MetaADEDB 2.0 @ LMMD
Amantadine
(DKNWSYNQZKUICI-UHFFFAOYSA-N)
Structure
SMILES
NC12CC3CC(C2)CC(C1)C3
Type(s)
Approved
ATC code(s)
N04BB01
Molecular Formula:
C10H17N
Molecular Weight:
151.249
Log P:
2.6142
Hydrogen Bond Acceptor:
1
Hydrogen Bond Donor:
1
TPSA:
26.02
CAS Number(s):
768-94-5
Synonym(s)
1.
Amantadine
2.
1-Aminoadamantane
3.
Adamantylamine
4.
Adekin
5.
Aman
6.
Amanta
7.
Amanta-HCI-AZU
8.
Amanta-Sulfate-AZU
9.
Amantadin AL
10.
Amantadin AZU
11.
Amantadin Stada
12.
Amantadin-neuraxpharm
13.
Amantadin-ratiopharm
14.
Amantadina Juventus
15.
Amantadina Llorente
16.
Amantadine Hydrochloride
17.
Amantadine Sulfate
18.
Amixx
19.
Cerebramed
20.
Endantadine
21.
Gen-Amantadine
22.
Infecto-Flu
23.
Infex
24.
Mantadix
25.
Midantan
26.
PMS-Amantadine
27.
Symadine
28.
Symmetrel
29.
Viregyt
30.
Wiregyt
31.
tregor
32.
1 Aminoadamantane
33.
AL, Amantadin
34.
AZU, Amantadin
35.
Amanta HCI AZU
36.
Amanta Sulfate AZU
37.
AmantaHCIAZU
38.
AmantaSulfateAZU
39.
Amantadin neuraxpharm
40.
Amantadin ratiopharm
41.
Amantadinneuraxpharm
42.
Amantadinratiopharm
43.
Gen Amantadine
44.
GenAmantadine
45.
Hydrochloride, Amantadine
46.
Infecto Flu
47.
InfectoFlu
48.
Juventus, Amantadina
49.
Llorente, Amantadina
50.
PMS Amantadine
51.
PMSAmantadine
52.
Stada, Amantadin
53.
Sulfate, Amantadine
External Link(s)
MeSHD000547
PubChem Compound2130
BindingDB50033369
50288951
ChEBI2618
CHEMBLCHEMBL660
CHEMBL19601
DrugBankDB00915
DrugCentral144
IUPHAR/BPS Guide to PHARMACOLOGY4128
KEGGcpd:C06818
dr:D07441
Therapeutic Target DatabaseD02KRS
ZINC968256
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 12US FAERS
2DizzinessFAERS: 11
Canada Vigilance: 1
7373087
12611370
CTD
SIDER
Canada Vigilance
US FAERS
3Toxicity to various agentsFAERS: 9US FAERS
4FatigueFAERS: 716573266CTD
OFFSIDES
SIDER
US FAERS
5SomnolenceFAERS: 7SIDER
US FAERS
6TremorFAERS: 7

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CTD
SIDER
US FAERS
7MalaiseFAERS: 5US FAERS
8Memory impairmentFAERS: 5US FAERS
9MyoclonusFAERS: 5

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CTD
US FAERS
10Peripheral swellingFAERS: 5US FAERS
11Product use in unapproved indicationFAERS: 5US FAERS
12Feeling abnormalFAERS: 4SIDER
US FAERS
13Livedo ReticularisFAERS: 4

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CTD
SIDER
US FAERS
14Altered state of consciousnessFAERS: 3
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
US FAERS
15Cardiac ArrestFAERS: 3SIDER
US FAERS
16ConstipationFAERS: 320350559CTD
SIDER
US FAERS
17DisorientationFAERS: 3SIDER
US FAERS
18Drug level increasedFAERS: 3US FAERS
19NauseaFAERS: 3
Canada Vigilance: 3
Canada Vigilance
SIDER
US FAERS
20AnxietyFAERS: 2OFFSIDES
SIDER
US FAERS
21AphasiaFAERS: 2US FAERS
22AstheniaFAERS: 2
Canada Vigilance: 2
19483487CTD
SIDER
Canada Vigilance
US FAERS
23Blood creatine phosphokinase increasedFAERS: 2OFFSIDES
US FAERS
24Depressed Level of ConsciousnessFAERS: 2OFFSIDES
SIDER
US FAERS
25DysarthriaFAERS: 2
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
26Eye painFAERS: 2OFFSIDES
US FAERS
27Musculoskeletal stiffnessFAERS: 2US FAERS
28Neuroleptic Malignant SyndromeFAERS: 22280828
7118846
10628507
CTD
OFFSIDES
SIDER
US FAERS
29ParanoiaFAERS: 2OFFSIDES
SIDER
US FAERS
30Sleep TalkingFAERS: 2US FAERS
31Therapy changeFAERS: 2US FAERS
32Abdominal discomfortFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
33AgitationFAERS: 1
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
34AlopeciaFAERS: 1SIDER
US FAERS
35AnorgasmiaFAERS: 1US FAERS
36AphoniaFAERS: 1US FAERS
37AstigmatismFAERS: 1US FAERS
38AtaxiaFAERS: 119116645CTD
SIDER
US FAERS
39AutophonyFAERS: 1US FAERS
40BlepharospasmFAERS: 1US FAERS
41BradykinesiaFAERS: 1US FAERS
42BronchopneumoniaFAERS: 1OFFSIDES
US FAERS
43Chest PainFAERS: 1US FAERS
44ChokingFAERS: 1US FAERS
45ChromatopsiaFAERS: 1US FAERS
46Completed SuicideFAERS: 1SIDER
US FAERS
47Corneal degenerationFAERS: 1US FAERS
48Corneal dystrophyFAERS: 1US FAERS
49Corneal endotheliitisFAERS: 1US FAERS
50Corneal leukomaFAERS: 1US FAERS
51DeliriumFAERS: 1
Canada Vigilance: 1

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CTD
SIDER
Canada Vigilance
US FAERS
52Diffuse alveolar damageFAERS: 1US FAERS
53DiplopiaFAERS: 1US FAERS
54Drug dose titration not performedFAERS: 1US FAERS
55DyschromatopsiaFAERS: 1US FAERS
56DyspepsiaFAERS: 1SIDER
US FAERS
57EpistaxisFAERS: 1US FAERS
58ErythemaFAERS: 1OFFSIDES
US FAERS
59ErythropsiaFAERS: 1US FAERS
60Eye inflammationFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
61Feeling jitteryFAERS: 1US FAERS
62Food aversionFAERS: 1US FAERS
63Gait inabilityFAERS: 1US FAERS
64General physical health deteriorationFAERS: 1OFFSIDES
US FAERS
65HeadacheFAERS: 1SIDER
US FAERS
66HypersensitivityFAERS: 1SIDER
US FAERS
67HypersomniaFAERS: 1US FAERS
68HypophagiaFAERS: 1US FAERS
69HypotensionFAERS: 1SIDER
US FAERS
70HypoxiaFAERS: 1US FAERS
71Impaired driving abilityFAERS: 1US FAERS
72LethargyFAERS: 119483487CTD
SIDER
US FAERS
73Loss of personal independence in daily activitiesFAERS: 1US FAERS
74MaculeFAERS: 1US FAERS
75Mental status changesFAERS: 1OFFSIDES
US FAERS
76Metabolic acidosisFAERS: 1US FAERS
77MyopathyFAERS: 1US FAERS
78NervousnessFAERS: 1SIDER
US FAERS
79Ocular ToxicityFAERS: 1US FAERS
80PalpitationsFAERS: 1SIDER
US FAERS
81Product dose omissionFAERS: 1US FAERS
82Product quality issueFAERS: 1US FAERS
83Product use issueFAERS: 1US FAERS
84PruritusFAERS: 1
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
85Pulmonary congestionFAERS: 1US FAERS
86Punctate keratitisFAERS: 1SIDER
US FAERS
87Sexual DysfunctionFAERS: 1US FAERS
88Skin lesionFAERS: 1US FAERS
89Squamous cell carcinomaFAERS: 1US FAERS
90Stevens-Johnson SyndromeFAERS: 1US FAERS
91Sudden deathFAERS: 1OFFSIDES
US FAERS
92SwellingFAERS: 1US FAERS
93SyncopeFAERS: 1US FAERS
94TachycardiaFAERS: 1SIDER
US FAERS
95Therapeutic response unexpectedFAERS: 1US FAERS
96ThirstFAERS: 1US FAERS
97Unevaluable eventFAERS: 1US FAERS
98UrticariaFAERS: 1US FAERS
99Vitreous floatersFAERS: 1US FAERS
100VomitingFAERS: 1
Canada Vigilance: 5
Canada Vigilance
SIDER
US FAERS
101Weight decreasedFAERS: 1US FAERS
102Wrong scheduleFAERS: 1US FAERS
103nervous system disorderFAERS: 1SIDER
US FAERS
104AbasiaOFFSIDES
105Abdominal PainCanada Vigilance: 1Canada Vigilance
106Abdominal massOFFSIDES
107AbuseOFFSIDES
108Acid refluxOFFSIDES
109Actinic keratosisOFFSIDES
110Activities of daily living impairedOFFSIDES
111Acute bronchitisOFFSIDES
112Acute respiratory failureOFFSIDES
SIDER
113AdenocarcinomaOFFSIDES
114Adjustment disorder with depressed moodCanada Vigilance: 1Canada Vigilance
115AgranulocytosisSIDER
116AkinesiaOFFSIDES
117Alanine Aminotransferase IncreasedOFFSIDES
118Amaurosis FugaxOFFSIDES
119AmimiaOFFSIDES
120AmnesiaOFFSIDES
SIDER
121Amniotic fluid volume decreasedOFFSIDES
122AmphetaminesOFFSIDES
123Anaphylactic shockSIDER
124Anemia18206139CTD
125AngiolipomaOFFSIDES
126AnhedoniaOFFSIDES
127Anorexia19483487CTD
OFFSIDES
SIDER
128Antiphospholipid antibodies positiveOFFSIDES
129Aortic valve sclerosisOFFSIDES
130ApneaOFFSIDES
131AppendectomyOFFSIDES
132AppendicitisOFFSIDES
133ArteriosclerosisOFFSIDES
134ArthropathyOFFSIDES
135Arthropod biteOFFSIDES
136Aspiration PneumoniaOFFSIDES
137AsthmaOFFSIDES
138AuraOFFSIDES
139Autistic Disorder19232924CTD
140Autoimmune thyroiditisOFFSIDES
141AutomatismOFFSIDES
142Autonomic neuropathyOFFSIDES
143Back disorderOFFSIDES
144Bacterial disease carrierOFFSIDES
145Basal Ganglia Diseases

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CTD
146Basal cell carcinomaOFFSIDES
147BedriddenOFFSIDES
148Beta 2 microglobulin urine increasedOFFSIDES
149Bipolar Disorder2564388CTD
150BlepharitisOFFSIDES
151Blood GlucoseOFFSIDES
152Blood alkaline phosphatase decreasedOFFSIDES
153Blood alkaline phosphatase increasedOFFSIDES
154Blood and lymphatic system disordersSIDER
155Blood bilirubin abnormalOFFSIDES
156Blood chloride decreasedOFFSIDES
157Blood cholesterol abnormalOFFSIDES
158Blood creatine abnormalOFFSIDES
159Blood creatinine increasedOFFSIDES
160Blood glucose decreasedOFFSIDES
161Blood glucose fluctuationOFFSIDES
162Blood lactate dehydrogenase increasedOFFSIDES
163Blood pH increasedOFFSIDES
164Blood urea increasedOFFSIDES
165Body TemperatureOFFSIDES
166Bone erosionOFFSIDES
167Bone fragmentationOFFSIDES
168Bone lesionOFFSIDES
169Bone painOFFSIDES
170Brain ContusionOFFSIDES
171Brain Injuries15769570CTD
172Breast cancer stage IIOFFSIDES
173Breast hyperplasiaOFFSIDES
174Breast tendernessOFFSIDES
175BruxismOFFSIDES
176BursitisOFFSIDES
177CYTOMEGALOVIRUS ANTIGENOFFSIDES
178Candida sepsisOFFSIDES
179Cardiac discomfortOFFSIDES
180Cardiac ventricular disorderOFFSIDES
181Cardiovascular Diseases8215867CTD
182Catalepsy

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CTD
183Catatonia

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CTD
184CellulitisOFFSIDES
185Central nervous system lesionOFFSIDES
186Cerebellar Ataxia11096749CTD
187Cerebral Amyloid AngiopathyOFFSIDES
188Cerebral artery stenosisOFFSIDES
189Cerebral atrophyOFFSIDES
190Cerebral ventricle dilatationOFFSIDES
191CholecystitisOFFSIDES
192Chorea8026137CTD
193Chromosome Breakage20575081CTD
194Chronic Obstructive Airway DiseaseOFFSIDES
195Chronic ulcerative colitisOFFSIDES
196Circumstance or information capable of leading to medication errorOFFSIDES
197Cocaine-Related Disorders11097979
12062456
CTD
198Compulsive shoppingOFFSIDES
199ConfabulationOFFSIDES
200Confusion

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CTD
201Congenital mitochondrial cytopathyOFFSIDES
202Congenital tricuspid valve incompetenceOFFSIDES
203Corneal OpacitySIDER
204Deep Brain StimulationOFFSIDES
205DehydrationOFFSIDES
206Dementia759472CTD
207DemyelinationOFFSIDES
208Dental abscessOFFSIDES
209Dental cariesOFFSIDES
210Dental prosthesis userOFFSIDES
211DermatitisSIDER
212DermatophytosisOFFSIDES
213Device FailureOFFSIDES
214Diarrhea9048728CTD
215Disease ProgressionOFFSIDES
216Disseminated Intravascular CoagulationOFFSIDES
217Disturbance in sexual arousalSIDER
218Disuse syndromeOFFSIDES
219DiverticulumOFFSIDES
220Dopamine dysregulation syndromeOFFSIDES
221DrowsinessOFFSIDES
222Drug toxicityOFFSIDES
223Duodenal ulcer perforationOFFSIDES
224Dyskinesia, Drug-Induced

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CTD
225DystoniaOFFSIDES
226Echocardiogram abnormalOFFSIDES
227EczemaSIDER
228Edema4102620CTD
229Ejection Fraction DecreasedOFFSIDES
230Elevated moodSIDER
231Emotional distressOFFSIDES
232EndocarditisOFFSIDES
233Endodontic procedureOFFSIDES
234EnteritisOFFSIDES
235Enterococcal infectionOFFSIDES
236Eosinophilic PneumoniaOFFSIDES
237EpilepsyCanada Vigilance: 1Canada Vigilance
238Erosive gastritisOFFSIDES
239ErythromelalgiaOFFSIDES
240Escherichia infectionOFFSIDES
241Euphoric moodSIDER
242ExophthalmosOFFSIDES
243Eye laser surgeryOFFSIDES
244Facial NeuralgiaOFFSIDES
245Fatty LiverOFFSIDES
246Fever1242323CTD
247FrustrationOFFSIDES
248Gambling21154480CTD
OFFSIDES
249Gamma-Glutamyltransferase IncreasedOFFSIDES
250GastroduodenitisOFFSIDES
251Gastrointestinal Diseases7347558CTD
252GlobulinuriaOFFSIDES
253GoiterOFFSIDES
254GranulomaOFFSIDES
255Grip strengthOFFSIDES
256Hallucinations, mixedOFFSIDES
257Hallucinations

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CTD
258Hearing disabilityOFFSIDES
259Heart failure65646
67309
CTD
260Heat illnessOFFSIDES
261HemiplegiaOFFSIDES
262Hepatitis A2167349CTD
263Hepatitis B antibody positiveOFFSIDES
264Hepatitis B16756086CTD
265Hepatitis C16756086CTD
OFFSIDES
266HiccoughOFFSIDES
267Huntington Disease12221159
12548355
CTD
268HydrothoraxOFFSIDES
269HypercapniaOFFSIDES
270HyperkinesiaSIDER
271Hypertensive heart diseaseOFFSIDES
272HyperventilationOFFSIDES
273HypogeusiaOFFSIDES
274HypogonadismOFFSIDES
275Hypokinesia3670563CTD
OFFSIDES
SIDER
276HypomaniaOFFSIDES
277Hyponatremia19483487CTD
278ImmobileOFFSIDES
279IncontinenceOFFSIDES
280IndurationOFFSIDES
281Infusion site inflammationOFFSIDES
282Infusion site mobility decreasedOFFSIDES
283Infusion site reactionOFFSIDES
284Injection site cellulitisOFFSIDES
285Intention tremorOFFSIDES
286Intervertebral disc compressionOFFSIDES
287Intestinal ObstructionOFFSIDES
288IntubationOFFSIDES
289Joint stiffnessOFFSIDES
290KeratitisSIDER
291Latex allergyOFFSIDES
292LeukocytosisSIDER
293LeukoencephalopathyOFFSIDES
294LeukopeniaSIDER
295LightheadednessSIDER
296Localised intraabdominal fluid collectionOFFSIDES
297Long QT Syndrome18072173
21158687
CTD
298Lumbar radiculopathyOFFSIDES
299Lymphocyte stimulation testOFFSIDES
300MalnutritionSIDER
301MalocclusionOFFSIDES
302Manic psychosisSIDER
303Mass excisionOFFSIDES
304MastectomyOFFSIDES
305Medication ErrorCanada Vigilance: 1Canada Vigilance
306MegacolonOFFSIDES
307Memory Disorders7275941
7347558
20575081
CTD
308MetamorphopsiaOFFSIDES
309Metastatic NeoplasmOFFSIDES
310Micrographic skin surgeryOFFSIDES
311Mitral valve sclerosisOFFSIDES
312Mood Disorders7275941CTD
313Movement Disorders17306893CTD
314Multiple Sclerosis16573266CTD
OFFSIDES
315Multiple drug overdose intentionalOFFSIDES
316Multiple sclerosis relapseOFFSIDES
317Muscle Rigidity3670563
3688511
4838913
CTD
318Muscle Weakness7465751
19483487
21242745
CTD
OFFSIDES
319Muscle strainOFFSIDES
320Musculoskeletal PainOFFSIDES
321Musculoskeletal chest painOFFSIDES
322MydriasisSIDER
323NasopharyngitisOFFSIDES
324Nervous tensionOFFSIDES
325Neurologic Manifestations15566030CTD
326NeutropeniaSIDER
327Nodule on extremityOFFSIDES
328NoduleOFFSIDES
329NystagmusOFFSIDES
330Oculogyric crisisSIDER
331Olfactory Nerve DisorderOFFSIDES
332OliguriaOFFSIDES
333Oral mucosal erythemaOFFSIDES
334Orthomyxoviridae Infections20575081CTD
335OrthopneaOFFSIDES
336Orthosis userOFFSIDES
337Osteitis DeformansOFFSIDES
338OsteolysisOFFSIDES
339OsteomyelitisOFFSIDES
340OsteopeniaOFFSIDES
341OsteoporosisOFFSIDES
342Ovarian cyst torsionOFFSIDES
343PCO2 increasedOFFSIDES
344PO2 decreasedOFFSIDES
345Pain, Postoperative14695734CTD
346PainCanada Vigilance: 1Canada Vigilance
347PallorOFFSIDES
348Panic Disorder8752025CTD
349Paranoid reactionSIDER
350Paresthesia10563642CTD
351Parkinson Disease

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CTD
352Parkinsonian Disorders

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CTD
353Pericardial effusionOFFSIDES
354PeriodontitisOFFSIDES
355Peripheral Nervous System Diseases10563642CTD
356Peripheral Vascular Diseases188158
4855664
CTD
357Peripheral occlusive diseaseOFFSIDES
358PeriphlebitisOFFSIDES
359Perivascular dermatitisOFFSIDES
360Personality Disorders

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CTD
361Physical disabilityOFFSIDES
362Pituitary enlargementOFFSIDES
363Poor dental conditionOFFSIDES
364Post procedural complicationOFFSIDES
365PovertyOFFSIDES
366Prescribed overdoseOFFSIDES
367Pressure of speechOFFSIDES
368Productive CoughOFFSIDES
369Progressive multiple sclerosisOFFSIDES
370Progressive supranuclear palsyOFFSIDES
371Protein total decreasedOFFSIDES
372Psychiatric symptomOFFSIDES
373Psychomotor Disorders2484011
14532914
CTD
374Psychoses, Substance-Induced2344084
10994027
20620094
CTD
375Psychotic Disorders2875665
8215867
CTD
376Pupillary light reflex tests abnormalOFFSIDES
377PyomyositisOFFSIDES
378Rash erythematousCanada Vigilance: 1Canada Vigilance
379Renal cystOFFSIDES
380Retinal pigment epithelial tearOFFSIDES
381RetrocollisOFFSIDES
382RhabdomyolysisOFFSIDES
383Rotavirus test positiveOFFSIDES
384SacroiliitisOFFSIDES
385ScabOFFSIDES
386Scan bone marrow abnormalOFFSIDES
387SclerodermaOFFSIDES
388ScotomaOFFSIDES
389Seizures2131763
3753115
12611370
CTD
390SequestrectomyOFFSIDES
391Serotonin Syndrome9048728CTD
392Sexual activity increasedOFFSIDES
393Shoulder PainOFFSIDES
394Skin Ulcer10563642CTD
395Skin hypertrophyOFFSIDES
396Skin neoplasm excisionOFFSIDES
397Sleep Wake Disorders

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CTD
398Slurred speechSIDER
399SoliloquyOFFSIDES
400Sperm count decreasedOFFSIDES
401SpondylolisthesisOFFSIDES
402Sputum retentionOFFSIDES
403Status EpilepticusOFFSIDES
404Stereotypic Movement Disorder17960816
20575081
CTD
405StridorOFFSIDES
406StuporSIDER
407Subepithelial opacitiesSIDER
408Substance Withdrawal Syndrome

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CTD
409Sudden Visual LossSIDER
410Sudden onset of sleepOFFSIDES
411SuicideSIDER
412Temperature regulation disorderOFFSIDES
413TensionSIDER
414Tetralogy of Fallot8186630CTD
415Therapy cessationCanada Vigilance: 1Canada Vigilance
416Therapy regimen changedOFFSIDES
417ThrombophlebitisOFFSIDES
418Thrombosed varicose veinOFFSIDES
419Tooth ExtractionOFFSIDES
420Tooth InfectionOFFSIDES
421Tooth repairOFFSIDES
422Torsades de Pointes6465184
18072173
CTD
423Transmission of drug via semenOFFSIDES
424Troponin I increasedOFFSIDES
425Upper respiratory tract inflammationOFFSIDES
426Urinary IncontinenceCanada Vigilance: 1Canada Vigilance
SIDER
427Urinary RetentionSIDER
428Urinary tract infection enterococcalOFFSIDES
429Urinary tract infection fungalOFFSIDES
430Urinary tract infection staphylococcalOFFSIDES
431Uterine CancerOFFSIDES
432Uterine PolypOFFSIDES
433Varicose vein operationOFFSIDES
434Venous InsufficiencyOFFSIDES
435Ventricular Fibrillation6465184CTD
436Ventricular hypokinesiaOFFSIDES
437Vision Disorders843253CTD
438Visual ImpairmentSIDER
439Visual disturbanceSIDER
440Vitreous DetachmentOFFSIDES
441Vulvovaginal burning sensationOFFSIDES
442Wound dehiscenceOFFSIDES
443Wound infection staphylococcalOFFSIDES
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