MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Atropine

(RKUNBYITZUJHSG-PJPHBNEVSA-N)

Structure

SMILES: OCC(c1ccccc1)C(=O)OC1C[C@@H]2CC[C@H](C1)N2C
Type(s): Approved; Vet_approved
ATC code(s): A03BA01; A03CB03; S01FA01
Molecular Formula:: C17H23NO3
Molecular Weight:: 289.369
Log P:: 1.8688
Hydrogen Bond Acceptor:: 4
Hydrogen Bond Donor:: 1
TPSA:: 49.77
CAS Number(s):: 51-55-8; 5908-99-6

Synonym(s)

Atropine

AtroPen

Atropin Augenöl

Atropine Sulfate

Atropine Sulfate Anhydrous

Atropinol

Anhydrous, Atropine Sulfate

Augenöl, Atropin

Sulfate Anhydrous, Atropine

10.

Sulfate, Atropine

External Link(s)

MeSH	D001285
PubChem Compound	174174
BindingDB	200229 50403547
ChEBI	78734 16684
CHEMBL	CHEMBL517712 CHEMBL475124
DrugBank	DB00572
DrugCentral	260
IUPHAR/BPS Guide to PHARMACOLOGY	320
KEGG	cpd:C01479 dr:D00113
Therapeutic Target Database	D0RD5W D0RG3O

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Flushing	FAERS: 7 Canada Vigilance: 8	1867419	CTD SIDER Canada Vigilance US FAERS
2	Toxicity to various agents	FAERS: 6		US FAERS
3	Anticholinergic Syndrome	FAERS: 4		OFFSIDES US FAERS
4	Drug ineffective	FAERS: 4 Canada Vigilance: 1		Canada Vigilance US FAERS
5	Mental status changes	FAERS: 4		OFFSIDES US FAERS
6	Agitation	FAERS: 3		SIDER US FAERS
7	Suicide attempt	FAERS: 3		US FAERS
8	Tachycardia	FAERS: 3 Canada Vigilance: 3	View details 278459 2570522 3720002 3775101 3996883 6696128 6831652 6849777 7472763 11668046 11740913 15670093 18719317 18831911	CTD SIDER Canada Vigilance US FAERS
9	Urinary Retention	FAERS: 3		SIDER US FAERS
10	Accidental exposure	FAERS: 2		US FAERS
11	Delirium	FAERS: 2	5102638	CTD SIDER US FAERS
12	Drug abuse	FAERS: 2		US FAERS
13	Drug administration error	FAERS: 2		US FAERS
14	Dysuria	FAERS: 2		SIDER US FAERS
15	Incorrect route of drug administration	FAERS: 2		US FAERS
16	Intentional drug misuse	FAERS: 2		US FAERS
17	Medication Error	FAERS: 2		US FAERS
18	Mydriasis	FAERS: 2	View details 2620933 11878186 14620526 16104118 22247005	CTD SIDER US FAERS
19	Ocular Hypertension	FAERS: 2		OFFSIDES US FAERS
20	Sinus Tachycardia	FAERS: 2		SIDER US FAERS
21	Supraventricular tachyarrhythmia	FAERS: 2		US FAERS
22	Syncope	FAERS: 2	7056119	CTD SIDER US FAERS
23	Urinary hesitation	FAERS: 2		SIDER US FAERS
24	Accidental overdose	FAERS: 1		OFFSIDES US FAERS
25	Angle Closure Glaucoma	FAERS: 1		OFFSIDES SIDER US FAERS
26	Asthenia	FAERS: 1		OFFSIDES SIDER US FAERS
27	Atrial Fibrillation	FAERS: 1	View details 9489317 11282081 17073912 18980425	CTD SIDER US FAERS
28	Bedridden	FAERS: 1		US FAERS
29	Cardiac Arrest	FAERS: 1		SIDER US FAERS
30	Compulsive lip biting	FAERS: 1		US FAERS
31	Constipation	FAERS: 1		SIDER US FAERS
32	Device defective	FAERS: 1		US FAERS
33	Device use issue	FAERS: 1		US FAERS
34	Discomfort	FAERS: 1		US FAERS
35	Disorientation	FAERS: 1		SIDER US FAERS
36	Dizziness	FAERS: 1		OFFSIDES SIDER US FAERS
37	Drug dispensing error	FAERS: 1		US FAERS
38	Drug level increased	FAERS: 1		US FAERS
39	Eczema	FAERS: 1		SIDER US FAERS
40	Eye inflammation	FAERS: 1		US FAERS
41	Headache	FAERS: 1	5354796 6928283	CTD SIDER US FAERS
42	Hypersensitivity	FAERS: 1 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
43	Hypophagia	FAERS: 1		OFFSIDES US FAERS
44	Hypotension	FAERS: 1 Canada Vigilance: 2	View details 538435 1352931 2122504 2168244 3720002 4186181 6510843 7864443 7915249 9180623 9489317 10190394 10713875 11740913 16803915 16984954 17351238 17628422 18282259 20533121	CTD SIDER Canada Vigilance US FAERS
45	Idiosyncratic drug reaction	FAERS: 1		US FAERS
46	Incoherent	FAERS: 1		US FAERS
47	Incorrect dose administered	FAERS: 1		US FAERS
48	Injection site pain	FAERS: 1		US FAERS
49	Intentional self-injury	FAERS: 1		US FAERS
50	Intercepted wrong patient selected	FAERS: 1		US FAERS
51	Overdose	FAERS: 1		OFFSIDES US FAERS
52	Pneumonia	FAERS: 1		US FAERS
53	Respiratory arrest	FAERS: 1		US FAERS
54	Restlessness	FAERS: 1		US FAERS
55	Rhabdomyolysis	FAERS: 1		OFFSIDES US FAERS
56	Somnolence	FAERS: 1 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
57	Syringe issue	FAERS: 1		US FAERS
58	Urinary tract infection	FAERS: 1		US FAERS
59	Visual disturbance	FAERS: 1		US FAERS
60	Wrong drug administered	FAERS: 1		US FAERS
61	Abdominal Pain			OFFSIDES SIDER
62	Abdominal adhesions			OFFSIDES
63	Abdominal cavity drainage			OFFSIDES
64	Abdominal discomfort	Canada Vigilance: 1		Canada Vigilance OFFSIDES
65	Acid reflux			OFFSIDES
66	Acidosis			OFFSIDES
67	Acquired diaphragmatic eventration			OFFSIDES
68	Actinomycosis			OFFSIDES
69	Activities of daily living impaired			OFFSIDES
70	Acute Coronary Syndrome			OFFSIDES SIDER
71	Acute angle-closure glaucoma			SIDER
72	Acute myocardial infarction			OFFSIDES
73	Acute prerenal failure			OFFSIDES
74	Acute respiratory failure			OFFSIDES
75	Ageusia			SIDER
76	Airway Obstruction		18651722	CTD
77	Alveolitis			OFFSIDES
78	Ammonia increased			OFFSIDES
79	Amnesia, Transient Global		17698416	CTD
80	Amnesia		16174677	CTD OFFSIDES SIDER
81	Anaphylactic shock			SIDER
82	Angina Pectoris		6305298	CTD SIDER
83	Angioedema			OFFSIDES SIDER
84	Angiomyolipoma			OFFSIDES
85	Anhidrosis			SIDER
86	Anorexia		1363306	CTD OFFSIDES
87	Anoxic Encephalopathy			OFFSIDES
88	Anxiety			OFFSIDES SIDER
89	Apnea		View details 20912 1855619 4326672 16953949	CTD OFFSIDES
90	Ascites			OFFSIDES
91	Aspergillosis			OFFSIDES
92	Aspiration Pneumonia			OFFSIDES
93	Ataxia	Canada Vigilance: 1		Canada Vigilance SIDER
94	Atelectasis			OFFSIDES
95	Atrial Flutter			OFFSIDES
96	Atrial arrhythmia			SIDER
97	Atrial bigeminy			OFFSIDES
98	Atrial tachycardia	Canada Vigilance: 2		Canada Vigilance OFFSIDES
99	Atrioventricular Block		View details 2778956 3510989 17711430 18282259 19008069	CTD OFFSIDES
100	Aura			OFFSIDES
101	Bile Duct Stenosis			OFFSIDES
102	Biliary Dyskinesia			OFFSIDES
103	Bladder spasm			OFFSIDES
104	Bladder trabeculation			OFFSIDES
105	Blepharitis			SIDER
106	Blepharoconjunctivitis			SIDER
107	Blepharoptosis			OFFSIDES
108	Blindness			SIDER
109	Bloated feeling			SIDER
110	Blood Glucose			OFFSIDES
111	Blood albumin decreased			OFFSIDES
112	Blood creatinine increased			OFFSIDES
113	Blood potassium decreased			OFFSIDES
114	Blood potassium increased			OFFSIDES
115	Blood sodium increased			OFFSIDES
116	Blood testosterone decreased			OFFSIDES
117	Blood urea increased			SIDER
118	Bone lesion			OFFSIDES
119	Borderline Personality Disorder			OFFSIDES
120	Bradycardia	Canada Vigilance: 1	View details 278459 937392 1413473 1684074 1867419 2122504 2213551 3234460 3263874 3301078 3341694 3414927 3525850 3537354 3675083 3749546 6123873 6230022 6251761 6466532 6510469 6762901 6831652 7803758 8302145 8489673 8534470 8958495 10713875 10756546 10995163 11089775 11149715 11181912 11320466 11740913 15762916 15795184 16803915 16953949 18282259 19008069 19675280 19834416 20533121	CTD OFFSIDES SIDER Canada Vigilance
121	Brain Death			OFFSIDES
122	Bronchial Diseases		9851584	CTD
123	Bronchitis			OFFSIDES
124	Bruxism			OFFSIDES
125	Cardiac enzymes increased			OFFSIDES
126	Carotid artery aneurysm			OFFSIDES
127	Catalepsy		View details 10058 40649 403561 987911 1033567 1172421 1239323 3925479 4279348 6540616 6891961 10958255 11900788 12907310 16047547	CTD
128	Cataplexy		8008205	CTD
129	Cataract operation			OFFSIDES
130	Cellulitis			OFFSIDES
131	Cerebral atrophy			OFFSIDES
132	Cerebral hypoperfusion			OFFSIDES
133	Cerebrovascular Disorders		15009014	CTD
134	Chemical and Drug Induced Liver Injury		22331495	CTD
135	Chest Pain		8892787 17262096	CTD OFFSIDES SIDER
136	Choking sensation			OFFSIDES
137	Chronic Obstructive Airway Disease			OFFSIDES
138	Chronic respiratory failure			OFFSIDES
139	Clonus			SIDER
140	Clumsiness			OFFSIDES SIDER
141	Cocaine-Related Disorders		20393457	CTD
142	Compression fracture			OFFSIDES
143	Confabulation			OFFSIDES
144	Congenital tricuspid valve incompetence			OFFSIDES
145	Conjunctivitis	Canada Vigilance: 3		Canada Vigilance SIDER
146	Corneal Ulcer			OFFSIDES
147	Coronary artery perforation			OFFSIDES
148	Craniocerebral Trauma		20816720	CTD
149	Cubital Tunnel Syndrome			OFFSIDES
150	Cyanosis	Canada Vigilance: 2		Canada Vigilance OFFSIDES SIDER
151	Cyclophoria			SIDER
152	Cycloplegia			SIDER
153	Dehydration			OFFSIDES SIDER
154	Delayed gastric emptying			SIDER
155	Demyelination			OFFSIDES
156	Dental Fistula			OFFSIDES
157	Dependent Personality Disorder			OFFSIDES
158	Depressed Level of Consciousness			OFFSIDES SIDER
159	Dermatitis	Canada Vigilance: 1		Canada Vigilance SIDER
160	Diabetes			OFFSIDES
161	Diabetes mellitus inadequate control			OFFSIDES
162	Diarrhea		10867622	CTD OFFSIDES
163	Disease complication			OFFSIDES
164	Diverticulum			OFFSIDES
165	Drooling	Canada Vigilance: 1		Canada Vigilance
166	Drowsiness			OFFSIDES SIDER
167	Drug Overdose		9711203 9928640	CTD
168	Drug administered at inappropriate site			OFFSIDES
169	Drug toxicity			OFFSIDES
170	Drug withdrawal headache			OFFSIDES
171	Dry skin			SIDER
172	Duodenal Ulcer		11595415	CTD
173	Dysarthria			SIDER
174	Dysgeusia			SIDER
175	Dyspepsia			SIDER
176	Economic problem			OFFSIDES
177	Electrocardiogram QRS complex			SIDER
178	Electromechanical dissociation			OFFSIDES
179	Emotional distress			OFFSIDES
180	Endophthalmitis			OFFSIDES
181	Enterocolitis			OFFSIDES
182	Enuresis			SIDER
183	Epilepsy		4058572	CTD
184	Erectile dysfunction		10098948	CTD SIDER
185	Erythema	Canada Vigilance: 6		Canada Vigilance SIDER
186	Escherichia infection			OFFSIDES
187	Expired drug administered			OFFSIDES
188	Extremity necrosis			OFFSIDES
189	Eye pain			SIDER
190	Facial Neuralgia			OFFSIDES
191	Failure to Thrive			OFFSIDES
192	Fatigue	Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER
193	Feeling Cold	Canada Vigilance: 1		Canada Vigilance
194	Feeling abnormal			SIDER
195	Fever		18719317 26205086	CTD
196	Flank Pain			OFFSIDES
197	Flatulence			OFFSIDES
198	Fluid overload			OFFSIDES
199	Follicular conjunctivitis			SIDER
200	Food craving			OFFSIDES
201	Gangrene			OFFSIDES
202	Gastric Bypass			OFFSIDES
203	Gastroenteritis			OFFSIDES
204	Gastrointestinal Diseases		18467537	CTD
205	Gastrointestinal Pain			SIDER
206	Gastrointestinal sounds abnormal			SIDER
207	General physical condition			OFFSIDES
208	General physical health deterioration			OFFSIDES
209	Globulinuria			OFFSIDES
210	Glossectomy			OFFSIDES
211	Granulocytosis			OFFSIDES
212	Hallucinations, mixed			OFFSIDES
213	Hallucinations		707647	CTD
214	Hay fever			OFFSIDES
215	Heart Block		11149715 16506357 26831068	CTD
216	Heart Rupture, Post-Infarction		10668020	CTD
217	Heart sounds abnormal			OFFSIDES
218	Heartburn			SIDER
219	Hemiparesis			OFFSIDES
220	Heparin-induced thrombocytopenia			OFFSIDES
221	Hot dry skin			SIDER
222	Hydrocephalus			OFFSIDES
223	Hypercapnia			OFFSIDES
224	Hyperemia		12468513 15009014	CTD
225	Hyperglycemia		22305719	CTD
226	Hyperkinesia			SIDER
227	Hyperpyrexia			SIDER
228	Hyperreflexia			SIDER
229	Hypohidrosis			SIDER
230	Hypokalemia		3168573	CTD
231	Hypoxia			OFFSIDES
232	Ileus	Canada Vigilance: 1		Canada Vigilance
233	Impaired gastric emptying			SIDER
234	Incontinence			OFFSIDES
235	Increased bronchial secretion			OFFSIDES
236	Increased upper airway secretion			OFFSIDES
237	Inflammation	Canada Vigilance: 2	22245128	CTD Canada Vigilance
238	Infusion site mobility decreased			OFFSIDES
239	Injection Site Reaction			SIDER
240	Intestinal Diseases		16944022	CTD
241	Intestinal Obstruction	Canada Vigilance: 1		Canada Vigilance
242	Intoxication			SIDER
243	Intra-aortic balloon placement			OFFSIDES
244	Intraocular inflammation			OFFSIDES
245	Joint prosthesis user			OFFSIDES
246	Keratitis			SIDER
247	Keratoconjunctivitis Sicca			SIDER
248	Kidney Failure			OFFSIDES
249	Labile blood pressure			SIDER
250	Labored breathing			SIDER
251	Laceration			OFFSIDES
252	Lacrimation decreased			SIDER
253	Laryngitis			SIDER
254	Laryngospasm			SIDER
255	Lethargy			OFFSIDES SIDER
256	Leukocytosis			SIDER
257	Leukoencephalopathy			OFFSIDES
258	Long QT Syndrome		17666066	CTD
259	Loose tooth			OFFSIDES
260	Lymphocyte stimulation test positive			OFFSIDES
261	Malignant neoplasm progression			OFFSIDES
262	Mechanical ventilation			OFFSIDES
263	Mental impairment			OFFSIDES
264	Metabolic acidosis			OFFSIDES
265	Morbid thoughts			OFFSIDES
266	Multiple drug overdose intentional			OFFSIDES
267	Muscle Rigidity		4124577 9017254	CTD
268	Muscle Weakness		3738227	CTD OFFSIDES
269	Muscle necrosis			OFFSIDES
270	Musculoskeletal Diseases		6724209	CTD
271	Musculoskeletal Pain			OFFSIDES
272	Myasthenia Gravis		4739612	CTD
273	Myocardial Infarction		11765483	CTD SIDER
274	Myocardial Ischemia		9691421 15220898 15670093	CTD
275	Myoclonus		526383 1620139 7078834	CTD
276	Myopia		12601066	CTD SIDER
277	Nasopharyngitis			OFFSIDES
278	Nausea		6711256	CTD OFFSIDES SIDER
279	Necrosis		6724209	CTD
280	Nerve Degeneration		28916328	CTD
281	Nervousness			SIDER
282	Neuralgia			OFFSIDES
283	Neuroblastoma recurrent			OFFSIDES
284	Neurogenic Bowel			OFFSIDES
285	Neuroleptic Malignant Syndrome			OFFSIDES
286	Neurotoxicity Syndromes		16536121	CTD
287	Neutrophil count decreased			OFFSIDES
288	Oliguria			OFFSIDES
289	Oral lesion			SIDER
290	Organophosphate poisoning		View details 1276991 1664807 1949606 3738227 3761745 20581384 22975155 22981459 23123253 26205086 26325216 27129421 29127032 29128314 29129798 30005893 30218682 30682440	CTD
291	Ovarian Hyperstimulation Syndrome			OFFSIDES
292	PCO2 increased			OFFSIDES
293	Pain			OFFSIDES SIDER
294	Palpitations			SIDER
295	Pancreatic Duct Stenosis			OFFSIDES
296	Pancreatitis			OFFSIDES
297	Paranoia			SIDER
298	Paraplegia			OFFSIDES
299	Peptic Ulcer		7034155	CTD
300	Pericardial effusion			OFFSIDES
301	Personality Change			OFFSIDES
302	Personality Disorders		145765	CTD
303	Petechiae			SIDER
304	Photophobia			SIDER
305	Poisoning		View details 5644266 11730559 12046725 16778709 17849254 18072136 18547553 20138854 20156430 20167212 20230808 20433814 20599844 21771644 29183815 30176331	CTD SIDER
306	Portal Vein Thrombosis			OFFSIDES
307	Post procedural complication			OFFSIDES
308	Postoperative Complications		5102638	CTD
309	Postoperative Nausea and Vomiting		58198	CTD
310	Pouchitis			OFFSIDES
311	Prenatal Exposure Delayed Effects		3988167	CTD
312	Priapism			OFFSIDES
313	Primary sequestrum			OFFSIDES
314	Procedural complication			OFFSIDES
315	Procedural hypotension			OFFSIDES
316	Pruritus	Canada Vigilance: 2		Canada Vigilance SIDER
317	Pulmonary Edema		19675280	CTD
318	Pulmonary Hypertension			OFFSIDES
319	Pulmonary congestion			OFFSIDES
320	Pulmonary function test decreased			SIDER
321	Pulse irregular			SIDER
322	Pyogenic granuloma			OFFSIDES
323	Rash erythematous	Canada Vigilance: 2		Canada Vigilance SIDER
324	Reflex, Abnormal		11920928	CTD
325	Renal tubular necrosis			OFFSIDES
326	Respiration Disorders		3738227	CTD
327	Respiratory Depression			SIDER
328	Respiratory Failure			OFFSIDES SIDER
329	Respiratory Insufficiency		3422794	CTD
330	Retrosternal pain			SIDER
331	Scab			SIDER
332	Secretion discharge			OFFSIDES
333	Seizures		View details 65671 444350 1172421 1933276 6301005 8028781 8224101 8434764 11074189 11218047 12660363 14975695 15036754 15919102 16962289 17157343 18719317 21097996 21600273 22245128 22796677 27287416 28693885 28916328 30218682	CTD
334	Septic Shock			OFFSIDES
335	Sequestrectomy			OFFSIDES
336	Shock			SIDER
337	Shoulder Pain			OFFSIDES
338	Sick Sinus Syndrome			OFFSIDES
339	Sinus Arrest, Cardiac		8534470 16167799	CTD
340	Sinus bradycardia			OFFSIDES
341	Sinus headache			OFFSIDES
342	Skin reaction	Canada Vigilance: 1		Canada Vigilance
343	Slurred speech			SIDER
344	Sphincter of Oddi Dysfunction			OFFSIDES
345	Splenic cyst			OFFSIDES
346	Stasis dermatitis			OFFSIDES
347	Status Epilepticus		View details 3582562 3612132 3948956 8817469 19111886 20498005 22245128 24785379 25689173	CTD OFFSIDES
348	Strabismus			SIDER
349	Stress			OFFSIDES
350	Stridor			SIDER
351	Stupor		22245128	CTD SIDER
352	Substance Withdrawal Syndrome		8829152	CTD
353	Supraventricular tachycardia			SIDER
354	Suture rupture			OFFSIDES
355	Sweating			SIDER
356	Swelling			SIDER
357	Synovial Cyst			OFFSIDES
358	Tachycardia, Atrioventricular Nodal Reentry		11752915	CTD
359	Tachycardia, Ventricular		10190394	CTD
360	Temperature intolerance			SIDER
361	Tendinitis			OFFSIDES
362	Tenosynovitis			OFFSIDES
363	Tension			SIDER
364	Therapy cessation			OFFSIDES
365	Thirst			SIDER
366	Tooth Extraction			OFFSIDES
367	Tooth Infection			OFFSIDES
368	Tooth Loss			OFFSIDES
369	Torsades de Pointes		7056119 9505930	CTD
370	Transaminases increased			OFFSIDES
371	Tremor		View details 2354039 2984330 6791238 8205054 9231353 10683491 11981227 15990178 17594079	CTD
372	Troponin increased			OFFSIDES
373	Unresponsive to stimuli			OFFSIDES
374	Urinary tract infection fungal			OFFSIDES
375	Urination Disorders		6711256	CTD
376	Urine ketone body present			OFFSIDES
377	Urine output increased			OFFSIDES
378	Urticaria			SIDER
379	Uveomeningoencephalitic Syndrome		20177954	CTD
380	Ventricular Fibrillation		View details 4044492 8892787 9691421 18594552	CTD OFFSIDES SIDER
381	Ventricular Flutter			SIDER
382	Ventricular arrhythmia	Canada Vigilance: 1		Canada Vigilance SIDER
383	Ventricular hypokinesia			OFFSIDES
384	Vertigo			SIDER
385	Vision Disorders		22247005	CTD
386	Vomiting	Canada Vigilance: 1	6711256	CTD SIDER Canada Vigilance
387	Weight Gain			OFFSIDES
388	Wheelchair user			OFFSIDES
389	Xerostomia		16104118	CTD

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