MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Nizatidine

(SGXXNSQHWDMGGP-IZZDOVSWSA-N)

Structure

SMILES: CN/C(=C\[N+](=O)[O-])/NCCSCc1csc(n1)CN(C)C
Type(s): Approved
ATC code(s): A02BA04
Molecular Formula:: C12H21N5O2S2
Molecular Weight:: 331.457
Log P:: 2.6275
Hydrogen Bond Acceptor:: 6
Hydrogen Bond Donor:: 2
TPSA:: 139.55
CAS Number(s):: 76963-41-2

Synonym(s)

Nizatidine

Axid

LY-139037

N-(2-(((2-((Dimethylamino)methyl)-4-thiazolyl)methyl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine

LY 139037

LY139037

External Link(s)

MeSH	D016567
PubChem Compound	3033637
ChEBI	7601
DrugBank	DB00585
IUPHAR/BPS Guide to PHARMACOLOGY	7248
KEGG	cpd:C07270 dr:D00440
Therapeutic Target Database	D0Q9DK
ZINC	1530736

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Product substitution issue	FAERS: 7		US FAERS
2	Drug ineffective	FAERS: 5 Canada Vigilance: 1		Canada Vigilance US FAERS
3	Nausea	FAERS: 4 Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER US FAERS
4	Pharmaceutical product complaint	FAERS: 3		US FAERS
5	Urticaria	FAERS: 3		SIDER US FAERS
6	Abdominal discomfort	FAERS: 2		OFFSIDES US FAERS
7	Dyspepsia	FAERS: 2 Canada Vigilance: 1	7769203	CTD OFFSIDES SIDER Canada Vigilance US FAERS
8	Medication Error	FAERS: 2		US FAERS
9	Therapeutic response unexpected with drug substitution	FAERS: 2		US FAERS
10	Throat irritation	FAERS: 2		US FAERS
11	Alopecia	FAERS: 1		OFFSIDES US FAERS
12	Arthralgia	FAERS: 1		US FAERS
13	Blepharospasm	FAERS: 1		US FAERS
14	Constipation	FAERS: 1		SIDER US FAERS
15	Cyst	FAERS: 1		OFFSIDES US FAERS
16	Dehydration	FAERS: 1		US FAERS
17	Diet refusal	FAERS: 1		US FAERS
18	Drug prescribing error	FAERS: 1		US FAERS
19	Euphoric mood	FAERS: 1		US FAERS
20	Feeling abnormal	FAERS: 1		SIDER US FAERS
21	Incorrect dose administered	FAERS: 1		US FAERS
22	Medication residue	FAERS: 1		US FAERS
23	Multiple allergies	FAERS: 1		OFFSIDES US FAERS
24	Non-cardiac chest pain	FAERS: 1		OFFSIDES US FAERS
25	Pain	FAERS: 1		OFFSIDES SIDER US FAERS
26	Pharmaceutical product counterfeit	FAERS: 1		OFFSIDES US FAERS
27	Product quality issue	FAERS: 1		US FAERS
28	Product taste abnormal	FAERS: 1		US FAERS
29	Pruritus	FAERS: 1	7769203	CTD SIDER US FAERS
30	Rash erythematous	FAERS: 1		US FAERS
31	Sepsis	FAERS: 1		US FAERS
32	Skin Ulcer	FAERS: 1		US FAERS
33	Therapy non-responder	FAERS: 1		US FAERS
34	Tongue pruritus	FAERS: 1		US FAERS
35	Toxic Epidermal Necrolysis	FAERS: 1		US FAERS
36	Vomiting	FAERS: 1		SIDER US FAERS
37	Abdominal Pain	Canada Vigilance: 2		Canada Vigilance OFFSIDES SIDER
38	Abnormal cervical smear			OFFSIDES
39	Abnormal vision			OFFSIDES
40	Abscess			OFFSIDES
41	Accidental overdose			OFFSIDES
42	Acid reflux			OFFSIDES
43	Acidosis			OFFSIDES
44	Actinomycosis			OFFSIDES
45	Activities of daily living impaired			OFFSIDES
46	Acute bronchitis			OFFSIDES
47	Acute myocardial infarction			OFFSIDES
48	Adenocarcinoma			OFFSIDES
49	Adnexitis			OFFSIDES
50	Agoraphobia			OFFSIDES
51	Akathisia, Drug-Induced		15303455	CTD
52	Alanine Aminotransferase Increased			OFFSIDES
53	Albumin globulin ratio increased			OFFSIDES
54	Alkalosis			OFFSIDES
55	Altered bowel function			OFFSIDES
56	Alveolitis			OFFSIDES
57	Alveoloplasty			OFFSIDES
58	Amblyopia			SIDER
59	Analgesia			OFFSIDES
60	Anaphylactic shock			SIDER
61	Anastomotic stenosis			OFFSIDES
62	Angiolipoma			OFFSIDES
63	Angioplasty			OFFSIDES
64	Anhedonia			OFFSIDES
65	Anhidrosis			OFFSIDES
66	Anorectal discomfort			OFFSIDES
67	Anorexia			OFFSIDES SIDER
68	Anticonvulsant drug level increased			OFFSIDES
69	Antithrombin III decreased			OFFSIDES
70	Anxiety			OFFSIDES SIDER
71	Apallic syndrome			OFFSIDES
72	Arteriosclerosis Obliterans			OFFSIDES
73	Arteriosclerosis			OFFSIDES
74	Arteriovenous fistula			OFFSIDES
75	Artificial crown procedure			OFFSIDES
76	Aspiration Pneumonia			OFFSIDES
77	Asthenia			OFFSIDES SIDER
78	Asthma			OFFSIDES
79	Atelectasis			OFFSIDES
80	Autoimmune hepatitis			OFFSIDES
81	Back Pain			SIDER
82	Back disorder			OFFSIDES
83	Bacterial disease carrier			OFFSIDES
84	Basal Ganglia Diseases		15303455	CTD
85	Beckwith-Wiedemann Syndrome			OFFSIDES
86	Benign neoplasm of adrenal gland			OFFSIDES
87	Beta 2 microglobulin increased			OFFSIDES
88	Beta 2 microglobulin urine increased			OFFSIDES
89	Biliary Dyskinesia			OFFSIDES
90	Biliary tract infection			OFFSIDES
91	Biopsy bone abnormal			OFFSIDES
92	Bipolar I disorder			OFFSIDES
93	Blepharitis			OFFSIDES
94	Blood Glucose			OFFSIDES
95	Blood albumin decreased			OFFSIDES
96	Blood albumin increased			OFFSIDES
97	Blood alkaline phosphatase increased			OFFSIDES
98	Blood alkaline phosphatase			OFFSIDES
99	Blood chloride increased			OFFSIDES
100	Blood cholinesterase decreased			OFFSIDES
101	Blood creatine phosphokinase MB increased			OFFSIDES
102	Blood creatine phosphokinase increased			OFFSIDES
103	Blood creatinine decreased			OFFSIDES
104	Blood creatinine increased			OFFSIDES
105	Blood immunoglobulin A increased			OFFSIDES
106	Blood immunoglobulin G increased			OFFSIDES
107	Blood iron decreased			OFFSIDES
108	Blood lactate dehydrogenase increased			OFFSIDES
109	Blood phosphorus decreased			OFFSIDES
110	Blood potassium increased			OFFSIDES
111	Blood sodium			OFFSIDES
112	Blood triglycerides increased			OFFSIDES
113	Blood urea increased			OFFSIDES
114	Blood uric acid			OFFSIDES
115	Blue Toe Syndrome			OFFSIDES
116	Blunted affect			OFFSIDES
117	Blurred vision			OFFSIDES
118	Body Temperature			OFFSIDES
119	Bone lesion			OFFSIDES
120	Bone marrow depression			OFFSIDES
121	Bone pain			OFFSIDES
122	Brain Death			OFFSIDES
123	Breast adenoma			OFFSIDES
124	Bronchiectasis			OFFSIDES
125	Bronchoscopy			OFFSIDES
126	Bronchospasm			SIDER
127	Bruxism			OFFSIDES
128	Bulbar palsy			OFFSIDES
129	Burning sensation			OFFSIDES
130	Bursitis			OFFSIDES
131	Cardiac stress test abnormal			OFFSIDES
132	Cataract			OFFSIDES
133	Catheter placement			OFFSIDES
134	Cellulitis			OFFSIDES
135	Cerebral artery occlusion			OFFSIDES
136	Cerebral artery stenosis			OFFSIDES
137	Charles Bonnet Syndrome			OFFSIDES
138	Chemotherapeutic drug level increased			OFFSIDES
139	Chest Pain			OFFSIDES SIDER
140	Cholangiolitis			OFFSIDES
141	Cholecystitis infective			OFFSIDES
142	Chronic Fatigue Syndrome			OFFSIDES
143	Chronic sinusitis			OFFSIDES
144	Cirrhosis			OFFSIDES
145	Clostridium colitis			OFFSIDES
146	Colectomy			OFFSIDES
147	Colitis			OFFSIDES
148	Confabulation			OFFSIDES
149	Congenital tricuspid valve incompetence			OFFSIDES
150	Conjunctival deposit			OFFSIDES
151	Deafness Neurosensory			OFFSIDES
152	Debridement			OFFSIDES
153	Delirium		9269259	CTD
154	Demyelination			OFFSIDES
155	Dental Fistula			OFFSIDES
156	Dental alveolar anomaly			OFFSIDES
157	Dental caries			OFFSIDES
158	Dental examination			OFFSIDES
159	Depressed Level of Consciousness			OFFSIDES
160	Dermatitis			SIDER
161	Device Failure			OFFSIDES
162	Device dislocation			OFFSIDES
163	Device related infection			OFFSIDES
164	Diabetes mellitus inadequate control			OFFSIDES
165	Diplopia			OFFSIDES
166	Disease Progression			OFFSIDES
167	Disease recurrence			OFFSIDES
168	Disseminated Intravascular Coagulation			OFFSIDES
169	Disturbance in sexual arousal			SIDER
170	Dizziness			OFFSIDES SIDER
171	Drug Tolerance			OFFSIDES
172	Drug abuser			OFFSIDES
173	Drug addict			OFFSIDES
174	Drug screen positive			OFFSIDES
175	Drug withdrawal headache			OFFSIDES
176	Duodenal Ulcer		15235935	CTD
177	Duodenitis			OFFSIDES
178	Dysgeusia			OFFSIDES
179	Dyslalia			OFFSIDES
180	Economic problem			OFFSIDES
181	Ejection Fraction Decreased			OFFSIDES
182	Embolic stroke			OFFSIDES
183	Emotional distress			OFFSIDES
184	Endocarditis enterococcal			OFFSIDES
185	Endocarditis			OFFSIDES
186	Endodontic procedure			OFFSIDES
187	Enterocolitis			OFFSIDES
188	Eosinophil percentage increased			OFFSIDES
189	Eosinophilia			SIDER
190	Erectile dysfunction			OFFSIDES SIDER
191	Erosive gastritis			OFFSIDES
192	Erythema Multiforme			OFFSIDES
193	Erythema			OFFSIDES
194	Esophageal Stenosis			OFFSIDES
195	Exanthema		7769203	CTD
196	Extremity necrosis			OFFSIDES
197	Fanconi Syndrome			OFFSIDES
198	Fever		15235935	CTD
199	Fistula repair			OFFSIDES
200	Flatulence			SIDER
201	Fluid overload			OFFSIDES
202	Foreign body sensation in eyes			OFFSIDES
203	Formication			OFFSIDES
204	Gamma-Glutamyltransferase Increased			OFFSIDES
205	Gamma-glutamyltransferase abnormal			OFFSIDES
206	Gastric ulcer			OFFSIDES
207	Gastrointestinal Pain			SIDER
208	General physical health deterioration			OFFSIDES
209	Gliosis			OFFSIDES
210	Gout			SIDER
211	Granulocyte count increased			OFFSIDES
212	Granuloma			OFFSIDES
213	Headache			SIDER
214	Hemiparesis			OFFSIDES
215	Hepatitis			SIDER
216	Hoarseness			OFFSIDES
217	Human herpes virus 6 serology positive			OFFSIDES
218	Hydrocephalus			OFFSIDES
219	Hydronephrosis			OFFSIDES
220	Hypercapnia			OFFSIDES
221	Hyperkeratosis			OFFSIDES
222	Hyperparathyroidism			OFFSIDES
223	Hypokinesia		15303455	CTD OFFSIDES
224	Hypoxia			OFFSIDES
225	Hysterectomy			OFFSIDES
226	Impetigo			OFFSIDES
227	Induration			OFFSIDES
228	Infection			OFFSIDES SIDER
229	Intention tremor			OFFSIDES
230	Intervertebral Disc Degeneration			OFFSIDES
231	Intervertebral disc compression			OFFSIDES
232	Intestinal Obstruction			OFFSIDES
233	Intestinal mucosal hypertrophy			OFFSIDES
234	Intracranial Aneurysm			OFFSIDES
235	Intubation			OFFSIDES
236	Joint warmth			OFFSIDES
237	Keratitis sicca			OFFSIDES
238	Klebsiella sepsis			OFFSIDES
239	Large intestine perforation			OFFSIDES
240	Legionella			OFFSIDES
241	Leukoencephalopathy			OFFSIDES
242	Leukopenia neonatal			OFFSIDES
243	Limb injury			OFFSIDES
244	Limb operation			OFFSIDES
245	Liver Abscess			OFFSIDES
246	Liver Cirrhosis		7769203	CTD
247	Liver Failure		7769203	CTD
248	Lung Injury			OFFSIDES
249	Lymphocyte count abnormal			OFFSIDES
250	Lymphocyte count decreased			OFFSIDES
251	Lymphocyte percentage decreased			OFFSIDES
252	Lymphocyte stimulation test positive			OFFSIDES
253	Lymphocytic infiltration			OFFSIDES
254	Macroglossia			OFFSIDES
255	Malignant Hypertension			OFFSIDES
256	Malignant neoplasm progression			OFFSIDES
257	Mandibular prosthesis user			OFFSIDES
258	Mastication disorder			OFFSIDES
259	Mechanical ventilation			OFFSIDES
260	Metabolic acidosis			OFFSIDES
261	Metaplasia			OFFSIDES
262	Monocyte percentage decreased			OFFSIDES
263	Mucormycosis			OFFSIDES
264	Multiple Myeloma			OFFSIDES
265	Multiple Sclerosis			OFFSIDES
266	Multiple sclerosis relapse			OFFSIDES
267	Muscle Rigidity		15303455	CTD
268	Muscle necrosis			OFFSIDES
269	Muscle tightness			OFFSIDES
270	Muscular Dystrophy			OFFSIDES
271	Musculoskeletal Pain			OFFSIDES
272	Musculoskeletal discomfort			SIDER
273	Myalgia			SIDER
274	Myelitis			OFFSIDES
275	Myeloma recurrence			OFFSIDES
276	Myotonia Congenita			OFFSIDES
277	Nasopharyngitis			OFFSIDES SIDER
278	Nephrolithiasis			OFFSIDES SIDER
279	Nephrotic Syndrome			OFFSIDES
280	Nervous tension			OFFSIDES
281	Nervousness			SIDER
282	Neuroleptic Malignant Syndrome			OFFSIDES
283	Neuropathic pain			OFFSIDES
284	Nocturia			OFFSIDES
285	Nuclear magnetic resonance imaging brain			OFFSIDES
286	Ocular Hypertension			OFFSIDES
287	Oliguria			OFFSIDES
288	Optic Neuritis			OFFSIDES
289	Oral infection			OFFSIDES
290	Osteolysis			OFFSIDES
291	Osteomyelitis			OFFSIDES
292	Osteopenia			OFFSIDES
293	Osteosclerosis			OFFSIDES
294	Pallor			OFFSIDES
295	Pancreatectomy			OFFSIDES
296	Pancreatic Cyst			OFFSIDES
297	Pancreatitis			OFFSIDES
298	Pancytopenia		15235935	CTD
299	Periarthritis			OFFSIDES
300	Peripheral arterial occlusive disease			OFFSIDES
301	Pharyngitis			SIDER
302	Physical disability			OFFSIDES
303	Pneumocystis jiroveci pneumonia			OFFSIDES
304	Pneumonia			SIDER
305	Polysubstance dependence			OFFSIDES
306	Poor quality sleep			OFFSIDES
307	Post procedural complication			OFFSIDES
308	Prescribed overdose			OFFSIDES
309	Primary sequestrum			OFFSIDES
310	Productive Cough			OFFSIDES
311	Progressive multiple sclerosis			OFFSIDES
312	Protein total abnormal			OFFSIDES
313	Prothrombin level decreased			OFFSIDES
314	Pulmonary Hypertension			OFFSIDES
315	Pulmonary Infarction			OFFSIDES
316	Pulmonary congestion			OFFSIDES
317	Pulmonary vascular disorder			OFFSIDES
318	Purulent discharge			OFFSIDES
319	Quadriplegia			OFFSIDES
320	Radiation skin injury			OFFSIDES
321	Rectal polyp			OFFSIDES
322	Respiratory Failure			OFFSIDES
323	Retinal exudates			OFFSIDES
324	Rhinitis			SIDER
325	Right Ventricular Hypertrophy			OFFSIDES
326	Sarcoidosis			OFFSIDES
327	Seizures		8619239	CTD
328	Septic Shock			OFFSIDES
329	Sequestrectomy			OFFSIDES
330	Serum Sickness			SIDER
331	Sick Sinus Syndrome			OFFSIDES
332	Sinus antrostomy			OFFSIDES
333	Sinus bradycardia			OFFSIDES
334	Sinus operation			OFFSIDES
335	Sinus rhythm			OFFSIDES
336	Sinusitis			OFFSIDES SIDER
337	Sjogren's Syndrome		18478182	CTD
338	Skin laceration			OFFSIDES
339	Somnolence			SIDER
340	Spinal column stenosis			OFFSIDES
341	Splenectomy			OFFSIDES
342	Stem cell transplant			OFFSIDES
343	Submandibular mass			OFFSIDES
344	Sweating			SIDER
345	Synovial Cyst			OFFSIDES
346	Systolic hypertension			OFFSIDES
347	Talipes			OFFSIDES
348	Temperature intolerance			OFFSIDES
349	Tenosynovitis			OFFSIDES
350	Tension			SIDER
351	Therapeutic procedure			OFFSIDES
352	Thrombectomy			OFFSIDES
353	Thrombocytopenia			SIDER
354	Thrombocytopenic purpura			SIDER
355	Thrombosis in device			OFFSIDES
356	Thrombotic stroke			OFFSIDES
357	Tooth Extraction			OFFSIDES
358	Tremor		15303455	CTD
359	Ulcer			OFFSIDES
360	Umbilical hernia perforation			OFFSIDES
361	Unemployment			OFFSIDES
362	Urethral stricture			OFFSIDES
363	Vaginal mycosis			OFFSIDES
364	Vasculitis			SIDER
365	Vena cava filter insertion			OFFSIDES
366	Venous stasis			OFFSIDES
367	Visual disturbance			OFFSIDES
368	Weight Gain		15303455	CTD OFFSIDES
369	Wound Debridement			OFFSIDES
370	Wound Infection			OFFSIDES
371	Wound abscess			OFFSIDES
372	Wound closure			OFFSIDES
373	Xerostomia		18478182	CTD
374	effusion			OFFSIDES
375	fibroma			OFFSIDES
376	jaundice		7769203	CTD SIDER
377	prostatitis			OFFSIDES

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234