MetaADEDB 2.0 @ LMMD
Thiotepa
(FOCVUCIESVLUNU-UHFFFAOYSA-N)
Structure
SMILES
S=P(N1CC1)(N1CC1)N1CC1
Type(s)
Approved; Investigational
ATC code(s)
L01AC01
Molecular Formula:
C6H12N3PS
Molecular Weight:
189.218
Log P:
0.6220
Hydrogen Bond Acceptor:
4
Hydrogen Bond Donor:
0
TPSA:
50.93
CAS Number(s):
52-24-4
Synonym(s)
1.
Thiotepa
2.
Thio-Tepa
3.
Thiophosphamide
4.
Triethylenethiophosphoramide
5.
AI3-24916
6.
Girostan
7.
NSC-6396
8.
Tespa
9.
Tespamin
10.
Tris(1-aziridinyl)phosphine Sulfide
11.
AI3 24916
12.
AI324916
13.
NSC 6396
14.
NSC6396
15.
Thio Tepa
External Link(s)
MeSHD013852
PubChem Compound5453
BindingDB50418086
ChEBI9570
CHEMBLCHEMBL671
DrugBankDB04572
DrugCentral2638
IUPHAR/BPS Guide to PHARMACOLOGY7622
KEGGcpd:C07641
dr:D00583
Therapeutic Target DatabaseD00YZA
ZINC1530867
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1InfectionFAERS: 24OFFSIDES
SIDER
US FAERS
2Body height below normalFAERS: 3US FAERS
3HeadacheFAERS: 39759389CTD
SIDER
US FAERS
4Reproductive toxicityFAERS: 3US FAERS
5Pneumonia herpes viralFAERS: 2US FAERS
6Stem cell transplantFAERS: 2OFFSIDES
US FAERS
7Abdominal Compartment SyndromeFAERS: 1US FAERS
8Abdominal PainFAERS: 1SIDER
US FAERS
9Acute graft versus host disease in intestineFAERS: 1US FAERS
10AgitationFAERS: 1SIDER
US FAERS
11AscitesFAERS: 1OFFSIDES
US FAERS
12AstheniaFAERS: 1SIDER
US FAERS
13BronchospasmFAERS: 1US FAERS
14Burning sensationFAERS: 1US FAERS
15Cytology abnormalFAERS: 1US FAERS
16Device computer issueFAERS: 1US FAERS
17Device malfunctionFAERS: 1US FAERS
18Disease complicationFAERS: 1US FAERS
19Fluid overloadFAERS: 1OFFSIDES
US FAERS
20General physical health deteriorationFAERS: 1OFFSIDES
US FAERS
21Hepatorenal SyndromeFAERS: 1US FAERS
22HypotensionFAERS: 1US FAERS
23HypoxiaFAERS: 1OFFSIDES
SIDER
US FAERS
24LymphopeniaFAERS: 1US FAERS
25MeningismFAERS: 1SIDER
US FAERS
26NeutropeniaFAERS: 19676843CTD
US FAERS
27OverdoseFAERS: 1US FAERS
28PneumonitisFAERS: 1US FAERS
29Polyomavirus-associated nephropathyFAERS: 1US FAERS
30Post procedural complicationFAERS: 1OFFSIDES
US FAERS
31Product preparation errorFAERS: 1US FAERS
32Product selection errorFAERS: 1US FAERS
33Renal tubular necrosisFAERS: 1US FAERS
34Respiratory FailureFAERS: 1OFFSIDES
US FAERS
35Respiratory distressFAERS: 1US FAERS
36Respiratory fatigueFAERS: 1US FAERS
37SyncopeFAERS: 1US FAERS
38ThrombocytopeniaFAERS: 12121628
6776297		CTD
SIDER
US FAERS
39Toxicity to various agentsFAERS: 1US FAERS
40Venoocclusive diseaseFAERS: 1OFFSIDES
US FAERS
41VomitingFAERS: 1SIDER
US FAERS
42Abnormal cervical smearOFFSIDES
43Abnormal visionOFFSIDES
44ActinomycosisOFFSIDES
45Agranulocytosis2121628CTD
SIDER
46AgraphiaOFFSIDES
47Alanine Aminotransferase IncreasedSIDER
48Alopecia2121628
3922100		CTD
OFFSIDES
SIDER
49Amylase increasedSIDER
50Anemia7786825CTD
51AnorexiaSIDER
52Anti-GAD antibodyOFFSIDES
53Antidepressant drug clearance increasedOFFSIDES
54AnxietyOFFSIDES
SIDER
55Apallic syndromeOFFSIDES
56AppendicitisOFFSIDES
57ArthralgiaSIDER
58Aspartate Aminotransferase IncreasedSIDER
59AspergillosisOFFSIDES
60AtaxiaSIDER
61AtelectasisOFFSIDES
62Atrial Fibrillation9676843CTD
63Axonal neuropathyOFFSIDES
64AzoospermiaSIDER
65BK virus infectionOFFSIDES
66Back PainSIDER
67Bacteria blood identifiedOFFSIDES
68Basal cell carcinomaOFFSIDES
69Bladder painSIDER
70Blood alkaline phosphatase increasedSIDER
71Blood amylase increasedOFFSIDES
SIDER
72Blood and lymphatic system disordersSIDER
73Blood bilirubin abnormalOFFSIDES
74Blood creatinine increasedSIDER
75Blood electrolytes abnormalSIDER
76Blood pressure inadequately controlledOFFSIDES
77Blood urea increasedSIDER
78Body TemperatureOFFSIDES
79Bone Marrow Diseases4216649CTD
80Bone SarcomaOFFSIDES
81Bone fragmentationOFFSIDES
82Bone scan abnormalOFFSIDES
83Brain DeathOFFSIDES
84Brain Diseases11303620CTD
85Brain Injuries17904307CTD
86Brain Neoplasms10482945CTD
87Capillary Leak SyndromeOFFSIDES
88Carcinoma, Transitional Cell806708CTD
89Cardiac ArrestSIDER
90Cardiomyopathies10534063CTD
91Cardiovascular insufficiencySIDER
92CataractSIDER
93Catheter related infectionOFFSIDES
94Catheter sepsisOFFSIDES
95Catheter site erythemaOFFSIDES
96Catheter site painOFFSIDES
97Central Nervous System Neoplasms10918425
16864853		CTD
98Cerebral atrophyOFFSIDES
99Cerebral disorderOFFSIDES
100Chemical and Drug Induced Liver Injury9676843
11019834
14595385		CTD
101Chemical cystitisSIDER
102ChillsSIDER
103Choking sensationOFFSIDES
104Chronic sinusitisOFFSIDES
105Clostridium difficile colitisOFFSIDES
106ColitisOFFSIDES
SIDER
107Completed SuicideOFFSIDES
108Complications of bone marrow transplantOFFSIDES
109ConfabulationOFFSIDES
110Congenital tracheomalaciaOFFSIDES
111Congenital tricuspid valve incompetenceOFFSIDES
112ConjunctivitisSIDER
113ConstipationSIDER
114Cystitis7495132CTD
SIDER
115CystSIDER
116CytopeniaSIDER
117DeafnessSIDER
118DebridementOFFSIDES
119Decreased LibidoOFFSIDES
120DehydrationSIDER
121DeliriumSIDER
122DemyelinationOFFSIDES
123Dental abscessOFFSIDES
124DermatitisSIDER
125Device related infectionOFFSIDES
126Diarrhea11019834CTD
OFFSIDES
127Diffuse large B-cell lymphoma recurrentOFFSIDES
128DiverticulosisOFFSIDES
129DizzinessSIDER
130DrowsinessOFFSIDES
131Drug toxicityOFFSIDES
132DyspepsiaSIDER
133DysuriaSIDER
134Ear and labyrinth disordersSIDER
135Ear dischargeOFFSIDES
136EmbolismSIDER
137EnteritisSIDER
138Enterococcal infectionOFFSIDES
139Enterococcal sepsisOFFSIDES
140Eosinophilia7495132CTD
141Eosinophilic cystitisSIDER
142EpistaxisOFFSIDES
SIDER
143Epstein-Barr virus test positiveOFFSIDES
144Erythema MultiformeOFFSIDES
145ErythemaSIDER
146Erythrodermic psoriasisSIDER
147Escherichia infectionOFFSIDES
148ExtravasationSIDER
149FatigueSIDER
150Fatty LiverOFFSIDES
151Febrile NeutropeniaOFFSIDES
SIDER
152Feeling abnormalSIDER
153Fever9676843CTD
154Foreign-Body Reaction9759389CTD
155FormicationOFFSIDES
156Gamma-Glutamyltransferase IncreasedSIDER
157Gastrointestinal Diseases10955873CTD
158Gastrointestinal PainSIDER
159Gastrointestinal infectionOFFSIDES
160Gastrointestinal perforationSIDER
161Gastrointestinal toxicityOFFSIDES
162Gastrointestinal ulcerSIDER
163Glioma17904307CTD
164Growth retardationSIDER
165HaematotoxicityOFFSIDES
166Heart Block8122625CTD
167Heart failure10534063CTD
168Hematologic Neoplasms11019834CTD
169Hepatic Veno-Occlusive Disease

View details

10534061
11019834
14595385
18587430
19767780
 		CTD
170Hepatic vein occlusionOFFSIDES
171HepatomegalySIDER
172HepatosplenomegalyOFFSIDES
173HepatotoxicityOFFSIDES
174Hodgkin Disease10955873CTD
175Human herpesvirus 8 infectionOFFSIDES
176HydronephrosisOFFSIDES
177HypersensitivitySIDER
178HypogonadismSIDER
179HypopituitarismSIDER
180HypothyroidismSIDER
181Idiopathic pneumonia syndromeSIDER
182IleusSIDER
183Immunosuppressant drug level decreasedOFFSIDES
184IncontinenceOFFSIDES
185InfestationSIDER
186Injection site inflammationSIDER
187Injection site painSIDER
188Intestinal ObstructionSIDER
189Intracranial AneurysmSIDER
190Intracranial HypotensionOFFSIDES
191Kidney Diseases10955873CTD
192Kidney FailureOFFSIDES
193Labile blood pressureOFFSIDES
194Left atrial dilatationOFFSIDES
195LeukodermaSIDER
196LeukoencephalopathyOFFSIDES
197Leukopenia neonatalOFFSIDES
198Leukopenia7786825CTD
SIDER
199LipaseOFFSIDES
200Liver diseases10918425
10955873		CTD
201Lumbar puncture abnormalOFFSIDES
202Lung diseases10918425CTD
203Lymphoma, Non-Hodgkin10955873
19767780		CTD
204Lymphoma10069464
10482945
16864853		CTD
205MYELODYSPLASTIC SYNDROMESIDER
206MalnutritionSIDER
207Medulloblastoma14595385CTD
OFFSIDES
208Memory Disorders20096731CTD
209Memory impairmentSIDER
210MenopauseSIDER
211Mental impairmentOFFSIDES
212Mental status changesOFFSIDES
SIDER
213Micronuclei, Chromosome-Defective6423448
22923490		CTD
214Morganella infectionOFFSIDES
215Mucosal necrosisOFFSIDES
216Multiple Myeloma7817232
10955873		CTD
217Multiple Organ Failure10918425CTD
218Musculoskeletal discomfortSIDER
219MyalgiaSIDER
220MyelitisOFFSIDES
221MyelodysplasiaOFFSIDES
222MyelosuppressionSIDER
223MyocarditisSIDER
224Nasogastric output highOFFSIDES
225NauseaSIDER
226Necrosis6790156CTD
227Neoplasm Metastasis9676843CTD
228Neoplasms, Experimental6800090CTD
229Neoplasms, Hormone-Dependent12058236CTD
230Neoplasms1982927
18854779		CTD
231NervousnessSIDER
232Neuroblastoma8761367CTD
233Neuroectodermal Tumors8761367
12837982		CTD
234Neurotoxicity Syndromes2131034CTD
235Neutropenic colitisOFFSIDES
236OliguriaOFFSIDES
SIDER
237Oral dischargeOFFSIDES
238OsteolysisOFFSIDES
239OsteomyelitisOFFSIDES
240OsteosclerosisOFFSIDES
241OtotoxicitySIDER
242PO2 decreasedOFFSIDES
243PainSIDER
244PancytopeniaCanada Vigilance: 14216648
4964489
10918425		CTD
SIDER
Canada Vigilance
245Paraplegia8711459CTD
OFFSIDES
246ParesisSIDER
247Pericardial effusionOFFSIDES
248Personality ChangeOFFSIDES
249Phlebitis7786825CTD
250Photophobia9759389CTD
SIDER
251PneumoniaSIDER
252PneumothoraxOFFSIDES
253Portal HypertensionOFFSIDES
254Portal Vein ThrombosisOFFSIDES
255Postoperative feverOFFSIDES
256Postoperative infectionOFFSIDES
257Precursor T-Cell Lymphoblastic Leukemia-Lymphoma8711459CTD
258Primary sequestrumOFFSIDES
259PruritusSIDER
260Pterygium9759389CTD
261Pulmonary HypertensionOFFSIDES
262Purulent dischargeOFFSIDES
263Recurrence9759389CTD
264Refusal of treatment by relativeOFFSIDES
265Renal Insufficiency4201562CTD
266Respiratory arrestSIDER
267Right atrial dilatationOFFSIDES
268SepsisSIDER
269SepticemiaSIDER
270SerositisOFFSIDES
271Skin necrosisOFFSIDES
272Skin toxicityOFFSIDES
273SomnolenceSIDER
274Stenotrophomonas infectionOFFSIDES
275Stomatitis10918425
11019834		CTD
SIDER
276Sudden deathOFFSIDES
277Supratentorial Neoplasms12837982CTD
278TachycardiaSIDER
279TensionSIDER
280Therapy non-responderOFFSIDES
281Thrombocythemia, Essential7817232CTD
282Thrombocytopenic purpuraSIDER
283TinnitusSIDER
284Tooth ExtractionOFFSIDES
285Tooth InfectionOFFSIDES
286Tooth LossOFFSIDES
287Torulopsis infectionOFFSIDES
288Toxic Shock SyndromeSIDER
289Transaminases increasedSIDER
290Treatment related secondary malignancyOFFSIDES
291Unresponsive to stimuliOFFSIDES
292Unresponsive to verbal stimuliOFFSIDES
293Urinary RetentionSIDER
294UrticariaSIDER
295VIIth nerve paralysisOFFSIDES
296Venous occlusionOFFSIDES
297Vocal Cord ParalysisOFFSIDES
298Wound DebridementOFFSIDES
299jaundiceSIDER
300nervous system disorderSIDER
301oligodendroglioma11303620CTD
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