MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Isoflurane

(PIWKPBJCKXDKJR-UHFFFAOYSA-N)

Structure

SMILES: FC(OC(C(F)(F)F)Cl)F
Type(s): Approved; Vet_approved
ATC code(s): N01AB06
Molecular Formula:: C3H2ClF5O
Molecular Weight:: 184.492
Log P:: 2.3528
Hydrogen Bond Acceptor:: 1
Hydrogen Bond Donor:: 0
TPSA:: 9.23
CAS Number(s):: 26675-46-7

Synonym(s)

Isoflurane

External Link(s)

MeSH	D007530
PubChem Compound	3763
BindingDB	217353
ChEBI	6015
CHEMBL	CHEMBL1256
DrugBank	DB00753
DrugCentral	1493
IUPHAR/BPS Guide to PHARMACOLOGY	2505
KEGG	cpd:C07518 dr:D00545
Therapeutic Target Database	D0DP6L

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Drug exposure during pregnancy	FAERS: 39		OFFSIDES US FAERS
2	nervous system disorder	FAERS: 11		US FAERS
3	Overdose	FAERS: 7		OFFSIDES US FAERS
4	Cerebral disorder	FAERS: 5 Canada Vigilance: 5		Canada Vigilance US FAERS
5	Hypotension	FAERS: 5	View details 1288905 1314526 1416116 1539484 1595919 1797359 1874198 1897344 1942503 2021202 2316893 2334626 2378781 2380754 2552735 2605776 2660963 2718706 2774235 2923291 2930005 3082250 3085554 3098138 3281701 3281763 3284271 3383316 3389567 3434889 3676049 3677277 3706797 3742295 3789446 3813073 3826683 3826686 6476434 6594955 6731908 6744087 6869861 7486177 7718375 8102224 8310785 8346819 8424298 8433482 8740929 9580963 10226861 11429359 11715459 11789275 12577332 12578047 12651645 12967683 12968239 15217654 15556163 15815236 16235461 19878017 20230556	CTD SIDER US FAERS
6	Cardiac Arrest	FAERS: 4		SIDER US FAERS
7	Drug abuse	FAERS: 4		US FAERS
8	Drug ineffective	FAERS: 4		US FAERS
9	Supraventricular tachycardia	FAERS: 4		US FAERS
10	Hypercapnia	FAERS: 3		SIDER US FAERS
11	Intentional drug misuse	FAERS: 3		OFFSIDES US FAERS
12	Tachycardia	FAERS: 3 Canada Vigilance: 1	View details 3674471 6391530 6594955 7992901 8891875 10051936 16104539	CTD Canada Vigilance US FAERS
13	jaundice	FAERS: 3 Canada Vigilance: 1	8533932	CTD SIDER Canada Vigilance US FAERS
14	Abdominal Pain	FAERS: 2		US FAERS
15	Blood potassium increased	FAERS: 2		US FAERS
16	Carbon dioxide increased	FAERS: 2		SIDER US FAERS
17	Chest discomfort	FAERS: 2		US FAERS
18	Device damage	FAERS: 2		US FAERS
19	Hepatotoxicity	FAERS: 2		OFFSIDES US FAERS
20	Mental status changes	FAERS: 2		US FAERS
21	Nausea	FAERS: 2	15868998	CTD SIDER US FAERS
22	Poor quality drug administered	FAERS: 2		US FAERS
23	Alanine Aminotransferase Increased	FAERS: 1		OFFSIDES US FAERS
24	Amniotic fluid volume decreased	FAERS: 1		US FAERS
25	Aspartate Aminotransferase Increased	FAERS: 1		US FAERS
26	Blood creatine phosphokinase increased	FAERS: 1		OFFSIDES US FAERS
27	Blood gases abnormal	FAERS: 1		US FAERS
28	Completed Suicide	FAERS: 1		US FAERS
29	Device malfunction	FAERS: 1		US FAERS
30	Disseminated Intravascular Coagulation	FAERS: 1		OFFSIDES US FAERS
31	Heart sounds abnormal	FAERS: 1		US FAERS
32	Hepatic necrosis	FAERS: 1		OFFSIDES SIDER US FAERS
33	Hepatorenal Syndrome	FAERS: 1		US FAERS
34	Hypersensitivity	FAERS: 1		US FAERS
35	Intentional misuse	FAERS: 1		US FAERS
36	Malignant Hypertension	FAERS: 1		US FAERS
37	Muscle tightness	FAERS: 1		US FAERS
38	Myocardial Infarction	FAERS: 1		US FAERS
39	Placental Insufficiency	FAERS: 1		US FAERS
40	Pneumothorax	FAERS: 1		US FAERS
41	Poisoning	FAERS: 1		US FAERS
42	Procedural complication	FAERS: 1		OFFSIDES US FAERS
43	Respiratory arrest	FAERS: 1		US FAERS
44	Rhabdomyolysis	FAERS: 1	20190256	CTD US FAERS
45	Sepsis	FAERS: 1	17414419 28003439	CTD US FAERS
46	Suspected counterfeit product	FAERS: 1		US FAERS
47	Abuse			OFFSIDES
48	Acidosis			OFFSIDES
49	Acute kidney injury		3657733	CTD
50	Acute psychosis			OFFSIDES
51	Acute respiratory failure			OFFSIDES
52	Adenoma		1069540	CTD
53	Agitation			SIDER
54	Agraphia			OFFSIDES
55	Air Embolism			OFFSIDES
56	Akinesia			OFFSIDES
57	Amnesia		9720333 19923508	CTD
58	Angle Closure Glaucoma			OFFSIDES
59	Anisocoria		8880823	CTD
60	Antibiotic level above therapeutic			OFFSIDES
61	Antipsychotic drug level above therapeutic			OFFSIDES
62	Antipsychotic drug level increased			OFFSIDES
63	Antiviral drug level above therapeutic			OFFSIDES
64	Apallic syndrome			OFFSIDES
65	Apnea		2311153	CTD OFFSIDES
66	Ataxia		8205811	CTD
67	Atrial tachycardia			OFFSIDES
68	Atrial thrombosis			OFFSIDES
69	Blepharospasm			OFFSIDES
70	Blood albumin decreased			OFFSIDES
71	Blood creatinine decreased			OFFSIDES
72	Blood creatinine increased			OFFSIDES
73	Blood lactate dehydrogenase increased			OFFSIDES
74	Blood pressure fluctuation			OFFSIDES
75	Body Temperature			OFFSIDES
76	Bradycardia			OFFSIDES
77	Brain Diseases		12574416	CTD
78	Brain Injuries		9039463 10928976	CTD
79	Brain Ischemia		8559304 16434762	CTD
80	Breath Holding			SIDER
81	Bronchospasm			SIDER
82	Bulbar palsy			OFFSIDES
83	Cardiac procedure complication			OFFSIDES
84	Cardiomyopathies		8606520	CTD
85	Cardiovascular Diseases		2221406 3813073 3826686	CTD
86	Catheter related complication			OFFSIDES
87	Causalgia			OFFSIDES
88	Chemical and Drug Induced Liver Injury		View details 3185174 8320812 8533932 9349074 9638441 9849287 11847945 11873055	CTD
89	Chest wall pain			OFFSIDES
90	Chills		8533932	CTD SIDER
91	Cholangiolitis			OFFSIDES
92	Cholestasis		11847945	CTD
93	Clonus			OFFSIDES
94	Coagulation test abnormal			OFFSIDES
95	Cognition Disorders		19352168 19726376 29289695	CTD
96	Confabulation			OFFSIDES
97	Confusion		8205811	CTD
98	Congenital pulmonary hypertension			OFFSIDES
99	Congenital urinary tract obstruction			OFFSIDES
100	Conversion disorder			OFFSIDES
101	Deafness Neurosensory			OFFSIDES
102	Delirium		17184433	CTD SIDER
103	Depressed Level of Consciousness			OFFSIDES
104	Dermatitis			SIDER
105	Dissociative disorder			OFFSIDES
106	Dizziness		15868998	CTD
107	Drowsiness			OFFSIDES
108	Drug toxicity			OFFSIDES
109	Dysphasia			OFFSIDES
110	Dystonia			OFFSIDES
111	Ejection Fraction Decreased			OFFSIDES
112	Electrocardiogram ST-T change			OFFSIDES
113	Electromechanical dissociation			OFFSIDES
114	Endocarditis			OFFSIDES
115	Enterobacter pneumonia			OFFSIDES
116	Eosinophilia		8533932	CTD
117	Erosive gastritis			OFFSIDES
118	Familial risk factor			OFFSIDES
119	Fever		8533932	CTD
120	Gangrene			OFFSIDES
121	Gas Poisoning		22343375	CTD
122	Gaze palsy			OFFSIDES
123	Genital erosion			OFFSIDES
124	Glasgow coma scale			OFFSIDES
125	Hallucinations		8205811	CTD
126	Headache		9689271	CTD
127	Heart failure		626424	CTD
128	Hemiparesis			OFFSIDES
129	Hemiplegia			OFFSIDES
130	Hepatitis	Canada Vigilance: 2		Canada Vigilance SIDER
131	Hepatomegaly		8533932	CTD
132	Hydronephrosis			OFFSIDES
133	Hyperalgesia		10910869	CTD
134	Hyperemia		8214724 12459681 15815331	CTD
135	Hyperglycemia		29289695	CTD
136	Hyperreflexia			OFFSIDES
137	Hyperventilation			OFFSIDES
138	Hypocoagulable state			OFFSIDES
139	Hypoxia		15868998	CTD OFFSIDES
140	Ileus			SIDER
141	Incorrect route of drug administration			OFFSIDES
142	Increased bronchial secretion			OFFSIDES
143	Infantile apnoeic attack			OFFSIDES
144	Inflammation		18382663	CTD
145	Kidney Diseases		9459267 10357366	CTD
146	Laryngospasm			SIDER
147	Left Ventricular Hypertrophy			OFFSIDES
148	Left atrial dilatation			OFFSIDES
149	Leukoencephalopathy			OFFSIDES
150	Liver Failure, Acute		9349074 11873055	CTD
151	Liver diseases		7647582	CTD
152	Liver neoplasms		1069540	CTD
153	Memory Disorders		View details 12574416 19352168 20068576 23922164 25597859	CTD
154	Metabolic acidosis			OFFSIDES
155	Metatarsalgia			OFFSIDES
156	Migraine with Aura			OFFSIDES
157	Mitral Valve Insufficiency		18455290	CTD
158	Mucosal erosion			OFFSIDES
159	Muscle Rigidity			SIDER
160	Muscle Spasticity		3674476	CTD
161	Muscle necrosis			OFFSIDES
162	Myocardial Ischemia		View details 1467104 1824584 1826989 2729620 7887099 7941950 8346818	CTD
163	Myocardial Reperfusion Injury		17693941	CTD
164	Myotonia			OFFSIDES
165	Necrosis			SIDER
166	Nerve Degeneration		18499598	CTD
167	Neurobehavioral Manifestations		19293705	CTD
168	Oculogyric crisis			OFFSIDES
169	Oligohydramnios			OFFSIDES
170	Oliguria			OFFSIDES
171	PCO2 decreased			OFFSIDES
172	Pain		10910869	CTD
173	Peritoneal Dialysis			OFFSIDES
174	Peritonitis		17414419	CTD
175	Post procedural complication			OFFSIDES
176	Post procedural nausea			OFFSIDES
177	Postoperative Complications		View details 2311153 2512822 9849287 19726376	CTD
178	Postoperative Nausea and Vomiting		8991468	CTD
179	Postoperative ileus			SIDER
180	Procedural hypotension			OFFSIDES
181	Pseudocholinesterase deficiency			OFFSIDES
182	Pulmonary Edema		16508399	CTD
183	Pulmonary Hypertension			OFFSIDES
184	Pulmonary Valve Insufficiency		18455290	CTD
185	Pulmonary artery thrombosis			OFFSIDES
186	Pulmonary function test decreased			SIDER
187	Refusal of treatment by relative			OFFSIDES
188	Renal tubular necrosis			OFFSIDES
189	Respiratory Depression			SIDER
190	Respiratory Insufficiency		626424 2311153	CTD
191	Seizures		2512822 6486511 8780283	CTD
192	Shivering			SIDER
193	Sinus bradycardia			OFFSIDES
194	Sinus rhythm			OFFSIDES
195	Somatoform Disorder			OFFSIDES
196	Status Asthmaticus		17251884	CTD
197	Status Epilepticus		2817458	CTD
198	Stridor			OFFSIDES
199	Substance Withdrawal Syndrome		572191 8241654 17251884	CTD
200	Tachycardia, Ventricular		5922	CTD
201	Tetany			OFFSIDES
202	Torsades de Pointes		12000977	CTD
203	Traumatic liver injury			SIDER
204	Trismus		15096252	CTD
205	Troponin increased			OFFSIDES
206	Uremia		3185174	CTD
207	Urination Disorders		8533932	CTD
208	Urinoma			OFFSIDES
209	Uterine Inversion			OFFSIDES
210	Vascular bypass graft			OFFSIDES
211	Vascular resistance systemic decreased			OFFSIDES
212	Ventricular Fibrillation			OFFSIDES
213	Ventricular arrhythmia			SIDER
214	Ventricular hypokinesia			OFFSIDES
215	Vomiting		9689271	CTD SIDER
216	Wrong drug administered			OFFSIDES

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