MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

alfuzosin

(WNMJYKCGWZFFKR-UHFFFAOYSA-N)

Structure

SMILES: COc1cc2nc(nc(c2cc1OC)N)N(CCCNC(=O)C1CCCO1)C
Type(s): Approved; Investigational
ATC code(s): G04CA01; G04CA51
Molecular Formula:: C19H27N5O4
Molecular Weight:: 389.449
Log P:: 2.3228
Hydrogen Bond Acceptor:: 9
Hydrogen Bond Donor:: 2
TPSA:: 111.83
CAS Number(s):: 81403-80-7

Synonym(s)

alfuzosin

Alfetim

Benestan

N-(3-((4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino)propyl)tetrahydro-2-furancarboxamide

Urion

UroXatral

Xatral

alfusozine

alfuzosin hydrochloride

10.

alphuzosine

External Link(s)

MeSH	C047638
PubChem Compound	2092
BindingDB	50033110
ChEBI	51141
CHEMBL	CHEMBL709
DrugBank	DB00346
DrugCentral	115
IUPHAR/BPS Guide to PHARMACOLOGY	7109
KEGG	dr:D07124
Therapeutic Target Database	D09MWJ

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Syncope	FAERS: 13 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
2	Hypotension	FAERS: 9	3023106	CTD SIDER US FAERS
3	Urinary Retention	FAERS: 8	7528458 9644979 16304557	CTD US FAERS
4	Product substitution issue	FAERS: 5 Canada Vigilance: 4		Canada Vigilance US FAERS
5	Atrial Fibrillation	FAERS: 4 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
6	Chest Pain	FAERS: 4		SIDER US FAERS
7	Constipation	FAERS: 4		SIDER US FAERS
8	Dizziness	FAERS: 4 Canada Vigilance: 3	7508331	CTD OFFSIDES SIDER Canada Vigilance US FAERS
9	Drug ineffective	FAERS: 4 Canada Vigilance: 4		Canada Vigilance OFFSIDES US FAERS
10	Urticaria	FAERS: 4		SIDER US FAERS
11	Bile output abnormal	FAERS: 3		US FAERS
12	Bone pain	FAERS: 3		US FAERS
13	Bursitis	FAERS: 3		SIDER US FAERS
14	Cholelithiasis obstructive	FAERS: 3		US FAERS
15	Chromaturia	FAERS: 3		US FAERS
16	Eczema	FAERS: 3		OFFSIDES US FAERS
17	Epistaxis	FAERS: 3		OFFSIDES US FAERS
18	Face and mouth X-ray abnormal	FAERS: 3		US FAERS
19	Limb discomfort	FAERS: 3		US FAERS
20	Pain	FAERS: 3		OFFSIDES SIDER US FAERS
21	Pulmonary Embolism	FAERS: 3		US FAERS
22	Snoring	FAERS: 3		US FAERS
23	Transaminases increased	FAERS: 3		OFFSIDES US FAERS
24	Vitreous Detachment	FAERS: 3		US FAERS
25	Vomiting	FAERS: 3		SIDER US FAERS
26	Angina Pectoris	FAERS: 2		SIDER US FAERS
27	Discomfort	FAERS: 2		SIDER US FAERS
28	Dysuria	FAERS: 2		OFFSIDES US FAERS
29	Hypersensitivity	FAERS: 2		US FAERS
30	Malaise	FAERS: 2		SIDER US FAERS
31	Medication Error	FAERS: 2		US FAERS
32	Nausea	FAERS: 2 Canada Vigilance: 2	7508331	CTD SIDER Canada Vigilance US FAERS
33	Palpitations	FAERS: 2		SIDER US FAERS
34	Product quality issue	FAERS: 2		US FAERS
35	Thrombocytopenia	FAERS: 2		SIDER US FAERS
36	Urinary Incontinence	FAERS: 2		US FAERS
37	Accidental overdose	FAERS: 1		US FAERS
38	Acute myocardial infarction	FAERS: 1		US FAERS
39	Agranulocytosis	FAERS: 1		US FAERS
40	Angioedema	FAERS: 1 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
41	Aphonia	FAERS: 1		US FAERS
42	Arthropathy	FAERS: 1		OFFSIDES SIDER US FAERS
43	Atrial Flutter	FAERS: 1		OFFSIDES US FAERS
44	Burning sensation	FAERS: 1		US FAERS
45	Cardiovascular insufficiency	FAERS: 1		US FAERS
46	Cataract operation complication	FAERS: 1		OFFSIDES US FAERS
47	Chest discomfort	FAERS: 1		US FAERS
48	Choking	FAERS: 1		US FAERS
49	Cholelithiasis	FAERS: 1		US FAERS
50	Circumstance or information capable of leading to medication error	FAERS: 1		US FAERS
51	Drug prescribing error	FAERS: 1		US FAERS
52	Erectile dysfunction	FAERS: 1		OFFSIDES SIDER US FAERS
53	Facial paralysis	FAERS: 1		US FAERS
54	Fatigue	FAERS: 1		OFFSIDES SIDER US FAERS
55	Feeling abnormal	FAERS: 1		OFFSIDES SIDER US FAERS
56	Fixed eruption	FAERS: 1		US FAERS
57	Fluid overload	FAERS: 1		US FAERS
58	Foreign body in respiratory tract	FAERS: 1		US FAERS
59	Gastritis	FAERS: 1		US FAERS
60	Gastrointestinal Pain	FAERS: 1		SIDER US FAERS
61	General symptom	FAERS: 1		US FAERS
62	Hepatitis A antibody positive	FAERS: 1		US FAERS
63	Hepatitis B antibody positive	FAERS: 1		US FAERS
64	Hyperacusis	FAERS: 1		US FAERS
65	Inappropriate schedule of drug administration	FAERS: 1		US FAERS
66	Incorrect product storage	FAERS: 1		US FAERS
67	Inflammation	FAERS: 1		US FAERS
68	Lethargy	FAERS: 1		US FAERS
69	Medication residue present	FAERS: 1		US FAERS
70	Oral mucosal erythema	FAERS: 1		OFFSIDES US FAERS
71	Oropharyngeal swelling	FAERS: 1		US FAERS
72	Overdose	FAERS: 1		US FAERS
73	Papule	FAERS: 1		US FAERS
74	Poor quality sleep	FAERS: 1		US FAERS
75	Rash erythematous	FAERS: 1		US FAERS
76	Retching	FAERS: 1		US FAERS
77	Retrograde ejaculation	FAERS: 1		US FAERS
78	Septic Shock	FAERS: 1		OFFSIDES US FAERS
79	Throat irritation	FAERS: 1		US FAERS
80	Thrombosis	FAERS: 1		US FAERS
81	Toxic Epidermal Necrolysis	FAERS: 1		SIDER US FAERS
82	Troponin increased	FAERS: 1		US FAERS
83	Visual Impairment	FAERS: 1		US FAERS
84	White blood cell count decreased	FAERS: 1		US FAERS
85	Abdominal Pain	Canada Vigilance: 1	7508331	CTD OFFSIDES SIDER Canada Vigilance
86	Abdominal discomfort			OFFSIDES
87	Abnormal vision			OFFSIDES
88	Acid reflux			OFFSIDES
89	Actinomycosis			OFFSIDES
90	Adenocarcinoma			OFFSIDES
91	Adrenal mass			OFFSIDES
92	Alpha-1 anti-trypsin increased			OFFSIDES
93	Alveoloplasty			OFFSIDES
94	Amaurosis Fugax			OFFSIDES
95	Amblyopia			OFFSIDES
96	Amphetamines			OFFSIDES
97	Anal Fissure			OFFSIDES
98	Anal Fistula			OFFSIDES
99	Anal abscess			OFFSIDES
100	Aneurysm			OFFSIDES
101	Angiomyolipoma			OFFSIDES
102	Anhedonia			OFFSIDES
103	Anti-erythropoietin antibody positive			OFFSIDES
104	Anxiety			OFFSIDES
105	Apathy			OFFSIDES
106	Aphagia			OFFSIDES
107	Apnea			OFFSIDES
108	Appendectomy			OFFSIDES
109	Appendicitis			OFFSIDES
110	Arthralgia			SIDER
111	Arthritis aggravated			SIDER
112	Arthritis			SIDER
113	Asthenia			OFFSIDES SIDER
114	Atelectasis			OFFSIDES
115	Autoimmune thrombocytopenia			OFFSIDES
116	Automatism			OFFSIDES
117	Back Pain			SIDER
118	Back disorder			OFFSIDES
119	Balanitis			OFFSIDES
120	Barium swallow abnormal			OFFSIDES
121	Benign Prostatic Hyperplasia			OFFSIDES
122	Biopsy			OFFSIDES
123	Bladder discomfort			OFFSIDES
124	Bladder neck obstruction			OFFSIDES
125	Blood 1,25-dihydroxycholecalciferol decreased			OFFSIDES
126	Blood Glucose			OFFSIDES
127	Blood alcohol increased			OFFSIDES
128	Blood and lymphatic system disorders			SIDER
129	Blood creatine phosphokinase increased			OFFSIDES
130	Blood immunoglobulin A decreased			OFFSIDES
131	Blood immunoglobulin M decreased			OFFSIDES
132	Blood parathyroid hormone			OFFSIDES
133	Blood pressure fluctuation			SIDER
134	Blurred vision			OFFSIDES
135	Bone density increased			OFFSIDES
136	Bone lesion			OFFSIDES
137	Bone marrow myelogram abnormal			OFFSIDES
138	Bone swelling			OFFSIDES
139	Bradycardia			OFFSIDES
140	Brain Death			OFFSIDES
141	Brain natriuretic peptide increased			OFFSIDES
142	Breakthrough Pain			OFFSIDES
143	Breast tenderness			OFFSIDES
144	Bronchial Obstruction			OFFSIDES
145	Bronchiolitis			OFFSIDES
146	Bronchitis			SIDER
147	Buccal mucosal roughening			OFFSIDES
148	Bulbar palsy			OFFSIDES
149	Cardiac ablation			OFFSIDES
150	Cataract operation			OFFSIDES
151	Cataract			OFFSIDES
152	Catatonia			OFFSIDES
153	Catheter site phlebitis			OFFSIDES
154	Cervical laser therapy			OFFSIDES
155	Cheilitis			OFFSIDES
156	Chemical and Drug Induced Liver Injury		15280514	CTD
157	Cholangiolitis			OFFSIDES
158	Cholecystitis infective			OFFSIDES
159	Cholestasis			SIDER
160	Cholestatic liver disease			SIDER
161	Cholestatic liver injury			SIDER
162	Clostridium difficile colitis			OFFSIDES
163	Cold sweat			OFFSIDES
164	Colectomy			OFFSIDES
165	Coma acidotic			OFFSIDES
166	Compression fracture			OFFSIDES
167	Concomitant disease progression			OFFSIDES
168	Confabulation			OFFSIDES
169	Conjunctival deposit			OFFSIDES
170	Corneal Ulcer			OFFSIDES
171	Coronary Artery Disease			SIDER
172	Cyanosis			OFFSIDES
173	Cytolytic hepatitis			OFFSIDES
174	Debridement			OFFSIDES
175	Decreased Libido			OFFSIDES
176	Demyelination			OFFSIDES
177	Dental Fistula			OFFSIDES
178	Dental caries			OFFSIDES
179	Dental prosthesis placement			OFFSIDES
180	Dermatitis			SIDER
181	Device breakage			OFFSIDES
182	Diabetes mellitus inadequate control			OFFSIDES
183	Diverticulosis			OFFSIDES
184	Diverticulum			OFFSIDES
185	Dreamy state			OFFSIDES
186	Drowsiness			OFFSIDES SIDER
187	Drug administered at inappropriate site			OFFSIDES
188	Drug withdrawal headache			OFFSIDES
189	Duodenal Ulcer			OFFSIDES
190	Dyspepsia			SIDER
191	Dysphasia			OFFSIDES
192	Ear and labyrinth disorders			SIDER
193	Economic problem			OFFSIDES
194	Ejection fraction abnormal			OFFSIDES
195	Endodontic procedure			OFFSIDES
196	Enterococcal sepsis			OFFSIDES
197	Enuresis			OFFSIDES
198	Eosinophilic myocarditis			OFFSIDES
199	Epilepsy			OFFSIDES
200	Erythrodermic psoriasis			OFFSIDES
201	Exfoliative rash			OFFSIDES
202	Eye pain			OFFSIDES
203	Febrile Neutropenia			OFFSIDES
204	Feeling Cold			OFFSIDES
205	Feeling of body temperature change			OFFSIDES
206	Fistula repair			OFFSIDES
207	Flank Pain			OFFSIDES
208	Floppy iris syndrome			SIDER
209	Flushing			SIDER
210	Foreign body aspiration			OFFSIDES
211	Foreign body trauma			OFFSIDES
212	Formication			OFFSIDES
213	Full blood count decreased			OFFSIDES
214	Fungus stool identified			OFFSIDES
215	Gamma-Glutamyltransferase Increased			OFFSIDES
216	Gastric Bypass			OFFSIDES
217	Gastrointestinal infection			OFFSIDES
218	Gastrointestinal inflammation			OFFSIDES
219	Gastrointestinal sounds abnormal			OFFSIDES
220	Gastrointestinal toxicity			OFFSIDES
221	General physical condition			OFFSIDES
222	General physical health deterioration			OFFSIDES
223	Genital burning sensation			OFFSIDES
224	Gingivectomy			OFFSIDES
225	Globulinuria			OFFSIDES
226	Granuloma			OFFSIDES
227	Headache			SIDER
228	Hepatitis B antigen positive			OFFSIDES
229	Hepatitis B, Chronic		15280514	CTD
230	Hernia obstructive			OFFSIDES
231	Hiccough			OFFSIDES
232	Hidradenitis			OFFSIDES
233	Hip surgery			OFFSIDES
234	Hydronephrosis			OFFSIDES
235	Hypophagia			OFFSIDES
236	Hyporeflexia			OFFSIDES
237	Hypotension, Orthostatic		7508331 10364649	CTD
238	Hypoxia			OFFSIDES
239	Iliac artery stenosis			OFFSIDES
240	Impaired work ability			OFFSIDES
241	Impetigo			OFFSIDES
242	Incontinence			OFFSIDES
243	Increased upper airway secretion			OFFSIDES
244	Induration			OFFSIDES
245	Infection			SIDER
246	Infestation			SIDER
247	Inflicted injury			SIDER
248	Influenza-like symptoms			SIDER
249	Initial insomnia			OFFSIDES
250	Injection site discomfort			OFFSIDES
251	Injection site nodule			OFFSIDES
252	Injection site phlebitis			OFFSIDES
253	Intermittent Claudication			OFFSIDES
254	Intervertebral disc disorder			OFFSIDES SIDER
255	Intestinal Obstruction			OFFSIDES
256	Intestinal hypomotility			OFFSIDES
257	Intraoperative floppy iris syndrome			SIDER
258	Iritis			OFFSIDES
259	Ischial neuralgia			SIDER
260	Joint injury			OFFSIDES
261	Karnofsky scale worsened			OFFSIDES
262	Lactose Intolerance			OFFSIDES
263	Laryngitis			SIDER
264	Leukoencephalopathy			OFFSIDES
265	Leukopenia neonatal			OFFSIDES
266	Life expectancy shortened			OFFSIDES
267	Long QT Syndrome		24052561	CTD
268	Loose tooth			OFFSIDES
269	Lumbar disc lesion			SIDER
270	Lung consolidation			OFFSIDES
271	Mastication disorder			OFFSIDES
272	Medication residue			OFFSIDES
273	Meningioma			OFFSIDES
274	Mental impairment			OFFSIDES
275	Metaplasia			OFFSIDES
276	Metastatic Neoplasm			OFFSIDES
277	Middle insomnia			OFFSIDES
278	Monoclonal immunoglobulin present			OFFSIDES
279	Multiple Myeloma			OFFSIDES
280	Muscle Fatigue			OFFSIDES
281	Musculoskeletal discomfort			OFFSIDES SIDER
282	Myalgia	Canada Vigilance: 1		Canada Vigilance
283	Myopia			OFFSIDES
284	Nephrolithiasis			OFFSIDES SIDER
285	Neuralgia			SIDER
286	Neuropathy			SIDER
287	Nipple pain			OFFSIDES
288	Nocturia	Canada Vigilance: 1		Canada Vigilance OFFSIDES
289	Open reduction of fracture			OFFSIDES
290	Orthopnea			OFFSIDES
291	Osteolysis			OFFSIDES
292	Osteomyelitis			OFFSIDES
293	Osteopenia			OFFSIDES
294	Osteoradionecrosis			OFFSIDES
295	Osteosclerosis			OFFSIDES
296	Overweight			OFFSIDES
297	Penile size reduced			OFFSIDES
298	Penile swelling			OFFSIDES
299	Perianal abscess			OFFSIDES
300	Pericarditis			OFFSIDES
301	Periodontitis			OFFSIDES
302	Peripheral arterial occlusive disease			OFFSIDES
303	Perirectal abscess			OFFSIDES
304	Pharyngitis			SIDER
305	Plasmacytoma			OFFSIDES
306	Posterior Capsulotomy			OFFSIDES
307	Posterior capsule opacification			OFFSIDES
308	Priapism		17070382	CTD SIDER
309	Primary sequestrum			OFFSIDES
310	Product complaint	Canada Vigilance: 2		Canada Vigilance
311	Prostatic Diseases		16407011	CTD
312	Prostatic Hyperplasia		View details 7508331 7524141 7528458 7534166 7904983 8104650 9352699 9644979 11583366 15470085 16304557 16401920 16842616 18299077 21256572 21556215	CTD
313	Prostatic Obstruction			OFFSIDES
314	Prostatic specific antigen decreased			OFFSIDES
315	Prostatism		10364649	CTD OFFSIDES
316	Pruritus			SIDER
317	Pseudomonal sepsis			OFFSIDES
318	Psoriasis			OFFSIDES
319	Pustular psoriasis			OFFSIDES
320	Pyogenic granuloma			OFFSIDES
321	Quadriparesis			OFFSIDES
322	Rales			OFFSIDES
323	Rebound effect			OFFSIDES
324	Regurgitation			OFFSIDES
325	Renal cyst			OFFSIDES
326	Residual urine			OFFSIDES
327	Retinal Artery Occlusion			OFFSIDES
328	Retinal Vascular Disorder			OFFSIDES
329	Rhabdomyolysis			OFFSIDES
330	Rhinitis			SIDER
331	Ruptured cerebral aneurysm			OFFSIDES
332	Sciatica			SIDER
333	Scleromalacia			OFFSIDES
334	Semen volume decreased			OFFSIDES
335	Sequestrectomy			OFFSIDES
336	Shock			SIDER
337	Sick Sinus Syndrome			OFFSIDES
338	Sinusitis			SIDER
339	Somnolence			SIDER
340	Spondylolysis			OFFSIDES
341	Spontaneous penile erection			OFFSIDES
342	Stem cell transplant			OFFSIDES
343	Stomach ache			SIDER
344	Stool analysis abnormal			OFFSIDES
345	Stress			OFFSIDES
346	Subcutaneous Abscess			OFFSIDES
347	Subileus			OFFSIDES
348	Sudden death			OFFSIDES
349	Supraventricular tachycardia			OFFSIDES
350	Sweat gland infection			OFFSIDES
351	Sweating			SIDER
352	Tachycardia			SIDER
353	Tendinitis			OFFSIDES
354	Tenosynovitis			OFFSIDES
355	Therapeutic response changed	Canada Vigilance: 1		Canada Vigilance
356	Therapy non-responder			OFFSIDES
357	Tinnitus			OFFSIDES
358	Tooth Extraction			OFFSIDES
359	Tooth Infection			OFFSIDES
360	Tooth Loss			OFFSIDES
361	Unexpected therapeutic drug effect			OFFSIDES
362	Urethral Stenosis			OFFSIDES
363	Urination Disorders		7508331	CTD
364	Urine flow decreased			OFFSIDES
365	Urologic Diseases		20126606 21556215	CTD
366	Ventricular arrhythmia			SIDER
367	Vertebroplasty			OFFSIDES
368	Vertigo			SIDER
369	Vitreous opacities			OFFSIDES
370	Weight Gain			OFFSIDES
371	Wound dehiscence			OFFSIDES
372	colonoscopy			OFFSIDES
373	furuncle			OFFSIDES
374	jaundice			SIDER
375	nervous system disorder			SIDER
376	prostatitis		1361435	CTD OFFSIDES

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