MetaADEDB 2.0 @ LMMD
Tiagabine
(PBJUNZJWGZTSKL-MRXNPFEDSA-N)
Structure
SMILES
OC(=O)[C@@H]1CCCN(C1)CCC=C(c1sccc1C)c1sccc1C
Type(s)
Approved; Investigational
ATC code(s)
N03AG06
Molecular Formula:
C20H25NO2S2
Molecular Weight:
375.548
Log P:
4.9827
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
1
TPSA:
97.02
CAS Number(s):
115103-54-3
Synonym(s)
1.
Tiagabine
2.
(R)-(4,4-bis(3-Methyl-2-thienyl)-3-butenyl)-3-piperidinecarboxylic acid, Hydrochloride
3.
Gabitril
4.
N-(4,4-di(3-Methylthien-2-yl)but-3-enyl)nipecotic acid
5.
NO 328
6.
NO 329
7.
NO-328
8.
NO-329
9.
Tiagabine Hydrochloride
10.
Tiagabine, (S)-isomer
External Link(s)
MeSHD000078308
PubChem Compound60648
40467242
BindingDB50368628
50039251
ChEBI9586
CHEMBLCHEMBL1027
DrugBankDB00906
DrugCentral2648
IUPHAR/BPS Guide to PHARMACOLOGY4685
4818
KEGGcpd:C07503
dr:D08588
Therapeutic Target DatabaseD0C1XB
D0ED7U
ZINC3831531
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1TremorFAERS: 15SIDER
US FAERS
2HeadacheFAERS: 14SIDER
US FAERS
3AgitationFAERS: 13SIDER
US FAERS
4AmnesiaFAERS: 12OFFSIDES
US FAERS
5OverdoseFAERS: 12OFFSIDES
US FAERS
6DizzinessFAERS: 11OFFSIDES
SIDER
US FAERS
7Feeling abnormalFAERS: 11SIDER
US FAERS
8AphasiaFAERS: 10US FAERS
9Memory impairmentFAERS: 10US FAERS
10NauseaFAERS: 8SIDER
US FAERS
11Complex partial seizuresFAERS: 6OFFSIDES
US FAERS
12Depressed Level of ConsciousnessFAERS: 6OFFSIDES
SIDER
US FAERS
13DisorientationFAERS: 6US FAERS
14Status EpilepticusFAERS: 611888262
18496267		CTD
OFFSIDES
US FAERS
15DysphemiaFAERS: 5US FAERS
16SomnolenceFAERS: 5SIDER
US FAERS
17Unresponsive to verbal stimuliFAERS: 5OFFSIDES
US FAERS
18AnxietyFAERS: 4OFFSIDES
SIDER
US FAERS
19DeliriumFAERS: 4US FAERS
20Drug ineffectiveFAERS: 4OFFSIDES
US FAERS
21DysarthriaFAERS: 4SIDER
US FAERS
22FatigueFAERS: 4OFFSIDES
SIDER
US FAERS
23Intentional misuseFAERS: 4OFFSIDES
US FAERS
24MalaiseFAERS: 4SIDER
US FAERS
25Medication ErrorFAERS: 4US FAERS
26Suicide attemptFAERS: 4SIDER
US FAERS
27Weight decreasedFAERS: 4SIDER
US FAERS
28AstheniaFAERS: 3OFFSIDES
SIDER
US FAERS
29EpilepsyFAERS: 3OFFSIDES
US FAERS
30Mental status changesFAERS: 3OFFSIDES
US FAERS
31MyoclonusFAERS: 3SIDER
US FAERS
32Respiratory DepressionFAERS: 3US FAERS
33Urinary IncontinenceFAERS: 3SIDER
US FAERS
34Adverse eventFAERS: 2US FAERS
35AlopeciaFAERS: 2OFFSIDES
SIDER
US FAERS
36AtaxiaFAERS: 2SIDER
US FAERS
37AuraFAERS: 2OFFSIDES
US FAERS
38CatatoniaFAERS: 2OFFSIDES
US FAERS
39ConstipationFAERS: 2SIDER
US FAERS
40DiplopiaFAERS: 2SIDER
US FAERS
41DroolingFAERS: 2US FAERS
42Drug screen positiveFAERS: 2OFFSIDES
US FAERS
43Food AllergyFAERS: 2OFFSIDES
US FAERS
44HypersensitivityFAERS: 2SIDER
US FAERS
45HypokinesiaFAERS: 2OFFSIDES
SIDER
US FAERS
46Intentional drug misuseFAERS: 2US FAERS
47MydriasisFAERS: 2US FAERS
48NephrolithiasisFAERS: 2US FAERS
49NervousnessFAERS: 2SIDER
US FAERS
50PalpitationsFAERS: 2SIDER
US FAERS
51Personality ChangeFAERS: 2OFFSIDES
US FAERS
52Pulmonary HypertensionFAERS: 2US FAERS
53RestlessnessFAERS: 2US FAERS
54ThirstFAERS: 2SIDER
US FAERS
55TinnitusFAERS: 2SIDER
US FAERS
56Toxicologic test abnormalFAERS: 2OFFSIDES
US FAERS
57Unresponsive to pain stimuliFAERS: 2OFFSIDES
US FAERS
58VertigoFAERS: 2SIDER
US FAERS
59Visual disturbanceFAERS: 2OFFSIDES
US FAERS
60AbasiaFAERS: 1US FAERS
61Accidental overdoseFAERS: 1US FAERS
62Alcohol interactionFAERS: 1US FAERS
63AsthmaFAERS: 1OFFSIDES
SIDER
US FAERS
64Bacteria urine identifiedFAERS: 1US FAERS
65Blood cholesterol increasedFAERS: 1US FAERS
66Blood triglycerides increasedFAERS: 1US FAERS
67Brain ContusionFAERS: 1US FAERS
68Burning sensationFAERS: 1OFFSIDES
US FAERS
69ChillsFAERS: 1SIDER
US FAERS
70Circumstance or information capable of leading to medication errorFAERS: 1OFFSIDES
US FAERS
71Completed SuicideFAERS: 1OFFSIDES
US FAERS
72DehydrationFAERS: 1SIDER
US FAERS
73Disease ProgressionFAERS: 1US FAERS
74Disease recurrenceFAERS: 1US FAERS
75Drug abuserFAERS: 1US FAERS
76Drug dispensing errorFAERS: 1OFFSIDES
US FAERS
77Drug dose omissionFAERS: 1US FAERS
78Drug ineffective for unapproved indicationFAERS: 1US FAERS
79Drug screen false positiveFAERS: 1US FAERS
80Drug toxicityFAERS: 1US FAERS
81Elevated moodFAERS: 1US FAERS
82Escherichia infectionFAERS: 1OFFSIDES
US FAERS
83Euphoric moodFAERS: 1OFFSIDES
SIDER
US FAERS
84Expired drug administeredFAERS: 1US FAERS
85Eyelid Function DisorderFAERS: 1US FAERS
86Feeling ColdFAERS: 1US FAERS
87FormicationFAERS: 1OFFSIDES
US FAERS
88General physical health deteriorationFAERS: 1OFFSIDES
US FAERS
89Gestational DiabetesFAERS: 1US FAERS
90HemiparesisFAERS: 1US FAERS
91HostilityFAERS: 1SIDER
US FAERS
92HypotensionFAERS: 1SIDER
US FAERS
93Impaired work abilityFAERS: 1OFFSIDES
US FAERS
94IncoherentFAERS: 1OFFSIDES
US FAERS
95Incorrect dose administeredFAERS: 1OFFSIDES
US FAERS
96Intentional product use issueFAERS: 1US FAERS
97Intentional self-injuryFAERS: 1OFFSIDES
US FAERS
98Joint sprainFAERS: 1US FAERS
99LacerationFAERS: 1US FAERS
100LethargyFAERS: 1OFFSIDES
US FAERS
101Maternal exposure during pregnancyFAERS: 1US FAERS
102Mental impairmentFAERS: 1OFFSIDES
US FAERS
103Muscle RigidityFAERS: 1US FAERS
104PainFAERS: 1OFFSIDES
SIDER
US FAERS
105Pharmaceutical product complaintFAERS: 1US FAERS
106PneumoniaFAERS: 1SIDER
US FAERS
107PresyncopeFAERS: 1US FAERS
108Primary Adrenal InsufficiencyFAERS: 1US FAERS
109Procedural complicationFAERS: 1US FAERS
110Product use in unapproved indicationFAERS: 1US FAERS
111Serotonin SyndromeFAERS: 1US FAERS
112StaringFAERS: 1OFFSIDES
US FAERS
113StomatitisFAERS: 1SIDER
US FAERS
114SyncopeFAERS: 1SIDER
US FAERS
115Therapeutic response unexpectedFAERS: 1US FAERS
116Tonic clonic movementsFAERS: 1OFFSIDES
US FAERS
117Toxicity to various agentsFAERS: 1US FAERS
118VerbigerationFAERS: 1US FAERS
119Vulvovaginal painFAERS: 1US FAERS
120Wrong drug administeredFAERS: 1US FAERS
121Wrong technique in product usage processFAERS: 1US FAERS
122Abdominal PainOFFSIDES
SIDER
123Abdominal adhesionsOFFSIDES
124Abdominal discomfortOFFSIDES
125Abnormal cervical smearOFFSIDES
126Abnormal visionSIDER
127AbscessSIDER
128Acid refluxOFFSIDES
129Acute Coronary SyndromeSIDER
130Acute psychosisOFFSIDES
131Acute respiratory failureOFFSIDES
132AdnexitisOFFSIDES
133AgeusiaSIDER
134AgraphiaOFFSIDES
135AkinesiaOFFSIDES
136Alcohol consumptionOFFSIDES
137Altered bowel functionOFFSIDES
138AmblyopiaSIDER
139Ammonia increasedOFFSIDES
140AmphetaminesOFFSIDES
141AnalgesiaOFFSIDES
142AngerOFFSIDES
143Angina PectorisSIDER
144AnhidrosisOFFSIDES
145AnorexiaOFFSIDES
SIDER
146AnosmiaOFFSIDES
147Anoxic EncephalopathyOFFSIDES
148Anticonvulsant drug level increasedOFFSIDES
149ApathyOFFSIDES
SIDER
150Application site irritationOFFSIDES
151Application site pruritusOFFSIDES
152Application site rashOFFSIDES
153ArachnoiditisOFFSIDES
154Arterial bypass operationOFFSIDES
155ArteriosclerosisOFFSIDES
156ArthralgiaSIDER
157ArthritisSIDER
158ArthropathySIDER
159Aseptic MeningitisOFFSIDES
160Aspiration PneumoniaOFFSIDES
161AtelectasisOFFSIDES
162AtherosclerosisOFFSIDES
163Athetosis16650148CTD
164Atrial tachycardiaOFFSIDES
165Atrioventricular Septal DefectOFFSIDES
166Attention concentration difficultySIDER
167AutomatismOFFSIDES
168Back PainSIDER
169Basal cell carcinomaOFFSIDES
170Basal ganglion degenerationOFFSIDES
171BelligerenceOFFSIDES
172Benign neoplasm of skinSIDER
173Bipolar DisorderOFFSIDES
174Bladder painSIDER
175Bladder prolapseOFFSIDES
176BlepharitisOFFSIDES
SIDER
177BlepharoptosisOFFSIDES
178BlepharospasmOFFSIDES
179BlindnessSIDER
180Blood GlucoseOFFSIDES
181Blood fibrinogen increasedOFFSIDES
182Blood glucose decreasedOFFSIDES
183Blood potassium decreasedOFFSIDES
184Blurred visionOFFSIDES
185Bone fistulaOFFSIDES
186Brain ConcussionOFFSIDES
187Brain natriuretic peptide increasedOFFSIDES
188BronchitisOFFSIDES
SIDER
189BruxismOFFSIDES
190BulimiaOFFSIDES
191Bullous lung diseaseOFFSIDES
192BursitisSIDER
193Carbon Monoxide PoisoningOFFSIDES
194Cardiac enzymes increasedOFFSIDES
195CataractOFFSIDES
196CellulitisOFFSIDES
SIDER
197Cerebral atrophyOFFSIDES
198Cerebral disorderOFFSIDES
199Cervical myelopathyOFFSIDES
200Cervicobrachial syndromeOFFSIDES
201Cervix carcinoma stage IOFFSIDES
202Chest PainOFFSIDES
SIDER
203ChloropsiaOFFSIDES
204CholecystitisOFFSIDES
SIDER
205CholelithiasisSIDER
206ChoreoathetosisSIDER
207ChromatopsiaOFFSIDES
208Chronic Obstructive Airway DiseaseOFFSIDES
209Circumoral paresthesiaSIDER
210Cocaine-Related Disorders

View details

14616189
15730351
15730354
15773068
16332385
16777090
16930857
 		CTD
211Cogwheel RigidityOFFSIDES
212Coital bleedingOFFSIDES
213Cold sweatOFFSIDES
214Color blindnessOFFSIDES
215ConfabulationOFFSIDES
216Congenital cystic kidney diseaseOFFSIDES
217ConjunctivitisSIDER
218ContractureOFFSIDES
219Conversion disorderOFFSIDES
220Cramps of lower extremitiesSIDER
221Creatinine renal clearance decreasedOFFSIDES
222Creutzfeldt-Jakob diseaseOFFSIDES
223CryingOFFSIDES
224CystitisSIDER
225DeafnessOFFSIDES
SIDER
226DebridementOFFSIDES
227Delusional disorder, unspecified typeOFFSIDES
228DemyelinationOFFSIDES
229Dental abscessOFFSIDES
230Dental cariesOFFSIDES
SIDER
231Dental discomfortOFFSIDES
232DermatitisSIDER
233Device FailureOFFSIDES
234Device leakageOFFSIDES
235DiabetesOFFSIDES
236Diabetes mellitus inadequate controlOFFSIDES
237Diabetic neuropathic ulcerOFFSIDES
238DiarrheaOFFSIDES
239DiscomfortSIDER
240Disturbance in sexual arousalSIDER
241Drug ToleranceOFFSIDES
242Drug addictOFFSIDES
243Drug administered at inappropriate siteOFFSIDES
244Drug chemical incompatibilityOFFSIDES
245Drug level below therapeuticOFFSIDES
246Drug withdrawal headacheOFFSIDES
247Dry skinSIDER
248DyscheziaOFFSIDES
249DysgeusiaSIDER
250DysmorphismOFFSIDES
251DyspepsiaSIDER
252Dysthymic DisorderOFFSIDES
253DystoniaOFFSIDES
254DysuriaSIDER
255EcchymosisSIDER
256EczemaSIDER
257Electrocardiogram ST-T changeOFFSIDES
258Electrocardiogram abnormalSIDER
259Electroconvulsive TherapyOFFSIDES
260EncephalitisOFFSIDES
261Epilepsies, Partial15229826CTD
262Epilepsy, Complex Partial10880283CTD
263EpistaxisSIDER
264Erectile dysfunctionOFFSIDES
SIDER
265EructationSIDER
266Essential HypertensionOFFSIDES
267Ethmoid sinus surgeryOFFSIDES
268ExophthalmosOFFSIDES
269Extremity contractureOFFSIDES
270Eye painSIDER
271Femoral artery occlusionOFFSIDES
272FibromyalgiaOFFSIDES
273Flat affectSIDER
274FlatulenceSIDER
275Fluid overloadOFFSIDES
276Fungal rashOFFSIDES
277FurunculosisSIDER
278Gastric BypassOFFSIDES
279GastritisSIDER
280GastroenteritisSIDER
281Gastrointestinal PainSIDER
282General physical conditionOFFSIDES
283Gingival HyperplasiaSIDER
284GingivitisSIDER
285GlossitisSIDER
286GoiterOFFSIDES
287GranulomaOFFSIDES
288Grip strengthOFFSIDES
289Hallucinations, mixedOFFSIDES
290HemiplegiaSIDER
291HepatomegalySIDER
292HerniaSIDER
293HirsutismSIDER
294HyperacusisSIDER
295HyperkinesiaSIDER
296HyperpigmentationOFFSIDES
297HyperreflexiaSIDER
298HyperventilationOFFSIDES
SIDER
299HyporeflexiaSIDER
300HypothyroidismSIDER
301Iatrogenic injuryOFFSIDES
302IncontinenceOFFSIDES
303InfectionOFFSIDES
SIDER
304InfluenzaSIDER
305Infusion site mobility decreasedOFFSIDES
306Injection site erythemaOFFSIDES
307Injection site warmthOFFSIDES
308Insulin-requiring type 2 diabetes mellitusOFFSIDES
309Intention tremorOFFSIDES
310Intermittent ClaudicationOFFSIDES
311Intervertebral disc disorderOFFSIDES
312Joint Range of Motion DecreasedOFFSIDES
313Joint stiffnessOFFSIDES
314Keratitis siccaOFFSIDES
315KeratitisSIDER
316KeratoconjunctivitisSIDER
317LaryngitisSIDER
318LeukoencephalopathyOFFSIDES
319LeukopeniaSIDER
320Lichen PlanusOFFSIDES
321LightheadednessSIDER
322Limb injuryOFFSIDES
323Lumbar radiculopathyOFFSIDES
324Lupus-like syndromeOFFSIDES
325LymphadenopathySIDER
326Male sexual dysfunctionOFFSIDES
327Malignant neoplasm of spinal cordOFFSIDES
328Maxillofacial operationOFFSIDES
329Mechanical ventilationOFFSIDES
330MeningiomaOFFSIDES
331MeningoceleOFFSIDES
332MenorrhagiaSIDER
333Metastatic NeoplasmOFFSIDES
334MetatarsalgiaOFFSIDES
335MetrorrhagiaSIDER
336Micrographic skin surgeryOFFSIDES
337Mood Disorders10880283CTD
338Mood swingsSIDER
339Motor retardationOFFSIDES
340Movement Disorders7857587CTD
341Multiple drug overdoseOFFSIDES
342Multiple drug overdose intentionalOFFSIDES
343Muscle WeaknessOFFSIDES
344Muscle relaxant therapySIDER
345Musculoskeletal discomfortSIDER
346Musculoskeletal stiffnessOFFSIDES
SIDER
347MyalgiaSIDER
348Myocardial InfarctionSIDER
349MyosclerosisOFFSIDES
350Neck PainSIDER
351Neck stiffnessSIDER
352Nephrotic SyndromeOFFSIDES
353Nerve BlockOFFSIDES
354Nervous tensionOFFSIDES
355NeuritisSIDER
356Neuroleptic Malignant SyndromeOFFSIDES
357Nicotine DependenceOFFSIDES
358NocturiaSIDER
359NoduleSIDER
360Nuchal RigiditySIDER
361NystagmusSIDER
362Ocular icterusOFFSIDES
363OsteomyelitisOFFSIDES
364OsteopeniaOFFSIDES
365Otitis ExternaSIDER
366Otitis MediaSIDER
367Pain of skinOFFSIDES
368PallorSIDER
369ParanoiaOFFSIDES
SIDER
370Paranoid reactionSIDER
371Pelvic PainSIDER
372Pelvic abscessOFFSIDES
373Performance status decreasedOFFSIDES
374PericarditisOFFSIDES
375PetechiaeSIDER
376PharyngitisSIDER
377PhlebitisSIDER
378PhotophobiaSIDER
379PlasmapheresisOFFSIDES
380Pneumocystis jiroveci pneumoniaOFFSIDES
381PneumothoraxOFFSIDES
382PolyuriaSIDER
383Poor dental conditionOFFSIDES
384Pregnancy of partnerOFFSIDES
385Prescribed overdoseOFFSIDES
386Pressure of speechOFFSIDES
387Procedural hypotensionOFFSIDES
388Prolapse repairOFFSIDES
389PruritusSIDER
390PsoriasisSIDER
391Psychiatric symptomOFFSIDES
392Psychomotor skills impairedOFFSIDES
393Psychotic Disorders10880283CTD
394Pulmonary thrombosisOFFSIDES
395PyelonephritisSIDER
396RadiculitisOFFSIDES
397Rectal ProlapseOFFSIDES
398Renal cystOFFSIDES
399Renal massOFFSIDES
400Respiratory FailureOFFSIDES
401RetrocollisOFFSIDES
402Retrograde amnesiaOFFSIDES
403RhinitisSIDER
404RhonchiOFFSIDES
405Risus sardonicusOFFSIDES
406SacroiliitisOFFSIDES
407SalmonellaOFFSIDES
408SalpingitisSIDER
409ScotomaSIDER
410ScreamingOFFSIDES
411Seizures10454489
11738929
15857624		CTD
412SepsisSIDER
413ShockSIDER
414Shoulder PainOFFSIDES
415Sinus antrostomyOFFSIDES
416SinusitisOFFSIDES
SIDER
417Skin IndurationOFFSIDES
418Skin UlcerSIDER
419Skin carcinomaSIDER
420Skin lacerationOFFSIDES
421Skin tightnessOFFSIDES
422Somatoform DisorderOFFSIDES
423Spousal AbuseOFFSIDES
424Stevens-Johnson Syndrome25811541CTD
425StuporSIDER
426Subcutaneous noduleSIDER
427Sudden deathSIDER
428Supraventricular tachycardiaOFFSIDES
429SweatingSIDER
430TachycardiaSIDER
431Tardive DyskinesiaOFFSIDES
432TensionSIDER
433Therapy non-responderOFFSIDES
434ThrombocytopeniaSIDER
435ThrombophlebitisSIDER
436Tobacco Use Disorder15983800CTD
437Tooth ExtractionOFFSIDES
438Tooth LossOFFSIDES
439Ulcerative stomatitisSIDER
440UlcerOFFSIDES
441Urethritis noninfectiveSIDER
442UrethritisSIDER
443Urinary RetentionSIDER
444Urinary tract infectionSIDER
445Urine output increasedSIDER
446UrticariaSIDER
447Uterovaginal prolapseOFFSIDES
448Vasodilation procedureSIDER
449VasodilationSIDER
450Vesiculobullous rashSIDER
451Visual ImpairmentSIDER
452VomitingSIDER
453Weight GainOFFSIDES
454Wound decompositionOFFSIDES
455furuncleSIDER
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