MetaADEDB 2.0 @ LMMD
Indomethacin
(CGIGDMFJXJATDK-UHFFFAOYSA-N)
Structure
SMILES
COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C
Type(s)
Approved; Investigational
ATC code(s)
C01EB03; M01AB01; M01AB51; M02AA23; S01BC01; S01CC02
Molecular Formula:
C19H16ClNO4
Molecular Weight:
357.788
Log P:
3.9273
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
1
TPSA:
68.53
CAS Number(s):
53-86-1
Synonym(s)
1.
Indomethacin
2.
Amuno
3.
Indocid
4.
Indocin
5.
Indomet 140
6.
Indometacin
7.
Indomethacin Hydrochloride
8.
Metindol
9.
Osmosin
External Link(s)
MeSHD007213
PubChem Compound3715
BindingDB17638
ChEBI49662
CHEMBLCHEMBL6
DrugBankDB00328
DrugCentral1440
IUPHAR/BPS Guide to PHARMACOLOGY1909
KEGGcpd:C01926
dr:D00141
Therapeutic Target DatabaseD0R1RS
ZINC601283
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 76
Canada Vigilance: 9		Canada Vigilance
US FAERS
2Retinopathy of PrematurityFAERS: 64SIDER
US FAERS
3DizzinessFAERS: 48
Canada Vigilance: 52		4164930
8219437		CTD
SIDER
Canada Vigilance
US FAERS
4NauseaFAERS: 42
Canada Vigilance: 33		627337
4916769
7268625		CTD
SIDER
Canada Vigilance
US FAERS
5Bronchopulmonary DysplasiaFAERS: 4112241754CTD
OFFSIDES
US FAERS
6Ductus arteriosus premature closureFAERS: 28OFFSIDES
US FAERS
7HeadacheFAERS: 22
Canada Vigilance: 26

View details

4164930
6023693
6612404
17478464
19080105
20197477
 		CTD
SIDER
Canada Vigilance
US FAERS
8VomitingFAERS: 22
Canada Vigilance: 19		11897121
16240705		CTD
SIDER
Canada Vigilance
US FAERS
9Product use issueFAERS: 20US FAERS
10Gastrointestinal perforationFAERS: 19US FAERS
11ThrombocytopeniaFAERS: 19
Canada Vigilance: 5		12632374
16240705		CTD
SIDER
Canada Vigilance
US FAERS
12AstheniaFAERS: 18
Canada Vigilance: 7		Canada Vigilance
OFFSIDES
SIDER
US FAERS
13Intestinal PerforationFAERS: 18
Canada Vigilance: 1		3050004
12632374		CTD
Canada Vigilance
US FAERS
14Abdominal PainFAERS: 15
Canada Vigilance: 6

View details

1065802
6023693
7268625
17478464
 		CTD
SIDER
Canada Vigilance
US FAERS
15MalaiseFAERS: 15
Canada Vigilance: 3		Canada Vigilance
SIDER
US FAERS
16Drug exposure during pregnancyFAERS: 14OFFSIDES
US FAERS
17Abdominal discomfortFAERS: 12
Canada Vigilance: 3		Canada Vigilance
OFFSIDES
SIDER
US FAERS
18Feeling abnormalFAERS: 12SIDER
US FAERS
19Neonatal disorderFAERS: 12US FAERS
20SepsisFAERS: 1212632374CTD
US FAERS
21Patent ductus arteriosusFAERS: 11US FAERS
22TremorFAERS: 11
Canada Vigilance: 4		8219437CTD
Canada Vigilance
US FAERS
23UrticariaFAERS: 11
Canada Vigilance: 5		1115460
11792017
15969659		CTD
SIDER
Canada Vigilance
US FAERS
24Blood creatinine increasedFAERS: 10
Canada Vigilance: 4		Canada Vigilance
OFFSIDES
US FAERS
25Maternal exposure during pregnancyFAERS: 10US FAERS
26FatigueFAERS: 9
Canada Vigilance: 3		Canada Vigilance
SIDER
US FAERS
27PalpitationsFAERS: 9
Canada Vigilance: 4		Canada Vigilance
SIDER
US FAERS
28Acute kidney injuryFAERS: 8
Canada Vigilance: 2

View details

448822
464454
718323
2191029
2872506
2886806
3071148
3600902
3616022
3727353
3975749
3978662
3980192
4000350
4071154
6589647
6781208
6949485
6952058
7017180
7305576
7375974
7386499
8163032
8240599
8671983
9052853
15007713
 		CTD
Canada Vigilance
US FAERS
29Blood urea increasedFAERS: 8
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
30HypotensionFAERS: 8
Canada Vigilance: 2

View details

439781
1888233
1908582
2196965
2404862
2880686
3541005
3706053
6804092
7413993
 		CTD
SIDER
Canada Vigilance
US FAERS
31Metabolic acidosisFAERS: 8US FAERS
32Myocardial InfarctionFAERS: 8US FAERS
33AnxietyFAERS: 7
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
34ChillsFAERS: 7
Canada Vigilance: 2		Canada Vigilance
US FAERS
35Coronary artery insufficiencyFAERS: 7US FAERS
36DisorientationFAERS: 7
Canada Vigilance: 6		Canada Vigilance
US FAERS
37HypersensitivityFAERS: 7
Canada Vigilance: 2		Canada Vigilance
SIDER
US FAERS
38OligohydramniosFAERS: 7

View details

1923225
2006947
3050004
3191072
6772782
8163032
8308583
 		CTD
US FAERS
39OliguriaFAERS: 7

View details

471605
1432432
2112558
3050004
3915162
4071154
7117089
7977526
8048989
8203268
10974130
12137683
12632374
16240705
 		CTD
SIDER
US FAERS
40Right Ventricular HypertrophyFAERS: 7US FAERS
41ShockFAERS: 7
Canada Vigilance: 2		Canada Vigilance
SIDER
US FAERS
42AgitationFAERS: 6
Canada Vigilance: 2		Canada Vigilance
US FAERS
43AmnesiaFAERS: 6
Canada Vigilance: 6		Canada Vigilance
US FAERS
44ArthralgiaFAERS: 61540795
2160914		CTD
US FAERS
45Corneal PerforationFAERS: 6US FAERS
46Disseminated Intravascular CoagulationFAERS: 68163032CTD
SIDER
US FAERS
47Drug ineffective for unapproved indicationFAERS: 6
Canada Vigilance: 1		Canada Vigilance
US FAERS
48DysarthriaFAERS: 6
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
49Gastric ulcerFAERS: 6
Canada Vigilance: 2		Canada Vigilance
OFFSIDES
US FAERS
50AphasiaFAERS: 5US FAERS
51Blood glucose increasedFAERS: 5
Canada Vigilance: 2		Canada Vigilance
US FAERS
52DehydrationFAERS: 5US FAERS
53Disease recurrenceFAERS: 5US FAERS
54DyspepsiaFAERS: 5
Canada Vigilance: 5		4916769
5723725
6023693		CTD
OFFSIDES
SIDER
Canada Vigilance
US FAERS
55GoutFAERS: 5

View details

3711369
7017180
7033849
7411769
7435695
11248219
17478464
20650042
 		CTD
OFFSIDES
SIDER
US FAERS
56HypoxiaFAERS: 53579483CTD
US FAERS
57PainFAERS: 5
Canada Vigilance: 1

View details

2872506
3145369
3291741
3777737
6814155
7735198
8778950
10813554
13679232
14598202
15994849
16099101
16113981
16563475
17440234
17627676
18227818
19517896
21372527
23562495
28559105
29655911
 		CTD
SIDER
Canada Vigilance
US FAERS
58Peritoneal DialysisFAERS: 5US FAERS
59Respiratory distressFAERS: 5
Canada Vigilance: 2		Canada Vigilance
SIDER
US FAERS
60Right Ventricular DysfunctionFAERS: 5US FAERS
61Right atrial dilatationFAERS: 5US FAERS
62Right ventricular hypertensionFAERS: 5US FAERS
63SyncopeFAERS: 5
Canada Vigilance: 7		Canada Vigilance
SIDER
US FAERS
64TachycardiaFAERS: 5
Canada Vigilance: 3		11677312CTD
SIDER
Canada Vigilance
US FAERS
65TinnitusFAERS: 5
Canada Vigilance: 2		Canada Vigilance
SIDER
US FAERS
66VertigoFAERS: 5
Canada Vigilance: 6		627337
7268625
17478464		CTD
SIDER
Canada Vigilance
US FAERS
67AscitesFAERS: 43579483
4071154
18227818		CTD
US FAERS
68Duodenal UlcerFAERS: 4
Canada Vigilance: 4

View details

1718290
10671773
11535926
11595415
11595431
11991626
16699067
17045617
17151854
17202747
17329845
17351913
 		CTD
OFFSIDES
Canada Vigilance
US FAERS
69Gastric mucosal lesionFAERS: 4US FAERS
70HydrocephalusFAERS: 4US FAERS
71Impaired work abilityFAERS: 4US FAERS
72Increased ventricular afterloadFAERS: 4US FAERS
73Large intestine perforationFAERS: 4US FAERS
74Musculoskeletal stiffnessFAERS: 4
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
75PancreatitisFAERS: 415028970
17883296		CTD
US FAERS
76PeritonitisFAERS: 4US FAERS
77PetechiaeFAERS: 4SIDER
US FAERS
78Product substitution issueFAERS: 4US FAERS
79Product use in unapproved indicationFAERS: 4
Canada Vigilance: 2		Canada Vigilance
US FAERS
80PruritusFAERS: 4
Canada Vigilance: 6		Canada Vigilance
SIDER
US FAERS
81Respiratory FailureFAERS: 4
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
82SomnolenceFAERS: 4
Canada Vigilance: 13		Canada Vigilance
SIDER
US FAERS
83Visual ImpairmentFAERS: 4
Canada Vigilance: 1		Canada Vigilance
US FAERS
84AcidosisFAERS: 3SIDER
US FAERS
85Apparent deathFAERS: 3US FAERS
86AtaxiaFAERS: 3
Canada Vigilance: 2		Canada Vigilance
US FAERS
87Blood creatine increasedFAERS: 3OFFSIDES
US FAERS
88Blood sodium decreasedFAERS: 3US FAERS
89Blood urine presentFAERS: 3US FAERS
90BradycardiaFAERS: 3
Canada Vigilance: 1		6804092CTD
OFFSIDES
SIDER
Canada Vigilance
US FAERS
91Cerebral vasoconstrictionFAERS: 3US FAERS
92Cerebrovascular accidentFAERS: 3
Canada Vigilance: 1		Canada Vigilance
US FAERS
93Chest PainFAERS: 3
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
SIDER
US FAERS
94ColitisFAERS: 311137876CTD
SIDER
US FAERS
95DiverticulumFAERS: 3SIDER
US FAERS
96Hypertensive crisisFAERS: 3US FAERS
97Intestinal infarctionFAERS: 3US FAERS
98IntussusceptionFAERS: 3
Canada Vigilance: 1		Canada Vigilance
US FAERS
99Large intestinal stenosisFAERS: 3
Canada Vigilance: 1		Canada Vigilance
US FAERS
100MyoclonusFAERS: 3US FAERS
101OverdoseFAERS: 3US FAERS
102Pharmaceutical product complaintFAERS: 3US FAERS
103PneumoperitoneumFAERS: 3US FAERS
104Post procedural complicationFAERS: 3
Canada Vigilance: 1		Canada Vigilance
US FAERS
105PurpuraFAERS: 3
Canada Vigilance: 2		4106997CTD
SIDER
Canada Vigilance
US FAERS
106SwellingFAERS: 3US FAERS
107Weight decreasedFAERS: 3
Canada Vigilance: 1		Canada Vigilance
US FAERS
108Wrong drug administeredFAERS: 3US FAERS
109treatment failureFAERS: 3US FAERS
110AbasiaFAERS: 2US FAERS
111Abdominal rigidityFAERS: 2US FAERS
112Adverse eventFAERS: 2US FAERS
113AgranulocytosisFAERS: 2
Canada Vigilance: 2		3747087CTD
SIDER
Canada Vigilance
US FAERS
114Alanine Aminotransferase IncreasedFAERS: 2OFFSIDES
US FAERS
115AngioedemaFAERS: 2
Canada Vigilance: 2		1115460CTD
OFFSIDES
SIDER
Canada Vigilance
US FAERS
116Blood potassium increasedFAERS: 2OFFSIDES
SIDER
US FAERS
117Cardiac ArrestFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
118CholelithiasisFAERS: 2US FAERS
119Congenital tricuspid valve incompetenceFAERS: 2US FAERS
120CystitisFAERS: 215322343
17638016		CTD
US FAERS
121Diastolic dysfunctionFAERS: 2US FAERS
122Drug dispensing errorFAERS: 2US FAERS
123Drug screen positiveFAERS: 2US FAERS
124Economic problemFAERS: 2US FAERS
125EnteritisFAERS: 210567023
16328016
17763956		CTD
US FAERS
126False positive investigation resultFAERS: 2US FAERS
127FlatulenceFAERS: 2
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
128FractureFAERS: 2US FAERS
129GastritisFAERS: 2
Canada Vigilance: 4

View details

2266080
15046732
16080005
29523851
 		CTD
SIDER
Canada Vigilance
US FAERS
130GastroenteritisFAERS: 2SIDER
US FAERS
131Gastrointestinal PainFAERS: 2SIDER
US FAERS
132Gastrointestinal ulcerFAERS: 2US FAERS
133General physical condition abnormalFAERS: 2US FAERS
134HemiparesisFAERS: 2US FAERS
135HepatotoxicityFAERS: 2US FAERS
136HypoperfusionFAERS: 2US FAERS
137Incorrect dose administeredFAERS: 2US FAERS
138InflammationFAERS: 2

View details

1065802
3291741
7812673
9065783
9181689
10792963
12568917
14518223
16113981
19517896
19839048
21731166
21873894
22387750
30291943
 		CTD
US FAERS
139InfluenzaFAERS: 2US FAERS
140Intestinal AtresiaFAERS: 2US FAERS
141Joint Range of Motion DecreasedFAERS: 2US FAERS
142Joint swellingFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
143LeukocytosisFAERS: 216537180CTD
US FAERS
144Limb discomfortFAERS: 2US FAERS
145MalabsorptionFAERS: 2US FAERS
146Malignant neoplasm progressionFAERS: 2US FAERS
147Medication ErrorFAERS: 2US FAERS
148Memory impairmentFAERS: 2
Canada Vigilance: 2		Canada Vigilance
US FAERS
149NervousnessFAERS: 2
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
150No adverse eventFAERS: 2US FAERS
151POEMS SyndromeFAERS: 2US FAERS
152PallorFAERS: 2US FAERS
153PhotophobiaFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
154PresyncopeFAERS: 2SIDER
US FAERS
155Product quality issueFAERS: 2US FAERS
156ProteinuriaFAERS: 2

View details

844248
2478751
7386499
9507210
11849393
16943303
 		CTD
SIDER
US FAERS
157RhabdomyolysisFAERS: 2US FAERS
158Right atrial enlargementFAERS: 2US FAERS
159Septic ShockFAERS: 2OFFSIDES
US FAERS
160Small intestine carcinomaFAERS: 2US FAERS
161UlcerFAERS: 2

View details

2345457
7986967
10574470
12529378
17380554
21691039
26689173
 		CTD
SIDER
US FAERS
162UnderweightFAERS: 2US FAERS
163Unhealthy dietFAERS: 2US FAERS
164Ureaplasma test positiveFAERS: 2US FAERS
165Urinary tract infectionFAERS: 2US FAERS
166Vitreous floatersFAERS: 2US FAERS
167Abdominal AbscessFAERS: 1US FAERS
168Abdominal tendernessFAERS: 1US FAERS
169Accidental overdoseFAERS: 1US FAERS
170AnencephalyFAERS: 1US FAERS
171Angina PectorisFAERS: 1
Canada Vigilance: 1		9220183CTD
Canada Vigilance
US FAERS
172AnorexiaFAERS: 14916769
22902858		CTD
SIDER
US FAERS
173AnuriaFAERS: 1

View details

311647
1870807
6772782
8092206
8308583
 		CTD
US FAERS
174Aorticopulmonary Septal DefectFAERS: 1US FAERS
175ArthritisFAERS: 16881008CTD
OFFSIDES
US FAERS
176Atrial FibrillationFAERS: 1US FAERS
177Bilirubin conjugated increasedFAERS: 1US FAERS
178Blood alkaline phosphatase increasedFAERS: 1OFFSIDES
US FAERS
179Blood cholesterol increasedFAERS: 1US FAERS
180Blood glucose abnormalFAERS: 1US FAERS
181Blood lactate dehydrogenase increasedFAERS: 1OFFSIDES
US FAERS
182Blood triglycerides increasedFAERS: 1OFFSIDES
US FAERS
183Brain natriuretic peptide increasedFAERS: 1US FAERS
184Carcinoembryonic antigen increasedFAERS: 1US FAERS
185CardiomegalyFAERS: 111677312CTD
US FAERS
186Catheter related complicationFAERS: 1US FAERS
187Cerebellar infarctionFAERS: 1US FAERS
188Chest discomfortFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
189Choking sensationFAERS: 1US FAERS
190Clostridium difficile infectionFAERS: 1US FAERS
191ClubbingFAERS: 1US FAERS
192Cold sweatFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
193ConstipationFAERS: 1SIDER
US FAERS
194DeafnessFAERS: 1SIDER
US FAERS
195Depressed Level of ConsciousnessFAERS: 1US FAERS
196Diabetes mellitus inadequate controlFAERS: 1US FAERS
197DiplopiaFAERS: 1OFFSIDES
SIDER
US FAERS
198DiscomfortFAERS: 1SIDER
US FAERS
199Drug administered to patient of inappropriate ageFAERS: 1US FAERS
200Drug administration errorFAERS: 1US FAERS
201Drug effect incompleteFAERS: 1US FAERS
202Drug resistanceFAERS: 1US FAERS
203Drug screen false positiveFAERS: 1US FAERS
204Drug toxicityFAERS: 1US FAERS
205Drug withdrawal syndromeFAERS: 1US FAERS
206Duodenal ulcer perforationFAERS: 1US FAERS
207DuodenitisFAERS: 1OFFSIDES
US FAERS
208DysuriaFAERS: 1US FAERS
209EczemaFAERS: 1US FAERS
210Electrocardiogram abnormalFAERS: 1US FAERS
211Electrocardiogram repolarisation abnormalityFAERS: 1US FAERS
212Electroencephalogram abnormalFAERS: 1US FAERS
213Emotional distressFAERS: 1OFFSIDES
SIDER
US FAERS
214Eosinophils urine presentFAERS: 1US FAERS
215Erythema MultiformeFAERS: 1SIDER
US FAERS
216ErythemaFAERS: 1
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
217Escherichia urinary tract infectionFAERS: 1OFFSIDES
US FAERS
218Feeding tube complicationFAERS: 1US FAERS
219Femoral pulse decreasedFAERS: 1US FAERS
220Fibromuscular DysplasiaFAERS: 1US FAERS
221Fluid overloadFAERS: 1US FAERS
222FlushingFAERS: 1
Canada Vigilance: 3		Canada Vigilance
SIDER
US FAERS
223Foreign body in respiratory tractFAERS: 1US FAERS
224Gastrointestinal erosionFAERS: 1US FAERS
225Gastrointestinal hypomotilityFAERS: 1US FAERS
226Gastrointestinal infectionFAERS: 1US FAERS
227General physical health deteriorationFAERS: 1OFFSIDES
US FAERS
228HELLP SyndromeFAERS: 1US FAERS
229HepatitisFAERS: 1
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
230HepatomegalyFAERS: 1US FAERS
231HyperacusisFAERS: 1US FAERS
232HyperventilationFAERS: 1
Canada Vigilance: 2		Canada Vigilance
US FAERS
233Idiopathic angioedemaFAERS: 1US FAERS
234IleusFAERS: 1SIDER
US FAERS
235Inappropriate affectFAERS: 1US FAERS
236IncoherentFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
237Incorrect drug administration durationFAERS: 1US FAERS
238Incorrect route of drug administrationFAERS: 1US FAERS
239InfectionFAERS: 1US FAERS
240Intentional product misuseFAERS: 1US FAERS
241Intentional product use issueFAERS: 1US FAERS
242Intestinal FistulaFAERS: 1US FAERS
243Intestinal ulcer perforationFAERS: 1US FAERS
244IridoceleFAERS: 1US FAERS
245Joint injuryFAERS: 1US FAERS
246Joint warmthFAERS: 1US FAERS
247KeratorhexisFAERS: 1US FAERS
248Left Ventricular HypertrophyFAERS: 1US FAERS
249Leukocytoclastic vasculitisFAERS: 1US FAERS
250Lip swellingFAERS: 1US FAERS
251ListeriosisFAERS: 1US FAERS
252Live BirthFAERS: 1US FAERS
253Low Cardiac Output SyndromeFAERS: 1US FAERS
254Meconium peritonitisFAERS: 1US FAERS
255MeningitisFAERS: 120197477CTD
US FAERS
256Metabolic alkalosisFAERS: 1US FAERS
257Mouth swellingFAERS: 1US FAERS
258Muscular DystrophyFAERS: 1US FAERS
259Mycosis FungoidesFAERS: 1US FAERS
260MydriasisFAERS: 1US FAERS
261Neck PainFAERS: 1US FAERS
262Neonatal respiratory failureFAERS: 1
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
263Neonatal tachycardiaFAERS: 1US FAERS
264NephritisFAERS: 1SIDER
US FAERS
265Nuchal RigidityFAERS: 1US FAERS
266ObesityFAERS: 1US FAERS
267Occult blood positiveFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
268PO2 decreasedFAERS: 1US FAERS
269Pain of skinFAERS: 1US FAERS
270PancytopeniaFAERS: 1SIDER
US FAERS
271ParanoiaFAERS: 1US FAERS
272Performance status decreasedFAERS: 1US FAERS
273Pericardial effusionFAERS: 11923225
2140240		CTD
US FAERS
274Peripancreatic fluid collectionFAERS: 1US FAERS
275Peripheral swellingFAERS: 1US FAERS
276Personality ChangeFAERS: 1US FAERS
277Pharmaceutical product counterfeitFAERS: 1US FAERS
278PhonophobiaFAERS: 1US FAERS
279PolyhydramniosFAERS: 1

View details

1748938
2405319
8163032
8379817
8498410
8843476
9507041
11677312
 		CTD
OFFSIDES
US FAERS
280PolyneuropathyFAERS: 1US FAERS
281PolyuriaFAERS: 1
Canada Vigilance: 1

View details

2123565
2454589
2719505
2949606
3568719
3921582
8132200
9044466
 		CTD
Canada Vigilance
US FAERS
282Procedural vomitingFAERS: 1US FAERS
283Product measured potency issueFAERS: 1US FAERS
284Product physical issueFAERS: 1US FAERS
285Product storage errorFAERS: 1US FAERS
286Pruritus allergicFAERS: 1US FAERS
287Pulmonary EmbolismFAERS: 1US FAERS
288Pulmonary HypertensionFAERS: 1SIDER
US FAERS
289Pulmonary artery thrombosisFAERS: 1US FAERS
290Pulmonary congestionFAERS: 1US FAERS
291Pulmonary thrombosisFAERS: 1US FAERS
292Pulmonary vascular disorderFAERS: 1US FAERS
293Rash erythematousFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
294Reaction to excipientFAERS: 1US FAERS
295Rebound effectFAERS: 1US FAERS
296Refusal of treatment by relativeFAERS: 1US FAERS
297Renal failure neonatalFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
298Renal tubular disorderFAERS: 1US FAERS
299Renal tubular necrosisFAERS: 1OFFSIDES
US FAERS
300Respiratory arrestFAERS: 1US FAERS
301Retinal pigmentationFAERS: 1US FAERS
302Reversible cerebral vasoconstriction syndromeFAERS: 1US FAERS
303Skin UlcerFAERS: 1US FAERS
304Skin necrosisFAERS: 1US FAERS
305Small Intestinal StenosisFAERS: 1US FAERS
306SpondylitisFAERS: 1US FAERS
307Stevens-Johnson SyndromeFAERS: 1
Canada Vigilance: 3		25811541CTD
SIDER
Canada Vigilance
US FAERS
308StillbirthFAERS: 1US FAERS
309Systolic dysfunctionFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
310Therapeutic response unexpectedFAERS: 1US FAERS
311Therapeutic response unexpected with drug substitutionFAERS: 1US FAERS
312Therapy non-responderFAERS: 1
Canada Vigilance: 2		Canada Vigilance
US FAERS
313ThrombosisFAERS: 1US FAERS
314Toxicity to various agentsFAERS: 1US FAERS
315Troponin I increasedFAERS: 1US FAERS
316Unevaluable eventFAERS: 1US FAERS
317Unresponsive to stimuliFAERS: 1US FAERS
318Urine flow decreasedFAERS: 1US FAERS
319Vascular resistance systemic increasedFAERS: 1US FAERS
320Wheelchair userFAERS: 1US FAERS
321WheezingFAERS: 1US FAERS
322Wrong technique in drug usage processFAERS: 1US FAERS
323Wrong technique in product usage processFAERS: 1
Canada Vigilance: 2		Canada Vigilance
US FAERS
324X-ray abnormalFAERS: 1US FAERS
325pH body fluid abnormalFAERS: 1US FAERS
326Abdominal Compartment SyndromeOFFSIDES
327Abdominal bloatingSIDER
328Abdominal distressSIDER
329AbuseOFFSIDES
330Acute anaphylaxisSIDER
331Acute myocardial infarctionOFFSIDES
332Adenocarcinoma7614682
16537180		CTD
OFFSIDES
333AdenoidectomyOFFSIDES
334Adenoma11497255CTD
335AgoraphobiaOFFSIDES
336AlkalosisSIDER
337AlopeciaCanada Vigilance: 1Canada Vigilance
SIDER
338Alveolar Bone Loss17225004CTD
339Anaphylactic shockSIDER
340Anaphylactoid ReactionCanada Vigilance: 2Canada Vigilance
341Anemia, Hemolytic17381629CTD
342Anemia5723725CTD
343Aneurysm10189013CTD
344AnhedoniaOFFSIDES
345Ankylosing spondylitisSIDER
346Anorectal discomfortOFFSIDES
SIDER
347AnosmiaCanada Vigilance: 1Canada Vigilance
348Anticonvulsant drug level decreasedOFFSIDES
349Anxiety Disorders8219437CTD
350Aortic Aneurysm, Abdominal10388637CTD
351Aortic Aneurysm10231640CTD
352ApathyCanada Vigilance: 1Canada Vigilance
SIDER
353Application site pruritusOFFSIDES
354Application site scarOFFSIDES
355Application site urticariaOFFSIDES
356Arterial thrombosisOFFSIDES
357ArteriosclerosisOFFSIDES
358Arthritis, Gouty6023116
17276548		CTD
359Arthritis, Infectious983356CTD
360Aseptic MeningitisOFFSIDES
361Aspiration PneumoniaOFFSIDES
362AsthmaCanada Vigilance: 1Canada Vigilance
OFFSIDES
SIDER
363AtherosclerosisOFFSIDES
364Athletic Injuries3305036CTD
365Atrial tachycardiaOFFSIDES
366Azotemia3362274
7033849
8308583		CTD
367Benign Prostatic HyperplasiaOFFSIDES
368Biopsy breast abnormalOFFSIDES
369Bipolar Disorder3597814CTD
370BlepharospasmOFFSIDES
371Blood GlucoseOFFSIDES
372Blood albumin decreasedOFFSIDES
373Blood antidiuretic hormone increasedOFFSIDES
374Blood chloride abnormalOFFSIDES
375Blood chloride decreasedOFFSIDES
376Blood cholesterolOFFSIDES
377Blood cholinesterase decreasedOFFSIDES
378Blood glucose decreasedCanada Vigilance: 1Canada Vigilance
OFFSIDES
379Blood sodiumOFFSIDES
380Blood uric acidOFFSIDES
381Body TemperatureOFFSIDES
382Bone fragmentationOFFSIDES
383Bone lesionOFFSIDES
384Bone marrow depressionSIDER
385Brain Diseases2257989
16203592		CTD
386Brain Edema11481608CTD
387Brain Injuries9500967
16223416		CTD
388Brain Ischemia

View details

2084459
2329439
12524144
16223416
 		CTD
389Brain Neoplasms16223416CTD
390Breast MicrocalcificationOFFSIDES
391Breast cancer recurrentOFFSIDES
392BronchospasmCanada Vigilance: 1Canada Vigilance
393BruxismOFFSIDES
394BursitisOFFSIDES
395Butterfly rashCanada Vigilance: 1Canada Vigilance
396Cachexia

View details

11239499
15141370
15625704
16537180
 		CTD
397CalcinosisOFFSIDES
398Carcinoma, Lewis Lung11053908CTD
399CarcinomaSIDER
400Cardiac HypertrophyOFFSIDES
401Cardiovascular Abnormalities7719872CTD
402Cardiovascular Diseases1478511CTD
403Catalepsy1378634
3362928
6440863		CTD
404Cataract operationOFFSIDES
405Cauda Equina SyndromeOFFSIDES
406Cecal Diseases7986967CTD
407CellulitisOFFSIDES
408Cerebral Hemorrhage8885773
9521382
16223416		CTD
409Cerebral ThrombosisCanada Vigilance: 1Canada Vigilance
410Cervicobrachial syndromeOFFSIDES
411Chemical and Drug Induced Liver Injury

View details

3442185
3602573
6071328
7654905
18227818
22107987
24014644
24085192
25051504
27485346
30252991
 		CTD
412Cholecystitis11181007CTD
413Cholestasis3047224CTD
414ChromaturiaCanada Vigilance: 1Canada Vigilance
415Chromosome Breakage30252991CTD
416Chronic Fatigue SyndromeOFFSIDES
417Chronic Obstructive Airway DiseaseOFFSIDES
418Clostridium difficile colitisOFFSIDES
419Cluster Headache16601942CTD
420Cognition Disorders2084459CTD
421Colon adenomaOFFSIDES
422Colonic Neoplasms

View details

11260862
15625704
15637740
15786552
15936596
15963497
 		CTD
423Colorectal Neoplasms

View details

11197048
12606626
17054584
18059344
20035423
 		CTD
424Completed SuicideOFFSIDES
425Concomitant disease progressionOFFSIDES
426Confusion6132175CTD
427Congenital cystic kidney diseaseOFFSIDES
428Conjunctival Diseases1115460CTD
429Consciousness Disorders1654720CTD
430Conversion disorderCanada Vigilance: 2Canada Vigilance
431Coronary Occlusion8721639CTD
432Coronavirus Infections17302372CTD
433CryingCanada Vigilance: 1Canada Vigilance
434CrystalluriaCanada Vigilance: 1Canada Vigilance
435CyanosisCanada Vigilance: 1Canada Vigilance
436Cytolytic hepatitisOFFSIDES
437DebridementOFFSIDES
438DeliriumCanada Vigilance: 16881008CTD
Canada Vigilance
439Dental abscessOFFSIDES
440Dermatitis, Irritant21319177CTD
441Dermatitis29127031CTD
SIDER
442DiabetesOFFSIDES
443Diabetic FootOFFSIDES
444Diabetic gastroenteropathyOFFSIDES
445Diarrhea7237001
7907874
16240705		CTD
446DistentionSIDER
447DistressSIDER
448DiverticulitisCanada Vigilance: 1Canada Vigilance
449DrowsinessSIDER
450Drug Eruptions1371395
11792017		CTD
451Drug diversionOFFSIDES
452Dry skinCanada Vigilance: 1Canada Vigilance
453Dyskinesia, Drug-Induced11711046CTD
454DyslaliaOFFSIDES
455Dysmenorrhea333681
627337		CTD
456Dyssomnias6132175CTD
457Dysthymic DisorderOFFSIDES
458EcchymosisSIDER
459Edema

View details

1870807
3050004
3579483
7508328
7735198
7907874
7990266
8190018
8273558
8985016
10653021
11820457
12424497
14515793
16100529
16155371
19212002
19703484
20054000
20108268
21731166
22446600
25698669
26418808
27474066
27568862
28559105
30291943
 		CTD
460Electrolyte imbalanceSIDER
461Electromechanical dissociationOFFSIDES
462Embolic strokeOFFSIDES
463Endometriosis15652904CTD
464Endotoxemia18509659CTD
465Eosinophilia11298111CTD
466Epigastric distressSIDER
467Epigastric painSIDER
468EpilepsySIDER
469EpistaxisCanada Vigilance: 1Canada Vigilance
SIDER
470Erectile dysfunctionOFFSIDES
471Erythema NodosumCanada Vigilance: 1Canada Vigilance
SIDER
472Escherichia infectionOFFSIDES
473Esophageal Neoplasms11005569CTD
474Exanthema16943303CTD
475ExcoriationOFFSIDES
476Exfoliative rashCanada Vigilance: 1Canada Vigilance
477Extravasation of Diagnostic and Therapeutic Materials7238673CTD
478Extremity necrosisOFFSIDES
479Eye painCanada Vigilance: 2Canada Vigilance
OFFSIDES
SIDER
480Facial paralysisCanada Vigilance: 1Canada Vigilance
481Facial wastingOFFSIDES
482Familial Mediterranean FeverOFFSIDES
483Fanconi Syndrome3856211CTD
484Fat necrosisOFFSIDES
485Febrile NeutropeniaOFFSIDES
486Fetal Diseases

View details

112867
445754
1478511
1870807
1923225
1930046
2335261
2405319
2524291
3393194
8498410
8645379
8843476
11677312
 		CTD
487Fetal Growth Retardation6772782CTD
488Fever

View details

6409656
10431976
11852909
17627676
 		CTD
489FibromyalgiaOFFSIDES
490Fibrosarcoma10962813CTD
491Fibrosis4071154
7986967
17994277		CTD
492Fixed eruptionCanada Vigilance: 1Canada Vigilance
493Flat affectSIDER
494Folliculitis11298111CTD
495Gastrointestinal Diseases

View details

333681
3329590
3896659
8222739
8949638
9502396
16187199
19220725
20035423
25014874
 		CTD
496Gastrointestinal Hemorrhage

View details

311647
1870807
3050004
4548752
6614039
7019841
9017686
15651117
 		CTD
497Gastrointestinal inflammationOFFSIDES
498Glioblastoma12870263CTD
499Glioma16487511
18371953		CTD
500Glomerulonephritis860058
4106997
9848785		CTD
501GlossitisOFFSIDES
502GlycosuriaCanada Vigilance: 1Canada Vigilance
SIDER
503Goiter22387750CTD
504Granuloma21731166CTD
505Group B streptococcus neonatal sepsisOFFSIDES
506Hallucinations3559156CTD
507Head and Neck Neoplasms15482327CTD
508Headache Disorders8262795CTD
509Heart Diseases8498410
8645379		CTD
510Heart failure2524291
8843476
17394181		CTD
511Heart sounds abnormalOFFSIDES
512Heartburn1065802CTD
SIDER
513Hematemesis3777737CTD
514Hematuria7880236CTD
515HemicephalalgiaOFFSIDES
516Hemorrhage

View details

6747765
12632374
17638016
18996434
23892052
 		CTD
517Hepatic Encephalopathy15633222CTD
518Hepatic congestionOFFSIDES
519Hepatitis B positiveOFFSIDES
520Hepatitis B15784032CTD
521Hepatitis C, Chronic15135802CTD
522Herpes simplex serology positiveOFFSIDES
523Hip surgeryOFFSIDES
524HistoplasmosisOFFSIDES
525Hydrops Fetalis11770593CTD
526Hyperalgesia

View details

2128375
2998815
10422945
10813554
10920437
12220967
12727271
15010267
16507304
17989504
18810243
19815945
20601862
 		CTD
527Hyperamylasemia17883296CTD
528Hypercalcemia

View details

1152883
2248514
4032577
4835887
 		CTD
529Hyperemia10792963
12524144
18688582		CTD
530Hyperesthesia8190269CTD
531Hyperglycemia28266800CTD
532Hyperkalemia

View details

3362274
3375885
3560096
4071154
6814155
7017180
7033849
7411769
8203268
 		CTD
533HyperkinesiaCanada Vigilance: 1Canada Vigilance
534Hypernatremia3921582CTD
535HyperparathyroidismOFFSIDES
536Hyperplasia1477515
22387750		CTD
537Hypertensive cardiomyopathyOFFSIDES
538Hypoalbuminemia7986967CTD
539Hypoaldosteronism3375885
6814155		CTD
540Hypokalemia3727353CTD
541Hyponatremia12632374CTD
542HypophagiaOFFSIDES
543Hypotension, Orthostatic6498036
14727996		CTD
544Ileal Diseases10574470
18306037		CTD
545Ileal ulcerOFFSIDES
546Ileitis

View details

10647630
10651667
12706472
16133968
 		CTD
547IncontinenceOFFSIDES
548Infant, Premature, Diseases

View details

2766920
3050004
6377215
7019841
7108667
10516392
10974130
12970633
15046280
16133044
 		CTD
549Inflammatory painCanada Vigilance: 1Canada Vigilance
550Initial insomniaOFFSIDES
551Injection site phlebitisOFFSIDES
552Intervertebral disc disorderOFFSIDES
553Intestinal Diseases

View details

10210152
11686837
11713966
11855677
15610444
15831440
16944022
17329856
17994277
18236018
28342779
 		CTD
554Intestinal Neoplasms1477515CTD
555Intestinal Polyps14991580CTD
556Intracranial Hypertension15241188
15752400
16223416		CTD
557Ischemia8092206
8949638		CTD
558Jejunal Diseases10574470
16133968
18306037		CTD
559Keratitis24598350CTD
560Kidney Diseases

View details

1489412
1913620
2112558
2284768
2424533
2766920
7019841
7108667
7661171
7791169
8308589
8440438
9284854
9507041
9521382
10516392
12970633
15037210
17190690
19445918
19761811
20035423
25110317
 		CTD
561Kidney Failure, Chronic6986554CTD
562Kidney FailureOFFSIDES
563Kidney Papillary Necrosis

View details

277165
861066
972771
3102426
4548752
6125715
6953356
9502396
12512867
 		CTD
564LaryngospasmCanada Vigilance: 1Canada Vigilance
565Leishmaniasis, Cutaneous10320625
11703811
12228301		CTD
566LeukoencephalopathyOFFSIDES
567Leukomalacia, Periventricular2329439
17980183		CTD
568LeukopeniaCanada Vigilance: 316240705CTD
SIDER
Canada Vigilance
569Leydig Cell Tumor1477515CTD
570LightheadednessSIDER
571Livedo ReticularisOFFSIDES
572Liver Abscess, Amebic11479899CTD
573Liver Cirrhosis, Experimental18194892CTD
574Liver diseases2112558
15784032		CTD
575Liver neoplasms1477515CTD
576Loose toothOFFSIDES
577Lung InjuryOFFSIDES
578Lung Neoplasms11053908
11497255
16537180		CTD
579Lung consolidationOFFSIDES
580Lung diseases11340680CTD
581Lupus Erythematosus, Systemic3600902
6694957		CTD
582LymphedemaOFFSIDES
583Malignant neoplasm of spinal cordOFFSIDES
584MalocclusionOFFSIDES
585MastectomyOFFSIDES
586Mastication disorderOFFSIDES
587Mastocytosis12559315CTD
588Mental disorders10205728CTD
589Mental impairmentCanada Vigilance: 1Canada Vigilance
590Metastatic Renal Cell CarcinomaOFFSIDES
591Micronuclei, Chromosome-Defective30252991CTD
592Migraine Disorders8869763
11903285
12220967		CTD
593Mitochondrial Diseases22214982CTD
594Mouth Neoplasms12636206CTD
595Muscle enzymeOFFSIDES
596Muscle movement involuntarySIDER
597Musculoskeletal discomfortOFFSIDES
598MyalgiaCanada Vigilance: 1Canada Vigilance
599Necrolysis epidermalSIDER
600Necrosis

View details

112867
1640321
2015844
4087309
8157128
8949638
9065783
16187199
20190399
22107987
30252991
 		CTD
601Necrotizing EnterocolitisSIDER
602Neoplasm Metastasis11053908
11239499
16537180		CTD
603Neoplasms, Experimental10663608
15625704		CTD
604Nephritic syndromeSIDER
605Nephritis, Interstitial

View details

3071148
3975749
3980192
10534532
16943303
 		CTD
606Nephrogenic Diabetes InsipidusOFFSIDES
607Nephrosis6618773CTD
608Nephrotic Syndrome844248
7172499		CTD
SIDER
609NeutropeniaCanada Vigilance: 1Canada Vigilance
610Optic Disc EdemaOFFSIDES
611Oral polypectomyOFFSIDES
612OsteopeniaOFFSIDES
613Ovarian Hyperstimulation Syndrome2112558CTD
614Pain, Postoperative12538197
18702446		CTD
615Paraneoplastic Syndromes16537180CTD
616Parkinsonian Disorders12349958CTD
617Paroxysmal Hemicrania

View details

9529768
11903285
16686914
17645760
 		CTD
618Peptic Ulcer

View details

5569832
11148446
15322343
20586863
 		CTD
SIDER
619Pericarditis7752506CTD
620Periodontitis17225004CTD
621Peripheral Nervous System Diseases165855
8219437		CTD
622Persistent Fetal Circulation Syndrome7294953
7450523
15008397		CTD
623PharyngitisCanada Vigilance: 1Canada Vigilance
624PleurisyOFFSIDES
625Pneumocystis jiroveci pneumoniaOFFSIDES
626Pneumonia21983654CTD
627PneumothoraxSIDER
628Poor peripheral circulationOFFSIDES
629Poor quality drug administeredOFFSIDES
630Post procedural swellingOFFSIDES
SIDER
631Postural Orthostatic Tachycardia SyndromeOFFSIDES
632Premature Birth7469626
12861172
17000239		CTD
633Primary sequestrumOFFSIDES
634ProctitisOFFSIDES
SIDER
635Protein urine presentSIDER
636Pseudohypoaldosteronism3856211CTD
637Pseudotumor Cerebri634325CTD
638Psychomotor skills impairedOFFSIDES
639Psychoses, Substance-Induced7956191
10512453		CTD
640Pulmonary Edema1559913
2125593		CTD
641Pulmonary vasculitisSIDER
642Pyelonephritis448822CTD
643Raynaud Disease6614039CTD
644Rectal tenesmusOFFSIDES
SIDER
645Reflex, Abnormal8032584CTD
646Renal Colic3720020
6854762		CTD
647Renal Insufficiency

View details

496125
2325052
3050004
3129900
3340956
3347121
3736188
6792007
6814155
6953356
7411769
8092206
8203268
8308583
8379817
8530800
10592922
12137683
12368969
16240705
 		CTD
648Reperfusion Injury10588920
10594344
11567657		CTD
649RestlessnessCanada Vigilance: 1Canada Vigilance
650Retinal Vascular DisorderCanada Vigilance: 1Canada Vigilance
651RhinitisCanada Vigilance: 1Canada Vigilance
652RhonchiCanada Vigilance: 1Canada Vigilance
653SarcoidosisOFFSIDES
654Sciatica4232743CTD
655ScotomaOFFSIDES
656Seizures

View details

8119479
9500967
10195372
10528118
18178179
 		CTD
657Serum SicknessOFFSIDES
658Serum potassium increasedSIDER
659Sinus bradycardiaOFFSIDES
660SinusitisCanada Vigilance: 1Canada Vigilance
661Sleep Wake Disorders11677312CTD
662SnoringOFFSIDES
663Spinal Cord Injuries8157128CTD
664Status Epilepticus1979027CTD
665Stomach Diseases

View details

6443622
10192188
10215738
10486359
11292068
11567657
15038085
15472012
15996031
16113693
16184426
16280098
17160473
17207306
17570478
17638125
18209964
18545984
20678495
25656915
 		CTD
666Stomach Neoplasms15609394CTD
667StomatitisCanada Vigilance: 3Canada Vigilance
SIDER
668StuporCanada Vigilance: 2Canada Vigilance
669Supraventricular tachycardiaOFFSIDES
670SweatingSIDER
671SynovitisOFFSIDES
672Tendinopathy1864449CTD
673TensionSIDER
674TeratomaCanada Vigilance: 1Canada Vigilance
675Thrombocytopenic purpuraCanada Vigilance: 1Canada Vigilance
SIDER
676ThrombophlebitisSIDER
677Tongue blisteringOFFSIDES
678Tongue spasmCanada Vigilance: 1Canada Vigilance
679TonsillectomyOFFSIDES
680TonsillitisOFFSIDES
681Toxic Epidermal NecrolysisSIDER
682Tricuspid Valve Insufficiency

View details

1923225
2405319
3393194
3579483
7719872
11677312
11770593
 		CTD
683Ulcerative stomatitisSIDER
684Umbilical hernia perforationOFFSIDES
685Uremia311647
3933537		CTD
SIDER
686Ureteral Calculi3720020CTD
687UreteritisOFFSIDES
688Urethral dischargeOFFSIDES
689Urinary Bladder Diseases8486095CTD
690Urinary RetentionCanada Vigilance: 2Canada Vigilance
691Urine osmolarity increasedOFFSIDES
692Urologic Neoplasms7614682CTD
693Varicose vein operationOFFSIDES
694Vascular calcificationOFFSIDES
695Vascular purpuraSIDER
696Vasculitis, Leukocytoclastic, Cutaneous3381715CTD
697VasculitisCanada Vigilance: 1Canada Vigilance
SIDER
698Vasospasm, Intracranial8138965CTD
699Visual disturbanceOFFSIDES
700Wound ComplicationOFFSIDES
701anaphylaxis9220183CTD
702jaundice18227818CTD
SIDER
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