MetaADEDB 2.0 @ LMMD
tipranavir
(SUJUHGSWHZTSEU-FYBSXPHGSA-N)
Structure
SMILES
CCC[C@@]1(CCc2ccccc2)CC(=C(C(=O)O1)[C@@H](c1cccc(c1)NS(=O)(=O)c1ccc(cn1)C(F)(F)F)CC)O
Type(s)
Approved; Investigational
ATC code(s)
J05AE09
Molecular Formula:
C31H33F3N2O5S
Molecular Weight:
602.664
Log P:
8.4793
Hydrogen Bond Acceptor:
7
Hydrogen Bond Donor:
2
TPSA:
113.97
CAS Number(s):
174484-41-4
Synonym(s)
1.
tipranavir
2.
3'-((1R)-1-((6R)-5,6-dihydro-4-hydroxy-2-oxo-6-phenethyl-6-propyl-2h-pyran-3-yl)propyl)-5-(trifluoromethyl)-2-pyridinesulfonanilide
3.
Aptivus
4.
PNU 140690
5.
PNU-140690
6.
tipranavir, (R-(R*,R*))-isomer
7.
tipranavir, (S-(R*,R*))-isomer
8.
tipranavir, (S-(R*,S*))-isomer
External Link(s)
MeSHC107201
PubChem Compound54682461
BindingDB50376465
558
ChEBI63628
CHEMBLCHEMBL183041
CHEMBL222559
DrugBankDB00932
DrugCentral3609
KEGGdr:D08605
Therapeutic Target DatabaseD0EV6T
ZINC100022637
100016058
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Alanine Aminotransferase IncreasedFAERS: 6
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
SIDER
US FAERS
2Aspartate Aminotransferase IncreasedFAERS: 6
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
3Drug ineffectiveFAERS: 3
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
4Accidental deathFAERS: 2OFFSIDES
US FAERS
5Completed SuicideFAERS: 2OFFSIDES
US FAERS
6Drug abuserFAERS: 2US FAERS
7General physical health deteriorationFAERS: 2OFFSIDES
US FAERS
8HeadacheFAERS: 2SIDER
US FAERS
9Hepatitis C positiveFAERS: 2OFFSIDES
US FAERS
10HepatitisFAERS: 2SIDER
US FAERS
11HepatotoxicityFAERS: 2SIDER
US FAERS
12OverdoseFAERS: 2OFFSIDES
US FAERS
13Acquired Immunodeficiency SyndromeFAERS: 1US FAERS
14AlopeciaFAERS: 1US FAERS
15Angina PectorisFAERS: 1US FAERS
16AsphyxiaFAERS: 1US FAERS
17AsthmaFAERS: 1US FAERS
18Blood triglycerides increasedFAERS: 1SIDER
US FAERS
19Cerebrovascular accidentFAERS: 1US FAERS
20CheilitisFAERS: 1US FAERS
21CholecystitisFAERS: 1OFFSIDES
US FAERS
22DizzinessFAERS: 1SIDER
US FAERS
23FatigueFAERS: 1SIDER
US FAERS
24Hepatitis BFAERS: 1OFFSIDES
SIDER
US FAERS
25Immune reconstitution syndromeFAERS: 1US FAERS
26Injection Site ReactionFAERS: 1US FAERS
27Injection site painFAERS: 1US FAERS
28Lip swellingFAERS: 1US FAERS
29NauseaFAERS: 1SIDER
US FAERS
30Neonatal aspirationFAERS: 1OFFSIDES
US FAERS
31PancreatitisFAERS: 1SIDER
US FAERS
32Portal HypertensionFAERS: 1OFFSIDES
US FAERS
33PruritusFAERS: 1SIDER
US FAERS
34RhabdomyolysisFAERS: 1SIDER
US FAERS
35Transaminases increasedFAERS: 1OFFSIDES
SIDER
US FAERS
36Weight decreasedFAERS: 1SIDER
US FAERS
37jaundiceFAERS: 1SIDER
US FAERS
38treatment failureFAERS: 1US FAERS
39AIDS Dementia ComplexOFFSIDES
40Abdominal PainSIDER
41Abdominal rigidityOFFSIDES
42Acute sinusitisOFFSIDES
43AdenocarcinomaOFFSIDES
44Amylase increasedSIDER
45Anal FissureOFFSIDES
46Anal abscessOFFSIDES
47Anorectal agenesisOFFSIDES
48AnorexiaSIDER
49Anti-HBc antibodyOFFSIDES
50Anti-neutrophil cytoplasmic antibody positive vasculitisOFFSIDES
51Anticonvulsant drug level decreasedOFFSIDES
52AscitesOFFSIDES
53AspergillosisOFFSIDES
54AstheniaSIDER
55Atrial tachycardiaOFFSIDES
56BicytopeniaOFFSIDES
57Bilirubin conjugated abnormalOFFSIDES
58Bilirubin conjugated increasedOFFSIDES
59Blood HIV RNAOFFSIDES
60Blood and lymphatic system disordersSIDER
61Blood bilirubin unconjugated increasedOFFSIDES
62Blood electrolytes abnormalOFFSIDES
63Blood iron decreasedOFFSIDES
64Blood iron increasedOFFSIDES
65Body TemperatureOFFSIDES
66Brain AbscessOFFSIDES
67BronchiolitisOFFSIDES
68BronchitisSIDER
69Buffalo humpSIDER
70Bulbar palsyOFFSIDES
71Cardiac TamponadeOFFSIDES
72Catheter related infectionOFFSIDES
73Caudal Regression SyndromeOFFSIDES
74Cerebellar AtaxiaOFFSIDES
75Chemical and Drug Induced Liver Injury24014644
28437613		CTD
76ChillsSIDER
77CholangiolitisOFFSIDES
78Chronic Obstructive Airway DiseaseOFFSIDES
79CirrhosisOFFSIDES
80Clostridium colitisOFFSIDES
81Clostridium difficile toxin test positiveOFFSIDES
82ConstipationSIDER
83CystSIDER
84Cytolytic hepatitisOFFSIDES
SIDER
85Cytomegalovirus chorioretinitisOFFSIDES
SIDER
86DehydrationSIDER
87DemyelinationOFFSIDES
88DermatitisSIDER
89Diabetes MellitusSIDER
90DiarrheaOFFSIDES
91DiscomfortSIDER
92Disease ProgressionCanada Vigilance: 1Canada Vigilance
OFFSIDES
93Drug resistanceOFFSIDES
94DyspepsiaSIDER
95EncephalitisOFFSIDES
96EpididymitisOFFSIDES
97EpilepsyOFFSIDES
98EpistaxisOFFSIDES
SIDER
99Erythema MultiformeSIDER
100ErythemaOFFSIDES
SIDER
101Escherichia infectionOFFSIDES
102Facial wastingSIDER
103Feeling abnormalSIDER
104Flank PainOFFSIDES
105FlatulenceSIDER
106Fluid overloadOFFSIDES
107Gamma-Glutamyltransferase IncreasedSIDER
108GastroenteritisSIDER
109Gastrointestinal PainSIDER
110Gastrointestinal disorder congenitalOFFSIDES
111GranulomaOFFSIDES
112Haptoglobin DecreasedOFFSIDES
113Hepatic impairmentSIDER
114Hepatitis B surface antigen positiveOFFSIDES
115Hepatitis C virus testOFFSIDES
116Hepatojugular refluxOFFSIDES
117HydrocephalusOFFSIDES
118HypersensitivitySIDER
119Hypertensive hydrocephalusOFFSIDES
120Hypertrophy of BreastSIDER
121InfectionSIDER
122InfestationSIDER
123InflammationSIDER
124Injection site dermatitisOFFSIDES
125Injection site massOFFSIDES
126Insulin ResistanceSIDER
127Intestinal PerforationOFFSIDES
128Intracranial AneurysmOFFSIDES
129Klebsiella sepsisOFFSIDES
130LeukoencephalopathyOFFSIDES
131Lipase increasedSIDER
132LipoatrophySIDER
133Lipodystrophy acquiredOFFSIDES
SIDER
134LipohypertrophySIDER
135Liver AbscessOFFSIDES
136Liver Failure19025478CTD
137Liver diseases20003457CTD
138Lung infection pseudomonalOFFSIDES
139LymphocytosisOFFSIDES
140LymphomaOFFSIDES
SIDER
141MalaiseSIDER
142MalnutritionSIDER
143MastoiditisOFFSIDES
144MegacolonOFFSIDES
145Meningeal disorderOFFSIDES
146MeningoceleOFFSIDES
147Mental status changesOFFSIDES
148MicrolithiasisOFFSIDES
149Migraine with AuraOFFSIDES
150Mitochondrial toxicitySIDER
151MonoparesisOFFSIDES
152Musculoskeletal DeformityOFFSIDES
153Musculoskeletal discomfortSIDER
154MyalgiaSIDER
155MyositisSIDER
156Nephritic syndromeOFFSIDES
157Nephrotic SyndromeOFFSIDES
158NeutropeniaSIDER
159OsteomyelitisOFFSIDES
160PainSIDER
161Perianal abscessOFFSIDES
162PneumoniaSIDER
163Post lumbar puncture syndromeOFFSIDES
164Postoperative infectionOFFSIDES
165PregnancySIDER
166Protein total increasedOFFSIDES
167PrurigoSIDER
168Pseudomonal sepsisOFFSIDES
169PsoriasisOFFSIDES
170Pulmonary HypertensionOFFSIDES
171Renal tubular acidosisOFFSIDES
172Respiratory tract infection bacterialOFFSIDES
173RetchingSIDER
174RhonchiOFFSIDES
175Septic ShockOFFSIDES
176SerositisOFFSIDES
177SigmoiditisOFFSIDES
178SinusitisOFFSIDES
179SomnolenceSIDER
180Splenic abscessOFFSIDES
181Stevens-Johnson SyndromeSIDER
182Subcutaneous AbscessOFFSIDES
183Subcutaneous noduleOFFSIDES
184Tethered Cord SyndromeOFFSIDES
185Therapy non-responderOFFSIDES
186ThrombocytopeniaSIDER
187Toxic Epidermal NecrolysisSIDER
188Toxicologic test abnormalOFFSIDES
189ToxoplasmosisOFFSIDES
190Unevaluable eventOFFSIDES
191Urine amphetamine positiveOFFSIDES
192UrticariaSIDER
193Varicella zosterSIDER
194Viral load decreasedOFFSIDES
195Viral mutation identifiedOFFSIDES
196VomitingSIDER
197Wheelchair userOFFSIDES
198White blood cell count decreasedSIDER
199nervous system disorderSIDER
200prostatitisOFFSIDES
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