MetaADEDB 2.0 @ LMMD
miglustat
(UQRORFVVSGFNRO-UTINFBMNSA-N)
Structure
SMILES
CCCCN1C[C@H](O)[C@H]([C@@H]([C@H]1CO)O)O
Type(s)
Approved
ATC code(s)
A16AX06
Molecular Formula:
C10H21NO4
Molecular Weight:
219.278
Log P:
-1.5164
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
4
TPSA:
84.16
CAS Number(s):
72599-27-0
Synonym(s)
1.
miglustat
2.
N-(n-butyl)deoxy-nojirimycin
3.
N-(n-butyl)deoxynojirimycin
4.
OGT 918
5.
SC 48334
6.
SC-48334
7.
Zavesca
8.
n-butyl deoxynojirimycin
9.
n-butyldeoxynojirimycin
External Link(s)
MeSHC059896
PubChem Compound51634
BindingDB18355
ChEBI50381
CHEMBLCHEMBL1029
DrugBankDB00419
DrugCentral1807
IUPHAR/BPS Guide to PHARMACOLOGY4841
KEGGdr:D05032
Therapeutic Target DatabaseD0HR8Z
ZINC3794711
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Weight decreasedFAERS: 67SIDER
US FAERS
2Disease ProgressionFAERS: 57
Canada Vigilance: 3
Canada Vigilance
OFFSIDES
US FAERS
3TremorFAERS: 42
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
4PneumoniaFAERS: 39US FAERS
5Concomitant disease aggravatedFAERS: 32US FAERS
6ThrombocytopeniaFAERS: 29SIDER
US FAERS
7EpilepsyFAERS: 26OFFSIDES
US FAERS
8Drug ineffectiveFAERS: 25OFFSIDES
US FAERS
9VomitingFAERS: 20SIDER
US FAERS
10Neurological decompensationFAERS: 19OFFSIDES
US FAERS
11GastrostomyFAERS: 18OFFSIDES
US FAERS
12Respiratory FailureFAERS: 18OFFSIDES
US FAERS
13Abdominal PainFAERS: 177905523CTD
OFFSIDES
SIDER
US FAERS
14Growth retardationFAERS: 15US FAERS
15AtaxiaFAERS: 14OFFSIDES
SIDER
US FAERS
16Product supply issueFAERS: 13US FAERS
17MalaiseFAERS: 12SIDER
US FAERS
18SepsisFAERS: 12US FAERS
19General physical health deteriorationFAERS: 11OFFSIDES
US FAERS
20HeadacheFAERS: 11SIDER
US FAERS
21FatigueFAERS: 10
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
SIDER
US FAERS
22AstheniaFAERS: 9
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
SIDER
US FAERS
23Chitotriosidase increasedFAERS: 9OFFSIDES
US FAERS
24AphasiaFAERS: 8US FAERS
25Bone painFAERS: 8OFFSIDES
US FAERS
26EpistaxisFAERS: 8US FAERS
27SplenomegalyFAERS: 8US FAERS
28DementiaFAERS: 7US FAERS
29HepatomegalyFAERS: 7US FAERS
30InfectionFAERS: 7US FAERS
31MalnutritionFAERS: 7SIDER
US FAERS
32Memory impairmentFAERS: 7SIDER
US FAERS
33Cardiac ArrestFAERS: 6US FAERS
34DehydrationFAERS: 6US FAERS
35DysarthriaFAERS: 6US FAERS
36GastroenteritisFAERS: 6US FAERS
37NauseaFAERS: 6SIDER
US FAERS
38PainFAERS: 6OFFSIDES
SIDER
US FAERS
39PolyneuropathyFAERS: 6OFFSIDES
SIDER
US FAERS
40Wheelchair userFAERS: 6US FAERS
41BedriddenFAERS: 5US FAERS
42Bone lesionFAERS: 5OFFSIDES
US FAERS
43Cerebral atrophyFAERS: 5US FAERS
44Enteral NutritionFAERS: 5US FAERS
45HypoxiaFAERS: 5US FAERS
46Intestinal ObstructionFAERS: 5US FAERS
47PallorFAERS: 5US FAERS
48PancytopeniaFAERS: 5US FAERS
49Tay-Sachs DiseaseFAERS: 5US FAERS
50AmnesiaFAERS: 4OFFSIDES
SIDER
US FAERS
51ApathyFAERS: 4OFFSIDES
US FAERS
52ArthralgiaFAERS: 4US FAERS
53CataplexyFAERS: 4US FAERS
54ConstipationFAERS: 4SIDER
US FAERS
55DermatomyositisFAERS: 4OFFSIDES
US FAERS
56DystoniaFAERS: 4US FAERS
57EnuresisFAERS: 4US FAERS
58Increased upper airway secretionFAERS: 4US FAERS
59Mental status changesFAERS: 4US FAERS
60Musculoskeletal stiffnessFAERS: 4US FAERS
61Myocardial InfarctionFAERS: 4US FAERS
62Pulmonary congestionFAERS: 4US FAERS
63Respiratory distressFAERS: 4US FAERS
64SomnolenceFAERS: 4
Canada Vigilance: 1
Canada Vigilance
US FAERS
65SplenectomyFAERS: 4US FAERS
66Urinary IncontinenceFAERS: 4US FAERS
67Urinary tract infectionFAERS: 4US FAERS
68AbasiaFAERS: 3US FAERS
69Amyotrophic Lateral SclerosisFAERS: 3US FAERS
70Barium swallowFAERS: 3US FAERS
71CachexiaFAERS: 3US FAERS
72Carpal Tunnel SyndromeFAERS: 3US FAERS
73DeafnessFAERS: 3OFFSIDES
US FAERS
74DisorientationFAERS: 3US FAERS
75DizzinessFAERS: 3SIDER
US FAERS
76Drug dose omissionFAERS: 3US FAERS
77Drug level below therapeuticFAERS: 3US FAERS
78DysenteryFAERS: 3US FAERS
79FlatulenceFAERS: 37905523CTD
OFFSIDES
SIDER
US FAERS
80Gaze palsyFAERS: 3US FAERS
81InfluenzaFAERS: 3US FAERS
82Muscle SpasticityFAERS: 3US FAERS
83OsteolysisFAERS: 3OFFSIDES
US FAERS
84PancreatitisFAERS: 3US FAERS
85Paradoxical drug reactionFAERS: 3US FAERS
86Productive CoughFAERS: 3US FAERS
87Septic ShockFAERS: 3OFFSIDES
US FAERS
88Skin lesionFAERS: 3US FAERS
89Suicide attemptFAERS: 3US FAERS
90Transaminases increasedFAERS: 3US FAERS
91Activities of daily living impairedFAERS: 2OFFSIDES
US FAERS
92Acute respiratory failureFAERS: 2US FAERS
93AgitationFAERS: 2US FAERS
94AngerFAERS: 2US FAERS
95AnorexiaFAERS: 2SIDER
US FAERS
96AnxietyFAERS: 2US FAERS
97Apallic syndromeFAERS: 2US FAERS
98AsphyxiaFAERS: 2US FAERS
99Back PainFAERS: 2SIDER
US FAERS
100Bone infarctionFAERS: 2OFFSIDES
US FAERS
101BronchitisFAERS: 2US FAERS
102BronchopneumoniaFAERS: 2US FAERS
103Catheter placementFAERS: 2US FAERS
104Cell marker increasedFAERS: 2US FAERS
105Cerebrovascular accidentFAERS: 2US FAERS
106ChokingFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
107Clostridium difficile colitisFAERS: 2US FAERS
108Colonoscopy abnormalFAERS: 2US FAERS
109CyanosisFAERS: 2US FAERS
110DeliriumFAERS: 2US FAERS
111DemyelinationFAERS: 2OFFSIDES
US FAERS
112Drug ineffective for unapproved indicationFAERS: 2US FAERS
113Dry skinFAERS: 2OFFSIDES
US FAERS
114Electroencephalogram abnormalFAERS: 2US FAERS
115Electrolyte imbalanceFAERS: 2US FAERS
116Electromyogram abnormalFAERS: 2US FAERS
117ErythemaFAERS: 2US FAERS
118Eye InfectionFAERS: 2US FAERS
119Feeding tube userFAERS: 2US FAERS
120Fluid imbalanceFAERS: 2US FAERS
121HypersensitivityFAERS: 2US FAERS
122HypertrichosisFAERS: 2OFFSIDES
US FAERS
123HypotensionFAERS: 2US FAERS
124Impaired quality of lifeFAERS: 2US FAERS
125Incorrect dose administeredFAERS: 2US FAERS
126Intestinal PerforationFAERS: 2US FAERS
127Lactose IntoleranceFAERS: 2US FAERS
128LethargyFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
129Lower respiratory tract infectionFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
130Mechanical ventilationFAERS: 2OFFSIDES
US FAERS
131Mental impairmentFAERS: 2OFFSIDES
US FAERS
132MyalgiaFAERS: 2US FAERS
133MyositisFAERS: 2US FAERS
134Night sweatsFAERS: 2US FAERS
135No adverse eventFAERS: 2US FAERS
136Palliative CareFAERS: 2US FAERS
137Peripheral motor neuropathyFAERS: 2US FAERS
138PhotophobiaFAERS: 2US FAERS
139PneumothoraxFAERS: 2US FAERS
140Progressive Muscular AtrophyFAERS: 2US FAERS
141PruritusFAERS: 2US FAERS
142Pseudobulbar PalsyFAERS: 2US FAERS
143RetchingFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
144ScabFAERS: 2OFFSIDES
US FAERS
145Sensory level abnormalFAERS: 2US FAERS
146Status EpilepticusFAERS: 2OFFSIDES
US FAERS
147SubileusFAERS: 2US FAERS
148Terminal stateFAERS: 2US FAERS
149Urinary tract inflammationFAERS: 2US FAERS
150Visual ImpairmentFAERS: 2SIDER
US FAERS
151White blood cell count decreasedFAERS: 2US FAERS
152jaundiceFAERS: 2US FAERS
153nervous system disorderFAERS: 2SIDER
US FAERS
154Accidental exposureFAERS: 1US FAERS
155Acute kidney injuryFAERS: 1US FAERS
156Acute sinusitisFAERS: 1US FAERS
157Alanine Aminotransferase IncreasedFAERS: 1US FAERS
158AlopeciaFAERS: 1US FAERS
159Anal FistulaFAERS: 1US FAERS
160Aspartate Aminotransferase IncreasedFAERS: 1US FAERS
161AspergillosisFAERS: 1US FAERS
162Atypical pneumoniaFAERS: 1US FAERS
163Axonal neuropathyFAERS: 1US FAERS
164Blood count abnormalFAERS: 1US FAERS
165Blood gastrin increasedFAERS: 1US FAERS
166Blood potassium decreasedFAERS: 1US FAERS
167BradycardiaFAERS: 1US FAERS
168BronchiolitisFAERS: 1US FAERS
169BronchoscopyFAERS: 1US FAERS
170Bulbar palsyFAERS: 1US FAERS
171Cell DeathFAERS: 1US FAERS
172Central nervous system lesionFAERS: 1US FAERS
173Central venous catheter removalFAERS: 1US FAERS
174Cerebellar AtaxiaFAERS: 1US FAERS
175ChemotherapyFAERS: 1US FAERS
176CholelithiasisFAERS: 1US FAERS
177CholestasisFAERS: 1US FAERS
178ColectomyFAERS: 1US FAERS
179Completed SuicideFAERS: 1US FAERS
180Complex partial seizuresFAERS: 1US FAERS
181Concomitant disease progressionFAERS: 1US FAERS
182ConfabulationFAERS: 1OFFSIDES
US FAERS
183Dengue FeverFAERS: 1US FAERS
184Dental cariesFAERS: 1US FAERS
185Dependence on oxygen therapyFAERS: 1US FAERS
186Depressed Level of ConsciousnessFAERS: 1US FAERS
187DermatitisFAERS: 1US FAERS
188Disease recurrenceFAERS: 1US FAERS
189Drug effect delayedFAERS: 1US FAERS
190Drug exposure during pregnancyFAERS: 1US FAERS
191Drug prescribing errorFAERS: 1US FAERS
192DyscheziaFAERS: 1US FAERS
193DysgeusiaFAERS: 1US FAERS
194DysphemiaFAERS: 1US FAERS
195DysphoniaFAERS: 1US FAERS
196DysuriaFAERS: 1US FAERS
197Endoscopy upper gastrointestinal tract abnormalFAERS: 1US FAERS
198Erectile dysfunctionFAERS: 1OFFSIDES
US FAERS
199Exanthema SubitumFAERS: 1US FAERS
200Extra dose administeredFAERS: 1US FAERS
201Extranodal marginal zone B-cell lymphoma (MALT type)FAERS: 1US FAERS
202FractureFAERS: 1US FAERS
203GanglioneuroblastomaFAERS: 1US FAERS
204Gastric DilatationFAERS: 1US FAERS
205GastrinomaFAERS: 1US FAERS
206GastroenterostomyFAERS: 1US FAERS
207Gastrointestinal carcinomaFAERS: 1US FAERS
208Gastrointestinal hypermotilityFAERS: 1US FAERS
209Gastrointestinal tract adenomaFAERS: 1US FAERS
210GliosisFAERS: 1US FAERS
211Hallucinations, mixedFAERS: 1US FAERS
212HemiplegiaFAERS: 1US FAERS
213Hepatic vein occlusionFAERS: 1US FAERS
214HepatosplenomegalyFAERS: 1US FAERS
215HyperreflexiaFAERS: 1US FAERS
216Hypocoagulable stateFAERS: 1US FAERS
217IleusFAERS: 1US FAERS
218ImmobileFAERS: 1US FAERS
219Inappropriate schedule of drug administrationFAERS: 1US FAERS
220Increased bronchial secretionFAERS: 1US FAERS
221Infectious MononucleosisFAERS: 1US FAERS
222Infrequent bowel movementsFAERS: 1US FAERS
223Injury asphyxiationFAERS: 1OFFSIDES
US FAERS
224Intellectual DisabilityFAERS: 1US FAERS
225Intentional self-injuryFAERS: 1US FAERS
226Investigation abnormalFAERS: 1US FAERS
227Joint swellingFAERS: 1US FAERS
228KeratitisFAERS: 1US FAERS
229LagophthalmosFAERS: 1US FAERS
230LaryngectomyFAERS: 1US FAERS
231Laryngotracheal operationFAERS: 1US FAERS
232Liver transplant rejectionFAERS: 1US FAERS
233Medication ErrorFAERS: 1US FAERS
234Mucopolysaccharidosis IIIFAERS: 1US FAERS
235Multiple SclerosisFAERS: 1US FAERS
236Musculoskeletal PainFAERS: 1US FAERS
237MutismFAERS: 1US FAERS
238MyoclonusFAERS: 1US FAERS
239Neck PainFAERS: 1US FAERS
240NeuralgiaFAERS: 1US FAERS
241NeutropeniaFAERS: 1US FAERS
242Noninfective sialoadenitisFAERS: 1US FAERS
243OphthalmoplegiaFAERS: 1US FAERS
244Oral candidiasisFAERS: 1US FAERS
245OsteomyelitisFAERS: 1US FAERS
246OverdoseFAERS: 1US FAERS
247Oxygen supplementationFAERS: 1US FAERS
248Paranasal cystFAERS: 1US FAERS
249ParesisFAERS: 1US FAERS
250Pathological fractureFAERS: 1US FAERS
251Platelet TransfusionFAERS: 1US FAERS
252Poor quality sleepFAERS: 1US FAERS
253PregnancyFAERS: 1US FAERS
254Procedural complicationFAERS: 1US FAERS
255Product dose omissionFAERS: 1US FAERS
256Product taste abnormalFAERS: 1US FAERS
257Prosthesis ImplantationFAERS: 1US FAERS
258Psychiatric symptomFAERS: 1US FAERS
259QuadriparesisFAERS: 1US FAERS
260Rash erythematousFAERS: 1US FAERS
261Renal tubular acidosisFAERS: 1US FAERS
262Repair of imperforate rectumFAERS: 1US FAERS
263Respiratory tract infection fungalFAERS: 1US FAERS
264Retinal pigmentationFAERS: 1OFFSIDES
US FAERS
265Right ventricular failureFAERS: 1US FAERS
266SchizophreniaFAERS: 1US FAERS
267ScotomaFAERS: 1OFFSIDES
US FAERS
268Septic embolusFAERS: 1OFFSIDES
US FAERS
269SinusitisFAERS: 1US FAERS
270Sleep disorder due to a general medical conditionFAERS: 1US FAERS
271SneezingFAERS: 1US FAERS
272StaringFAERS: 1US FAERS
273Stomach granulomaFAERS: 1US FAERS
274SwellingFAERS: 1US FAERS
275SyncopeFAERS: 1US FAERS
276TachycardiaFAERS: 1US FAERS
277Therapy non-responderFAERS: 1US FAERS
278TinnitusFAERS: 1US FAERS
279UnderweightFAERS: 1US FAERS
280Unevaluable eventFAERS: 1US FAERS
281VertigoFAERS: 1SIDER
US FAERS
282Vibratory sense increasedFAERS: 1US FAERS
283Viral upper respiratory tract infectionFAERS: 1US FAERS
284Visual disturbanceFAERS: 1SIDER
US FAERS
285Waxy flexibilityFAERS: 1US FAERS
286White matter lesionFAERS: 1US FAERS
287Yellow FeverFAERS: 1US FAERS
288cancer surgeryFAERS: 1US FAERS
289prostatitisFAERS: 1OFFSIDES
US FAERS
290Abdominal bloatingSIDER
291AcidosisOFFSIDES
292Administration site reactionSIDER
293AgraphiaOFFSIDES
294Blood and lymphatic system disordersSIDER
295Blood testosterone decreasedOFFSIDES
296Bronchial ObstructionOFFSIDES
297ChillsSIDER
298Chitotriosidase decreasedOFFSIDES
299CholangiolitisOFFSIDES
300Cramps of lower extremitiesSIDER
301Cystic Fibrosis19299496CTD
302Device occlusionOFFSIDES
303Diarrhea7905523
17067996
CTD
OFFSIDES
304Diet refusalOFFSIDES
305DiscomfortSIDER
306Disturbance in sexual arousalSIDER
307Drug withdrawal headacheOFFSIDES
308DyspepsiaSIDER
309Eating disorder symptomOFFSIDES
310Epigastric pain not food-relatedSIDER
311Escherichia urinary tract infectionOFFSIDES
312Feeling abnormalSIDER
313Feeling jitterySIDER
314FibromyalgiaOFFSIDES
315FormicationOFFSIDES
316Gastrointestinal PainSIDER
317Gastrointestinal inflammationOFFSIDES
318Gaucher Disease19299496
19959168
CTD
319HIV Infections7905523CTD
320Heaviness in limbsSIDER
321Hepatitis B positiveOFFSIDES
322Inappropriate schedule of product administrationCanada Vigilance: 1Canada Vigilance
323Influenza-like symptomsSIDER
324Intention tremorOFFSIDES
325Joint sprainOFFSIDES
326LaryngospasmOFFSIDES
327LeukoencephalopathyOFFSIDES
328Localised numbnessSIDER
329Memory LossSIDER
330MononeuritisOFFSIDES
331Muscle WeaknessOFFSIDES
332NervousnessSIDER
333NeuritisSIDER
334NeuropathySIDER
335NumbnessSIDER
336OsteopeniaOFFSIDES
337Sudden deathOFFSIDES
338effusionOFFSIDES
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