MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Clomipramine

(GDLIGKIOYRNHDA-UHFFFAOYSA-N)

Structure

SMILES: CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C
Type(s): Approved; Investigational; Vet_approved
ATC code(s): N06AA04
Molecular Formula:: C19H23ClN2
Molecular Weight:: 314.852
Log P:: 4.5934
Hydrogen Bond Acceptor:: 1
Hydrogen Bond Donor:: 0
TPSA:: 6.48
CAS Number(s):: 303-49-1; 17321-77-6; 2241983-11-7

Synonym(s)

Clomipramine

Chlorimipramine

Anafranil

Chlomipramine

Clomipramine Hydrochloride

Clomipramine Maleate (1:1)

Clomipramine Monohydrochloride

Hydiphen

Hydrochloride, Clomipramine

10.

Monohydrochloride, Clomipramine

External Link(s)

MeSH	D002997
PubChem Compound	2801
BindingDB	77970 50021927
ChEBI	47780
CHEMBL	CHEMBL415
DrugBank	DB01242
DrugCentral	701
IUPHAR/BPS Guide to PHARMACOLOGY	2398
KEGG	cpd:C06918 dr:D00811 dr:D07727
Therapeutic Target Database	D0ZS8P
ZINC	20248

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Anxiety	FAERS: 9 Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER US FAERS
2	Malaise	FAERS: 7		SIDER US FAERS
3	Nausea	FAERS: 5 Canada Vigilance: 1	View details 1530086 7096611 11476129 19698552	CTD SIDER Canada Vigilance US FAERS
4	Agitation	FAERS: 4		SIDER US FAERS
5	Drug ineffective	FAERS: 4		US FAERS
6	Obsessive-Compulsive Disorder	FAERS: 4	View details 1154013 1527234 1552034 1757451 1919549 2607791 3276283 3458554 6805722 7091416 7694926 8071291 8151009 8562664 8835709 8923100 9004062 9316681 10327925 10505588 10770480 11147933 11551293 11551294 12432978 15253471	CTD US FAERS
7	Overdose	FAERS: 4		OFFSIDES US FAERS
8	Somnolence	FAERS: 4		SIDER US FAERS
9	Toxicity to various agents	FAERS: 4		SIDER US FAERS
10	Tremor	FAERS: 4 Canada Vigilance: 1	View details 1530086 6388247 7058100 8238650 8296581 8835709 9291715 11476129	CTD SIDER Canada Vigilance US FAERS
11	Vomiting	FAERS: 4	7096611 19698552	CTD SIDER US FAERS
12	Wrong drug administered	FAERS: 4		OFFSIDES US FAERS
13	Angioedema	FAERS: 3		OFFSIDES US FAERS
14	Atrial Fibrillation	FAERS: 3		US FAERS
15	Constipation	FAERS: 3	8835709	CTD SIDER US FAERS
16	Eye pain	FAERS: 3		OFFSIDES SIDER US FAERS
17	Feeling abnormal	FAERS: 3		SIDER US FAERS
18	Gastrointestinal carcinoma	FAERS: 3		US FAERS
19	Hypotension	FAERS: 3	11465569 17098328	CTD SIDER US FAERS
20	Neutropenic sepsis	FAERS: 3		US FAERS
21	Product substitution issue	FAERS: 3		US FAERS
22	Respiratory Failure	FAERS: 3		SIDER US FAERS
23	Acute kidney injury	FAERS: 2		US FAERS
24	Acute respiratory failure	FAERS: 2		US FAERS
25	Angle Closure Glaucoma	FAERS: 2		OFFSIDES SIDER US FAERS
26	Drug dispensing error	FAERS: 2		US FAERS
27	Drug withdrawal syndrome	FAERS: 2		SIDER US FAERS
28	Dysgeusia	FAERS: 2		SIDER US FAERS
29	Failure to Thrive	FAERS: 2		US FAERS
30	Foaming at mouth	FAERS: 2		US FAERS
31	Metrorrhagia	FAERS: 2		US FAERS
32	Mydriasis	FAERS: 2		SIDER US FAERS
33	Pancreatitis	FAERS: 2		US FAERS
34	Pneumonia	FAERS: 2		SIDER US FAERS
35	Sinus Tachycardia	FAERS: 2		SIDER US FAERS
36	Suicide attempt	FAERS: 2		SIDER US FAERS
37	Urinary Incontinence	FAERS: 2		SIDER US FAERS
38	Accidental exposure to product	FAERS: 1		US FAERS
39	Agoraphobia	FAERS: 1		US FAERS
40	Akathisia	FAERS: 1		SIDER US FAERS
41	Anger	FAERS: 1		US FAERS
42	Anorgasmia	FAERS: 1		US FAERS
43	Anosmia	FAERS: 1		US FAERS
44	Aphagia	FAERS: 1		US FAERS
45	Back Pain	FAERS: 1		SIDER US FAERS
46	Blindness	FAERS: 1		US FAERS
47	Blood creatine phosphokinase increased	FAERS: 1		OFFSIDES US FAERS
48	Cardiac dysfunction	FAERS: 1		US FAERS
49	Cataplexy	FAERS: 1	4359162 6976152	CTD OFFSIDES US FAERS
50	Cerebral disorder	FAERS: 1		US FAERS
51	Chest Pain	FAERS: 1		SIDER US FAERS
52	Chest discomfort	FAERS: 1		US FAERS
53	Chills	FAERS: 1		SIDER US FAERS
54	Chromaturia	FAERS: 1		US FAERS
55	Cold sweat	FAERS: 1		US FAERS
56	Crying	FAERS: 1		OFFSIDES US FAERS
57	Deafness	FAERS: 1		SIDER US FAERS
58	Depressed Level of Consciousness	FAERS: 1		OFFSIDES SIDER US FAERS
59	Dizziness	FAERS: 1	View details 6388247 8835709 9771062 10770480	CTD SIDER US FAERS
60	Drug ineffective for unapproved indication	FAERS: 1		US FAERS
61	Emotional distress	FAERS: 1		US FAERS
62	Erectile dysfunction	FAERS: 1	8835709	CTD OFFSIDES SIDER US FAERS
63	Exposure via breast milk	FAERS: 1		US FAERS
64	Fatigue	FAERS: 1	1919549 11476129	CTD SIDER US FAERS
65	Female sexual arousal disorder	FAERS: 1		US FAERS
66	Formication	FAERS: 1		US FAERS
67	Gastrointestinal sounds abnormal	FAERS: 1		US FAERS
68	Headache	FAERS: 1 Canada Vigilance: 1	7885518 9315999	CTD SIDER Canada Vigilance US FAERS
69	Hypercapnia	FAERS: 1		OFFSIDES US FAERS
70	Hypersensitivity myocarditis	FAERS: 1		US FAERS
71	Hypersensitivity	FAERS: 1		SIDER US FAERS
72	Hypersomnia	FAERS: 1		US FAERS
73	Illness anxiety disorder	FAERS: 1		US FAERS
74	Impatience	FAERS: 1		US FAERS
75	Incorrect dose administered	FAERS: 1		US FAERS
76	Incorrect route of drug administration	FAERS: 1		US FAERS
77	Infection	FAERS: 1		US FAERS
78	Intentional self-injury	FAERS: 1		OFFSIDES US FAERS
79	Kayser-Fleischer ring	FAERS: 1		US FAERS
80	Live Birth	FAERS: 1		US FAERS
81	Maternal exposure during pregnancy	FAERS: 1		US FAERS
82	Muscle Rigidity	FAERS: 1		US FAERS
83	Muscle tightness	FAERS: 1		US FAERS
84	Musculoskeletal discomfort	FAERS: 1		SIDER US FAERS
85	Myoglobin blood increased	FAERS: 1		OFFSIDES US FAERS
86	Nasal discomfort	FAERS: 1		US FAERS
87	Obsessive thoughts	FAERS: 1		US FAERS
88	Pain	FAERS: 1	12798668	CTD SIDER US FAERS
89	Palpitations	FAERS: 1		SIDER US FAERS
90	Periodontitis	FAERS: 1		US FAERS
91	Product availability issue	FAERS: 1		US FAERS
92	Product use in unapproved indication	FAERS: 1		US FAERS
93	Pruritus	FAERS: 1		SIDER US FAERS
94	Rectal discharge	FAERS: 1		US FAERS
95	Respiratory distress	FAERS: 1		US FAERS
96	Restless Legs Syndrome	FAERS: 1		US FAERS
97	Serotonin Syndrome	FAERS: 1	View details 1530086 8238650 8443525 8681579 9329236	CTD SIDER US FAERS
98	Soft tissue inflammation	FAERS: 1		US FAERS
99	Stupor	FAERS: 1	9315999	CTD SIDER US FAERS
100	Swelling	FAERS: 1		US FAERS
101	Therapy non-responder	FAERS: 1		US FAERS
102	Tinnitus	FAERS: 1	8835709	CTD SIDER US FAERS
103	Tonic clonic movements	FAERS: 1		US FAERS
104	Unevaluable event	FAERS: 1		OFFSIDES US FAERS
105	Urine copper increased	FAERS: 1		US FAERS
106	Weight decreased	FAERS: 1		SIDER US FAERS
107	Writer's Cramp	FAERS: 1		US FAERS
108	treatment failure	FAERS: 1		US FAERS
109	Abdominal Pain	Canada Vigilance: 1		Canada Vigilance SIDER
110	Abnormal vision			SIDER
111	Abnormalities, Drug-Induced		16406480	CTD
112	Abulia			OFFSIDES
113	Abuse			OFFSIDES
114	Acanthosis			OFFSIDES
115	Accidental overdose			OFFSIDES
116	Acidosis		7058100	CTD OFFSIDES
117	Acne			SIDER
118	Activation syndrome			OFFSIDES
119	Activities of daily living impaired			OFFSIDES
120	Acute Coronary Syndrome			SIDER
121	Adenitis			OFFSIDES
122	Ageusia			SIDER
123	Aggressive reaction			SIDER
124	Agranulocytosis			SIDER
125	Albuminuria			SIDER
126	Alcohol consumption			OFFSIDES
127	Alcoholic Intoxication			OFFSIDES
128	Alopecia			SIDER
129	Alveolitis			OFFSIDES
130	Ammonia increased			OFFSIDES
131	Anaphylactic shock			SIDER
132	Anaphylactoid Reaction			SIDER
133	Aneurysm			SIDER
134	Anorectal discomfort			OFFSIDES
135	Anorexia		9291715	CTD SIDER
136	Antibody test abnormal			OFFSIDES
137	Anticholinergic Syndrome			OFFSIDES SIDER
138	Antidepressant drug level increased			OFFSIDES
139	Antinuclear antibody increased			OFFSIDES
140	Antiphospholipid Syndrome			OFFSIDES
141	Antipsychotic drug level increased			OFFSIDES
142	Anuria		17891354	CTD OFFSIDES
143	Anxiety Disorders		2775959 7318761 20619828	CTD
144	Anxiety state			SIDER
145	Apathy			SIDER
146	Aphasia			SIDER
147	Aphonia		7096611	CTD
148	Apnea			OFFSIDES
149	Appendectomy			OFFSIDES
150	Arthralgia		17891354	CTD SIDER
151	Arthropathy			SIDER
152	Aspergillosis			OFFSIDES
153	Asterixis			OFFSIDES
154	Asthenia			SIDER
155	Ataxia			SIDER
156	Atrial Flutter			SIDER
157	Atrioventricular Block			SIDER
158	Aura			OFFSIDES
159	Autistic Disorder		11476129	CTD
160	Bacillus infection			OFFSIDES
161	Beta 2 microglobulin increased			OFFSIDES
162	Bipolar Disorder		View details 435016 2607791 3458554 7397287 7586996 8088239 8923100 9315999 10629901 14509206	CTD
163	Bipolar I disorder			OFFSIDES
164	Bladder pain			SIDER
165	Blepharitis			SIDER
166	Blepharospasm			SIDER
167	Blood alcohol increased			OFFSIDES
168	Blood aldosterone increased			OFFSIDES
169	Blood alkaline phosphatase increased			SIDER
170	Blood and lymphatic system disorders			SIDER
171	Blood cholesterol abnormal			OFFSIDES
172	Blood cortisol increased			OFFSIDES
173	Blood creatinine decreased			OFFSIDES
174	Blood immunoglobulin A decreased			OFFSIDES
175	Blood in stool			SIDER
176	Blood prolactin increased			OFFSIDES SIDER
177	Blood sodium increased			OFFSIDES
178	Blood sodium			OFFSIDES
179	Blood testosterone decreased			OFFSIDES
180	Blood triglycerides increased			OFFSIDES
181	Blood triglycerides			OFFSIDES
182	Body Temperature Changes		12818981	CTD
183	Body temperature fluctuation			OFFSIDES
184	Bone marrow depression			SIDER
185	Bradycardia		153969 6105186	CTD SIDER
186	Brain Infarction		9329236	CTD
187	Breast engorgement			SIDER
188	Bronchiolitis			OFFSIDES
189	Bronchitis			SIDER
190	Bronchospasm			SIDER
191	Bruxism	Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER
192	Calcium deficiency			OFFSIDES
193	Carcinoembryonic antigen increased			OFFSIDES
194	Cardiac Arrest			SIDER
195	Cardiotoxicity			OFFSIDES
196	Cardiovascular Diseases		17098328	CTD
197	Cartilage injury			OFFSIDES
198	Catalepsy		108749 1963685 9567763	CTD SIDER
199	Catatonia			OFFSIDES
200	Cellulitis			OFFSIDES SIDER
201	Cerebral atrophy			OFFSIDES
202	Cerebral ventricle dilatation			OFFSIDES
203	Cerebrovascular accident			SIDER
204	Cervical dysplasia			SIDER
205	Cheilitis			SIDER
206	Chloasma			SIDER
207	Choreoathetosis			SIDER
208	Chorioretinitis			OFFSIDES
209	Chromatopsia			SIDER
210	Chronic left ventricular failure			OFFSIDES
211	Circumstance or information capable of leading to medication error			OFFSIDES
212	Clonus			OFFSIDES
213	Clumsiness			OFFSIDES
214	Colitis			SIDER
215	Completed Suicide			OFFSIDES SIDER
216	Complications of maternal exposure to therapeutic drugs			OFFSIDES
217	Concomitant disease progression			OFFSIDES
218	Conduct Disorder		11151486 11494958	CTD
219	Confabulation			OFFSIDES
220	Congenital pulmonary hypertension			OFFSIDES
221	Conjunctivitis			SIDER
222	Consciousness fluctuating			OFFSIDES
223	Cramps of lower extremities			SIDER
224	Creatinine renal clearance decreased			OFFSIDES
225	Cyanosis		7058100	CTD OFFSIDES SIDER
226	Cystitis			SIDER
227	Cytolytic hepatitis			OFFSIDES
228	Cytomegalovirus antibody positive			OFFSIDES
229	Decreased Libido			OFFSIDES
230	Dehydration			OFFSIDES SIDER
231	Dehydroepiandrosterone increased			OFFSIDES
232	Delirium		11145466	CTD SIDER
233	Delusional disorder, persecutory type			OFFSIDES
234	Dental caries			SIDER
235	Depressed mood			OFFSIDES
236	Depression aggravated			SIDER
237	Depressive disorder		View details 656719 1154013 1277983 1530086 1749054 1790470 2456791 2775959 2920499 3693873 3929308 6388247 7058100 7096611 7127350 7201341 7318761 7397287 7496659 8238650 8443525 8837978 8955926 9029750 9108813 9547136 9663805 9716319 11064842 11145466 11496033 14658981 15482629 16195134 18083778 18679104 19043277	CTD
238	Dermatitis			SIDER
239	Device Failure			OFFSIDES
240	Diabetes			OFFSIDES
241	Diabetes Mellitus			SIDER
242	Diarrhea		9291715 17891354	CTD
243	Diplopia			SIDER
244	Discomfort			SIDER
245	Disorders of Excessive Somnolence		9663805 10770480	CTD
246	Disorientation			SIDER
247	Disruptive, Impulse Control, and Conduct Disorders		View details 1757451 9291715 11151486 11494958 15482629	CTD
248	Disseminated Intravascular Coagulation		3631476	CTD
249	Disturbance in sexual arousal			OFFSIDES
250	Dopamine dysregulation syndrome			OFFSIDES
251	Drowsiness			OFFSIDES SIDER
252	Drug Overdose		17098328	CTD
253	Drug abuser			OFFSIDES
254	Drug addict			OFFSIDES
255	Drug exposure during pregnancy			OFFSIDES
256	Drug level below therapeutic			OFFSIDES
257	Drug toxicity			OFFSIDES
258	Dry skin			SIDER
259	Duodenitis			SIDER
260	Dyskinesia, Drug-Induced		1111773	CTD
261	Dyspepsia			SIDER
262	Dysphonia			SIDER
263	Dyspnoea exacerbated			OFFSIDES
264	Dysthymic Disorder			OFFSIDES
265	Dystonia		18679104 19014097	CTD
266	Dysuria			SIDER
267	Ear and labyrinth disorders			SIDER
268	Eczema			OFFSIDES SIDER
269	Edema		12798668	CTD
270	Ejection Fraction Decreased			OFFSIDES
271	Electrocardiogram QRS complex			SIDER
272	Electrocardiogram abnormal			SIDER
273	Electroencephalogram abnormal			SIDER
274	Endometrial Hyperplasia			SIDER
275	Endometriosis			SIDER
276	Enteritis			SIDER
277	Enuresis		12432978	CTD OFFSIDES
278	Eosinophilia			SIDER
279	Eosinophilic myocarditis			OFFSIDES
280	Epididymitis			SIDER
281	Epilepsy			OFFSIDES
282	Epistaxis			SIDER
283	Epstein-Barr virus antibody positive			OFFSIDES
284	Eructation			SIDER
285	Erythema Infectiosum			OFFSIDES
286	Euphoric mood			OFFSIDES SIDER
287	Exophthalmos			SIDER
288	Failure of implant			OFFSIDES
289	Fanconi Syndrome			OFFSIDES
290	Fat intolerance			SIDER
291	Fatty Liver			OFFSIDES
292	Febrile bone marrow aplasia			OFFSIDES
293	Feeding and Eating Disorders		17891354	CTD
294	Feeding disorder neonatal			OFFSIDES
295	Fever		3631476 9315999	CTD
296	Fibroadenoma of breast			SIDER
297	Fibroadenosis of breast			SIDER
298	Flat affect			SIDER
299	Flatulence			SIDER
300	Flushing			SIDER
301	Folliculitis			SIDER
302	Foreign body sensation in eyes			OFFSIDES
303	Fracture			SIDER
304	Galactorrhea			OFFSIDES
305	Gambling			OFFSIDES
306	Gastric Bypass			OFFSIDES
307	Gastric Dilatation			SIDER
308	Gastric ulcer			SIDER
309	Gastritis			SIDER
310	Gastrointestinal Pain			SIDER
311	General physical health deterioration			OFFSIDES
312	Gingivitis			SIDER
313	Glasgow coma scale			OFFSIDES
314	Glaucoma			SIDER
315	Glossitis			OFFSIDES SIDER
316	Glycosuria			SIDER
317	Gout			SIDER
318	Granulocytosis			OFFSIDES
319	Granuloma			OFFSIDES
320	Hallucinations		1790470 10353456 11064842	CTD
321	Heart Diseases		7318761	CTD
322	Hemiparesis			SIDER
323	Hepatic necrosis			SIDER
324	Hepatic siderosis			OFFSIDES
325	Hepatitis		1937386	CTD SIDER
326	Histrionic Personality Disorder			OFFSIDES
327	Hoarding Disorder		20619828	CTD
328	Hostility			SIDER
329	Hyperacusis			SIDER
330	Hyperkinesia			SIDER
331	Hyperpyrexia			SIDER
332	Hyperreflexia			SIDER
333	Hypertensive heart disease			OFFSIDES
334	Hyperthyroidism			SIDER
335	Hypertrichosis			SIDER
336	Hyperventilation			OFFSIDES SIDER
337	Hypokinesia			OFFSIDES SIDER
338	Hypomania			OFFSIDES SIDER
339	Hypotension, Orthostatic		View details 221881 503823 2920499 3929308 16195134	CTD
340	Hypothyroidism			SIDER
341	Hypoventilation			SIDER
342	Hypoxia			SIDER
343	Immunosuppressant drug level decreased			OFFSIDES
344	Impaired self-care			OFFSIDES
345	Infantile apnoeic attack			OFFSIDES
346	Inflammation		12798668	CTD
347	Intention tremor			OFFSIDES
348	Intentional drug misuse			OFFSIDES
349	Intentional misuse			OFFSIDES
350	Interleukin-2 receptor increased			OFFSIDES
351	Intestinal Obstruction			SIDER
352	Intracranial Thrombosis		3236028	CTD
353	Intracranial injury			OFFSIDES
354	Intraoperative Complications		11465569	CTD
355	Intubation			OFFSIDES
356	Irritable Bowel Syndrome			SIDER
357	Joint sprain			OFFSIDES
358	Keratitis			SIDER
359	Kidney Neoplasm			OFFSIDES
360	Labile blood pressure			OFFSIDES
361	Labyrinthine disorder			SIDER
362	Laceration			OFFSIDES
363	Lacrimation abnormal NOS			SIDER
364	Lactose Intolerance			OFFSIDES
365	Laryngitis			SIDER
366	Laryngomalacia			OFFSIDES
367	Laryngospasm			SIDER
368	Left Ventricular Hypertrophy			OFFSIDES
369	Lethargy		7058100	CTD OFFSIDES
370	Leukoencephalopathy			OFFSIDES
371	Leukopenia			SIDER
372	Leukorrhea			SIDER
373	Libido disorder			SIDER
374	Lichenification			OFFSIDES
375	Limb injury			OFFSIDES
376	Long QT Syndrome		341940	CTD
377	Lupus Erythematosus			SIDER
378	Lymphadenopathy			SIDER
379	Lymphangiosis carcinomatosa			OFFSIDES
380	Macrophages increased			OFFSIDES
381	Male Orgasmic Disorder	Canada Vigilance: 1		Canada Vigilance
382	Malnutrition			SIDER
383	Manic psychosis			SIDER
384	Mechanical ventilation			OFFSIDES
385	Memory Disorders		20619828	CTD
386	Memory impairment			SIDER
387	Mental disorders		16856516	CTD
388	Microcephaly			OFFSIDES
389	Monocytosis			OFFSIDES
390	Mood Disorders		1757451 8238650	CTD
391	Mood swings			SIDER
392	Morbid thoughts			OFFSIDES
393	Motor Skills Disorders		8238650	CTD
394	Movement Disorders		3841069 9291715 10343185	CTD
395	Multiple drug overdose			OFFSIDES
396	Multiple drug overdose intentional			OFFSIDES
397	Muscle Hypertonia		7058100	CTD
398	Muscle hypotonia		7058100	CTD
399	Mutism			OFFSIDES SIDER
400	Myalgia			SIDER
401	Myocardial Infarction			SIDER
402	Myoclonus		View details 520416 1530086 3693873 3777258 7091416 8238650 8296581 8835709 10770480 20578939	CTD SIDER
403	Myopathy			SIDER
404	Myositis			SIDER
405	Neonatal respiratory acidosis			OFFSIDES
406	Neonatal tachycardia			OFFSIDES
407	Neoplasms		10487422	CTD
408	Nephritis, Interstitial		17891354	CTD
409	Nephrogenic Diabetes Insipidus			OFFSIDES
410	Nephrolithiasis			SIDER
411	Nervousness			SIDER
412	Neuralgia		221881	CTD SIDER
413	Neurobehavioral Manifestations		22396798	CTD
414	Neurodermatitis		11465569	CTD
415	Neuroleptic Malignant Syndrome			OFFSIDES SIDER
416	Neuropathy			SIDER
417	Nocturia			SIDER
418	Nystagmus			SIDER
419	Obesity surgery			OFFSIDES
420	Oculogyric crisis			SIDER
421	Oliguria			SIDER
422	Opisthotonus			OFFSIDES
423	Oral Cavity Fistula			OFFSIDES
424	Orthopnea			OFFSIDES
425	Otitis Media			SIDER
426	Oxygen saturation abnormal			OFFSIDES
427	PCO2 increased			OFFSIDES
428	Pallor			SIDER
429	Pancreatic Pseudocyst			OFFSIDES
430	Pancytopenia			SIDER
431	Panic Disorder		1790470	CTD
432	Paranoia			SIDER
433	Paranoid Personality Disorder			OFFSIDES
434	Paresis			SIDER
435	Parkinsonian rest tremor			OFFSIDES
436	Parotid swelling			SIDER
437	Peptic Ulcer			SIDER
438	Performance status decreased			OFFSIDES
439	Pericarditis			OFFSIDES
440	Perineal pain			SIDER
441	Peripheral Nervous System Diseases		221881	CTD
442	Personality Disorders		575199 9512081 15482629	CTD
443	Pharyngitis			SIDER
444	Pheochromocytoma		9315999	CTD
445	Phimosis			OFFSIDES
446	Photophobia			SIDER
447	Piloerection			SIDER
448	Plasmacytosis			OFFSIDES
449	Pneumococcal sepsis			OFFSIDES
450	Polyarteritis Nodosa			SIDER
451	Polyhydramnios			OFFSIDES
452	Polyuria			SIDER
453	Poor sucking reflex			OFFSIDES
454	Postoperative Complications		12818981	CTD
455	Pre-Eclampsia			OFFSIDES
456	Pregnancy with implant contraceptive			OFFSIDES
457	Premature Ejaculation			SIDER
458	Prenatal Exposure Delayed Effects		View details 1749054 3841069 7058100 16406480	CTD
459	Pseudolymphoma			SIDER
460	Psoriasis			SIDER
461	Psychomotor Agitation		9291715	CTD
462	Psychotic Disorders		15380868	CTD
463	Pulmonary arterial pressure increased			OFFSIDES
464	Pulmonary congestion			OFFSIDES
465	Pupillary light reflex tests abnormal			OFFSIDES
466	Purpura			SIDER
467	Pyelonephritis			SIDER
468	Pyuria			SIDER
469	QRS axis abnormal			OFFSIDES
470	Quadriparesis			OFFSIDES
471	Quality of life decreased			OFFSIDES
472	REM Sleep Behavior Disorder		3183074 10646174	CTD
473	Radiation mucositis			OFFSIDES
474	Rash erythematous			SIDER
475	Reflex, Abnormal		7091416	CTD
476	Renal Colic			OFFSIDES
477	Renal cyst			SIDER
478	Renal pain			SIDER
479	Renin increased			OFFSIDES
480	Respiratory Tract Diseases		7096611	CTD
481	Reticulocyte count abnormal			OFFSIDES
482	Retinitis			OFFSIDES
483	Retrograde ejaculation			OFFSIDES
484	Retroperitoneal effusion			OFFSIDES
485	Retroperitoneal fibrosis			OFFSIDES
486	Rhabdomyolysis			OFFSIDES SIDER
487	Rheumatoid factor increased			OFFSIDES
488	Rhinitis			SIDER
489	Saliva altered			OFFSIDES
490	Schizophrenic reaction			SIDER
491	Scleritis			SIDER
492	Scotoma			SIDER
493	Seizures		4069320 10353456 10770480	CTD
494	Self Mutilation		7496659	CTD
495	Septic Shock			OFFSIDES
496	Sexual Dysfunction	Canada Vigilance: 1		Canada Vigilance
497	Shock			SIDER
498	Sinoatrial Block			OFFSIDES
499	Sinus bradycardia			OFFSIDES
500	Sinusitis			SIDER
501	Skin Ulcer			SIDER
502	Skin hypertrophy			SIDER
503	Sleep Initiation and Maintenance Disorders		8835709 9291715	CTD
504	Sleep Paralysis			OFFSIDES
505	Sleep Wake Disorders		3777258 7930386	CTD
506	Somnambulism			SIDER
507	Speech Disorders		20578939	CTD
508	Splenic Infarction			OFFSIDES
509	Staring			OFFSIDES
510	Status Epilepticus		3427564 9029750 9663805	CTD OFFSIDES
511	Stevens-Johnson Syndrome			OFFSIDES
512	Stomach dilation procedure			SIDER
513	Stridor			OFFSIDES
514	Substance Withdrawal Syndrome		View details 656719 1459499 2456791 6805722 8889907 11551294	CTD
515	Substance-Related Disorders		9108813	CTD
516	Sudden death			OFFSIDES SIDER
517	Sudden onset of sleep			OFFSIDES
518	Suicide			SIDER
519	Sweating			SIDER
520	Syncope			SIDER
521	Tachycardia, Ventricular		7127350	CTD
522	Tachycardia	Canada Vigilance: 1	9315999 11476129	CTD SIDER Canada Vigilance
523	Tachyphrenia			OFFSIDES
524	Tardive Dyskinesia			SIDER
525	Tension			SIDER
526	Therapeutic product ineffective			OFFSIDES
527	Thirst	Canada Vigilance: 1		Canada Vigilance SIDER
528	Thrombocytopenia			SIDER
529	Thrombophlebitis			SIDER
530	Tongue biting			OFFSIDES
531	Tooth Erosion			OFFSIDES
532	Torticollis			SIDER
533	Transaminases increased			OFFSIDES SIDER
534	Troponin increased			OFFSIDES
535	Ulcerative stomatitis			SIDER
536	Unrest			SIDER
537	Urinary Retention		3678059	CTD SIDER
538	Urinary tract infection			SIDER
539	Urine output increased			SIDER
540	Urticaria			SIDER
541	Uterine inflammation			SIDER
542	Vaginal Discharge			SIDER
543	Vascular purpura			SIDER
544	Vasospasm			SIDER
545	Ventricular Fibrillation			SIDER
546	Vertigo			SIDER
547	Vision Disorders		9315999	CTD
548	Visual Impairment			SIDER
549	Vitamin K Deficiency			OFFSIDES
550	Vocal Cord Paralysis			OFFSIDES
551	Vulvovaginal dryness			OFFSIDES
552	Waxy flexibility			SIDER
553	Weight Gain			OFFSIDES
554	Wound Debridement			OFFSIDES
555	Xerostomia		8835709 9421348 10770480	CTD
556	Yawning			SIDER
557	jaundice			SIDER
558	nervous system disorder			SIDER

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