MetaADEDB 2.0 @ LMMD
Chlorambucil
(JCKYGMPEJWAADB-UHFFFAOYSA-N)
Structure
SMILES
ClCCN(c1ccc(cc1)CCCC(=O)O)CCCl
Type(s)
Approved
ATC code(s)
L01AA02
Molecular Formula:
C14H19Cl2NO2
Molecular Weight:
304.212
Log P:
3.3779
Hydrogen Bond Acceptor:
3
Hydrogen Bond Donor:
1
TPSA:
40.54
CAS Number(s):
305-03-3
Synonym(s)
1.
Chlorambucil
2.
4-(Bis(2-chloroethyl)amino)benzenebutanoic Acid
3.
Amboclorin
4.
CB-1348
5.
Chloraminophene
6.
Chlorbutin
7.
Leukeran
8.
Lympholysin
9.
N,N-Di-(2-chloroethyl)-p-aminophenylbutyric Acid
10.
NSC-3088
11.
CB 1348
12.
CB1348
13.
NSC 3088
14.
NSC3088
External Link(s)
MeSHD002699
PubChem Compound2708
BindingDB50003677
ChEBI28830
CHEMBLCHEMBL515
DrugBankDB00291
DrugCentral588
IUPHAR/BPS Guide to PHARMACOLOGY7143
KEGGcpd:C06900
dr:D00266
Therapeutic Target DatabaseD0V8QT
ZINC1115
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1PneumoniaFAERS: 20
Canada Vigilance: 2		Canada Vigilance
SIDER
US FAERS
2NeutropeniaFAERS: 14
Canada Vigilance: 3		2797556CTD
SIDER
Canada Vigilance
US FAERS
3Febrile NeutropeniaFAERS: 12SIDER
US FAERS
4EmpyemaFAERS: 11US FAERS
5GastroenteritisFAERS: 11US FAERS
6Incorrect product storageFAERS: 11US FAERS
7Neutropenic sepsisFAERS: 11OFFSIDES
US FAERS
8SepsisFAERS: 9US FAERS
9Drug administration errorFAERS: 8US FAERS
10Product storage errorFAERS: 8US FAERS
11Urinary tract infectionFAERS: 8US FAERS
12ThrombocytopeniaFAERS: 7SIDER
US FAERS
13NauseaFAERS: 6SIDER
US FAERS
14BronchopneumoniaFAERS: 5OFFSIDES
US FAERS
15Drug ineffectiveFAERS: 5US FAERS
16PancytopeniaFAERS: 57753270
15656036		CTD
SIDER
US FAERS
17White blood cell count decreasedFAERS: 5US FAERS
18Back PainFAERS: 4US FAERS
19Chest PainFAERS: 4US FAERS
20Febrile infectionFAERS: 4US FAERS
21General physical health deteriorationFAERS: 4OFFSIDES
US FAERS
22LeukopeniaFAERS: 41206673CTD
SIDER
US FAERS
23Medication ErrorFAERS: 4US FAERS
24Therapy cessationFAERS: 4US FAERS
25AnorexiaFAERS: 3SIDER
US FAERS
26Basal cell carcinomaFAERS: 3
Canada Vigilance: 3		Canada Vigilance
US FAERS
27Disease ProgressionFAERS: 3US FAERS
28DizzinessFAERS: 3US FAERS
29ErysipelasFAERS: 3US FAERS
30FatigueFAERS: 3SIDER
US FAERS
31HypotensionFAERS: 3US FAERS
32MYELODYSPLASTIC SYNDROMEFAERS: 3SIDER
US FAERS
33MalaiseFAERS: 3US FAERS
34Pneumococcal sepsisFAERS: 3US FAERS
35PruritusFAERS: 3SIDER
US FAERS
36Respiratory FailureFAERS: 3US FAERS
37Septic ShockFAERS: 3US FAERS
38VomitingFAERS: 3SIDER
US FAERS
39Weight decreasedFAERS: 3US FAERS
40Accidental overdoseFAERS: 2US FAERS
41Acute myocardial infarctionFAERS: 2US FAERS
42Anal abscessFAERS: 2US FAERS
43AstheniaFAERS: 2SIDER
US FAERS
44CholestasisFAERS: 211319447CTD
US FAERS
45DementiaFAERS: 2US FAERS
46Drug dose omissionFAERS: 2US FAERS
47Electrocardiogram abnormalFAERS: 2US FAERS
48ErythemaFAERS: 2US FAERS
49Feeling abnormalFAERS: 2SIDER
US FAERS
50InfectionFAERS: 2OFFSIDES
SIDER
US FAERS
51InflammationFAERS: 2US FAERS
52Lower respiratory tract infectionFAERS: 2US FAERS
53Oropharyngeal painFAERS: 2US FAERS
54Otitis MediaFAERS: 2US FAERS
55PharyngitisFAERS: 2US FAERS
56Squamous cell carcinomaFAERS: 2US FAERS
57Transaminases increasedFAERS: 2US FAERS
58jaundiceFAERS: 2SIDER
US FAERS
59Acute Coronary SyndromeFAERS: 1US FAERS
60Adverse eventFAERS: 1US FAERS
61AgranulocytosisFAERS: 1US FAERS
62AphasiaFAERS: 1US FAERS
63Apparent deathFAERS: 1US FAERS
64Aspartate Aminotransferase IncreasedFAERS: 1US FAERS
65AsthmaFAERS: 1US FAERS
66Autoimmune neutropeniaFAERS: 1OFFSIDES
US FAERS
67Body temperature fluctuationFAERS: 1US FAERS
68Bone marrow depressionFAERS: 1US FAERS
69Burning sensationFAERS: 1US FAERS
70Central nervous system lesionFAERS: 1US FAERS
71ChillsFAERS: 1US FAERS
72ChromaturiaFAERS: 1US FAERS
73Clostridium difficile colitisFAERS: 1US FAERS
74Diabetes MellitusFAERS: 1US FAERS
75Diffuse Large B-Cell LymphomaFAERS: 1OFFSIDES
US FAERS
76DiscomfortFAERS: 1US FAERS
77Disease recurrenceFAERS: 1US FAERS
78Drug dispensing errorFAERS: 1US FAERS
79Drug toxicityFAERS: 1US FAERS
80DysarthriaFAERS: 1US FAERS
81DystoniaFAERS: 1US FAERS
82Endometrial adenocarcinomaFAERS: 1US FAERS
83Flank PainFAERS: 1US FAERS
84FolliculitisFAERS: 1US FAERS
85General physical condition abnormalFAERS: 1US FAERS
86HeadacheFAERS: 1US FAERS
87HepatitisFAERS: 1US FAERS
88HepatotoxicityFAERS: 1SIDER
US FAERS
89Hospice CareFAERS: 1US FAERS
90HypersensitivityFAERS: 1SIDER
US FAERS
91Iatrogenic injuryFAERS: 1US FAERS
92ImmunosuppressionFAERS: 1US FAERS
93LeukoencephalopathyFAERS: 1OFFSIDES
US FAERS
94Lip swellingFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
95Lung consolidationFAERS: 1US FAERS
96LymphadenopathyFAERS: 1SIDER
US FAERS
97LymphomaFAERS: 110745627CTD
US FAERS
98Medication residueFAERS: 1US FAERS
99Memory impairmentFAERS: 1US FAERS
100MetastasisFAERS: 1US FAERS
101Monocyte count decreasedFAERS: 1US FAERS
102Myocardial InfarctionFAERS: 1US FAERS
103MyoclonusFAERS: 17410114
9034417
12755202		CTD
US FAERS
104NervousnessFAERS: 1US FAERS
105No adverse eventFAERS: 1US FAERS
106NoduleFAERS: 1US FAERS
107OliguriaFAERS: 1US FAERS
108Peripheral swellingFAERS: 1US FAERS
109Pharmaceutical product complaintFAERS: 1US FAERS
110PhlebitisFAERS: 1US FAERS
111Product dispensing errorFAERS: 1US FAERS
112Product quality issueFAERS: 1US FAERS
113Prostatic AdenomaFAERS: 1US FAERS
114PyelonephritisFAERS: 1US FAERS
115Radiation skin injuryFAERS: 1US FAERS
116Renal artery stent placementFAERS: 1US FAERS
117Rheumatoid ArthritisFAERS: 1US FAERS
118Soft Tissue InfectionFAERS: 1US FAERS
119SoporFAERS: 1US FAERS
120Sudden deathFAERS: 1US FAERS
121T-Cell LymphomaFAERS: 1OFFSIDES
US FAERS
122Therapy changeFAERS: 1US FAERS
123TinnitusFAERS: 1US FAERS
124UrticariaFAERS: 1
Canada Vigilance: 2		Canada Vigilance
SIDER
US FAERS
125Visual ImpairmentFAERS: 1US FAERS
126Visual disturbanceFAERS: 1US FAERS
127WheezingFAERS: 1US FAERS
128Abdominal PainSIDER
129Abnormalities, Drug-Induced10378468CTD
130Acute bronchitisOFFSIDES
131Acute kidney injury19122478CTD
132Acute overdoseSIDER
133Adenocarcinoma7753270CTD
134AgitationSIDER
135AgraphiaOFFSIDES
136AlopeciaSIDER
137Amenorrhea4700007CTD
138Anemia, Hemolytic2816917CTD
139Anemia, Megaloblastic15656036CTD
140Aneuploidy22025197CTD
141AngioedemaSIDER
142AnhidrosisOFFSIDES
143ApoptosisOFFSIDES
144ArteriosclerosisOFFSIDES
145AtaxiaSIDER
146AuraOFFSIDES
147Autoimmune thrombocytopeniaOFFSIDES
148Behcet Syndrome4796513
9173749		CTD
149Bladder NeoplasmOFFSIDES
150Bladder painSIDER
151BlepharospasmOFFSIDES
152Blood brain barrier defectOFFSIDES
153Blurred visionOFFSIDES
154Bone Marrow Diseases3868382CTD
155Bradycardia7410114CTD
156Bronchial Neoplasms7753270CTD
157BronchitisOFFSIDES
158Carcinoma, Transitional Cell1949449CTD
159Carcinoma7377464CTD
160CataractOFFSIDES
161Cell marker increasedOFFSIDES
162Cerebral calcificationOFFSIDES
163Chemical and Drug Induced Liver Injury11319447CTD
164CholangiolitisOFFSIDES
165Circumstance or information capable of leading to medication errorOFFSIDES
166Citrobacter sepsisOFFSIDES
167ConfabulationOFFSIDES
168Cutaneous hypersensitivitySIDER
169Cystitis7377464CTD
SIDER
170DemyelinationOFFSIDES
171DiabetesOFFSIDES
172Drug Eruptions19122478CTD
173Drug exposure during pregnancyOFFSIDES
174DyspepsiaSIDER
175Dyspnoea exacerbatedOFFSIDES
176Embolic strokeOFFSIDES
177EncephalitisOFFSIDES
178Eosinophilia19122478CTD
179Epilepsies, Partial118440CTD
180Erythema InfectiosumOFFSIDES
181Erythema MultiformeSIDER
182Exanthema19122478CTD
183Fetal Diseases10378468CTD
184Fever19122478CTD
185GangreneOFFSIDES
186Gastric DilatationOFFSIDES
187Gastrointestinal PainSIDER
188GiardiasisOFFSIDES
189Hallucinations6480330CTD
190Hematologic Neoplasms2265409CTD
191Hematuria1138180
7377464		CTD
192HemiplegiaOFFSIDES
193InfertilitySIDER
194Infusion site mobility decreasedOFFSIDES
195Intestinal Diseases3868382CTD
196JC virus infectionOFFSIDES
197Kidney Diseases3868382CTD
198Liver Failure, Acute10922320CTD
199Liver neoplasms3465877CTD
200Low set earsOFFSIDES
201Lower respiratory tract infection viralOFFSIDES
202Lung Neoplasms2265409CTD
203Lupus Erythematosus, Systemic4700007CTD
204Lupus Nephritis4700007
6508447		CTD
205Lymphatic Diseases3868382CTD
206Lymphoma, Non-Hodgkin

View details

2217048
8435605
12512972
16958652
 		CTD
207LymphopeniaSIDER
208Meningoencephalitis9173749CTD
209Metastatic NeoplasmSIDER
210Micronuclei, Chromosome-Defective22025197
22923490		CTD
211Molluscum ContagiosumOFFSIDES
212Mood disorder due to a general medical conditionOFFSIDES
213Muscle WeaknessOFFSIDES
214MyelodysplasiaOFFSIDES
215Neoplasms, Experimental1449967CTD
216Nephritic syndromeOFFSIDES
217Nephrotic Syndrome

View details

690782
2242305
2465858
2797556
6508447
9513907
17211287
 		CTD
SIDER
218Neural Tube Defects10378468CTD
219NeuritisSIDER
220OculogyrationOFFSIDES
221Optic Atrophy8435605CTD
SIDER
222Oral infectionOFFSIDES
223Oral torusOFFSIDES
224OverdoseSIDER
225PainSIDER
226Pancreatic Diseases3868382CTD
227ParesisSIDER
228Peripheral Nervous System Diseases201333CTD
229Peripheral motor neuropathySIDER
230Pseudomonal sepsisOFFSIDES
231PubertySIDER
232Pulmonary FibrosisSIDER
233Rash erythematousCanada Vigilance: 1Canada Vigilance
234Relapsing FeverOFFSIDES
235Renal cystOFFSIDES
236Respiratory Insufficiency7410114CTD
237ReticulocytopeniaOFFSIDES
238Sarcoma, Experimental3698174
7107385		CTD
239Seizures690782CTD
240Serum SicknessOFFSIDES
241Skin necrosisOFFSIDES
242Status EpilepticusOFFSIDES
243Stevens-Johnson Syndrome25811541CTD
SIDER
244StomatitisSIDER
245Subacute endocarditisOFFSIDES
246Synovitis3970039CTD
247Testicular Diseases3868382CTD
248Toxic Epidermal NecrolysisSIDER
249TremorSIDER
250Vascular calcificationOFFSIDES
251Vision Disorders8435605CTD
252Vitamin B 12 Deficiency15656036CTD
253Waldenstrom Macroglobulinemia16432856CTD
254leukemia118440CTD
Powered by :

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120141

Copyright © 2019-2020 Laboratory of Molecular Modeling and Design, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology. All rights reserved.