MetaADEDB 2.0 @ LMMD
Ivermectin
(AZSNMRSAGSSBNP-XPNPUAGNSA-N)
Structure
SMILES
CO[C@H]1C[C@H](O[C@H]2[C@@H](C)/C=C/C=C/3\CO[C@H]4[C@]3(O)[C@@H](C=C([C@H]4O)C)C(=O)O[C@H]3C[C@@H](C/C=C/2\C)O[C@]2(C3)CC[C@@H]([C@H](O2)[C@H](CC)C)C)O[C@H]([C@@H]1O[C@H]1C[C@H](OC)[C@H]([C@@H](O1)C)O)C
Molecular Formula:
C48H74O14
Molecular Weight:
875.093
Log P:
5.6014
Hydrogen Bond Acceptor:
14
Hydrogen Bond Donor:
3
TPSA:
170.06
CAS Number(s):
70288-86-7; 71827-03-7
Synonym(s)
1.
Ivermectin
2.
Eqvalan
3.
Ivomec
4.
MK-933
5.
Mectizan
6.
Stromectol
7.
MK 933
8.
MK933
External Link(s)
MeSHD007559
PubChem Compound6321424
BindingDB50409816
ChEBI63941
94551
CHEMBLCHEMBL263291
ZINC238808778
252286706
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1AstheniaFAERS: 46OFFSIDES
SIDER
US FAERS
2HeadacheFAERS: 268555762CTD
SIDER
US FAERS
3Urinary IncontinenceFAERS: 17US FAERS
4HypotensionFAERS: 15SIDER
US FAERS
5MalariaFAERS: 13OFFSIDES
US FAERS
6nervous system disorderFAERS: 11US FAERS
7Back PainFAERS: 10SIDER
US FAERS
8Depressed Level of ConsciousnessFAERS: 10OFFSIDES
SIDER
US FAERS
9VertigoFAERS: 8SIDER
US FAERS
10VomitingFAERS: 825419811CTD
SIDER
US FAERS
11AgitationFAERS: 7US FAERS
12DisorientationFAERS: 6US FAERS
13Drug ineffective for unapproved indicationFAERS: 6US FAERS
14MyalgiaFAERS: 6SIDER
US FAERS
15StrongyloidiasisFAERS: 6
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
16AbasiaFAERS: 5OFFSIDES
US FAERS
17Drug ineffectiveFAERS: 5US FAERS
18Peripheral swellingFAERS: 5US FAERS
19SomnolenceFAERS: 5SIDER
US FAERS
20Adverse eventFAERS: 4OFFSIDES
US FAERS
21Product quality issueFAERS: 4US FAERS
22PruritusFAERS: 48555762CTD
SIDER
US FAERS
23Toxic Epidermal NecrolysisFAERS: 4SIDER
US FAERS
24ArthralgiaFAERS: 38555762CTD
SIDER
US FAERS
25Coma scale abnormalFAERS: 3US FAERS
26LethargyFAERS: 322924731CTD
SIDER
US FAERS
27PneumoniaFAERS: 3US FAERS
28Product use issueFAERS: 3US FAERS
29Rash erythematousFAERS: 3US FAERS
30TachycardiaFAERS: 3SIDER
US FAERS
31Abdominal PainFAERS: 2OFFSIDES
SIDER
US FAERS
32AcarodermatitisFAERS: 2US FAERS
33Altered state of consciousnessFAERS: 2US FAERS
34ApathyFAERS: 2SIDER
US FAERS
35BlindnessFAERS: 2SIDER
US FAERS
36Blood creatinine abnormalFAERS: 2US FAERS
37Cerebrovascular accidentFAERS: 2US FAERS
38Clostridium difficile colitisFAERS: 2US FAERS
39Deep Vein ThrombosisFAERS: 2US FAERS
40DizzinessFAERS: 2SIDER
US FAERS
41EncephalitisFAERS: 211164753CTD
US FAERS
42Escherichia test positiveFAERS: 2US FAERS
43Extra dose administeredFAERS: 2US FAERS
44Human T-cell lymphotropic virus infectionFAERS: 2US FAERS
45HypoxiaFAERS: 2US FAERS
46IncontinenceFAERS: 2OFFSIDES
US FAERS
47Musculoskeletal stiffnessFAERS: 2OFFSIDES
US FAERS
48Product use in unapproved indicationFAERS: 2US FAERS
49Respiratory distressFAERS: 2US FAERS
50SepsisFAERS: 2US FAERS
51Stevens-Johnson SyndromeFAERS: 225811541CTD
OFFSIDES
SIDER
US FAERS
52SwellingFAERS: 2US FAERS
53AmnesiaFAERS: 1US FAERS
54Anal sphincter atonyFAERS: 1OFFSIDES
US FAERS
55AphasiaFAERS: 1US FAERS
56AphoniaFAERS: 1OFFSIDES
US FAERS
57Blood alkaline phosphatase increasedFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
58Body TemperatureFAERS: 1OFFSIDES
US FAERS
59Burning sensationFAERS: 1US FAERS
60Cerebral ventricle dilatationFAERS: 1US FAERS
61Chest PainFAERS: 1SIDER
US FAERS
62ChillsFAERS: 1SIDER
US FAERS
63ConjunctivitisFAERS: 1SIDER
US FAERS
64ConstipationFAERS: 1SIDER
US FAERS
65CystostomyFAERS: 1US FAERS
66DermatitisFAERS: 1SIDER
US FAERS
67Diet refusalFAERS: 1OFFSIDES
US FAERS
68Disease ProgressionFAERS: 1US FAERS
69Drug resistanceFAERS: 1US FAERS
70DysarthriaFAERS: 1US FAERS
71DysgraphiaFAERS: 1US FAERS
72ErythromelalgiaFAERS: 1US FAERS
73Eye painFAERS: 1US FAERS
74FatigueFAERS: 1SIDER
US FAERS
75Feeling ColdFAERS: 1OFFSIDES
US FAERS
76Feeling abnormalFAERS: 1SIDER
US FAERS
77FilariasisFAERS: 1OFFSIDES
US FAERS
78FormicationFAERS: 1US FAERS
79Head discomfortFAERS: 1US FAERS
80HemiplegiaFAERS: 1OFFSIDES
US FAERS
81HydrocephalusFAERS: 1OFFSIDES
US FAERS
82HypersensitivityFAERS: 1SIDER
US FAERS
83HypersomniaFAERS: 1US FAERS
84IncoherentFAERS: 1OFFSIDES
US FAERS
85Incorrect dose administeredFAERS: 1US FAERS
86InfectionFAERS: 1US FAERS
87InfluenzaFAERS: 1US FAERS
88Joint swellingFAERS: 1US FAERS
89MalaiseFAERS: 1US FAERS
90MutismFAERS: 1OFFSIDES
US FAERS
91NasopharyngitisFAERS: 1US FAERS
92NauseaFAERS: 1SIDER
US FAERS
93No adverse eventFAERS: 1US FAERS
94Nuchal RigidityFAERS: 1OFFSIDES
US FAERS
95PalpitationsFAERS: 1US FAERS
96Poor quality sleepFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
97PyuriaFAERS: 1US FAERS
98Quality of life decreasedFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
99SchistosomiasisFAERS: 1US FAERS
100ScreamingFAERS: 1US FAERS
101TremorFAERS: 122044330
25419811		CTD
SIDER
US FAERS
102Urinary RetentionFAERS: 1US FAERS
103White blood cell count abnormalFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
104Wound InfectionFAERS: 1US FAERS
105treatment failureFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
106Abdominal discomfortSIDER
107Abdominal tendernessOFFSIDES
108Accidental exposureOFFSIDES
109Acute glomerulonephritisOFFSIDES
110AgraphiaOFFSIDES
111Alcohol consumptionOFFSIDES
112Alcoholic IntoxicationOFFSIDES
113AngioedemaOFFSIDES
114AnorexiaOFFSIDES
SIDER
115Anterior uveitisSIDER
116Anuria8555762CTD
117Ascaridida Infections16962243
19201100
20471177		CTD
118Aspiration PneumoniaOFFSIDES
119Asthenozoospermia28880400CTD
120AsthmaSIDER
121Ataxia22044330
22924731
25419811		CTD
OFFSIDES
122BedriddenOFFSIDES
123Blighted ovumOFFSIDES
124Blood fibrinogen increasedOFFSIDES
125Blood smear test abnormalOFFSIDES
126Blurred visionOFFSIDES
127Body fat disorderOFFSIDES
128Bone marrow toxicityOFFSIDES
129Bronchoalveolar LavageOFFSIDES
130BronchopneumoniaOFFSIDES
131Bulbar palsyOFFSIDES
132Carcinoma, Ovarian Epithelial28811376CTD
133Cardiovascular Diseases22044330CTD
134Cerebral atrophyOFFSIDES
135Cerebral disorderOFFSIDES
136CheilitisOFFSIDES
137Chest discomfortSIDER
138ChorioretinitisSIDER
139ChoroiditisSIDER
140ConfabulationOFFSIDES
141Confusion22924731CTD
142Conjunctival depositOFFSIDES
143DeafnessOFFSIDES
144Diabetes InsipidusOFFSIDES
145DiarrheaOFFSIDES
146Dirofilariasis

View details

18602759
18930598
21300438
25936435
 		CTD
147DiscomfortSIDER
148Dog Diseases18602759CTD
149Drug withdrawal headacheOFFSIDES
150Dry skinSIDER
151DysprosodyOFFSIDES
152EndophthalmitisSIDER
153EnophthalmosOFFSIDES
154Enterobiasis20307935CTD
155Enterococcal infectionOFFSIDES
156EosinophiliaSIDER
157Epigastric painSIDER
158Erythema MultiformeSIDER
159Escherichia infectionOFFSIDES
160Eye RednessOFFSIDES
SIDER
161Eye irritationSIDER
162Fever8555762
22044330		CTD
163Fish Diseases25255455CTD
164Flat affectSIDER
165Gastrointestinal Diseases20307935
20471177		CTD
166Gastrointestinal PainSIDER
167Gastrointestinal motility disorderOFFSIDES
168General symptomOFFSIDES
169Glasgow coma scaleOFFSIDES
170GlossitisOFFSIDES
171Helminthiasis, Animal22024132
23067512		CTD
172Helminthiasis22024132CTD
173Hematuria8555762CTD
174HepatitisSIDER
175HiccoughOFFSIDES
176Hookworm Infections30007544CTD
177Horse Diseases

View details

16962243
17719664
18389281
18470536
19201100
20307935
20471177
 		CTD
178HypereosinophiliaSIDER
179Hyperpigmentation26443706CTD
180HyperreflexiaOFFSIDES
181HypervitaminosisOFFSIDES
182Inappropriate schedule of drug administrationOFFSIDES
183Incorrect route of drug administrationOFFSIDES
184IridocyclitisSIDER
185Jejunal ulcerOFFSIDES
186Joint stiffnessOFFSIDES
187KeratitisSIDER
188Klebsiella sepsisOFFSIDES
189LeukoencephalopathyOFFSIDES
190LeukopeniaSIDER
191Limb discomfortOFFSIDES
192Loiasis8555762CTD
193LymphadenitisSIDER
194LymphadenopathySIDER
195MarasmusOFFSIDES
196Mazzotti reactionOFFSIDES
197Mental status changesOFFSIDES
SIDER
198Mite Infestations28653460CTD
199Monkey Diseases17536622CTD
200MonoparesisOFFSIDES
201Movement Disorders21494842CTD
202Musculoskeletal discomfortOFFSIDES
SIDER
203Mydriasis22044330CTD
204MyelitisOFFSIDES
205Myeloid maturation arrestOFFSIDES
206Nematode infections17719664CTD
207Neoplasm Metastasis26078298CTD
208NephrolithiasisOFFSIDES
209Neurologic Manifestations29210346CTD
210Neurotoxicity Syndromes25419811CTD
211Ocular icterusOFFSIDES
212Oligospermia28880400CTD
213Onchocerciasis

View details

15993957
16257066
19712154
20595473
20630055
28746337
29210346
 		CTD
OFFSIDES
214Oropharyngeal discomfortSIDER
215Oropharyngeal painSIDER
216OtotoxicityOFFSIDES
217Oxyuriasis17536622CTD
218PainOFFSIDES
SIDER
219ParaparesisOFFSIDES
220Parasitic Diseases, Animal25255455CTD
221Parasitic Diseases12184502CTD
222Penile swellingOFFSIDES
223Physical disabilityOFFSIDES
224Polyomavirus Infections25463609CTD
225Prescribed overdoseOFFSIDES
226Proteinuria8555762CTD
227Pulmonary Embolism18602759CTD
228Purulent dischargeOFFSIDES
229Relapsing FeverOFFSIDES
230Renal Insufficiency8555762CTD
231Renal tubular disorderOFFSIDES
232Respiratory tract congestionOFFSIDES
233Restrictive cardiomyopathyOFFSIDES
234Rosacea28653460CTD
235Seizures12184502
17308985
25419811		CTD
236Sialorrhea25419811CTD
237Skin lesionOFFSIDES
238Strongyle Infections, Equine

View details

17013652
17186406
18389281
18470536
20340086
 		CTD
239Stupor22924731CTD
SIDER
240Sudden deathOFFSIDES
241Superinfection bacterialOFFSIDES
242SynovitisSIDER
243Teratozoospermia28880400CTD
244Trichostrongyloidiasis21683705CTD
245Umbilical herniaOFFSIDES
246Unspecified visual lossSIDER
247UrticariaSIDER
248Watery diarrhoeaSIDER
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