MetaADEDB 2.0 @ LMMD
Amoxapine
(QWGDMFLQWFTERH-UHFFFAOYSA-N)
Structure
SMILES
Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1
Type(s)
Approved
ATC code(s)
N06AA17
Molecular Formula:
C17H16ClN3O
Molecular Weight:
313.781
Log P:
3.1315
Hydrogen Bond Acceptor:
4
Hydrogen Bond Donor:
1
TPSA:
36.86
CAS Number(s):
14028-44-5
Synonym(s)
1.
Amoxapine
2.
2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine
3.
Asendin
4.
Asendis
5.
CL-67,772
6.
Demolox
7.
Desmethylloxapine
8.
Défanyl
9.
CL 67,772
10.
CL67,772
External Link(s)
MeSHD000657
PubChem Compound2170
BindingDB22870
ChEBI2675
CHEMBLCHEMBL1113
DrugBankDB00543
DrugCentral191
IUPHAR/BPS Guide to PHARMACOLOGY201
KEGGdr:D00228
Therapeutic Target DatabaseD09IOI
ZINC931
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1NauseaFAERS: 2SIDER
US FAERS
2Wrong technique in product usage processFAERS: 2US FAERS
3Abdominal discomfortFAERS: 1US FAERS
4AnxietyFAERS: 1US FAERS
5Cold sweatFAERS: 1US FAERS
6PainFAERS: 1US FAERS
7Product solubility abnormalFAERS: 1US FAERS
8SomnolenceFAERS: 1
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
9Abdominal Compartment SyndromeOFFSIDES
10Abdominal PainSIDER
11AbuliaOFFSIDES
12Acidosis20702294CTD
OFFSIDES
13Activation syndromeOFFSIDES
14Activities of daily living impairedOFFSIDES
15Acute Coronary SyndromeSIDER
16Acute kidney injury4002015
6870433		CTD
17Acute myocardial infarctionOFFSIDES
18AdenitisSIDER
19AgitationSIDER
20AgranulocytosisSIDER
21Akathisia, Drug-Induced3737838
6847973
7137406		CTD
22Alanine Aminotransferase IncreasedOFFSIDES
23Alcoholic IntoxicationOFFSIDES
24AlopeciaSIDER
25Altered state of consciousnessOFFSIDES
26Angina PectorisCanada Vigilance: 1Canada Vigilance
27AnorexiaOFFSIDES
SIDER
28Anticholinergic SyndromeOFFSIDES
29Antidepressant drug level above therapeuticOFFSIDES
30ApathyOFFSIDES
31ApneaOFFSIDES
32Aspiration PneumoniaOFFSIDES
33AstheniaSIDER
34AtaxiaSIDER
35AtelectasisOFFSIDES
36Atrial FibrillationCanada Vigilance: 1Canada Vigilance
SIDER
37Atrial Flutter7294224CTD
38Atrial arrhythmiaSIDER
39Atrioventricular BlockSIDER
40AutomatismOFFSIDES
41Basal Ganglia Diseases2864332CTD
42Bipolar Disorder7160178CTD
43Black hairy tongueSIDER
44Blood creatine phosphokinase decreasedOFFSIDES
45Blood creatine phosphokinase increasedOFFSIDES
46Blood glucose decreasedOFFSIDES
47Blood lactate dehydrogenase increasedOFFSIDES
48Blood osmolarity decreasedOFFSIDES
49Blood potassium increasedOFFSIDES
50Blood sodiumOFFSIDES
51BradycardiaOFFSIDES
52Brain Diseases, Metabolic3281327CTD
53Brain Injuries20702294CTD
54Cancer PainOFFSIDES
55Cardiac ArrestCanada Vigilance: 1Canada Vigilance
56Cardiac ventricular disorderOFFSIDES
57Catalepsy6847973
11180191		CTD
58Cerebrovascular accidentSIDER
59Chemical and Drug Induced Liver Injury8349085CTD
60Chorea6879286CTD
61Cognition Disorders3558331CTD
62Completed SuicideOFFSIDES
63Compression fractureOFFSIDES
64ConstipationCanada Vigilance: 1Canada Vigilance
SIDER
65Cytomegalovirus enterocolitisOFFSIDES
66Dental abscessOFFSIDES
67Depressed Level of ConsciousnessOFFSIDES
68Depressive disorder

View details

6363397
6847973
7114318
7294224
8955926
10967655
12645397
 		CTD
69DermatitisSIDER
70Disease recurrenceOFFSIDES
71DisorientationSIDER
72Disseminated Intravascular CoagulationOFFSIDES
73Disturbance in sexual arousalSIDER
74DizzinessSIDER
75DrowsinessOFFSIDES
SIDER
76Drug Overdose4002015
6870433		CTD
77Drug toxicityOFFSIDES
78DysgeusiaSIDER
79DysgraphiaOFFSIDES
80Dyskinesia, Drug-Induced6624971
6625005		CTD
81DyslaliaOFFSIDES
82DyspepsiaSIDER
83Dysthymic DisorderOFFSIDES
84Dystonia6701281CTD
85DysuriaCanada Vigilance: 1Canada Vigilance
86EmpyemaOFFSIDES
87Enterocolitis bacterialOFFSIDES
88EosinophiliaSIDER
89Epigastric distressSIDER
90EpilepsyOFFSIDES
91Erectile dysfunction6137152
7114318		CTD
SIDER
92Erythema MultiformeCanada Vigilance: 1Canada Vigilance
OFFSIDES
93Esophageal PerforationOFFSIDES
94Euphoric moodOFFSIDES
95Eyelid Function DisorderOFFSIDES
96FatigueSIDER
97Feeding disorder neonatalOFFSIDES
98Feeling abnormalSIDER
99Fever10710250CTD
100FlatulenceSIDER
101Gait Disorders, Neurologic6695233
7137406		CTD
102Galactorrhea6363397
7137406		CTD
OFFSIDES
103Gamma-Glutamyltransferase IncreasedOFFSIDES
104Gastrointestinal PainSIDER
105General physical health deteriorationOFFSIDES
106Glasgow coma scaleOFFSIDES
107GlossoptosisOFFSIDES
108Hallucinations7160178CTD
109HeadacheCanada Vigilance: 1Canada Vigilance
SIDER
110Heart failure3351008CTD
111HepatitisSIDER
112HypercapniaOFFSIDES
113HypercreatininaemiaOFFSIDES
114HyperparathyroidismOFFSIDES
115HypomaniaSIDER
116HypotensionCanada Vigilance: 120865899CTD
SIDER
Canada Vigilance
117IncoherentOFFSIDES
118Infection in an immunocompromised hostOFFSIDES
119InfectionOFFSIDES
120Intention tremorOFFSIDES
121Intentional misuseOFFSIDES
122Intervertebral disc compressionOFFSIDES
123Intestinal hypomotilityOFFSIDES
124Joint stiffnessOFFSIDES
125LacerationOFFSIDES
126LacrimationSIDER
127LaryngospasmCanada Vigilance: 1Canada Vigilance
128LeukoencephalopathyOFFSIDES
129LeukopeniaSIDER
130Lipids abnormalOFFSIDES
131LymphadenitisSIDER
132Malignant neoplasm progressionOFFSIDES
133Mechanical ventilationOFFSIDES
134Mental impairmentOFFSIDES
135Movement Disorders6711697
10967655		CTD
136Multiple MyelomaOFFSIDES
137Multiple drug overdoseOFFSIDES
138Multiple drug overdose intentionalOFFSIDES
139Muscle Rigidity

View details

6137151
6691496
6695233
6847973
7137406
10710250
 		CTD
140Muscle necrosisOFFSIDES
141Musculoskeletal stiffnessOFFSIDES
142MydriasisSIDER
143Myocardial InfarctionSIDER
144Myoglobin blood increasedOFFSIDES
145Myoglobinuria6870433CTD
146NervousnessSIDER
147Neuroleptic Malignant Syndrome10710250CTD
OFFSIDES
SIDER
148NumbnessSIDER
149NystagmusOFFSIDES
150Occult blood positiveOFFSIDES
151Oculogyric crisisCanada Vigilance: 1Canada Vigilance
152OliguriaOFFSIDES
153Oral Cavity FistulaOFFSIDES
154Oral mucosal exfoliationOFFSIDES
155OverdoseOFFSIDES
156Painful ejaculationSIDER
157PalpitationsSIDER
158PancreatitisSIDER
159Paresthesia of limbsSIDER
160Parkinsonian Disorders6232518
6711697		CTD
161Parotid swellingSIDER
162PetechiaeCanada Vigilance: 1Canada Vigilance
SIDER
163PoriomaniaOFFSIDES
164Post procedural infectionOFFSIDES
165PruritusCanada Vigilance: 1Canada Vigilance
SIDER
166Psychiatric symptomOFFSIDES
167Pulmonary congestionOFFSIDES
168PurpuraSIDER
169PyelonephritisOFFSIDES
170QRS axis abnormalOFFSIDES
171Renal tubular necrosisOFFSIDES
172Respiratory FailureOFFSIDES
173Retinal depigmentationOFFSIDES
174Rhabdomyolysis6870433CTD
OFFSIDES
175RhinorrheaOFFSIDES
176ScreamingOFFSIDES
177Seizures

View details

4002015
4069320
6146603
6690829
6805341
6870433
7621219
12645397
 		CTD
178ShockSIDER
179Sinus bradycardiaOFFSIDES
180SpondylolisthesisOFFSIDES
181Sputum retentionOFFSIDES
182Status Epilepticus7621219CTD
OFFSIDES
183Stevens-Johnson SyndromeOFFSIDES
184StomatitisSIDER
185Substance Withdrawal Syndrome6624971
6625005		CTD
186SyncopeSIDER
187TachycardiaCanada Vigilance: 1Canada Vigilance
SIDER
188Tardive DyskinesiaSIDER
189Taste peculiarSIDER
190TensionSIDER
191ThrombocytopeniaSIDER
192TinnitusSIDER
193Torticollis6695233
7137406		CTD
194TremorSIDER
195Urinary RetentionCanada Vigilance: 37114318CTD
SIDER
Canada Vigilance
196UrticariaCanada Vigilance: 1Canada Vigilance
SIDER
197Vascular purpuraSIDER
198VasculitisSIDER
199Visual ImpairmentCanada Vigilance: 1Canada Vigilance
200VomitingSIDER
201jaundiceSIDER
Powered by :

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234

Copyright © 2019-2020 Laboratory of Molecular Modeling and Design, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology. All rights reserved.