eribulin
(QAMYWGZHLCQOOJ-WRNBYXCMSA-N)
Structure
- SMILES
- CS(=O)(=O)O.NC[C@H](C[C@H]1O[C@@H]2[C@@H]([C@H]1OC)CC(=O)C[C@H]1CC[C@H]3[C@H](O1)[C@@H]1O[C@]4(CC[C@@H]5O[C@@H](CC[C@@H]6O[C@H](C2)C(=C)[C@@H](C6)C)C(=C)C5)O[C@@H]2[C@H](O3)[C@H]1O[C@@H]2C4)O
- Molecular Formula:
- C41H63NO14S
- Molecular Weight:
- 826.002
- Log P:
- 4.7231
- Hydrogen Bond Acceptor:
- 15
- Hydrogen Bond Donor:
- 3
- TPSA:
- 209.14
- CAS Number(s):
- 441045-17-6
Synonym(s)
1.
eribulin
2.
B 1793
3.
B 1939
4.
B-1793
5.
B-1939
6.
E 7389
7.
E-7389
8.
ER 086526
9.
ER-086526
10.
ER-86526
11.
ER086526
12.
Halaven
13.
NSC 707389
14.
NSC-707389
15.
NSC707389
16.
eribulin (as mesylate)
17.
eribulin mesilate
18.
eribulin mesylate
19.
eribulin monomethanesulfonate
External Link(s)
| MeSH | C490954 |
| PubChem Compound | 17755248 |
| ChEBI | 70710 |
| CHEMBL | CHEMBL1683544 |
| KEGG | dr:D08914 |
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Neutropenia | FAERS: 241 | US FAERS | |
| 2 | Febrile Neutropenia | FAERS: 160 | US FAERS | |
| 3 | Malignant neoplasm progression | FAERS: 153 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 4 | Leukopenia | FAERS: 98 | US FAERS | |
| 5 | Fatigue | FAERS: 49 | US FAERS | |
| 6 | Stomatitis | FAERS: 45 | US FAERS | |
| 7 | Pneumonia | FAERS: 43 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 8 | Alopecia | FAERS: 39 | US FAERS | |
| 9 | Nausea | FAERS: 39 | US FAERS | |
| 10 | Malaise | FAERS: 33 | US FAERS | |
| 11 | Sepsis | FAERS: 31 | US FAERS | |
| 12 | Vomiting | FAERS: 31 | US FAERS | |
| 13 | Asthenia | FAERS: 29 | US FAERS | |
| 14 | Thrombocytopenia | FAERS: 26 | US FAERS | |
| 15 | Pancytopenia | FAERS: 19 | US FAERS | |
| 16 | White blood cell count decreased | FAERS: 17 | US FAERS | |
| 17 | General physical health deterioration | FAERS: 16 | US FAERS | |
| 18 | Headache | FAERS: 16 | US FAERS | |
| 19 | Neutrophil count decreased | FAERS: 16 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 20 | Pulmonary Embolism | FAERS: 16 | US FAERS | |
| 21 | Dehydration | FAERS: 13 | US FAERS | |
| 22 | Infection | FAERS: 13 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 23 | Pneumothorax | FAERS: 13 | US FAERS | |
| 24 | Dysgeusia | FAERS: 12 | US FAERS | |
| 25 | Abdominal Pain | FAERS: 11 | US FAERS | |
| 26 | Dizziness | FAERS: 11 | US FAERS | |
| 27 | Polyneuropathy | FAERS: 11 | US FAERS | |
| 28 | Constipation | FAERS: 10 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 29 | Neutropenic sepsis | FAERS: 10 | US FAERS | |
| 30 | Chest Pain | FAERS: 9 | US FAERS | |
| 31 | Lymphopenia | FAERS: 9 | US FAERS | |
| 32 | Deep Vein Thrombosis | FAERS: 8 | US FAERS | |
| 33 | Septic Shock | FAERS: 8 | US FAERS | |
| 34 | Tachycardia | FAERS: 8 | US FAERS | |
| 35 | Urinary tract infection | FAERS: 8 | US FAERS | |
| 36 | Ascites | FAERS: 7 | US FAERS | |
| 37 | Drug ineffective | FAERS: 7 | US FAERS | |
| 38 | Pneumonitis | FAERS: 7 | US FAERS | |
| 39 | Vertigo | FAERS: 7 | US FAERS | |
| 40 | Disseminated Intravascular Coagulation | FAERS: 6 | US FAERS | |
| 41 | Lymphangiosis carcinomatosa | FAERS: 6 | US FAERS | |
| 42 | Oral candidiasis | FAERS: 6 | US FAERS | |
| 43 | Weight decreased | FAERS: 6 | US FAERS | |
| 44 | Aspartate Aminotransferase Increased | FAERS: 5 | US FAERS | |
| 45 | Cerebral Infarction | FAERS: 5 | US FAERS | |
| 46 | Dysphonia | FAERS: 5 | US FAERS | |
| 47 | Extravasation | FAERS: 5 | US FAERS | |
| 48 | Hypotension | FAERS: 5 | US FAERS | |
| 49 | Myocardial Infarction | FAERS: 5 | US FAERS | |
| 50 | Pain | FAERS: 5 | US FAERS | |
| 51 | Respiratory Failure | FAERS: 5 | US FAERS | |
| 52 | Acute kidney injury | FAERS: 4 | US FAERS | |
| 53 | Back Pain | FAERS: 4 | US FAERS | |
| 54 | Bronchitis | FAERS: 4 | US FAERS | |
| 55 | Cataract | FAERS: 4 | US FAERS | |
| 56 | Deafness | FAERS: 4 | US FAERS | |
| 57 | Erythema | FAERS: 4 | US FAERS | |
| 58 | Erythropenia | FAERS: 4 | US FAERS | |
| 59 | Myalgia | FAERS: 4 | US FAERS | |
| 60 | Nasopharyngitis | FAERS: 4 | US FAERS | |
| 61 | Overdose | FAERS: 4 | US FAERS | |
| 62 | Urinary Retention | FAERS: 4 | US FAERS | |
| 63 | Alanine Aminotransferase Increased | FAERS: 3 | US FAERS | |
| 64 | Aphasia | FAERS: 3 | US FAERS | |
| 65 | Blood glucose increased | FAERS: 3 | US FAERS | |
| 66 | Cellulitis | FAERS: 3 | US FAERS | |
| 67 | Cerebrovascular accident | FAERS: 3 | US FAERS | |
| 68 | Chills | FAERS: 3 | US FAERS | |
| 69 | Diabetes Mellitus | FAERS: 3 | US FAERS | |
| 70 | Diplopia | FAERS: 3 | US FAERS | |
| 71 | Disease Progression | FAERS: 3 | US FAERS | |
| 72 | Ejection Fraction Decreased | FAERS: 3 | US FAERS | |
| 73 | Epistaxis | FAERS: 3 | US FAERS | |
| 74 | Erythema Infectiosum | FAERS: 3 | US FAERS | |
| 75 | Hepatotoxicity | FAERS: 3 | US FAERS | |
| 76 | Influenza | FAERS: 3 | US FAERS | |
| 77 | Neck Pain | FAERS: 3 | US FAERS | |
| 78 | Osteonecrosis of Jaw | FAERS: 3 | US FAERS | |
| 79 | Pancreatitis | FAERS: 3 | US FAERS | |
| 80 | Pharyngitis | FAERS: 3 | US FAERS | |
| 81 | Product use issue | FAERS: 3 | US FAERS | |
| 82 | Pseudocirrhosis | FAERS: 3 | US FAERS | |
| 83 | Respiratory arrest | FAERS: 3 | US FAERS | |
| 84 | Rhabdomyolysis | FAERS: 3 | US FAERS | |
| 85 | Stevens-Johnson Syndrome | FAERS: 3 | US FAERS | |
| 86 | Thrombosis | FAERS: 3 | US FAERS | |
| 87 | Tremor | FAERS: 3 | US FAERS | |
| 88 | jaundice | FAERS: 3 | US FAERS | |
| 89 | Abasia | FAERS: 2 | US FAERS | |
| 90 | Abdominal discomfort | FAERS: 2 | US FAERS | |
| 91 | Allodynia | FAERS: 2 | US FAERS | |
| 92 | Altered state of consciousness | FAERS: 2 | US FAERS | |
| 93 | Arthralgia | FAERS: 2 | US FAERS | |
| 94 | Arthritis | FAERS: 2 | US FAERS | |
| 95 | Atelectasis | FAERS: 2 | US FAERS | |
| 96 | Bone marrow toxicity | FAERS: 2 | US FAERS | |
| 97 | Chest discomfort | FAERS: 2 | US FAERS | |
| 98 | Colitis | FAERS: 2 | US FAERS | |
| 99 | Corneal Perforation | FAERS: 2 | US FAERS | |
| 100 | Cystitis | FAERS: 2 | US FAERS | |
| 101 | Diverticular perforation | FAERS: 2 | US FAERS | |
| 102 | Haematotoxicity | FAERS: 2 | US FAERS | |
| 103 | Hypophagia | FAERS: 2 | US FAERS | |
| 104 | Incorrect route of drug administration | FAERS: 2 | US FAERS | |
| 105 | Laryngitis | FAERS: 2 | US FAERS | |
| 106 | Leukocytosis | FAERS: 2 | US FAERS | |
| 107 | MYELODYSPLASTIC SYNDROME | FAERS: 2 | US FAERS | |
| 108 | Meningitis | FAERS: 2 | US FAERS | |
| 109 | Myopathy | FAERS: 2 | US FAERS | |
| 110 | Nephritis | FAERS: 2 | US FAERS | |
| 111 | Oral pain | FAERS: 2 | US FAERS | |
| 112 | Oropharyngeal pain | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 113 | Osteomyelitis | FAERS: 2 | US FAERS | |
| 114 | Paraplegia | FAERS: 2 | US FAERS | |
| 115 | Pericarditis | FAERS: 2 | US FAERS | |
| 116 | Peripheral arterial occlusive disease | FAERS: 2 | US FAERS | |
| 117 | Peripheral motor neuropathy | FAERS: 2 | US FAERS | |
| 118 | Peripheral swelling | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 119 | Q Fever | FAERS: 2 | US FAERS | |
| 120 | Staphylococcus test positive | FAERS: 2 | US FAERS | |
| 121 | Strabismus | FAERS: 2 | US FAERS | |
| 122 | Acute myocardial infarction | FAERS: 1 | US FAERS | |
| 123 | Acute respiratory failure | FAERS: 1 | US FAERS | |
| 124 | Agitation | FAERS: 1 | US FAERS | |
| 125 | Agnosia | FAERS: 1 | US FAERS | |
| 126 | Agranulocytosis | FAERS: 1 | US FAERS | |
| 127 | Angina Pectoris | FAERS: 1 | US FAERS | |
| 128 | Anxiety | FAERS: 1 | US FAERS | |
| 129 | Asthma | FAERS: 1 | US FAERS | |
| 130 | Ataxia | FAERS: 1 | US FAERS | |
| 131 | Atrial Fibrillation | FAERS: 1 | US FAERS | |
| 132 | Bedridden | FAERS: 1 | US FAERS | |
| 133 | Blindness | FAERS: 1 | US FAERS | |
| 134 | Blood albumin decreased | FAERS: 1 | US FAERS | |
| 135 | Blood alkaline phosphatase increased | FAERS: 1 | US FAERS | |
| 136 | Blood count abnormal | FAERS: 1 | US FAERS | |
| 137 | Blood creatine increased | FAERS: 1 | US FAERS | |
| 138 | Blood creatinine increased | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 139 | Blood thyroid stimulating hormone decreased | FAERS: 1 | US FAERS | |
| 140 | Bone erosion | FAERS: 1 | US FAERS | |
| 141 | Bone pain | FAERS: 1 | US FAERS | |
| 142 | Bradycardia | FAERS: 1 | US FAERS | |
| 143 | Burning sensation | FAERS: 1 | US FAERS | |
| 144 | Cancer Pain | FAERS: 1 | US FAERS | |
| 145 | Candida pneumonia | FAERS: 1 | US FAERS | |
| 146 | Cardiac Tamponade | FAERS: 1 | US FAERS | |
| 147 | Cardiothoracic ratio increased | FAERS: 1 | US FAERS | |
| 148 | Catheter site infection | FAERS: 1 | US FAERS | |
| 149 | Cholangitis | FAERS: 1 | US FAERS | |
| 150 | Cholecystitis | FAERS: 1 | US FAERS | |
| 151 | Cholestasis | FAERS: 1 | US FAERS | |
| 152 | Colonic fistula | FAERS: 1 | US FAERS | |
| 153 | Compression fracture | FAERS: 1 | US FAERS | |
| 154 | Conjunctivitis | FAERS: 1 | US FAERS | |
| 155 | Culture wound positive | FAERS: 1 | US FAERS | |
| 156 | Delirium | FAERS: 1 | US FAERS | |
| 157 | Demyelination | FAERS: 1 | US FAERS | |
| 158 | Depressed Level of Consciousness | FAERS: 1 | US FAERS | |
| 159 | Dermatitis | FAERS: 1 | US FAERS | |
| 160 | Device related infection | FAERS: 1 | US FAERS | |
| 161 | Diabetes mellitus inadequate control | FAERS: 1 | US FAERS | |
| 162 | Diabetic Ketoacidosis | FAERS: 1 | US FAERS | |
| 163 | Diabetic foot infection | FAERS: 1 | US FAERS | |
| 164 | Diplegia | FAERS: 1 | US FAERS | |
| 165 | Disuse syndrome | FAERS: 1 | US FAERS | |
| 166 | Dry skin | FAERS: 1 | US FAERS | |
| 167 | Dyspepsia | FAERS: 1 | US FAERS | |
| 168 | Dysuria | FAERS: 1 | US FAERS | |
| 169 | Electrolyte imbalance | FAERS: 1 | US FAERS | |
| 170 | Enterocolitis | FAERS: 1 | US FAERS | |
| 171 | Epilepsy | FAERS: 1 | US FAERS | |
| 172 | Erysipelas | FAERS: 1 | US FAERS | |
| 173 | Erythema Multiforme | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 174 | Eschar | FAERS: 1 | US FAERS | |
| 175 | Eye pain | FAERS: 1 | US FAERS | |
| 176 | Febrile infection | FAERS: 1 | US FAERS | |
| 177 | Feeling Cold | FAERS: 1 | US FAERS | |
| 178 | Flatulence | FAERS: 1 | US FAERS | |
| 179 | Flushing | FAERS: 1 | US FAERS | |
| 180 | Fracture | FAERS: 1 | US FAERS | |
| 181 | Frontotemporal dementia | FAERS: 1 | US FAERS | |
| 182 | Fulminant type 1 diabetes mellitus | FAERS: 1 | US FAERS | |
| 183 | Gamma-Glutamyltransferase Increased | FAERS: 1 | US FAERS | |
| 184 | Gastric ulcer | FAERS: 1 | US FAERS | |
| 185 | Gastrointestinal Pain | FAERS: 1 | US FAERS | |
| 186 | Gastrointestinal erosion | FAERS: 1 | US FAERS | |
| 187 | General physical condition abnormal | FAERS: 1 | US FAERS | |
| 188 | Hepatic Encephalopathy | FAERS: 1 | US FAERS | |
| 189 | Hepatitis | FAERS: 1 | US FAERS | |
| 190 | Hepatomegaly | FAERS: 1 | US FAERS | |
| 191 | Hypertensive crisis | FAERS: 1 | US FAERS | |
| 192 | Hypoxia | FAERS: 1 | US FAERS | |
| 193 | Injection Site Reaction | FAERS: 1 | US FAERS | |
| 194 | Injection site pain | FAERS: 1 | US FAERS | |
| 195 | Intestinal Obstruction | FAERS: 1 | US FAERS | |
| 196 | Intestinal infarction | FAERS: 1 | US FAERS | |
| 197 | Laceration | FAERS: 1 | US FAERS | |
| 198 | Lethargy | FAERS: 1 | US FAERS | |
| 199 | Leukoencephalopathy | FAERS: 1 | US FAERS | |
| 200 | Limbic Encephalitis | FAERS: 1 | US FAERS | |
| 201 | Liver carcinoma ruptured | FAERS: 1 | US FAERS | |
| 202 | Lymphangioma | FAERS: 1 | US FAERS | |
| 203 | Medication Error | FAERS: 1 | US FAERS | |
| 204 | Mental status changes | FAERS: 1 | US FAERS | |
| 205 | Monoparesis | FAERS: 1 | US FAERS | |
| 206 | Monoplegia | FAERS: 1 | US FAERS | |
| 207 | Musculoskeletal Pain | FAERS: 1 | US FAERS | |
| 208 | Musculoskeletal discomfort | FAERS: 1 | US FAERS | |
| 209 | Nervousness | FAERS: 1 | US FAERS | |
| 210 | Neuralgia | FAERS: 1 | US FAERS | |
| 211 | Night sweats | FAERS: 1 | US FAERS | |
| 212 | No adverse event | FAERS: 1 | US FAERS | |
| 213 | Nodule | FAERS: 1 | US FAERS | |
| 214 | Onychoclasis | FAERS: 1 | US FAERS | |
| 215 | Onychomycosis | FAERS: 1 | US FAERS | |
| 216 | Pain of skin | FAERS: 1 | US FAERS | |
| 217 | Pallor | FAERS: 1 | US FAERS | |
| 218 | Palpitations | FAERS: 1 | US FAERS | |
| 219 | Paraparesis | FAERS: 1 | US FAERS | |
| 220 | Pathological fracture | FAERS: 1 | US FAERS | |
| 221 | Pelvic Pain | FAERS: 1 | US FAERS | |
| 222 | Pericardial effusion | FAERS: 1 | US FAERS | |
| 223 | Periodontitis | FAERS: 1 | US FAERS | |
| 224 | Pneumocystis jiroveci pneumonia | FAERS: 1 | US FAERS | |
| 225 | Presenile dementia | FAERS: 1 | US FAERS | |
| 226 | Proctitis | FAERS: 1 | US FAERS | |
| 227 | Pruritus | FAERS: 1 | US FAERS | |
| 228 | Purulence | FAERS: 1 | US FAERS | |
| 229 | Pyelonephritis | FAERS: 1 | US FAERS | |
| 230 | Quadriplegia | FAERS: 1 | US FAERS | |
| 231 | Quality of life decreased | FAERS: 1 | US FAERS | |
| 232 | Rash erythematous | FAERS: 1 | US FAERS | |
| 233 | Recall phenomenon | FAERS: 1 | US FAERS | |
| 234 | Rheumatoid Vasculitis | FAERS: 1 | US FAERS | |
| 235 | Skin Ulcer | FAERS: 1 | US FAERS | |
| 236 | Skin lesion | FAERS: 1 | US FAERS | |
| 237 | Skin toxicity | FAERS: 1 | US FAERS | |
| 238 | Stridor | FAERS: 1 | US FAERS | |
| 239 | Sudden death | FAERS: 1 | US FAERS | |
| 240 | Syncope | FAERS: 1 | US FAERS | |
| 241 | Thrombophlebitis | FAERS: 1 | US FAERS | |
| 242 | Tinnitus | FAERS: 1 | US FAERS | |
| 243 | Tongue blistering | FAERS: 1 | US FAERS | |
| 244 | Tooth Loss | FAERS: 1 | US FAERS | |
| 245 | Toxicity to various agents | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 246 | Tracheobronchitis | FAERS: 1 | US FAERS | |
| 247 | Transaminases increased | FAERS: 1 | US FAERS | |
| 248 | Trigeminal Neuralgia | FAERS: 1 | US FAERS | |
| 249 | Ulcer | FAERS: 1 | US FAERS | |
| 250 | Urinary tract infection enterococcal | FAERS: 1 | US FAERS | |
| 251 | VIIth nerve paralysis | FAERS: 1 | US FAERS | |
| 252 | Vascular rupture | FAERS: 1 | US FAERS | |
| 253 | Vein pain | FAERS: 1 | US FAERS | |
| 254 | Venous Thrombosis | FAERS: 1 | US FAERS | |
| 255 | Viral upper respiratory tract infection | FAERS: 1 | US FAERS | |
| 256 | Visual brightness | FAERS: 1 | US FAERS | |
| 257 | Infusion site erythema | Canada Vigilance: 1 | Canada Vigilance | |
| 258 | Swelling | Canada Vigilance: 1 | Canada Vigilance |
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