MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Cyclizine

(UVKZSORBKUEBAZ-UHFFFAOYSA-N)

Structure

SMILES: CN1CCN(CC1)C(c1ccccc1)c1ccccc1
Type(s): Approved
ATC code(s): R06AE03; R06AE53
Molecular Formula:: C18H22N2
Molecular Weight:: 266.381
Log P:: 2.8992
Hydrogen Bond Acceptor:: 2
Hydrogen Bond Donor:: 0
TPSA:: 6.48
CAS Number(s):: 82-92-8; 303-25-3

Synonym(s)

Cyclizine

Cyclizine HCl

Cyclizine Hydrochloride

Marezine

HCl, Cyclizine

Hydrochloride, Cyclizine

External Link(s)

MeSH	D003501
PubChem Compound	6726
ChEBI	3994
CHEMBL	CHEMBL648
DrugBank	DB01176
DrugCentral	749
IUPHAR/BPS Guide to PHARMACOLOGY	7151
KEGG	cpd:C06930 dr:D03621
Therapeutic Target Database	D08HRJ
ZINC	19156872

Adverse Drug Event(s)

	Name	Reference(s)	Data Source
1	Abdominal sepsis		OFFSIDES
2	Abdominal tenderness		OFFSIDES
3	Acidosis		OFFSIDES
4	Acute psychosis		OFFSIDES
5	Agitation		SIDER
6	Agranulocytosis		SIDER
7	Alanine Aminotransferase Increased		OFFSIDES
8	Alanine aminotransferase abnormal		OFFSIDES
9	Altered state of consciousness		SIDER
10	Anaphylactic shock		SIDER
11	Angioedema		SIDER
12	Anorexia		OFFSIDES
13	Antidepressant drug clearance decreased		OFFSIDES
14	Aortic Injury		OFFSIDES
15	Aphagia		OFFSIDES
16	Ascites infection		OFFSIDES
17	Ascites		OFFSIDES
18	Aspartate aminotransferase abnormal		OFFSIDES
19	Asthenia		SIDER
20	Ataxia	5058102	CTD OFFSIDES
21	Atelectasis		OFFSIDES
22	Athetosis		OFFSIDES
23	Atrial tachycardia		OFFSIDES
24	Auditory and visual hallucinations		SIDER
25	Aura		OFFSIDES
26	Autonomic neuropathy		OFFSIDES
27	Blood albumin decreased		OFFSIDES
28	Blood cortisol increased		OFFSIDES
29	Blood creatine phosphokinase increased		OFFSIDES
30	Blood creatinine increased		OFFSIDES
31	Blurred vision		OFFSIDES
32	Bowel movement irregularity		OFFSIDES
33	Bronchopneumonia		OFFSIDES
34	Bronchospasm		SIDER
35	Capillary Leak Syndrome		OFFSIDES
36	Cardiac Tamponade		OFFSIDES
37	Catheter related infection		OFFSIDES
38	Cellulitis		OFFSIDES
39	Central line infection		OFFSIDES
40	Cerebral atrophy		OFFSIDES
41	Chills		SIDER
42	Choking sensation		OFFSIDES
43	Cholangiolitis		OFFSIDES
44	Chorea	839234	CTD SIDER
45	Chronic left ventricular failure		OFFSIDES
46	Clostridium colitis		OFFSIDES
47	Cogwheel Rigidity		OFFSIDES
48	Cold sweat		OFFSIDES
49	Concomitant disease progression		OFFSIDES
50	Confabulation		OFFSIDES
51	Confusion	5058102	CTD
52	Congenital heart disease		OFFSIDES
53	Congenital hydronephrosis		OFFSIDES
54	Consciousness fluctuating		OFFSIDES
55	Constipation		SIDER
56	Conversion disorder		OFFSIDES
57	Culture wound positive		OFFSIDES
58	Deafness Neurosensory		OFFSIDES
59	Dehydration		OFFSIDES
60	Demyelination		OFFSIDES
61	Depressed Level of Consciousness		SIDER
62	Device Failure		OFFSIDES
63	Diarrhea		OFFSIDES
64	Diplopia		OFFSIDES
65	Disorientation		SIDER
66	Dizziness		SIDER
67	Drowsiness		SIDER
68	Drug administration error		OFFSIDES
69	Drug exposure during pregnancy		OFFSIDES
70	Drug toxicity		OFFSIDES
71	Drug withdrawal headache		OFFSIDES
72	Dysphasia		OFFSIDES
73	Dystonia	View details 12603456 12790833 12911389 15023130 17090261	CTD
74	Electromechanical dissociation		OFFSIDES
75	Embolism		OFFSIDES
76	Endotracheal intubation complication		OFFSIDES
77	Enterococcal infection		OFFSIDES
78	Epstein-Barr virus associated lymphoproliferative disorder		OFFSIDES
79	Erythema toxicum neonatorum		OFFSIDES
80	Erythema		SIDER
81	Escherichia infection		OFFSIDES
82	Fixed drug eruption		SIDER
83	Flushing	5058102	CTD
84	Food Poisoning		OFFSIDES
85	Gastric ulcer		OFFSIDES
86	Gastrointestinal erosion		OFFSIDES
87	Gastrointestinal motility disorder		OFFSIDES
88	Gastroschisis		OFFSIDES
89	General physical health deterioration		OFFSIDES
90	Glasgow coma scale		OFFSIDES
91	Glioblastoma		OFFSIDES
92	Hallucinations, mixed		SIDER
93	Hallucinations	5058102	CTD
94	Headache		SIDER
95	Hemiparesis		OFFSIDES
96	Hepatic necrosis		OFFSIDES
97	Hepatitis		SIDER
98	Hyperreflexia		OFFSIDES
99	Hypersensitivity		SIDER
100	Hyperventilation		OFFSIDES
101	Hypoaesthesia facial		OFFSIDES
102	Hypophagia		OFFSIDES
103	Hyporeflexia		OFFSIDES
104	Hypotension		SIDER
105	Hypothermia neonatal		OFFSIDES
106	Incorrect route of drug administration		OFFSIDES
107	Infection		OFFSIDES
108	Infusion site mobility decreased		OFFSIDES
109	Injection Site Reaction		SIDER
110	Intentional self-injury		OFFSIDES
111	Intestinal Obstruction		OFFSIDES
112	Intraoperative Complications	17090261	CTD
113	Laceration		OFFSIDES
114	Laparotomy		OFFSIDES
115	Laryngospasm		OFFSIDES
116	Leukoencephalopathy		OFFSIDES
117	Leukopenia neonatal		OFFSIDES
118	Lipase		OFFSIDES
119	Malaria		OFFSIDES
120	Malignant neoplasm progression		OFFSIDES
121	Meconium abnormal		OFFSIDES
122	Morbid thoughts		OFFSIDES
123	Muscle Weakness		OFFSIDES
124	Musculoskeletal stiffness		OFFSIDES
125	Mydriasis	5058102	CTD
126	Nausea		OFFSIDES
127	Nephrotic Syndrome		OFFSIDES
128	Nervousness		SIDER
129	Neutropenic colitis		OFFSIDES
130	Neutropenic sepsis		OFFSIDES
131	Nystagmus		OFFSIDES
132	Oculogyric crisis		SIDER
133	Oliguria		OFFSIDES
134	Ophthalmoplegia		OFFSIDES
135	Optic Neuritis		OFFSIDES
136	Oropharyngeal pain		OFFSIDES
137	Overdose		OFFSIDES
138	Pain		SIDER
139	Pallor		OFFSIDES
140	Peripheral occlusive disease		OFFSIDES
141	Plasmodium falciparum infection		OFFSIDES
142	Post procedural pain		OFFSIDES
143	Pregnancy with contraceptive device		OFFSIDES
144	Productive Cough		OFFSIDES
145	Pruritus		SIDER
146	Pulmonary arterial hypertension		OFFSIDES
147	Renal tubular acidosis		OFFSIDES
148	Respiratory Insufficiency	17090261	CTD
149	Rhinalgia		OFFSIDES
150	Somnolence		SIDER
151	Tachycardia	5058102	CTD SIDER
152	Tension		SIDER
153	Thrombophlebitis		SIDER
154	Transaminases decreased		OFFSIDES
155	Tremor		SIDER
156	Urinary Retention		SIDER
157	Urticaria		SIDER
158	Vomiting	16764227	CTD
159	Xerostomia	5058102	CTD
160	anaphylaxis	5762012	CTD
161	effusion		OFFSIDES
162	nervous system disorder		SIDER

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