MetaADEDB 2.0 @ LMMD
Irinotecan
(UWKQSNNFCGGAFS-XIFFEERXSA-N)
Structure
SMILES
CC[C@@]1(O)C(=O)OCc2c1cc1c3nc4ccc(cc4c(c3Cn1c2=O)CC)OC(=O)N1CCC(CC1)N1CCCCC1
Type(s)
Approved; Investigational
ATC code(s)
L01XX19
Molecular Formula:
C33H38N4O6
Molecular Weight:
586.678
Log P:
3.9669
Hydrogen Bond Acceptor:
10
Hydrogen Bond Donor:
1
TPSA:
114.2
CAS Number(s):
97682-44-5
Synonym(s)
1.
Irinotecan
2.
7-Ethyl-10-hydroxycamptothecin
3.
CPT 11
4.
CPT-11
5.
Camptosar
6.
Camptothecin-11
7.
Irinotecan Hydrochloride
8.
Irrinotecan
9.
NK012 Compound
10.
SN 38
11.
SN 38 11
12.
SN-38
13.
SN-38-11
14.
7 Ethyl 10 hydroxycamptothecin
15.
CPT11
16.
Camptothecin 11
17.
SN3811
External Link(s)
MeSHD000077146
PubChem Compound60838
BindingDB50128267
ChEBI80630
CHEMBLCHEMBL481
DrugBankDB00762
DrugCentral1482
IUPHAR/BPS Guide to PHARMACOLOGY6823
KEGGcpd:C16641
dr:D08086
Therapeutic Target DatabaseD07HOB
ZINC1612996
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Disease ProgressionFAERS: 151OFFSIDES
US FAERS
2NauseaFAERS: 31

View details

12794247
15493359
15930889
17679458
18480965
 		CTD
OFFSIDES
SIDER
US FAERS
3VomitingFAERS: 27

View details

12794247
12963697
15493359
17679458
18480965
 		CTD
SIDER
US FAERS
4Abdominal PainFAERS: 22SIDER
US FAERS
5NeutropeniaFAERS: 21

View details

11822757
12794247
12963697
15365766
17679458
18480965
 		CTD
SIDER
US FAERS
6MalaiseFAERS: 18SIDER
US FAERS
7Pancreatic carcinomaFAERS: 18US FAERS
8FatigueFAERS: 1518480965CTD
OFFSIDES
SIDER
US FAERS
9DehydrationFAERS: 1412963697CTD
OFFSIDES
SIDER
US FAERS
10Infection reactivationFAERS: 12US FAERS
11DysarthriaFAERS: 1115205214CTD
SIDER
US FAERS
12DizzinessFAERS: 9SIDER
US FAERS
13LeukopeniaFAERS: 9

View details

15365766
19401694
21852251
24380837
30130528
 		CTD
SIDER
US FAERS
14Malignant neoplasm progressionFAERS: 9
Canada Vigilance: 1		Canada Vigilance
US FAERS
15PneumoniaFAERS: 9SIDER
US FAERS
16SepsisFAERS: 911822757CTD
SIDER
US FAERS
17ChillsFAERS: 8SIDER
US FAERS
18PainFAERS: 8SIDER
US FAERS
19ThrombocytopeniaFAERS: 815365766
17679458
21852251		CTD
SIDER
US FAERS
20AlopeciaFAERS: 7SIDER
US FAERS
21HypersensitivityFAERS: 7
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
22PruritusFAERS: 7
Canada Vigilance: 1		Canada Vigilance
US FAERS
23Toxicity to various agentsFAERS: 7SIDER
US FAERS
24UrticariaFAERS: 7
Canada Vigilance: 2		Canada Vigilance
US FAERS
25AphasiaFAERS: 615205214CTD
US FAERS
26AstheniaFAERS: 6
Canada Vigilance: 2		Canada Vigilance
OFFSIDES
SIDER
US FAERS
27Chest PainFAERS: 6US FAERS
28Chest discomfortFAERS: 6US FAERS
29ConstipationFAERS: 6SIDER
US FAERS
30FlushingFAERS: 6SIDER
US FAERS
31HypotensionFAERS: 611740913
12794247		CTD
SIDER
US FAERS
32LethargyFAERS: 6US FAERS
33Neutrophil count decreasedFAERS: 6OFFSIDES
US FAERS
34Pulmonary EmbolismFAERS: 6SIDER
US FAERS
35Septic ShockFAERS: 6OFFSIDES
US FAERS
36TremorFAERS: 6US FAERS
37Weight decreasedFAERS: 6SIDER
US FAERS
38AngioedemaFAERS: 5US FAERS
39Back PainFAERS: 5SIDER
US FAERS
40Drug ineffectiveFAERS: 5US FAERS
41Febrile NeutropeniaFAERS: 5OFFSIDES
SIDER
US FAERS
42Intestinal ObstructionFAERS: 5OFFSIDES
SIDER
US FAERS
43Product use issueFAERS: 5US FAERS
44AnxietyFAERS: 4US FAERS
45Blood potassium decreasedFAERS: 4US FAERS
46Bone marrow depressionFAERS: 4OFFSIDES
US FAERS
47Disease recurrenceFAERS: 4US FAERS
48Disseminated Intravascular CoagulationFAERS: 4OFFSIDES
US FAERS
49Drug effect incompleteFAERS: 4US FAERS
50Full blood count decreasedFAERS: 4US FAERS
51Gastrointestinal toxicityFAERS: 4OFFSIDES
US FAERS
52General physical health deteriorationFAERS: 4US FAERS
53MyoclonusFAERS: 4US FAERS
54ObstructionFAERS: 4US FAERS
55Oral painFAERS: 4US FAERS
56OverdoseFAERS: 4US FAERS
57Respiratory FailureFAERS: 4OFFSIDES
US FAERS
58TachycardiaFAERS: 4US FAERS
59Alanine Aminotransferase IncreasedFAERS: 3US FAERS
60Aspartate Aminotransferase IncreasedFAERS: 3SIDER
US FAERS
61BlepharospasmFAERS: 3US FAERS
62BradycardiaFAERS: 39861240
11740913		CTD
SIDER
US FAERS
63ColitisFAERS: 326431797CTD
SIDER
US FAERS
64Depressed Level of ConsciousnessFAERS: 3OFFSIDES
US FAERS
65Drug dose omissionFAERS: 3US FAERS
66DysphoniaFAERS: 3US FAERS
67Eye irritationFAERS: 3US FAERS
68HypophagiaFAERS: 3US FAERS
69IleusFAERS: 3SIDER
US FAERS
70InfectionFAERS: 3SIDER
US FAERS
71Joint stiffnessFAERS: 3US FAERS
72LymphopeniaFAERS: 3SIDER
US FAERS
73No adverse eventFAERS: 3US FAERS
74PneumonitisFAERS: 3US FAERS
75Product quality issueFAERS: 3US FAERS
76Product use in unapproved indicationFAERS: 3US FAERS
77ShockFAERS: 3SIDER
US FAERS
78SomnolenceFAERS: 3SIDER
US FAERS
79SyncopeFAERS: 3SIDER
US FAERS
80Throat irritationFAERS: 3US FAERS
81ThrombosisFAERS: 3SIDER
US FAERS
82White blood cell count decreasedFAERS: 3US FAERS
83treatment failureFAERS: 3US FAERS
84Abdominal discomfortFAERS: 2US FAERS
85Acute kidney injuryFAERS: 2US FAERS
86Adverse eventFAERS: 2US FAERS
87AgranulocytosisFAERS: 2US FAERS
88ArthralgiaFAERS: 2US FAERS
89Atrial FibrillationFAERS: 2US FAERS
90Blood count abnormalFAERS: 2US FAERS
91Blood creatinine increasedFAERS: 2SIDER
US FAERS
92Cerebral InfarctionFAERS: 2SIDER
US FAERS
93Cerebrovascular accidentFAERS: 2SIDER
US FAERS
94CyanosisFAERS: 2US FAERS
95DermatitisFAERS: 2SIDER
US FAERS
96EpilepsyFAERS: 2OFFSIDES
US FAERS
97ErythemaFAERS: 2US FAERS
98ExtravasationFAERS: 2SIDER
US FAERS
99Febrile bone marrow aplasiaFAERS: 2OFFSIDES
US FAERS
100Gastrointestinal inflammationFAERS: 2US FAERS
101Glioblastoma MultiformeFAERS: 2US FAERS
102HeadacheFAERS: 2
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
103HepatitisFAERS: 2US FAERS
104HypoxiaFAERS: 2US FAERS
105MacroglossiaFAERS: 2US FAERS
106MyositisFAERS: 2US FAERS
107PancreatitisFAERS: 2SIDER
US FAERS
108PancytopeniaFAERS: 2US FAERS
109Pulmonary FibrosisFAERS: 2US FAERS
110Recall phenomenonFAERS: 2US FAERS
111Respiratory distressFAERS: 2US FAERS
112Retinal Vein OcclusionFAERS: 2US FAERS
113Skin lesionFAERS: 2US FAERS
114Thrombocytopenic purpuraFAERS: 2US FAERS
115Wound infection bacterialFAERS: 2US FAERS
116Accidental exposureFAERS: 1US FAERS
117Acute respiratory failureFAERS: 1US FAERS
118AgeusiaFAERS: 1US FAERS
119AgitationFAERS: 1US FAERS
120AkinesiaFAERS: 1US FAERS
121AnorexiaFAERS: 1OFFSIDES
SIDER
US FAERS
122Application site rashFAERS: 1US FAERS
123AscitesFAERS: 1US FAERS
124Autoimmune thrombocytopeniaFAERS: 1OFFSIDES
US FAERS
125Blood alkaline phosphatase increasedFAERS: 1SIDER
US FAERS
126Blood glucose increasedFAERS: 1US FAERS
127Blood lactate dehydrogenase increasedFAERS: 1US FAERS
128Blood sodium abnormalFAERS: 1US FAERS
129Blood sodium decreasedFAERS: 1US FAERS
130Bone lesionFAERS: 1US FAERS
131BronchospasmFAERS: 1US FAERS
132Cardiac FlutterFAERS: 1US FAERS
133Cardiac TamponadeFAERS: 1US FAERS
134CholangiocarcinomaFAERS: 1US FAERS
135CholestasisFAERS: 1US FAERS
136Colon cancer recurrentFAERS: 1US FAERS
137Culture wound positiveFAERS: 1US FAERS
138Deep Vein ThrombosisFAERS: 1US FAERS
139DeliriumFAERS: 1US FAERS
140Device related infectionFAERS: 1US FAERS
141Diabetes MellitusFAERS: 1US FAERS
142Diabetic KetoacidosisFAERS: 1US FAERS
143DiplopiaFAERS: 1US FAERS
144Drug dispensing errorFAERS: 1US FAERS
145Drug level increasedFAERS: 1US FAERS
146Drug resistanceFAERS: 1US FAERS
147Drug toxicityFAERS: 1OFFSIDES
US FAERS
148DyslaliaFAERS: 1US FAERS
149DyspepsiaFAERS: 1SIDER
US FAERS
150DysphemiaFAERS: 1US FAERS
151EczemaFAERS: 1US FAERS
152EnterocolitisFAERS: 1OFFSIDES
US FAERS
153Enzyme abnormalityFAERS: 1OFFSIDES
US FAERS
154EpistaxisFAERS: 1US FAERS
155Erectile dysfunctionFAERS: 1US FAERS
156Feeling abnormalFAERS: 1SIDER
US FAERS
157Gamma-Glutamyltransferase IncreasedFAERS: 1US FAERS
158Gastric ulcerFAERS: 1US FAERS
159Gastrointestinal PainFAERS: 1SIDER
US FAERS
160Gastrointestinal candidiasisFAERS: 1US FAERS
161Gastrointestinal sounds abnormalFAERS: 1US FAERS
162Gastrointestinal tract adenomaFAERS: 1US FAERS
163Hepatitis CFAERS: 1US FAERS
164Hormone level abnormalFAERS: 1US FAERS
165Hospice CareFAERS: 1US FAERS
166Human metapneumovirus test positiveFAERS: 1US FAERS
167HydrocephalusFAERS: 1US FAERS
168HypersomniaFAERS: 1US FAERS
169Inappropriate schedule of drug administrationFAERS: 1US FAERS
170Incorrect drug administration durationFAERS: 1US FAERS
171Incorrect route of drug administrationFAERS: 1US FAERS
172Incorrect route of product administrationFAERS: 1US FAERS
173Infection in an immunocompromised hostFAERS: 1US FAERS
174InflammationFAERS: 1US FAERS
175Injection site discomfortFAERS: 1US FAERS
176Injection site extravasationFAERS: 1US FAERS
177Intercepted drug dispensing errorFAERS: 1US FAERS
178Intestinal PerforationFAERS: 1OFFSIDES
SIDER
US FAERS
179Large intestine perforationFAERS: 1OFFSIDES
US FAERS
180LaryngospasmFAERS: 1US FAERS
181LeukoencephalopathyFAERS: 1US FAERS
182Livedo ReticularisFAERS: 1US FAERS
183Liver AbscessFAERS: 1US FAERS
184Long QT SyndromeFAERS: 1US FAERS
185Lung AbscessFAERS: 1US FAERS
186Medication ErrorFAERS: 1US FAERS
187MetastasisFAERS: 1US FAERS
188Muscle tightnessFAERS: 1US FAERS
189Musculoskeletal stiffnessFAERS: 1US FAERS
190MyalgiaFAERS: 1US FAERS
191Neutropenic colitisFAERS: 1SIDER
US FAERS
192Neutropenic sepsisFAERS: 1SIDER
US FAERS
193Neutrophil count abnormalFAERS: 1US FAERS
194NystagmusFAERS: 1US FAERS
195Optic NeuritisFAERS: 1US FAERS
196Oropharyngeal candidiasisFAERS: 1US FAERS
197Oxygen saturation abnormalFAERS: 1OFFSIDES
US FAERS
198PallorFAERS: 1US FAERS
199PalpitationsFAERS: 1US FAERS
200Performance status decreasedFAERS: 1OFFSIDES
US FAERS
201Pericardial effusionFAERS: 1US FAERS
202Peripheral arterial occlusive diseaseFAERS: 1US FAERS
203PhotophobiaFAERS: 1US FAERS
204Platelet count abnormalFAERS: 1US FAERS
205Pneumococcal sepsisFAERS: 1US FAERS
206PolyneuropathyFAERS: 1OFFSIDES
US FAERS
207Prerenal failureFAERS: 1US FAERS
208PresyncopeFAERS: 1US FAERS
209Product storage errorFAERS: 1US FAERS
210Psychomotor skills impairedFAERS: 1US FAERS
211Radiation PneumonitisFAERS: 1US FAERS
212Radiation injuryFAERS: 1US FAERS
213Radiation skin injuryFAERS: 1US FAERS
214Refusal of treatment by relativeFAERS: 1OFFSIDES
US FAERS
215Reproductive toxicityFAERS: 1US FAERS
216Respiratory DepressionFAERS: 1US FAERS
217Sense of oppressionFAERS: 1US FAERS
218Sick Sinus SyndromeFAERS: 1US FAERS
219Skin irritationFAERS: 1US FAERS
220Skin reactionFAERS: 1US FAERS
221Small intestine carcinomaFAERS: 1US FAERS
222Solar lentigoFAERS: 1US FAERS
223Sperm donationFAERS: 1US FAERS
224StomatitisFAERS: 1SIDER
US FAERS
225Superior Vena Cava SyndromeFAERS: 1US FAERS
226Therapy cessationFAERS: 1US FAERS
227Toxic Epidermal NecrolysisFAERS: 1US FAERS
228Transaminases increasedFAERS: 1US FAERS
229TrismusFAERS: 1US FAERS
230Tumour haemorrhageFAERS: 1US FAERS
231Unevaluable eventFAERS: 1US FAERS
232VertigoFAERS: 1SIDER
US FAERS
233Vessel puncture site reactionFAERS: 1US FAERS
234Visual ImpairmentFAERS: 1SIDER
US FAERS
235WheezingFAERS: 1US FAERS
236Abdominal AbscessOFFSIDES
237Abdominal CrampsSIDER
238Abdominal rigidityOFFSIDES
239AcneOFFSIDES
240Acute Coronary SyndromeSIDER
241Adenocarcinoma

View details

8504425
12698181
12794247
15930889
 		CTD
242AkathisiaSIDER
243Anal inflammationOFFSIDES
244Anaphylactic shockSIDER
245Anaphylactoid ReactionSIDER
246Anemia15365766
17679458		CTD
247Angina PectorisSIDER
248Anticonvulsant drug level decreasedOFFSIDES
249Arterial thrombosisSIDER
250Bacillus infectionOFFSIDES
251Bacteremia27838229CTD
252Biliary dilatationOFFSIDES
253Bilirubin abnormalSIDER
254Blood bilirubin abnormalSIDER
255Blood magnesium decreasedOFFSIDES
256Blood pressure immeasurableOFFSIDES
257Body TemperatureOFFSIDES
258Bronchial ObstructionOFFSIDES
259CarcinomaOFFSIDES
260Cardiac ArrestSIDER
261Carotid aneurysm ruptureOFFSIDES
262Carotid bruitOFFSIDES
263CheilitisOFFSIDES
264Chemical and Drug Induced Liver Injury28454924CTD
265CholangiolitisOFFSIDES
266Circumstance or information capable of leading to medication errorOFFSIDES
267Colonic Neoplasms

View details

8504425
11905508
15205214
17166623
17287894
17725105
24549232
26706406
 		CTD
268Colorectal Neoplasms

View details

9861240
15273666
15746067
16303861
16317265
16391804
16491956
17159606
17454858
18259882
18509181
18842611
20097248
20637188
21852251
22111927
24191041
29913120
 		CTD
269Conjunctival depositOFFSIDES
270Corneal UlcerOFFSIDES
271Cytomegalovirus enterocolitisOFFSIDES
272Diarrhea

View details

9861240
11822757
12794247
12911669
12963697
15365766
15930889
17679458
18480965
19401694
20097248
21852251
24191041
26431797
29913120
 		CTD
OFFSIDES
273Differential white blood cell count abnormalOFFSIDES
274Dilatation intrahepatic duct acquiredOFFSIDES
275DiscomfortSIDER
276Dry skinOFFSIDES
277Dyspnea12794247CTD
278DystoniaOFFSIDES
279Ejection fraction abnormalOFFSIDES
280Electrolyte imbalanceSIDER
281EmbolismSIDER
282Embolus legSIDER
283Enlargement abdomenSIDER
284Enterobacter sepsisOFFSIDES
285Enterovesical FistulaOFFSIDES
286ErythrosisOFFSIDES
287Escherichia coli Infections28454924CTD
288ExcoriationOFFSIDES
289Eye RednessOFFSIDES
290Eyelid Function DisorderOFFSIDES
291Fanconi Syndrome19584382CTD
292Fatty Liver24469900CTD
293Fever12794247CTD
294FlatulenceSIDER
295Gastric DilatationOFFSIDES
296GastroenteritisOFFSIDES
297Gastrointestinal Diseases12911669CTD
298Gastrointestinal Neoplasms12794247CTD
299Genetic PolymorphismSIDER
300Glioblastoma15570079CTD
301Glioma

View details

12481416
12675310
15134629
20842591
 		CTD
302Granulocyte count decreasedOFFSIDES
303HaematotoxicityOFFSIDES
304Hand rashSIDER
305Hepatic cancer metastaticSIDER
306Hepatitis BOFFSIDES
307HepatomegalySIDER
308Hypocalcemia19584382CTD
309Hypokalemia19584382CTD
310HypokinesiaSIDER
311Hypophosphatemia19584382CTD
312Hypotension orthostatic symptomaticSIDER
313Ileal ulcerOFFSIDES
314Implantable defibrillator malfunctionOFFSIDES
315Intestinal cystOFFSIDES
316Intestinal hypomotilityOFFSIDES
317Keratitis siccaOFFSIDES
318Kidney Diseases24220752CTD
319LacrimationSIDER
320Leukocyte Disorders27838229CTD
321Leukocytosis19401694CTD
322Leukopenia neonatalOFFSIDES
323Lipase increasedSIDER
324LipaseOFFSIDES
325Liver scan abnormalOFFSIDES
326LividityOFFSIDES
327Lymphangiosis carcinomatosaOFFSIDES
328Mallory-Weiss SyndromeOFFSIDES
329Markedly reduced dietary intakeOFFSIDES
330Medical device complicationOFFSIDES
331MegacolonSIDER
332Metabolic acidosisOFFSIDES
333Metastases to thoraxOFFSIDES
334Muscle FatigueOFFSIDES
335Muscular Atrophy19401694CTD
336Myocardial InfarctionSIDER
337Necrosis16432164
27838229		CTD
338Neoplasm Metastasis18259882
18842611
29913120		CTD
339Neoplasms, Experimental11751522
20164124
25269479		CTD
340Neoplasms12963697CTD
341Neuroblastoma8761367CTD
342NeuroborreliosisOFFSIDES
343Neuroectodermal Tumors8761367CTD
344Neutropenic infectionSIDER
345Non-alcoholic Fatty Liver Disease28454924CTD
346Oculogyric crisisOFFSIDES
347OnycholysisOFFSIDES
348Osteosarcoma24380837CTD
349PO2 decreasedOFFSIDES
350Pacemaker complicationOFFSIDES
351Paraneoplastic dermatomyositisOFFSIDES
352ParaparesisOFFSIDES
353Paresthesia12963697CTD
354Pelvic sepsisOFFSIDES
355Perineal infectionOFFSIDES
356Peripheral embolismSIDER
357Peripheral occlusive diseaseOFFSIDES
358PeritonitisOFFSIDES
359Phlebitis12801060CTD
360PiloerectionSIDER
361Polyomavirus-associated nephropathyOFFSIDES
362Portal HypertensionOFFSIDES
363Post inflammatory pigmentation changeOFFSIDES
364ProctocolitisSIDER
365Prothrombin level decreasedOFFSIDES
366Pulmonary thrombosisOFFSIDES
367QuadriparesisOFFSIDES
368Rebound effectOFFSIDES
369Rectal examination abnormalOFFSIDES
370Retroperitoneal abscessOFFSIDES
371RhabdomyolysisOFFSIDES
372Rhabdomyosarcoma8504425CTD
373RhinitisSIDER
374Skin toxicityOFFSIDES
375Small cell lung cancer extensive stageOFFSIDES
376Splenic vein thrombosisOFFSIDES
377Splenomegaly19401694CTD
378Stomach Neoplasms15723263
15930889
17679458		CTD
379Subacute endocarditisOFFSIDES
380Sudden Cardiac DeathOFFSIDES
381Sudden deathSIDER
382Supraventricular tachycardiaCanada Vigilance: 1Canada Vigilance
383SweatingSIDER
384Therapeutic product effect decreasedCanada Vigilance: 1Canada Vigilance
385Therapy non-responderOFFSIDES
386ThrombophlebitisSIDER
387TroponinOFFSIDES
388UlcerSIDER
389Unresponsive to pain stimuliOFFSIDES
390Vasodilation procedureSIDER
391VasodilationSIDER
392Visual disturbanceSIDER
393White blood cell count abnormalOFFSIDES
394Wound abscessOFFSIDES
395jaundiceSIDER
396nervous system disorderSIDER
397oligodendroglioma18480965CTD
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