MetaADEDB 2.0 @ LMMD
Heroin
(GVGLGOZIDCSQPN-PVHGPHFFSA-N)
Structure
SMILES
CC(=O)O[C@H]1C=C[C@@H]2[C@@]34[C@H]1Oc1c4c(C[C@H]2N(CC3)C)ccc1OC(=O)C
Type(s)
Approved; Illicit; Investigational
ATC code(s)
N07BC06
Molecular Formula:
C21H23NO5
Molecular Weight:
369.411
Log P:
1.9265
Hydrogen Bond Acceptor:
6
Hydrogen Bond Donor:
0
TPSA:
65.07
CAS Number(s):
561-27-3
Synonym(s)
1.
Heroin
2.
Diacetylmorphine
3.
Diamorphine
4.
Diacetylmorphine Hydrochloride
5.
Diagesil
6.
Diamorf
7.
Heroin Hydrochloride
8.
Min-I-Jet Morphine Sulphate
9.
Hydrochloride, Diacetylmorphine
10.
Hydrochloride, Heroin
11.
Min I Jet Morphine Sulphate
External Link(s)
MeSHD003932
PubChem Compound5462328
ChEBI27808
CHEMBLCHEMBL459324
DrugBankDB01452
DrugCentral4412
IUPHAR/BPS Guide to PHARMACOLOGY9082
KEGGcpd:C06534
dr:D07286
Therapeutic Target DatabaseD0T6WT
ZINC4097183
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1OverdoseFAERS: 1OFFSIDES
US FAERS
2Abdominal Compartment SyndromeOFFSIDES
3Abdominal PainOFFSIDES
4Abdominal massOFFSIDES
5Abnormal visionOFFSIDES
6AbuseOFFSIDES
7Accidental exposureOFFSIDES
8Accidental overdoseCanada Vigilance: 4Canada Vigilance
OFFSIDES
9Acute kidney injury11971848CTD
10Aneurysm16355064CTD
11AnhidrosisOFFSIDES
12Anxiety Disorders16002042CTD
13Asthma12576374CTD
14AstigmatismOFFSIDES
15Basal Ganglia Diseases15200561CTD
16Blood 1,25-dihydroxycholecalciferol decreasedOFFSIDES
17Blood albumin decreasedOFFSIDES
18Blood parathyroid hormone increasedOFFSIDES
19Blood sodiumOFFSIDES
20Bradycardia4743335
14550686		CTD
21Brain Infarction19681452CTD
22Bronchial Hyperreactivity11948057CTD
23Bronchopulmonary DysplasiaOFFSIDES
24Cardiac TamponadeOFFSIDES
25Cardiovascular insufficiencyOFFSIDES
26Catalepsy6543399CTD
27Cerebral Hemorrhage16134399CTD
28Cerebral PalsyOFFSIDES
29Cerebrovascular Disorders12629538CTD
30Chemical burns of eyeOFFSIDES
31Cheyne-Stokes Respiration14550686CTD
32Cholestasis of pregnancyOFFSIDES
33Circumstance or information capable of leading to medication errorOFFSIDES
34Cocaine-Related Disorders11270509
19692689		CTD
35Cognition Disorders7121694
10882838		CTD
36Completed SuicideOFFSIDES
37ConfabulationOFFSIDES
38Congenital nystagmusOFFSIDES
39Congenital visual acuity reducedOFFSIDES
40Dental cariesOFFSIDES
41DependenceOFFSIDES
42Disseminated Intravascular Coagulation11971848CTD
43Dizziness9799024CTD
44DrowningOFFSIDES
45Drug Overdose6676478CTD
46Drug abuserOFFSIDES
47Drug abuseCanada Vigilance: 1Canada Vigilance
48Drug addictOFFSIDES
49Drug diversionOFFSIDES
50Drug exposure during pregnancyOFFSIDES
51Drug screen positiveOFFSIDES
52Drug toxicityOFFSIDES
53DysmorphismOFFSIDES
54Dyspnea9799024CTD
55Dysthymic DisorderOFFSIDES
56Dystonia15200561CTD
OFFSIDES
57Edema11933563CTD
58Endocarditis5084991CTD
OFFSIDES
59Eosinophilia11933563CTD
60Erectile dysfunction4474860CTD
61Exanthema20506546CTD
62Exotropia12844273
19150250		CTD
63Feeling of body temperature changeOFFSIDES
64Fetal Growth Retardation11732233CTD
65General physical health deteriorationOFFSIDES
66Headache9799024CTD
67Hearing Loss, Bilateral19253779CTD
68Hepatic necrosisOFFSIDES
69Heroin Dependence

View details

225122
4433085
6676478
9643465
9824469
10529020
11173169
11519628
11862373
15717844
15986265
16002042
16085366
16598705
16759341
18365934
19067385
19948382
 		CTD
70HiccoughOFFSIDES
71Hyperkalemia11971848CTD
72HyperreflexiaOFFSIDES
73Hypotension15766337
16355064		CTD
74Hypoventilation6676478CTD
75Hypoxia14550686CTD
76Hysteria18365934CTD
77Incorrect route of drug administrationOFFSIDES
78InfectionOFFSIDES
79Intentional drug misuseOFFSIDES
80Intentional misuseOFFSIDES
81Kidney Diseases8770954CTD
82Labor Pain1547044CTD
83LethargyOFFSIDES
84LeukoencephalopathyOFFSIDES
85Live BirthOFFSIDES
86Malignant neoplasm progressionOFFSIDES
87Malnutrition15717844CTD
88Mental disorder due to a general medical conditionOFFSIDES
89Mental status changesOFFSIDES
90Metastases to adrenalsOFFSIDES
91MicrocephalyOFFSIDES
92Movement Disorders16137723CTD
93Multiple drug overdoseOFFSIDES
94Multiple drug overdose intentionalOFFSIDES
95Myelitis, Transverse19092572CTD
96Myocardial Infarction16034268CTD
97Myocardial ruptureOFFSIDES
98Myoclonic EpilepsyOFFSIDES
99MyopiaOFFSIDES
100Narcotic intoxicationOFFSIDES
101Nausea1547044
10447906		CTD
102Necrosis20506546
20600547		CTD
103Neonatal Abstinence Syndrome3348657
4748595		CTD
104Nephritis allergicOFFSIDES
105Neutropenic sepsisOFFSIDES
106Neutrophil count decreasedOFFSIDES
107NystagmusOFFSIDES
108Ocular Motility Disorders9597667CTD
109Opioid-Related Disorders9799024CTD
110Oropharyngeal painOFFSIDES
111OsteopeniaOFFSIDES
112OsteoporosisOFFSIDES
113Pain, Postoperative8214466
9466101
10447906		CTD
114Pain9539228
10070450
12565182		CTD
115PallorOFFSIDES
116Pericardial effusionOFFSIDES
117Personality Disorders18365934CTD
118Polysubstance abuseOFFSIDES
119Poor quality sleepOFFSIDES
120Post procedural painOFFSIDES
121Postoperative ileusOFFSIDES
122Pregnancy Complications16471094CTD
123Prenatal Exposure Delayed Effects16598705CTD
124Pruritus

View details

1547044
8214466
10193215
10447906
 		CTD
125Psychoses, Substance-Induced20193724CTD
126Pulmonary Edema3234243
9422191
11933563		CTD
127Pupil Disorders9173676CTD
128Respiratory FailureOFFSIDES
129Retroperitoneal lymphadenopathyOFFSIDES
130Rhabdomyolysis

View details

10863119
11971848
18446076
19392810
 		CTD
131RhinorrheaOFFSIDES
132Right atrial pressure increasedOFFSIDES
133Seizures2788249
11714588
19692689		CTD
134Septic ShockOFFSIDES
135Similar reaction on previous exposure to drugOFFSIDES
136Skin lacerationOFFSIDES
137Substance Abuse, Intravenous3348657CTD
138Substance Withdrawal Syndrome

View details

2756964
4433085
6649643
6794076
9824469
10529020
12844273
16471094
16598705
17122286
19067385
 		CTD
139Substance-Related Disorders

View details

3177071
11534540
16157230
16956865
 		CTD
140Supraventricular tachycardiaOFFSIDES
141Terminal stateOFFSIDES
142Torsades de Pointes15875343CTD
143Toxicologic test abnormalOFFSIDES
144Unevaluable eventOFFSIDES
145Unresponsive to stimuliOFFSIDES
146Urinary Retention8214466
10447906		CTD
147Venous Insufficiency7975873CTD
148Ventricular Fibrillation11971848CTD
149Vision abnormal neonatalOFFSIDES
150Vomiting1547044CTD
151Wolff-Parkinson-White SyndromeOFFSIDES
Powered by :

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234

Copyright © 2019-2020 Laboratory of Molecular Modeling and Design, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology. All rights reserved.