MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Tegafur

(WFWLQNSHRPWKFK-UHFFFAOYSA-N)

Structure

SMILES: O=c1[nH]c(=O)n(cc1F)C1CCCO1
Type(s): Approved; Investigational
ATC code(s): L01BC03; L01BC53
Molecular Formula:: C8H9FN2O3
Molecular Weight:: 200.167
Log P:: -0.0153
Hydrogen Bond Acceptor:: 4
Hydrogen Bond Donor:: 1
TPSA:: 64.09
CAS Number(s):: 17902-23-7; 37076-68-9; 79107-97-4; 82294-77-7

Synonym(s)

Tegafur

1-(2-Tetrahydrofuryl)-5-fluorouracil

1-(Tetrahydro-2-furanyl)-5-fluorouracil

5-Fluoro-1-(tetrahydro-2-furanyl)-2,4-pyrimidinedione

FT-207

FT207

Florafur

Fluorofur

Ftorafur

10.

Futraful

11.

N1-(2'-Tetrahydrofuryl)-5-fluorouracil

12.

Sunfural S

13.

Uftoral

14.

Utefos

15.

FT 207

External Link(s)

MeSH	D005641
PubChem Compound	5386
ChEBI	32188
CHEMBL	CHEMBL20883
DrugBank	DB09256
DrugCentral	4398
IUPHAR/BPS Guide to PHARMACOLOGY	10513
KEGG	cpd:C12673 dr:D01244

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Leukoencephalopathy	FAERS: 1		OFFSIDES US FAERS
2	Toxicity to various agents	FAERS: 1		US FAERS
3	Acute myocardial infarction			OFFSIDES
4	Adams-Stokes Syndrome			OFFSIDES
5	Adverse event			OFFSIDES
6	Altered state of consciousness			OFFSIDES
7	Amphetamines			OFFSIDES
8	Anemia, Macrocytic		2117887	CTD
9	Angina Pectoris, Variant		3150118	CTD
10	Anorexia			OFFSIDES
11	Antithrombin III increased			OFFSIDES
12	Apathy			OFFSIDES
13	Arterial thrombosis			OFFSIDES
14	Ascites			OFFSIDES
15	Atrial tachycardia			OFFSIDES
16	Biliary sepsis			OFFSIDES
17	Blepharoptosis			OFFSIDES
18	Blepharospasm			OFFSIDES
19	Blood albumin decreased			OFFSIDES
20	Blood creatinine increased			OFFSIDES
21	Blood fibrinogen increased			OFFSIDES
22	Blood pH decreased			OFFSIDES
23	Blood sodium increased			OFFSIDES
24	Blood sodium			OFFSIDES
25	Blood urea increased			OFFSIDES
26	Cancer Pain			OFFSIDES
27	Catheter site pain			OFFSIDES
28	Cerebellar Ataxia			OFFSIDES
29	Colonic Diseases		15006714	CTD
30	Cyanosis			OFFSIDES
31	Dehydration			OFFSIDES
32	Dermatomyositis			OFFSIDES
33	Diarrhea			OFFSIDES
34	Disseminated Intravascular Coagulation		1729088	CTD
35	Diverticular perforation			OFFSIDES
36	Duodenal ulcer perforation			OFFSIDES
37	Dysuria			OFFSIDES
38	Electrocardiogram repolarisation abnormality			OFFSIDES
39	Enterocolitis			OFFSIDES
40	Eosinophilic myocarditis			OFFSIDES
41	Febrile Neutropenia			OFFSIDES
42	Fever		1268838	CTD
43	Gastrointestinal Diseases		1268838	CTD
44	Gastrointestinal Neoplasms		1268838	CTD
45	Gastrointestinal cancer metastatic			OFFSIDES
46	Gastrointestinal perforation			OFFSIDES
47	Hyperesthesia		15206584	CTD
48	Incontinence			OFFSIDES
49	Kidney Diseases		6412636	CTD
50	Kidney Failure			OFFSIDES
51	Leukopenia neonatal			OFFSIDES
52	Lung Neoplasms		1268838 1729088	CTD
53	Malignant neoplasm progression			OFFSIDES
54	Maximal Voluntary Ventilation			OFFSIDES
55	Myelitis			OFFSIDES
56	Neoplasm Metastasis		12720104	CTD
57	Neoplasms		338900	CTD
58	Neutrophil count decreased			OFFSIDES
59	Oculogyric crisis			OFFSIDES
60	Pancreatic carcinoma recurrent			OFFSIDES
61	Paraplegia			OFFSIDES
62	Peripheral embolism			OFFSIDES
63	Peritonitis			OFFSIDES
64	Phlebitis		1268838	CTD
65	Pneumopericardium			OFFSIDES
66	Prothrombin time ratio increased			OFFSIDES
67	Rhabdomyolysis			OFFSIDES
68	Seizures		15206584	CTD
69	Skin Erosion			OFFSIDES
70	Skin necrosis			OFFSIDES
71	Stomach Neoplasms		2117887 6412636 18537153	CTD
72	Subileus			OFFSIDES

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