES
92	Burning sensation		OFFSIDES
93	Calcinosis		OFFSIDES
94	Candida sepsis		OFFSIDES
95	Cardiac Death		OFFSIDES
96	Cardioactive drug level above therapeutic		OFFSIDES
97	Cardioactive drug level increased		OFFSIDES
98	Carotid artery occlusion		OFFSIDES
99	Catatonia		OFFSIDES
100	Cerebral disorder		OFFSIDES
101	Chemotherapeutic drug level increased		OFFSIDES
102	Choking sensation		OFFSIDES
103	Cholangiolitis		OFFSIDES
104	Cholecystitis		OFFSIDES
105	Cholestatic liver injury		OFFSIDES
106	Chronic Obstructive Airway Disease		OFFSIDES
107	Chronic active hepatitis		OFFSIDES
108	Cirrhosis		OFFSIDES
109	Claustrophobia		OFFSIDES
110	Cogwheel Rigidity		OFFSIDES
111	Colitis		OFFSIDES
112	Completed Suicide		OFFSIDES
113	Complications of maternal exposure to therapeutic drugs		OFFSIDES
114	Confabulation		OFFSIDES
115	Congenital tricuspid valve incompetence		OFFSIDES
116	Conjunctival deposit		OFFSIDES
117	Consciousness fluctuating		OFFSIDES
118	Cor pulmonale		OFFSIDES
119	Creatinine renal clearance decreased		OFFSIDES
120	Crying		OFFSIDES
121	Cyanosis		OFFSIDES
122	Cytolytic hepatitis		OFFSIDES
123	Depressed Level of Consciousness		OFFSIDES
124	Diabetes mellitus inadequate control		OFFSIDES
125	Diabetic Foot		OFFSIDES
126	Diabetic Nephropathy		OFFSIDES
127	Diet refusal		OFFSIDES
128	Diplopia		SIDER
129	Disease recurrence		OFFSIDES
130	Diverticulosis		OFFSIDES
131	Dizziness		SIDER
132	Drowsiness		OFFSIDES SIDER
133	Drug abuser		OFFSIDES
134	Drug addict		OFFSIDES
135	Drug exposure during pregnancy		OFFSIDES
136	Drug screen positive		OFFSIDES
137	Drug toxicity		OFFSIDES
138	Duodenitis		OFFSIDES
139	Dysarthria		SIDER
140	Dysphonia		OFFSIDES
141	Dysthymic Disorder		OFFSIDES
142	Dystonia		OFFSIDES
143	Economic problem		OFFSIDES
144	Ejection Fraction Decreased		OFFSIDES
145	Electrocardiogram change		OFFSIDES
146	Electrocardiogram poor R-wave progression		OFFSIDES
147	Electromyogram abnormal		OFFSIDES
148	Enteral Nutrition		OFFSIDES
149	Enterocolitis		OFFSIDES
150	Epistaxis		OFFSIDES
151	Erectile dysfunction		OFFSIDES
152	Erythema		OFFSIDES
153	Erythrosis		OFFSIDES
154	Escherichia infection		OFFSIDES
155	Excoriation		OFFSIDES
156	Exophthalmos		OFFSIDES
157	External ear pain		OFFSIDES
158	Extremity necrosis		OFFSIDES
159	Factor V deficiency		OFFSIDES
160	Familial Mediterranean Fever		OFFSIDES
161	Fascial infection		OFFSIDES
162	Fatigue		SIDER
163	Febrile bone marrow aplasia		OFFSIDES
164	Feeding disorder neonatal		OFFSIDES
165	Feeling Cold		OFFSIDES
166	Fluid overload		OFFSIDES
167	Galactorrhea		OFFSIDES
168	Gambling		OFFSIDES
169	Gamma-Glutamyltransferase Increased		OFFSIDES
170	Gangrene		OFFSIDES
171	Gastric ulcer		OFFSIDES
172	Gastrointestinal hypomotility		OFFSIDES
173	Gastrointestinal obstruction		OFFSIDES
174	Gastrointestinal sounds abnormal		OFFSIDES
175	Glasgow coma scale		OFFSIDES
176	Granulocytosis		OFFSIDES
177	Granuloma Annulare		OFFSIDES
178	Headache		SIDER
179	Hemiparesis		OFFSIDES
180	Hemiplegia		OFFSIDES
181	Hepatitis		OFFSIDES
182	Hepatosplenomegaly		OFFSIDES
183	Histiocytosis haematophagic		OFFSIDES
184	Hydrocephalus		OFFSIDES
185	Hypercapnia		OFFSIDES
186	Hyperreflexia		OFFSIDES
187	Hyperventilation		OFFSIDES
188	Hypoaesthesia facial		OFFSIDES
189	Hypomania		OFFSIDES
190	Hyporeflexia		OFFSIDES
191	Hypoxia		OFFSIDES
192	Hysteroscopy		OFFSIDES
193	Idiosyncratic drug reaction		OFFSIDES
194	Inappropriate affect		OFFSIDES
195	Infection in an immunocompromised host		OFFSIDES
196	Initial insomnia		OFFSIDES
197	Injection site burning		OFFSIDES
198	Injection site erythema		OFFSIDES
199	Injection site irritation		OFFSIDES
200	Insulin-requiring type 2 diabetes mellitus		OFFSIDES
201	Intention tremor		OFFSIDES
202	Intentional drug misuse		OFFSIDES
203	Intentional misuse		OFFSIDES
204	Intentional self-injury		OFFSIDES
205	Joint Range of Motion Decreased		OFFSIDES
206	Joint injury		OFFSIDES
207	Joint sprain		OFFSIDES
208	Laceration		OFFSIDES
209	Laryngitis bacterial		OFFSIDES
210	Laryngitis fungal		OFFSIDES
211	Laryngomalacia		OFFSIDES
212	Left Ventricular Hypertrophy		OFFSIDES
213	Legionella		OFFSIDES
214	Leukoencephalopathy		OFFSIDES
215	Leukoplakia		OFFSIDES
216	Limb injury		OFFSIDES
217	Lipase		OFFSIDES
218	Livedo Reticularis		OFFSIDES
219	Locked-In Syndrome		OFFSIDES
220	Loss of proprioception		OFFSIDES
221	Lymphocele		OFFSIDES
222	Malignant neoplasm progression		OFFSIDES
223	Meningioma		OFFSIDES
224	Meniscus operation		OFFSIDES
225	Metabolic acidosis		OFFSIDES
226	Metamorphopsia		OFFSIDES
227	Microcephaly		OFFSIDES
228	Microlithiasis		OFFSIDES
229	Migraine with Aura		OFFSIDES
230	Moaning		OFFSIDES
231	Monocytosis		OFFSIDES
232	Morbid thoughts		OFFSIDES
233	Multiple Sclerosis		OFFSIDES
234	Multiple drug overdose		OFFSIDES
235	Multiple drug overdose intentional		OFFSIDES
236	Muscular Dystrophy		OFFSIDES
237	Mutism		OFFSIDES
238	Negativism		OFFSIDES
239	Neonatal aspiration		OFFSIDES
240	Nephrogenic Diabetes Insipidus		OFFSIDES
241	Nephrolithiasis		OFFSIDES
242	Nervous tension		OFFSIDES
243	Nervousness		SIDER
244	Neuroleptic Malignant Syndrome		OFFSIDES
245	Nicotine Dependence		OFFSIDES
246	Obsessive thoughts		OFFSIDES
247	Ocular icterus		OFFSIDES
248	Oculogyration		OFFSIDES
249	Onycholysis		OFFSIDES
250	Optic Atrophy		OFFSIDES
251	Optic Disc Edema		OFFSIDES
252	Orthopnea		OFFSIDES
253	Overdose		OFFSIDES
254	Pain of skin		OFFSIDES
255	Pain		OFFSIDES
256	Pallor		OFFSIDES
257	Pancreatic enzymes increased		OFFSIDES
258	Pancreatitis		OFFSIDES
259	Panic Disorder		OFFSIDES
260	Parotitis		OFFSIDES
261	Partner stress		OFFSIDES
262	Periarthritis		OFFSIDES
263	Pharmaceutical product complaint		OFFSIDES
264	Pharyngolaryngeal Pain		OFFSIDES
265	Phimosis		OFFSIDES
266	Phlebitis		OFFSIDES
267	Physical abuse		OFFSIDES
268	Pneumocystis jiroveci pneumonia		OFFSIDES
269	Polyhydramnios		OFFSIDES
270	Polysubstance abuse		OFFSIDES
271	Polyuria		OFFSIDES
272	Poor sucking reflex		OFFSIDES
273	Post-anoxic myoclonus		OFFSIDES
274	Posterior capsule opacification		OFFSIDES
275	Pre-Eclampsia		OFFSIDES
276	Procedural site reaction		OFFSIDES
277	Proctitis		OFFSIDES
278	Proctocolitis		OFFSIDES
279	Productive Cough		OFFSIDES
280	Protein total decreased		OFFSIDES
281	Prothrombin level decreased		OFFSIDES
282	Pseudodementia		OFFSIDES
283	Pseudomonal sepsis		OFFSIDES
284	Pulmonary Valve Stenosis		OFFSIDES
285	Pulmonary arterial pressure increased		OFFSIDES
286	Quality of life decreased		OFFSIDES
287	Renal tubular disorder		OFFSIDES
288	Renal tubular necrosis		OFFSIDES
289	Respiratory Failure		OFFSIDES
290	Respiratory depth decreased		OFFSIDES
291	Retrograde portal vein flow		OFFSIDES
292	Retroperitoneal fibrosis		OFFSIDES
293	Rhabdomyolysis		OFFSIDES
294	Rhinalgia		OFFSIDES
295	Rhonchi		OFFSIDES
296	Schizoaffective Disorder		OFFSIDES
297	Schizophrenia		OFFSIDES
298	Scotoma		OFFSIDES
299	Self-induced vomiting		OFFSIDES
300	Sense of oppression		OFFSIDES
301	Sinoatrial Block		OFFSIDES
302	Skin necrosis		OFFSIDES
303	Slurred speech		SIDER
304	Smoker		OFFSIDES
305	Sopor		OFFSIDES
306	Splenic necrosis		OFFSIDES
307	Splenic vein thrombosis		OFFSIDES
308	Stevens-Johnson Syndrome		OFFSIDES
309	Subileus		OFFSIDES
310	Sudden death		OFFSIDES
311	Sudden onset of sleep		OFFSIDES
312	Supraventricular tachycardia		OFFSIDES
313	Suture rupture		OFFSIDES
314	Talipes		OFFSIDES
315	Tardive Dyskinesia		OFFSIDES
316	Temperature intolerance		OFFSIDES
317	Tension		SIDER
318	Therapeutic response unexpected		OFFSIDES
319	Tinea Pedis		OFFSIDES
320	Tinnitus		OFFSIDES
321	Tongue biting		OFFSIDES
322	Toxicologic test abnormal		OFFSIDES
323	Transaminases increased		OFFSIDES
324	Unresponsive to stimuli		OFFSIDES
325	Ventricular Fibrillation		OFFSIDES
326	Violence-related symptom		OFFSIDES
327	Weight Gain		OFFSIDES
328	colonoscopy		OFFSIDES

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