MetaADEDB 2.0 @ LMMD
Disulfiram
(AUZONCFQVSMFAP-UHFFFAOYSA-N)
Structure
SMILES
CCN(C(=S)SSC(=S)N(CC)CC)CC
Type(s)
Approved
ATC code(s)
N07BB01; P03AA04; P03AA54
Molecular Formula:
C10H20N2S4
Molecular Weight:
296.539
Log P:
3.6212
Hydrogen Bond Acceptor:
6
Hydrogen Bond Donor:
0
TPSA:
121.26
CAS Number(s):
97-77-8
Synonym(s)
1.
Disulfiram
2.
Tetraethylthiuram Disulfide
3.
Alcophobin
4.
Antabus
5.
Antabuse
6.
Anticol
7.
Bis(diethylthiocarbamoyl) Disulfide
8.
Dicupral
9.
Esperal
10.
Tetraethylthioperoxydicarbonic Diamide, ((H2N)C(S))2S2
11.
Teturam
12.
Disulfide, Tetraethylthiuram
External Link(s)
MeSHD004221
PubChem Compound3117
BindingDB50058655
ChEBI4659
CHEMBLCHEMBL964
DrugBankDB00822
DrugCentral928
IUPHAR/BPS Guide to PHARMACOLOGY7168
KEGGdr:D00131
cpd:C01692
Therapeutic Target DatabaseD0X5SD
ZINC1529266
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1NauseaFAERS: 15
Canada Vigilance: 1		2196696
17074964
21053676		CTD
Canada Vigilance
US FAERS
2Alanine Aminotransferase IncreasedFAERS: 12OFFSIDES
US FAERS
3MalaiseFAERS: 11US FAERS
4AstheniaFAERS: 10OFFSIDES
SIDER
US FAERS
5Toxicity to various agentsFAERS: 9US FAERS
6jaundiceFAERS: 9

View details

2646364
2688328
4479092
8404476
16487618
 		CTD
SIDER
US FAERS
7FatigueFAERS: 82688328
4479092		CTD
OFFSIDES
SIDER
US FAERS
8Mental status changesFAERS: 8OFFSIDES
US FAERS
9VomitingFAERS: 8

View details

2196696
2688328
17074964
21053676
 		CTD
US FAERS
10Abdominal PainFAERS: 717074964CTD
US FAERS
11AnxietyFAERS: 7OFFSIDES
US FAERS
12HypotensionFAERS: 7

View details

90468
2402817
3718622
5334883
17220694
17620917
21053676
 		CTD
US FAERS
13MyalgiaFAERS: 7US FAERS
14Aspartate Aminotransferase IncreasedFAERS: 6US FAERS
15DisorientationFAERS: 6US FAERS
16Alcohol interactionFAERS: 5OFFSIDES
US FAERS
17Blood alcohol increasedFAERS: 5OFFSIDES
US FAERS
18CatatoniaFAERS: 5

View details

681921
1503145
2224697
7416268
 		CTD
US FAERS
19Drug ineffectiveFAERS: 5US FAERS
20PolyneuropathyFAERS: 5OFFSIDES
SIDER
US FAERS
21SomnolenceFAERS: 5
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
22Drug toxicityFAERS: 4OFFSIDES
US FAERS
23HepatomegalyFAERS: 428108177CTD
US FAERS
24Alcohol IntoleranceFAERS: 3OFFSIDES
US FAERS
25BlepharospasmFAERS: 3OFFSIDES
US FAERS
26ChromaturiaFAERS: 3US FAERS
27DeliriumFAERS: 36625283
17313059		CTD
US FAERS
28DysarthriaFAERS: 31252149
6860122
19224591		CTD
US FAERS
29ErythemaFAERS: 3
Canada Vigilance: 1		Canada Vigilance
US FAERS
30Gamma-Glutamyltransferase IncreasedFAERS: 3OFFSIDES
US FAERS
31HeadacheFAERS: 32196696
17414256		CTD
SIDER
US FAERS
32HepatotoxicityFAERS: 3US FAERS
33MalnutritionFAERS: 3US FAERS
34Memory impairmentFAERS: 3US FAERS
35Metabolic acidosisFAERS: 3OFFSIDES
US FAERS
36OphthalmoplegiaFAERS: 3OFFSIDES
US FAERS
37ParanoiaFAERS: 3OFFSIDES
US FAERS
38Sinus TachycardiaFAERS: 3US FAERS
39Suicide attemptFAERS: 3US FAERS
40SyncopeFAERS: 3US FAERS
41VertigoFAERS: 3US FAERS
42Weight decreasedFAERS: 3US FAERS
43Accidental exposure to product by childFAERS: 2US FAERS
44Acute polyneuropathyFAERS: 2US FAERS
45AgitationFAERS: 2US FAERS
46AkinesiaFAERS: 2OFFSIDES
US FAERS
47Altered state of consciousnessFAERS: 2US FAERS
48ArthralgiaFAERS: 27150382CTD
US FAERS
49BlindnessFAERS: 2US FAERS
50Blood creatine phosphokinase increasedFAERS: 2US FAERS
51Cerebellar AtaxiaFAERS: 26860122CTD
OFFSIDES
US FAERS
52Cerebral disorderFAERS: 2US FAERS
53Cogwheel RigidityFAERS: 2US FAERS
54DizzinessFAERS: 2SIDER
US FAERS
55DystoniaFAERS: 28745631CTD
US FAERS
56Electroencephalogram abnormalFAERS: 2US FAERS
57FlushingFAERS: 2
Canada Vigilance: 1		17220694
17414256
21053676		CTD
Canada Vigilance
US FAERS
58Hepatic necrosisFAERS: 2SIDER
US FAERS
59HepatitisFAERS: 22646364CTD
SIDER
US FAERS
60LethargyFAERS: 2OFFSIDES
US FAERS
61Ocular icterusFAERS: 2US FAERS
62Posterior reversible encephalopathy syndromeFAERS: 2US FAERS
63PruritusFAERS: 22688328
6483711		CTD
US FAERS
64SoporFAERS: 2US FAERS
65TachycardiaFAERS: 221053676CTD
US FAERS
66ThrombocytopeniaFAERS: 2US FAERS
67Toxic Optic NeuropathyFAERS: 2US FAERS
68TremorFAERS: 217220694
19224591
21053676		CTD
US FAERS
69Urine alcohol test positiveFAERS: 2US FAERS
70Wrong technique in product usage processFAERS: 2US FAERS
71AbasiaFAERS: 1US FAERS
72Acute Coronary SyndromeFAERS: 1US FAERS
73Adverse eventFAERS: 1US FAERS
74AmnesiaFAERS: 1
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
75Anaphylactic shockFAERS: 1US FAERS
76AngerFAERS: 1OFFSIDES
US FAERS
77AphasiaFAERS: 1US FAERS
78AsphyxiaFAERS: 1US FAERS
79Blood pressure fluctuationFAERS: 1US FAERS
80BradyphreniaFAERS: 1US FAERS
81Central nervous system lesionFAERS: 1US FAERS
82Coagulation factor V level decreasedFAERS: 1US FAERS
83CystitisFAERS: 1US FAERS
84DehydrationFAERS: 1US FAERS
85Drug abuseFAERS: 1US FAERS
86Drug administration errorFAERS: 1US FAERS
87DysphoniaFAERS: 1US FAERS
88Elevated moodFAERS: 1US FAERS
89Facial paralysisFAERS: 16255404CTD
US FAERS
90Flight of ideasFAERS: 1US FAERS
91GastritisFAERS: 1US FAERS
92GoutFAERS: 1US FAERS
93HemiparesisFAERS: 1US FAERS
94Hepatic EncephalopathyFAERS: 12646364CTD
US FAERS
95Hepatic infiltration eosinophilicFAERS: 1US FAERS
96HerniaFAERS: 1US FAERS
97HyperreflexiaFAERS: 1US FAERS
98HypomaniaFAERS: 1US FAERS
99Impaired work abilityFAERS: 1US FAERS
100Incorrect route of drug administrationFAERS: 1US FAERS
101InfectionFAERS: 1US FAERS
102Intervertebral Disc DegenerationFAERS: 1US FAERS
103Medication ErrorFAERS: 1US FAERS
104MenorrhagiaFAERS: 1US FAERS
105Mental impairmentFAERS: 1US FAERS
106MyoclonusFAERS: 18745631CTD
US FAERS
107Nasal PolypsFAERS: 1US FAERS
108NystagmusFAERS: 1US FAERS
109Optic NeuropathyFAERS: 1US FAERS
110Oral painFAERS: 1US FAERS
111OverdoseFAERS: 1OFFSIDES
US FAERS
112Pain of skinFAERS: 1US FAERS
113PainFAERS: 118023325CTD
SIDER
US FAERS
114PallorFAERS: 1US FAERS
115ParaparesisFAERS: 1US FAERS
116Peripheral motor neuropathyFAERS: 1US FAERS
117Peripheral swellingFAERS: 1US FAERS
118PoisoningFAERS: 1US FAERS
119Poverty of speechFAERS: 1US FAERS
120Product counterfeitFAERS: 1US FAERS
121Product substitution issueFAERS: 1US FAERS
122RadiculopathyFAERS: 1US FAERS
123Respiratory TherapyFAERS: 1US FAERS
124RestlessnessFAERS: 1US FAERS
125ScreamingFAERS: 1US FAERS
126ShockFAERS: 1US FAERS
127StrabismusFAERS: 1US FAERS
128Transaminases increasedFAERS: 1US FAERS
129Unevaluable eventFAERS: 1US FAERS
130Unresponsive to stimuliFAERS: 1US FAERS
131UrticariaFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
132VIIth nerve paralysisFAERS: 1US FAERS
133Visual ImpairmentFAERS: 1US FAERS
134Vocal Cord ParalysisFAERS: 118023325CTD
US FAERS
135WheezingFAERS: 1US FAERS
136Abdominal discomfortSIDER
137Abnormalities, Drug-Induced6941103
17676605
20045017		CTD
138AbuseOFFSIDES
139Acidosis, Lactic19702547CTD
140AcidosisOFFSIDES
141AcneOFFSIDES
142Acquired Immunodeficiency Syndrome9207937CTD
143Acute bronchitisOFFSIDES
144Acute psychosisOFFSIDES
145AgeusiaOFFSIDES
146Alcohol abuseOFFSIDES
147Alcohol consumptionOFFSIDES
148Alcohol withdrawal syndromeOFFSIDES
149Alcoholic Intoxication6295192CTD
150Ammonia increasedOFFSIDES
151Amphetamine-Related Disorders18474395CTD
152AmphetaminesOFFSIDES
153Anorexia2688328CTD
154Anticholinergic SyndromeOFFSIDES
155Antipsychotic drug level increasedOFFSIDES
156Anxiety Disorders18083142
18474395		CTD
157ApathyOFFSIDES
158AphagiaOFFSIDES
159Aspiration PneumoniaOFFSIDES
160Ataxia1252149
18023325		CTD
OFFSIDES
161Atrial tachycardiaOFFSIDES
162Basal Ganglia Cerebrovascular Disease11359117CTD
163Basal Ganglia Diseases8745631CTD
164Bipolar Disorder

View details

3711369
6295192
17414256
17904262
20553782
 		CTD
165Blood albumin decreasedOFFSIDES
166Blood alkaline phosphatase increasedOFFSIDES
167Blood creatinine decreasedOFFSIDES
168Blood glucose fluctuationOFFSIDES
169Blood sodium increasedOFFSIDES
170Blood thromboplastinOFFSIDES
171Blood thyroid stimulating hormoneOFFSIDES
172Blurred visionOFFSIDES
173Bone Diseases28017615CTD
174Bone painOFFSIDES
175Brain Diseases

View details

1252149
2742552
2988411
4321579
6857682
8554646
17918114
19224591
 		CTD
176Brain Infarction3960233
5640350		CTD
177Brain Ischemia3764016CTD
178BruxismOFFSIDES
179Candidiasis15325261CTD
180Capgras Syndrome3423903CTD
181Carcinoma17026967CTD
182CardiotoxicityOFFSIDES
183Cardiovascular Diseases5334883CTD
184Carpal Tunnel Syndrome7150382CTD
185Cataract15003327
17936468		CTD
186Cerebral Infarction11359117CTD
187Cerebral atrophyOFFSIDES
188Chemical and Drug Induced Liver Injury

View details

401083
1471554
2196696
2343506
2625187
2646364
2688328
2992895
3053669
4479092
6453500
6483711
6521575
7315533
7501079
7890903
8404476
9833921
16165719
16487618
24014644
24085192
 		CTD
189Chills6483711CTD
190CholangiolitisOFFSIDES
191CirrhosisOFFSIDES
192ClonusOFFSIDES
193Coagulation factor IX level decreasedOFFSIDES
194Cocaine-Related Disorders

View details

10723850
10862808
10932843
11048353
12503902
14762242
14993114
15063917
15236812
16425053
16979847
18079068
18329701
19462300
 		CTD
195Cognition Disorders19224591
20553782		CTD
196ColectomyOFFSIDES
197Completed SuicideOFFSIDES
198ConfabulationOFFSIDES
199Confusion

View details

1252149
2224697
6255404
8745631
17313059
20553782
 		CTD
200Craniofacial Abnormalities20530235CTD
201Deglutition Disorders19224591CTD
202Depressed Level of ConsciousnessOFFSIDES
203Depressive disorder4321579CTD
204Dermatitis acneiformSIDER
205Dermatitis, Allergic Contact26795242CTD
206Dermatitis6483711CTD
207Disturbance in sexual arousalOFFSIDES
208DiverticulitisOFFSIDES
209DrowsinessSIDER
210Drug abuserOFFSIDES
211Drug addictOFFSIDES
212Drug withdrawal headacheOFFSIDES
213DysphemiaOFFSIDES
214Dysthymic DisorderOFFSIDES
215Eosinophilia2196696
6483711
16943303		CTD
216EpilepsyOFFSIDES
217Erectile dysfunctionSIDER
218Erosive gastritisOFFSIDES
219Esophageal Neoplasms3972888CTD
220Exanthema2196696CTD
221Eye painOFFSIDES
SIDER
222FatigabilitySIDER
223Fetal Alcohol Spectrum Disorders6941103CTD
224Fever2196696
2625187
6483711		CTD
225Flat affectOFFSIDES
226FormicationOFFSIDES
227Gait Disorders, Neurologic19224591
20553782		CTD
228GlaucomaOFFSIDES
229Hallucinations6255404
17414256		CTD
230Haptoglobin DecreasedOFFSIDES
231Heart Diseases6645200CTD
232Hepatitis AOFFSIDES
233Hypesthesia6266628
8554646		CTD
234Hypoalbuminemia6483711CTD
235Hypokinesia19224591CTD
236Intention tremorOFFSIDES
237Intentional drug misuseOFFSIDES
238Intentional self-injuryOFFSIDES
239Intestinal Neoplasms7197594CTD
240LassitudeSIDER
241LeukoencephalopathyOFFSIDES
242Limb Deformities, Congenital17676605CTD
243Liver Failure, Acute

View details

8404476
9625138
15128079
15379082
15811896
 		CTD
244Liver Failure2646364CTD
245Malignant neoplasm progressionOFFSIDES
246Mammary Neoplasms, Experimental20424113CTD
247MarasmusOFFSIDES
248MastectomyOFFSIDES
249MegacolonOFFSIDES
250Memory Disorders1252149
17313059		CTD
251Mesothelioma24690739CTD
252Mood Disorders9212576CTD
253Multiple drug overdoseOFFSIDES
254Musculoskeletal chest painOFFSIDES
255Musculoskeletal discomfortOFFSIDES
256Myocardial Infarction3764016
19225254		CTD
257Myocardial Ischemia17620917CTD
258Necrosis6645200CTD
259Neoplasm Invasiveness18047805CTD
260Neoplasm Metastasis15367699CTD
261Neoplasms, Experimental24126434
25320179		CTD
262Neoplasms17079463CTD
263Nephritis, Interstitial16943303CTD
264NeuritisSIDER
265Neuroleptic Malignant SyndromeOFFSIDES
266NeuropathySIDER
267Neurotoxicity Syndromes11005259CTD
268NoduleOFFSIDES
269Nose Neoplasms3972888CTD
270NumbnessSIDER
271Open woundOFFSIDES
272Optic Neuritis494426CTD
SIDER
273Osteochondrodysplasias17626489CTD
274Osteosarcoma18047805CTD
275Panic DisorderOFFSIDES
276Paresis1324145CTD
277Paresthesia

View details

6266628
6299681
17786501
18023325
20553782
 		CTD
278Parkinsonian Disorders4321579CTD
279Peripheral Nervous System Diseases

View details

222249
1324145
2988411
4321579
4328367
6245358
6255404
6266628
6278365
6860122
8763661
12434653
18023325
18363127
20553782
 		CTD
280Personality Disorders1168580CTD
281Polyarteritis Nodosa4943
4394929		CTD
282PolyneuritisSIDER
283Polyradiculopathy3960233CTD
284Polysubstance abuseOFFSIDES
285Prenatal Exposure Delayed Effects6941103CTD
286Prenatal Injuries20045017CTD
287Prescribed overdoseOFFSIDES
288Pressure of speechOFFSIDES
289Prostatic Neoplasms19789329
25320179		CTD
290Prothrombin level decreasedOFFSIDES
291Psychoses, Substance-Induced

View details

1422334
9212576
11938582
17414256
17904262
20553782
 		CTD
292Pulmonary Edema4732960CTD
293Quadriplegia6255404
18023325
19902819		CTD
294Rash erythematousCanada Vigilance: 1Canada Vigilance
295Reflex, Abnormal1252149
20553782		CTD
296Renal Insufficiency8404476CTD
297Respiratory Insufficiency17414256CTD
298Schizoaffective DisorderOFFSIDES
299Scotoma17786501CTD
300Seizures

View details

1252149
1880990
3423903
4732960
6632888
7800657
7875556
8224101
18329701
19902819
 		CTD
301Self MutilationOFFSIDES
302SequestrectomyOFFSIDES
303Shock, Cardiogenic19390700CTD
304SinobronchitisOFFSIDES
305Sleep TalkingOFFSIDES
306Speech Disorders17414256CTD
307Sputum culture positiveOFFSIDES
308Stevens-Johnson SyndromeCanada Vigilance: 1Canada Vigilance
309StressSIDER
310StuporCanada Vigilance: 16860122CTD
Canada Vigilance
311Substance Withdrawal Syndrome3624520CTD
312Therapy non-responderOFFSIDES
313TinnitusOFFSIDES
314Upset stomachSIDER
315Urinary Bladder Diseases

View details

2587846
2724678
7058285
8090696
 		CTD
316Vision Disorders17075509CTD
317Vulvovaginal discomfortOFFSIDES
318melanoma12467214
15367699		CTD
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