MetaADEDB 2.0 @ LMMD
Sevoflurane
(DFEYYRMXOJXZRJ-UHFFFAOYSA-N)
Structure
SMILES
FCOC(C(F)(F)F)C(F)(F)F
Type(s)
Approved; Vet_approved
ATC code(s)
N01AB08
Molecular Formula:
C4H3F7O
Molecular Weight:
200.055
Log P:
2.4232
Hydrogen Bond Acceptor:
1
Hydrogen Bond Donor:
0
TPSA:
9.23
CAS Number(s):
28523-86-6
Synonym(s)
1.
Sevoflurane
2.
BAX 3084
3.
Fluoromethyl Hexafluoroisopropyl Ether
4.
Fluoromethyl-2,2,2-trifluoro-1-(trifluoromethyl)ethyl Ether
5.
Sevorane
6.
Ultane
External Link(s)
MeSHD000077149
PubChem Compound5206
ChEBI9130
CHEMBLCHEMBL1200694
DrugBankDB01236
DrugCentral2439
IUPHAR/BPS Guide to PHARMACOLOGY7296
KEGGcpd:C07520
dr:D00547
Therapeutic Target DatabaseD0W6ZF
ZINC1530810
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Cardiac ArrestFAERS: 35
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
2Electroencephalogram abnormalFAERS: 28US FAERS
3Drug ineffectiveFAERS: 27US FAERS
4HypotensionFAERS: 24
Canada Vigilance: 2

View details

7486177
7553996
10226861
11251433
12094919
12932066
15064263
16077295
18377704
19295389
 		CTD
SIDER
Canada Vigilance
US FAERS
5Product quality issueFAERS: 24US FAERS
6Product tamperingFAERS: 24US FAERS
7Drug exposure during pregnancyFAERS: 23US FAERS
8TachycardiaFAERS: 2316037151CTD
SIDER
US FAERS
9NauseaFAERS: 1311843743CTD
SIDER
US FAERS
10BradycardiaFAERS: 12
Canada Vigilance: 3		12932066CTD
OFFSIDES
SIDER
Canada Vigilance
US FAERS
11Myocardial InfarctionFAERS: 1219881297CTD
US FAERS
12BronchospasmFAERS: 11SIDER
US FAERS
13Occupational exposure to productFAERS: 11US FAERS
14OverdoseFAERS: 11OFFSIDES
US FAERS
15AgitationFAERS: 10SIDER
US FAERS
16CyanosisFAERS: 10OFFSIDES
US FAERS
17Atrial FibrillationFAERS: 9SIDER
US FAERS
18Device malfunctionFAERS: 9US FAERS
19Muscle RigidityFAERS: 9SIDER
US FAERS
20RhabdomyolysisFAERS: 9
Canada Vigilance: 1		18947162CTD
OFFSIDES
SIDER
Canada Vigilance
US FAERS
21Ventricular FibrillationFAERS: 9OFFSIDES
SIDER
US FAERS
22VomitingFAERS: 911843743CTD
SIDER
US FAERS
23Drug toxicityFAERS: 8US FAERS
24HypersensitivityFAERS: 8SIDER
US FAERS
25Occupational exposure to drugFAERS: 8US FAERS
26ThrombocytopeniaFAERS: 8SIDER
US FAERS
27DystoniaFAERS: 715200561CTD
OFFSIDES
US FAERS
28HypoxiaFAERS: 719340552CTD
OFFSIDES
SIDER
US FAERS
29Drug abuseFAERS: 6US FAERS
30Hepatic necrosisFAERS: 6OFFSIDES
SIDER
US FAERS
31HypercapniaFAERS: 6OFFSIDES
US FAERS
32LaryngospasmFAERS: 6OFFSIDES
SIDER
US FAERS
33Metabolic acidosisFAERS: 6OFFSIDES
US FAERS
34Respiratory DepressionFAERS: 6SIDER
US FAERS
35Respiratory FailureFAERS: 6OFFSIDES
SIDER
US FAERS
36Toxicity to various agentsFAERS: 6US FAERS
37jaundiceFAERS: 6
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
38Accidental exposureFAERS: 5US FAERS
39AmnesiaFAERS: 520807582CTD
US FAERS
40Blood creatine phosphokinase increasedFAERS: 5OFFSIDES
US FAERS
41CatatoniaFAERS: 5OFFSIDES
US FAERS
42Disseminated Intravascular CoagulationFAERS: 5US FAERS
43HepatitisFAERS: 5
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
SIDER
US FAERS
44Incorrect dose administeredFAERS: 5US FAERS
45PCO2 increasedFAERS: 5OFFSIDES
US FAERS
46ScreamingFAERS: 5OFFSIDES
US FAERS
47StaringFAERS: 5OFFSIDES
US FAERS
48Thermal burnFAERS: 5US FAERS
49White blood cell count abnormalFAERS: 5US FAERS
50White blood cell count decreasedFAERS: 5US FAERS
51AcidosisFAERS: 418947162CTD
OFFSIDES
SIDER
US FAERS
52Acute respiratory failureFAERS: 4US FAERS
53Alanine Aminotransferase IncreasedFAERS: 4OFFSIDES
US FAERS
54Aspartate Aminotransferase IncreasedFAERS: 4US FAERS
55Carbon dioxide increasedFAERS: 4US FAERS
56ChillsFAERS: 4SIDER
US FAERS
57DeliriumFAERS: 4

View details

9416712
10357335
10886700
16324031
17184433
17359403
19538532
20735801
 		CTD
US FAERS
58Endotracheal intubation complicationFAERS: 4OFFSIDES
US FAERS
59Increased bronchial secretionFAERS: 4OFFSIDES
SIDER
US FAERS
60LethargyFAERS: 4US FAERS
61MalaiseFAERS: 4US FAERS
62Medication ErrorFAERS: 4US FAERS
63Mental impairmentFAERS: 4US FAERS
64PainFAERS: 4SIDER
US FAERS
65Poor quality sleepFAERS: 4OFFSIDES
US FAERS
66Product expiration date issueFAERS: 4US FAERS
67SepsisFAERS: 4US FAERS
68SomnolenceFAERS: 4SIDER
US FAERS
69Suicide attemptFAERS: 4US FAERS
70Suspected counterfeit productFAERS: 4US FAERS
71Transaminases increasedFAERS: 4US FAERS
72Unevaluable eventFAERS: 4US FAERS
73Activated partial thromboplastin time abnormalFAERS: 3OFFSIDES
US FAERS
74AnuriaFAERS: 3US FAERS
75AtelectasisFAERS: 3OFFSIDES
US FAERS
76Atrioventricular BlockFAERS: 3OFFSIDES
US FAERS
77Burning sensationFAERS: 3US FAERS
78Completed SuicideFAERS: 3US FAERS
79Depressed Level of ConsciousnessFAERS: 3OFFSIDES
US FAERS
80EpilepsyFAERS: 316037151CTD
US FAERS
81Gastric mucosal lesionFAERS: 3OFFSIDES
US FAERS
82Hepatorenal SyndromeFAERS: 3US FAERS
83Hypertensive crisisFAERS: 3US FAERS
84Idiosyncratic drug reactionFAERS: 3OFFSIDES
US FAERS
85Left atrial dilatationFAERS: 3OFFSIDES
US FAERS
86PneumoniaFAERS: 3US FAERS
87Poor peripheral circulationFAERS: 3OFFSIDES
US FAERS
88Post procedural complicationFAERS: 3OFFSIDES
US FAERS
89Procedural complicationFAERS: 3OFFSIDES
US FAERS
90Product container issueFAERS: 3US FAERS
91PruritusFAERS: 3SIDER
US FAERS
92Respiratory arrestFAERS: 3US FAERS
93TremorFAERS: 3US FAERS
94Ventricular DysfunctionFAERS: 3US FAERS
95WheezingFAERS: 3SIDER
US FAERS
96AbasiaFAERS: 2US FAERS
97Abdominal PainFAERS: 2US FAERS
98Accidental exposure to productFAERS: 2US FAERS
99Blood pH decreasedFAERS: 2OFFSIDES
US FAERS
100Chest PainFAERS: 2SIDER
US FAERS
101ChromaturiaFAERS: 2OFFSIDES
US FAERS
102Device use errorFAERS: 2US FAERS
103DisabilityFAERS: 2US FAERS
104DizzinessFAERS: 2SIDER
US FAERS
105Drug DependenceFAERS: 2US FAERS
106Drug delivery device removalFAERS: 2US FAERS
107DysarthriaFAERS: 2US FAERS
108Expired drug administeredFAERS: 2US FAERS
109FlushingFAERS: 2US FAERS
110General physical health deteriorationFAERS: 2US FAERS
111HepatotoxicityFAERS: 2OFFSIDES
US FAERS
112Incorrect dose administered by deviceFAERS: 2US FAERS
113Medical device complicationFAERS: 2OFFSIDES
US FAERS
114Musculoskeletal stiffnessFAERS: 2OFFSIDES
US FAERS
115Nephrogenic Diabetes InsipidusFAERS: 2US FAERS
116NervousnessFAERS: 2SIDER
US FAERS
117Oropharyngeal spasmFAERS: 2US FAERS
118Pharmaceutical product complaintFAERS: 2US FAERS
119Procedural nauseaFAERS: 2US FAERS
120Procedural vomitingFAERS: 2OFFSIDES
US FAERS
121Product packaging issueFAERS: 2US FAERS
122Respiratory distressFAERS: 2US FAERS
123ShockFAERS: 2SIDER
US FAERS
124SwellingFAERS: 2US FAERS
125Unresponsive to stimuliFAERS: 2OFFSIDES
US FAERS
126Upper airway obstructionFAERS: 2OFFSIDES
US FAERS
127UrticariaFAERS: 2SIDER
US FAERS
128Accidental deathFAERS: 1US FAERS
129Accidental overdoseFAERS: 1US FAERS
130Acute promyelocytic leukaemia differentiation syndromeFAERS: 1US FAERS
131Adverse eventFAERS: 1US FAERS
132Airway burnsFAERS: 1OFFSIDES
US FAERS
133Altered state of consciousnessFAERS: 1US FAERS
134Anaphylactoid syndrome of pregnancyFAERS: 1US FAERS
135AnxietyFAERS: 1US FAERS
136Apallic syndromeFAERS: 1OFFSIDES
US FAERS
137AscitesFAERS: 1US FAERS
138AsthmaFAERS: 1US FAERS
139Atrial tachycardiaFAERS: 1OFFSIDES
US FAERS
140Autoimmune hepatitisFAERS: 1US FAERS
141Blood potassium abnormalFAERS: 1US FAERS
142Blood thyroid stimulating hormone increasedFAERS: 1US FAERS
143Brain DeathFAERS: 1OFFSIDES
US FAERS
144Brain HypoxiaFAERS: 1US FAERS
145BronchopneumoniaFAERS: 1US FAERS
146Carbon dioxide abnormalFAERS: 1US FAERS
147CardiomegalyFAERS: 1US FAERS
148Central nervous system lesionFAERS: 1US FAERS
149Cerebrovascular accidentFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
150CholelithiasisFAERS: 1US FAERS
151CholestasisFAERS: 119455019CTD
US FAERS
152Cholestatic liver injuryFAERS: 1US FAERS
153Circumstance or information capable of leading to medication errorFAERS: 1US FAERS
154CryingFAERS: 1US FAERS
155Device interactionFAERS: 1US FAERS
156Device leakageFAERS: 1US FAERS
157Device use issueFAERS: 1US FAERS
158Diffuse alveolar damageFAERS: 1US FAERS
159DisorientationFAERS: 1US FAERS
160Drug administration errorFAERS: 1US FAERS
161Drug dispensing errorFAERS: 1US FAERS
162Drug effect delayedFAERS: 1US FAERS
163Drug prescribing errorFAERS: 1US FAERS
164Drug resistanceFAERS: 1US FAERS
165DuodenitisFAERS: 1US FAERS
166DysgeusiaFAERS: 1SIDER
US FAERS
167DysplasiaFAERS: 1US FAERS
168Electrocardiogram R on T phenomenonFAERS: 1US FAERS
169Electrocardiogram changeFAERS: 1US FAERS
170Embolic strokeFAERS: 1US FAERS
171EmbolismFAERS: 1US FAERS
172End-tidal CO2 increasedFAERS: 1OFFSIDES
US FAERS
173Enzyme level increasedFAERS: 1US FAERS
174FatigueFAERS: 1US FAERS
175GlossoptosisFAERS: 1OFFSIDES
US FAERS
176HeadacheFAERS: 1SIDER
US FAERS
177HemiparesisFAERS: 1OFFSIDES
US FAERS
178Hepatic InfarctionFAERS: 1US FAERS
179Hepatic artery occlusionFAERS: 1US FAERS
180HyperchlorhydriaFAERS: 1US FAERS
181HypermetabolismFAERS: 1US FAERS
182HypoperfusionFAERS: 1US FAERS
183HypophagiaFAERS: 1US FAERS
184Impaired work abilityFAERS: 1US FAERS
185Inadequate analgesiaFAERS: 1US FAERS
186InfectionFAERS: 1US FAERS
187Intentional misuseFAERS: 1US FAERS
188Intentional self-injuryFAERS: 1US FAERS
189Intra-abdominal fluid collectionFAERS: 1US FAERS
190Jugular vein distensionFAERS: 1US FAERS
191Long QT SyndromeFAERS: 1OFFSIDES
US FAERS
192Mechanical ventilation complicationFAERS: 1US FAERS
193Mental status changesFAERS: 1US FAERS
194Muscle SpasticityFAERS: 1US FAERS
195MyoclonusFAERS: 1US FAERS
196Myoglobin urine absentFAERS: 1US FAERS
197Neonatal disorderFAERS: 1US FAERS
198Nephrotic SyndromeFAERS: 1US FAERS
199Norepinephrine increasedFAERS: 1US FAERS
200Oropharyngeal painFAERS: 1US FAERS
201Oxygen saturation increasedFAERS: 1US FAERS
202ParaparesisFAERS: 1US FAERS
203Pericardial effusionFAERS: 1US FAERS
204Product formulation issueFAERS: 1US FAERS
205Product packaging quantity issueFAERS: 1US FAERS
206Product physical consistency issueFAERS: 1US FAERS
207Product use issueFAERS: 1US FAERS
208Protein total decreasedFAERS: 1US FAERS
209Pulmonary congestionFAERS: 1OFFSIDES
US FAERS
210Pulmonary vasculitisFAERS: 1US FAERS
211Refusal of treatment by relativeFAERS: 1US FAERS
212RestlessnessFAERS: 1US FAERS
213Septic ShockFAERS: 1US FAERS
214Sputum retentionFAERS: 1OFFSIDES
US FAERS
215Status EpilepticusFAERS: 1OFFSIDES
US FAERS
216Supraventricular tachycardiaFAERS: 1OFFSIDES
US FAERS
217SyncopeFAERS: 1SIDER
US FAERS
218Therapeutic response delayedFAERS: 1US FAERS
219ThrombosisFAERS: 1US FAERS
220Tidal volume decreasedFAERS: 1US FAERS
221Tonic clonic movementsFAERS: 1OFFSIDES
SIDER
US FAERS
222TrismusFAERS: 118947162CTD
US FAERS
223VasculitisFAERS: 1US FAERS
224VertigoFAERS: 1US FAERS
225Vital functions abnormalFAERS: 1US FAERS
226Weight decreasedFAERS: 1US FAERS
227Wound dehiscenceFAERS: 1US FAERS
228Wrong technique in drug usage processFAERS: 1US FAERS
229Wrong technique in product usage processFAERS: 1US FAERS
230Abdominal Compartment SyndromeOFFSIDES
231Acute myocardial infarctionOFFSIDES
232Acute right ventricular failureOFFSIDES
233Akathisia, Drug-Induced18095967CTD
234AkinesiaOFFSIDES
235AlbuminuriaSIDER
236AmblyopiaSIDER
237Anaphylactic shockSIDER
238Anaphylactoid ReactionSIDER
239Angle Closure GlaucomaOFFSIDES
240AnisocoriaOFFSIDES
241AnoxiaOFFSIDES
242Anticholinergic SyndromeOFFSIDES
243Apnea20865877CTD
OFFSIDES
244AstheniaSIDER
245Atrial arrhythmiaSIDER
246Basal Ganglia Diseases15200561CTD
247Blood alkaline phosphatase abnormalOFFSIDES
248Blood corticotrophin increasedOFFSIDES
249Blood gases abnormalOFFSIDES
250Blood lactate dehydrogenase increasedOFFSIDES
251Blood magnesium increasedOFFSIDES
252Blood phosphorus increasedOFFSIDES
253Blood potassium increasedOFFSIDES
254Blood potassiumOFFSIDES
255Blood pressure fluctuationOFFSIDES
256Blood pressure immeasurableOFFSIDES
257Brain Ischemia17291693CTD
258Breath HoldingOFFSIDES
SIDER
259Bronchial ObstructionOFFSIDES
260BronchomalaciaOFFSIDES
261Bulbar palsyOFFSIDES
262Carbon Monoxide PoisoningOFFSIDES
263Cardio-respiratory distressOFFSIDES
264Cardiovascular Diseases11843743CTD
265Cardiovascular insufficiencyOFFSIDES
266Cerebral disorderOFFSIDES
267Cerebral hypoperfusionOFFSIDES
268CheilitisOFFSIDES
269Chemical and Drug Induced Liver Injury12934853
15271707
19455019		CTD
270Chemical injuryOFFSIDES
271Chest discomfortSIDER
272CholangiolitisOFFSIDES
273ClonusOFFSIDES
274Coagulation factor V level decreasedOFFSIDES
275Cognition Disorders20042477CTD
276Complications of transplant surgeryOFFSIDES
277Congenital tracheomalaciaOFFSIDES
278ConjunctivitisSIDER
279Creatinine renal clearance decreasedOFFSIDES
280Creatinine renal clearance increasedOFFSIDES
281Cytokine Release SyndromeOFFSIDES
282Dacryostenosis acquiredOFFSIDES
283DermatitisSIDER
284DermatomyositisOFFSIDES
285Device FailureOFFSIDES
286Drug ToleranceOFFSIDES
287DysuriaSIDER
288Echocardiogram abnormalOFFSIDES
289Electrocardiogram ST segment abnormalOFFSIDES
290Electrocardiogram ST-T segment depressionOFFSIDES
291Electrocardiogram repolarisation abnormalityOFFSIDES
292Electromechanical dissociationOFFSIDES
293Eosinophilic myocarditisOFFSIDES
294Epidural AbscessOFFSIDES
295Feeling ColdOFFSIDES
296Feeling abnormalSIDER
297Fluoride increasedSIDER
298GastroenteritisOFFSIDES
299Global AmnesiaOFFSIDES
300GlobulinuriaOFFSIDES
301GlossectomyOFFSIDES
302Glycosuria11149433CTD
SIDER
303Grip strengthOFFSIDES
304Head circumference abnormalOFFSIDES
305Hepatic congestionOFFSIDES
306Hepatomegaly15271707CTD
307HydrocephalusOFFSIDES
308Hyperalgesia19247760CTD
309Hyperkalemia18947162CTD
310HyperventilationSIDER
311Hypoglossal Nerve DisorderOFFSIDES
312HypoventilationSIDER
313Iatrogenic injuryOFFSIDES
314Incorrect drug administration rateOFFSIDES
315Infantile apnoeic attackOFFSIDES
316Injection site inflammationOFFSIDES
317IntubationOFFSIDES
318Kidney Diseases

View details

9356118
9356119
9805693
10357366
 		CTD
319Labile blood pressureOFFSIDES
320LeukocytosisSIDER
321LeukoencephalopathyOFFSIDES
322Liver Failure11375824CTD
323Low Cardiac Output SyndromeOFFSIDES
324LymphoceleOFFSIDES
325MalnutritionSIDER
326Mechanical ventilationOFFSIDES
327Memory Disorders19212262
30842370		CTD
328Migraine with AuraOFFSIDES
329Muscle necrosisOFFSIDES
330Myoclonic EpilepsyOFFSIDES
331Myoglobin blood increasedOFFSIDES
332Myoglobin urine presentOFFSIDES
333MyoglobinaemiaOFFSIDES
334MyotoniaOFFSIDES
335Necrosis19455019CTD
336Nerve Degeneration26206149CTD
337NoduleOFFSIDES
338NystagmusOFFSIDES
339Olfaction Disorders20962652CTD
340OliguriaOFFSIDES
SIDER
341OphthalmoplegiaOFFSIDES
342PCO2 decreasedOFFSIDES
343PO2 decreasedOFFSIDES
344Pain, Postoperative16297693
20735801		CTD
345PancreatitisSIDER
346ParotitisOFFSIDES
347PharyngitisSIDER
348PityriasisOFFSIDES
349Postoperative Complications26045204CTD
350Postoperative Nausea and Vomiting10220941
19538532
20735801		CTD
351Postoperative feverOFFSIDES
352Postoperative respiratory distressOFFSIDES
353Prenatal Exposure Delayed Effects30842370CTD
354Procedural hypertensionOFFSIDES
355Procedural hypotensionOFFSIDES
356Proteinuria9710388
11149433		CTD
357Psychomotor Agitation10886700
20964769		CTD
358Pulmonary arterial pressure increasedOFFSIDES
359Pulmonary function test decreasedSIDER
360Pustular psoriasisOFFSIDES
361RalesOFFSIDES
362Reperfusion Injury20137656CTD
363Respiration Disorders11843743CTD
364Right atrial pressure increasedOFFSIDES
365Risus sardonicusOFFSIDES
366Seizures

View details

8780283
8936550
9895084
15101868
15278670
17666720
 		CTD
367Sensorimotor disorderOFFSIDES
368ShiveringSIDER
369Sinoatrial BlockOFFSIDES
370Sinus bradycardiaOFFSIDES
371Sleep Wake Disorders17377082CTD
372StridorSIDER
373TensionSIDER
374Therapy non-responderOFFSIDES
375Torsades de Pointes10402818CTD
376Tracheal StenosisOFFSIDES
377Transurethral resection syndromeOFFSIDES
378Tryptase increasedOFFSIDES
379Urinary RetentionSIDER
380Urine ketone body presentOFFSIDES
381Ventricular Dysfunction, Left16750736CTD
382Ventricular bigeminySIDER
383Ventricular hypokinesiaOFFSIDES
384nervous system disorderSIDER
385procalcitoninOFFSIDES
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