Sodium picosulfate
(GOZDTZWAMGHLDY-UHFFFAOYSA-L)
Structure
- SMILES
- [O-]S(=O)(=O)Oc1ccc(cc1)C(c1ccccn1)c1ccc(cc1)OS(=O)(=O)[O-].[Na+].[Na+]
- Molecular Formula:
- C18H13NNa2O8S2
- Molecular Weight:
- 481.407
- Log P:
- 4.1014
- Hydrogen Bond Acceptor:
- 9
- Hydrogen Bond Donor:
- 0
- TPSA:
- 162.51
- CAS Number(s):
- 10040-45-6
Synonym(s)
1.
Sodium picosulfate
2.
CID 92131819
External Link(s)
| PubChem Compound | 68654 92131819 |
| ChEBI | 32147 |
| CHEMBL | CHEMBL1697768 |
| KEGG | cpd:C13072 |
| Therapeutic Target Database | D00TGR |
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Vomiting | FAERS: 26 Canada Vigilance: 17 | Canada Vigilance US FAERS | |
| 2 | Nausea | FAERS: 24 Canada Vigilance: 13 | Canada Vigilance US FAERS | |
| 3 | Drug ineffective | FAERS: 21 Canada Vigilance: 13 | Canada Vigilance US FAERS | |
| 4 | Malaise | FAERS: 18 Canada Vigilance: 6 | Canada Vigilance US FAERS | |
| 5 | Syncope | FAERS: 17 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 6 | Headache | FAERS: 16 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 7 | Abdominal Pain | FAERS: 13 Canada Vigilance: 11 | Canada Vigilance OFFSIDES US FAERS | |
| 8 | Dizziness | FAERS: 11 Canada Vigilance: 8 | Canada Vigilance US FAERS | |
| 9 | Asthenia | FAERS: 9 Canada Vigilance: 8 | Canada Vigilance US FAERS | |
| 10 | Dehydration | FAERS: 7 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 11 | Electrolyte imbalance | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 12 | Laceration | FAERS: 4 | US FAERS | |
| 13 | No adverse event | FAERS: 4 | US FAERS | |
| 14 | Product use issue | FAERS: 4 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 15 | Tremor | FAERS: 4 Canada Vigilance: 6 | Canada Vigilance US FAERS | |
| 16 | Blood sodium decreased | FAERS: 3 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 17 | Chills | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 18 | Colitis erosive | FAERS: 3 | US FAERS | |
| 19 | Flushing | FAERS: 3 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 20 | Hypersensitivity | FAERS: 3 | US FAERS | |
| 21 | Product quality issue | FAERS: 3 | US FAERS | |
| 22 | Product use in unapproved indication | FAERS: 3 | US FAERS | |
| 23 | Pruritus | FAERS: 3 | US FAERS | |
| 24 | Retching | FAERS: 3 | US FAERS | |
| 25 | Tachycardia | FAERS: 3 | US FAERS | |
| 26 | Amnesia | FAERS: 2 | US FAERS | |
| 27 | Anaphylactic shock | FAERS: 2 | US FAERS | |
| 28 | Burning sensation | FAERS: 2 | US FAERS | |
| 29 | Chest Pain | FAERS: 2 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 30 | Cold sweat | FAERS: 2 Canada Vigilance: 2 | Canada Vigilance OFFSIDES US FAERS | |
| 31 | Coma scale abnormal | FAERS: 2 | US FAERS | |
| 32 | Conjunctivitis | FAERS: 2 | US FAERS | |
| 33 | Delirium | FAERS: 2 | US FAERS | |
| 34 | Depressed Level of Consciousness | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance OFFSIDES US FAERS | |
| 35 | Diabetic Ketoacidosis | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 36 | Dysphonia | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 37 | Enteritis | FAERS: 2 | OFFSIDES US FAERS | |
| 38 | Epilepsy | FAERS: 2 | US FAERS | |
| 39 | Epistaxis | FAERS: 2 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 40 | Fatigue | FAERS: 2 | US FAERS | |
| 41 | Hyperventilation | FAERS: 2 | US FAERS | |
| 42 | Hypotension | FAERS: 2 | US FAERS | |
| 43 | Inappropriate schedule of drug administration | FAERS: 2 | US FAERS | |
| 44 | Influenza | FAERS: 2 | US FAERS | |
| 45 | Loose tooth | FAERS: 2 | US FAERS | |
| 46 | Malocclusion | FAERS: 2 | US FAERS | |
| 47 | Mastication disorder | FAERS: 2 | US FAERS | |
| 48 | Neuralgia | FAERS: 2 | US FAERS | |
| 49 | Presyncope | FAERS: 2 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 50 | Toothache | FAERS: 2 | US FAERS | |
| 51 | Urticaria | FAERS: 2 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 52 | Weight decreased | FAERS: 2 | US FAERS | |
| 53 | Abdominal rigidity | FAERS: 1 | US FAERS | |
| 54 | Activities of daily living impaired | FAERS: 1 | US FAERS | |
| 55 | Acute myocardial infarction | FAERS: 1 | US FAERS | |
| 56 | Alanine Aminotransferase Increased | FAERS: 1 | OFFSIDES US FAERS | |
| 57 | Altered state of consciousness | FAERS: 1 | OFFSIDES US FAERS | |
| 58 | Aspartate Aminotransferase Increased | FAERS: 1 | US FAERS | |
| 59 | Atrial Fibrillation | FAERS: 1 | US FAERS | |
| 60 | Bladder pain | FAERS: 1 | US FAERS | |
| 61 | Blood alkaline phosphatase increased | FAERS: 1 | OFFSIDES US FAERS | |
| 62 | Blood potassium decreased | FAERS: 1 | US FAERS | |
| 63 | Blood urine present | FAERS: 1 | US FAERS | |
| 64 | Brain Death | FAERS: 1 | US FAERS | |
| 65 | Bronchopneumonia | FAERS: 1 | US FAERS | |
| 66 | Cardiac Arrest | FAERS: 1 | US FAERS | |
| 67 | Cerebral disorder | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 68 | Cerebrovascular accident | FAERS: 1 | US FAERS | |
| 69 | Colitis | FAERS: 1 | US FAERS | |
| 70 | Cyst | FAERS: 1 | US FAERS | |
| 71 | Diplegia | FAERS: 1 | US FAERS | |
| 72 | Disorientation | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 73 | Drug abuse | FAERS: 1 | US FAERS | |
| 74 | Drug administration error | FAERS: 1 | US FAERS | |
| 75 | Drug effect incomplete | FAERS: 1 | US FAERS | |
| 76 | Dysarthria | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 77 | Dyspepsia | FAERS: 1 | US FAERS | |
| 78 | Ear canal injury | FAERS: 1 | US FAERS | |
| 79 | Endotoxic shock | FAERS: 1 | US FAERS | |
| 80 | Enterocolitis viral | FAERS: 1 | US FAERS | |
| 81 | Feeling abnormal | FAERS: 1 | US FAERS | |
| 82 | Flatulence | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 83 | Gastritis | FAERS: 1 | US FAERS | |
| 84 | Gastrointestinal hypomotility | FAERS: 1 | US FAERS | |
| 85 | Gastrointestinal sounds abnormal | FAERS: 1 | US FAERS | |
| 86 | Hemiplegia | FAERS: 1 | OFFSIDES US FAERS | |
| 87 | Hypoxia | FAERS: 1 | US FAERS | |
| 88 | Ileus | FAERS: 1 | US FAERS | |
| 89 | Incorrect drug administration duration | FAERS: 1 | US FAERS | |
| 90 | Inflammation | FAERS: 1 | US FAERS | |
| 91 | Intestinal Obstruction | FAERS: 1 | OFFSIDES US FAERS | |
| 92 | Medication Error | FAERS: 1 | US FAERS | |
| 93 | Memory impairment | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 94 | Metabolic acidosis | FAERS: 1 | US FAERS | |
| 95 | Muscle Rigidity | FAERS: 1 | US FAERS | |
| 96 | Musculoskeletal stiffness | FAERS: 1 | US FAERS | |
| 97 | Myocardial Infarction | FAERS: 1 | US FAERS | |
| 98 | Neck Pain | FAERS: 1 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 99 | Olfactory Nerve Disorder | FAERS: 1 | US FAERS | |
| 100 | Oropharyngeal pain | FAERS: 1 | OFFSIDES US FAERS | |
| 101 | Overdose | FAERS: 1 | US FAERS | |
| 102 | Pain | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 103 | Pneumothorax | FAERS: 1 | US FAERS | |
| 104 | Prescribed overdose | FAERS: 1 | US FAERS | |
| 105 | Product prescribing issue | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 106 | Product used for unknown indication | FAERS: 1 | US FAERS | |
| 107 | Proteinuria | FAERS: 1 | US FAERS | |
| 108 | Regurgitation | FAERS: 1 | US FAERS | |
| 109 | Respiratory Failure | FAERS: 1 | OFFSIDES US FAERS | |
| 110 | Respiratory arrest | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 111 | Retrograde amnesia | FAERS: 1 | US FAERS | |
| 112 | Rhabdomyolysis | FAERS: 1 | OFFSIDES US FAERS | |
| 113 | Scab | FAERS: 1 | OFFSIDES US FAERS | |
| 114 | Sepsis | FAERS: 1 | US FAERS | |
| 115 | Sluggishness | FAERS: 1 | US FAERS | |
| 116 | Somnolence | FAERS: 1 | US FAERS | |
| 117 | Spinal column injury | FAERS: 1 | US FAERS | |
| 118 | Staring | FAERS: 1 | US FAERS | |
| 119 | Teeth brittle | FAERS: 1 | US FAERS | |
| 120 | Tetany | FAERS: 1 | US FAERS | |
| 121 | Therapeutic response changed | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 122 | Throat irritation | FAERS: 1 | US FAERS | |
| 123 | Tinnitus | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 124 | Tooth Loss | FAERS: 1 | US FAERS | |
| 125 | Unresponsive to stimuli | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 126 | Urinary Incontinence | FAERS: 1 | US FAERS | |
| 127 | Urinary Retention | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 128 | Urine output increased | FAERS: 1 | US FAERS | |
| 129 | Vertigo | FAERS: 1 | US FAERS | |
| 130 | Vulvovaginal mycotic infection | FAERS: 1 | US FAERS | |
| 131 | Abdominal discomfort | Canada Vigilance: 1 | Canada Vigilance | |
| 132 | Abdominal rebound tenderness | OFFSIDES | ||
| 133 | Acantholysis | OFFSIDES | ||
| 134 | Acne | OFFSIDES | ||
| 135 | Acute kidney injury | Canada Vigilance: 2 | Canada Vigilance | |
| 136 | Acute otitis media | OFFSIDES | ||
| 137 | Adenocarcinoma | OFFSIDES | ||
| 138 | Ageusia | OFFSIDES | ||
| 139 | Akinesia | OFFSIDES | ||
| 140 | Alcohol consumption | OFFSIDES | ||
| 141 | Alcoholic Intoxication | OFFSIDES | ||
| 142 | Alopecia | OFFSIDES | ||
| 143 | Amyloidosis | OFFSIDES | ||
| 144 | Anal Fissure | OFFSIDES | ||
| 145 | Anal Fistula | OFFSIDES | ||
| 146 | Anion gap abnormal | OFFSIDES | ||
| 147 | Anisocoria | OFFSIDES | ||
| 148 | Anorectal discomfort | Canada Vigilance: 1 | Canada Vigilance | |
| 149 | Anorexia | OFFSIDES | ||
| 150 | Anuria | OFFSIDES | ||
| 151 | Anxiety | Canada Vigilance: 1 | Canada Vigilance | |
| 152 | Aphonia | OFFSIDES | ||
| 153 | Apnea | OFFSIDES | ||
| 154 | Arteriosclerosis Obliterans | OFFSIDES | ||
| 155 | Arthralgia | Canada Vigilance: 1 | Canada Vigilance | |
| 156 | Ascites | OFFSIDES | ||
| 157 | Aspergillosis | OFFSIDES | ||
| 158 | Aspiration Pneumonia | OFFSIDES | ||
| 159 | Aura | OFFSIDES | ||
| 160 | Balanitis | OFFSIDES | ||
| 161 | Base excess increased | OFFSIDES | ||
| 162 | Bedridden | OFFSIDES | ||
| 163 | Beta-N-acetyl-D-glucosaminidase increased | OFFSIDES | ||
| 164 | Bladder cancer recurrent | OFFSIDES | ||
| 165 | Blood albumin abnormal | OFFSIDES | ||
| 166 | Blood albumin decreased | OFFSIDES | ||
| 167 | Blood beta-D-glucan increased | OFFSIDES | ||
| 168 | Blood creatine phosphokinase increased | Canada Vigilance: 1 | Canada Vigilance OFFSIDES | |
| 169 | Blood creatinine increased | OFFSIDES | ||
| 170 | Blood glucose fluctuation | OFFSIDES | ||
| 171 | Blood lactate dehydrogenase increased | OFFSIDES | ||
| 172 | Blood phosphorus | OFFSIDES | ||
| 173 | Blood potassium | OFFSIDES | ||
| 174 | Blood pressure fluctuation | OFFSIDES | ||
| 175 | Blood sodium | OFFSIDES | ||
| 176 | Blood thyroid stimulating hormone increased | OFFSIDES | ||
| 177 | Blood urea increased | OFFSIDES | ||
| 178 | Blood uric acid decreased | OFFSIDES | ||
| 179 | Blood zinc decreased | OFFSIDES | ||
| 180 | Bowel movement irregularity | OFFSIDES | ||
| 181 | Bronchitis | OFFSIDES | ||
| 182 | Bronchoalveolar Lavage | OFFSIDES | ||
| 183 | Cancer Pain | OFFSIDES | ||
| 184 | Cardiac Hypertrophy | OFFSIDES | ||
| 185 | Cardiotoxicity | OFFSIDES | ||
| 186 | Cell marker increased | OFFSIDES | ||
| 187 | Coagulation factor increased | OFFSIDES | ||
| 188 | Compulsive sexual behaviour | OFFSIDES | ||
| 189 | Concomitant disease progression | OFFSIDES | ||
| 190 | Constipation | Canada Vigilance: 1 | Canada Vigilance | |
| 191 | Corneal erosion | OFFSIDES | ||
| 192 | Cyanosis | OFFSIDES | ||
| 193 | Disease Progression | OFFSIDES | ||
| 194 | Disseminated Intravascular Coagulation | OFFSIDES | ||
| 195 | Diverticulitis | OFFSIDES | ||
| 196 | Dyslalia | OFFSIDES | ||
| 197 | Dystonia | OFFSIDES | ||
| 198 | Dysuria | Canada Vigilance: 1 | Canada Vigilance | |
| 199 | Embolism | OFFSIDES | ||
| 200 | Encephalitis | OFFSIDES | ||
| 201 | Enterocolitis | OFFSIDES | ||
| 202 | Entropion | OFFSIDES | ||
| 203 | Enzyme abnormality | OFFSIDES | ||
| 204 | Eosinophil percentage increased | OFFSIDES | ||
| 205 | Epidermal necrosis | OFFSIDES | ||
| 206 | Epstein-Barr virus antibody positive | OFFSIDES | ||
| 207 | Erythema | Canada Vigilance: 1 | Canada Vigilance OFFSIDES | |
| 208 | Escherichia infection | OFFSIDES | ||
| 209 | Eyelid Diseases | OFFSIDES | ||
| 210 | Eyelid erosion | OFFSIDES | ||
| 211 | Feeling Cold | Canada Vigilance: 2 | Canada Vigilance | |
| 212 | Fibrin decreased | OFFSIDES | ||
| 213 | Gamma-Glutamyltransferase Increased | OFFSIDES | ||
| 214 | Gastric ulcer | OFFSIDES | ||
| 215 | Gastroenteritis | OFFSIDES | ||
| 216 | Gastrointestinal motility disorder | Canada Vigilance: 1 | Canada Vigilance | |
| 217 | Gastrointestinal tract adenoma | OFFSIDES | ||
| 218 | General physical health deterioration | OFFSIDES | ||
| 219 | Genital erosion | OFFSIDES | ||
| 220 | Glioblastoma Multiforme | OFFSIDES | ||
| 221 | Gum neoplasm malignant stage unspecified | OFFSIDES | ||
| 222 | Head discomfort | Canada Vigilance: 1 | Canada Vigilance | |
| 223 | Hepatic cancer metastatic | OFFSIDES | ||
| 224 | Hiccough | OFFSIDES | ||
| 225 | Hypertrophic Cardiomyopathy | OFFSIDES | ||
| 226 | Ileal ulcer | Canada Vigilance: 5 | Canada Vigilance | |
| 227 | Incorrect product administration duration | Canada Vigilance: 2 | Canada Vigilance | |
| 228 | Infection | OFFSIDES | ||
| 229 | Infrequent bowel movements | Canada Vigilance: 2 | Canada Vigilance | |
| 230 | Intercostal neuralgia | OFFSIDES | ||
| 231 | Intestinal Perforation | OFFSIDES | ||
| 232 | Iron binding capacity total abnormal | OFFSIDES | ||
| 233 | Jejunal ulcer | OFFSIDES | ||
| 234 | Kidney Failure | OFFSIDES | ||
| 235 | Large intestine perforation | OFFSIDES | ||
| 236 | Laryngospasm | OFFSIDES | ||
| 237 | Lethargy | Canada Vigilance: 2 | Canada Vigilance | |
| 238 | Leukoencephalopathy | OFFSIDES | ||
| 239 | Leukopenia neonatal | OFFSIDES | ||
| 240 | Lipase | OFFSIDES | ||
| 241 | Livedo Reticularis | OFFSIDES | ||
| 242 | Liver Abscess | OFFSIDES | ||
| 243 | Long QT Syndrome | OFFSIDES | ||
| 244 | Lung Abscess | OFFSIDES | ||
| 245 | Lymphocyte count decreased | OFFSIDES | ||
| 246 | Lymphocytic infiltration | OFFSIDES | ||
| 247 | Malabsorption | OFFSIDES | ||
| 248 | Malignant neoplasm progression | OFFSIDES | ||
| 249 | Mallory-Weiss Syndrome | OFFSIDES | ||
| 250 | Mental impairment | Canada Vigilance: 1 | Canada Vigilance | |
| 251 | Metastatic Neoplasm | OFFSIDES | ||
| 252 | Microcytosis | OFFSIDES | ||
| 253 | Mucosal erosion | OFFSIDES | ||
| 254 | Mutism | OFFSIDES | ||
| 255 | Myalgia | Canada Vigilance: 1 | Canada Vigilance | |
| 256 | Neonatal respiratory arrest | OFFSIDES | ||
| 257 | Neonatal respiratory failure | OFFSIDES | ||
| 258 | Neutropenic colitis | OFFSIDES | ||
| 259 | Neutrophil count decreased | OFFSIDES | ||
| 260 | Occult blood positive | OFFSIDES | ||
| 261 | Oculomucocutaneous syndrome | OFFSIDES | ||
| 262 | Oral polypectomy | OFFSIDES | ||
| 263 | Oropharyngeal discomfort | OFFSIDES | ||
| 264 | PO2 decreased | OFFSIDES | ||
| 265 | PROTHROMBIN TIME | OFFSIDES | ||
| 266 | Palpitations | Canada Vigilance: 2 | Canada Vigilance | |
| 267 | Pancreatic enzymes abnormal | OFFSIDES | ||
| 268 | Parvovirus B19 serology positive | OFFSIDES | ||
| 269 | Perianal abscess | OFFSIDES | ||
| 270 | Periarthritis | OFFSIDES | ||
| 271 | Pericarditis | OFFSIDES | ||
| 272 | Peripheral arterial occlusive disease | OFFSIDES | ||
| 273 | Peritonitis | OFFSIDES | ||
| 274 | Peritonsillar Abscess | OFFSIDES | ||
| 275 | Platelet Transfusion | OFFSIDES | ||
| 276 | Pleurisy | OFFSIDES | ||
| 277 | Polymyalgia Rheumatica | OFFSIDES | ||
| 278 | Post procedural complication | OFFSIDES | ||
| 279 | Postrenal failure | OFFSIDES | ||
| 280 | Protein total increased | OFFSIDES | ||
| 281 | Psychiatric symptom | OFFSIDES | ||
| 282 | Pulmonary Infarction | OFFSIDES | ||
| 283 | Pyelonephritis | OFFSIDES | ||
| 284 | Pyloric Stenosis | OFFSIDES | ||
| 285 | Rectal Stenosis | OFFSIDES | ||
| 286 | Rectal spasm | Canada Vigilance: 1 | Canada Vigilance | |
| 287 | Renal abscess | OFFSIDES | ||
| 288 | Renal pain | Canada Vigilance: 1 | Canada Vigilance | |
| 289 | Reticulocyte count increased | OFFSIDES | ||
| 290 | Septic Shock | OFFSIDES | ||
| 291 | Shock | Canada Vigilance: 1 | Canada Vigilance | |
| 292 | Sigmoidoscopy abnormal | OFFSIDES | ||
| 293 | Sinus bradycardia | OFFSIDES | ||
| 294 | Sjogren's Syndrome | OFFSIDES | ||
| 295 | Skin necrosis | OFFSIDES | ||
| 296 | Small intestine carcinoma | OFFSIDES | ||
| 297 | Snoring | OFFSIDES | ||
| 298 | Sputum culture positive | OFFSIDES | ||
| 299 | Sputum retention | OFFSIDES | ||
| 300 | Status Epilepticus | OFFSIDES | ||
| 301 | Subcutaneous Emphysema | OFFSIDES | ||
| 302 | Sudden death | OFFSIDES | ||
| 303 | Sympathicotonia | OFFSIDES | ||
| 304 | Tachyarrhythmia | Canada Vigilance: 2 | Canada Vigilance | |
| 305 | Therapeutic product effect decreased | Canada Vigilance: 1 | Canada Vigilance | |
| 306 | Therapeutic product effect incomplete | Canada Vigilance: 1 | Canada Vigilance | |
| 307 | Therapy cessation | Canada Vigilance: 1 | Canada Vigilance | |
| 308 | Tinea | OFFSIDES | ||
| 309 | Upper respiratory tract inflammation | OFFSIDES | ||
| 310 | Ureterostomy site discomfort | OFFSIDES | ||
| 311 | Vanishing bile duct syndrome | OFFSIDES | ||
| 312 | Wound Infection | OFFSIDES | ||
| 313 | Wound dehiscence | OFFSIDES |
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