MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Terazosin

(VCKUSRYTPJJLNI-UHFFFAOYSA-N)

Structure

SMILES: COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)C1CCCO1
Type(s): Approved
ATC code(s): G04CA03
Molecular Formula:: C19H25N5O4
Molecular Weight:: 387.433
Log P:: 1.6409
Hydrogen Bond Acceptor:: 9
Hydrogen Bond Donor:: 1
TPSA:: 103.04
CAS Number(s):: 63590-64-7; 109351-34-0; 141269-44-5; 141269-45-6

Synonym(s)

Terazosin

A 45975

Adecur

Apo-Terazosin

Deflox

Dysalfa

Flotrin

Heitrin

Hytrin

10.

Hytrin BPH

11.

Hytrine

12.

Magnurol

13.

Novo-Terazosin

14.

Nu-Terazosin

15.

PMS-Terazosin

16.

Sutif

17.

Tazusin

18.

Terazoflo

19.

Terazosin AZU

20.

Terazosin Hexal

21.

Terazosin hydrochloride

22.

Terazosina Alter

23.

Terazosina Kern

24.

Terazosina Qualix

25.

Zayasel

26.

ratio-Terazosin

27.

terazosin hydrochloride anhydrous

28.

terazosin, monohydrochloride, dihydrate

External Link(s)

MeSH	C041226
PubChem Compound	5401
BindingDB	50033111
ChEBI	9445
CHEMBL	CHEMBL611
DrugBank	DB01162
DrugCentral	3584
IUPHAR/BPS Guide to PHARMACOLOGY	7302
KEGG	cpd:C07127 dr:D08569
Therapeutic Target Database	D0P9RF

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Hypotension	FAERS: 30	7911308 8633398 10503165	CTD SIDER US FAERS
2	Syncope	FAERS: 29		SIDER US FAERS
3	Dizziness	FAERS: 23 Canada Vigilance: 5	View details 9160069 9650545 10503165 17617290	CTD OFFSIDES SIDER Canada Vigilance US FAERS
4	Drug ineffective	FAERS: 8 Canada Vigilance: 2		Canada Vigilance OFFSIDES US FAERS
5	Hypersensitivity	FAERS: 6		SIDER US FAERS
6	Cerebral Infarction	FAERS: 5		US FAERS
7	Headache	FAERS: 5 Canada Vigilance: 3		Canada Vigilance SIDER US FAERS
8	Priapism	FAERS: 5		OFFSIDES SIDER US FAERS
9	Asthenia	FAERS: 4 Canada Vigilance: 1	9160069	CTD OFFSIDES SIDER Canada Vigilance US FAERS
10	Dysuria	FAERS: 4		OFFSIDES SIDER US FAERS
11	Fatigue	FAERS: 4		OFFSIDES SIDER US FAERS
12	Product substitution issue	FAERS: 4 Canada Vigilance: 1		Canada Vigilance US FAERS
13	Wrong drug administered	FAERS: 4		US FAERS
14	Nausea	FAERS: 3 Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER US FAERS
15	Peripheral swelling	FAERS: 3		US FAERS
16	Pharmaceutical product complaint	FAERS: 3		OFFSIDES US FAERS
17	Product quality issue	FAERS: 3		US FAERS
18	Sinus bradycardia	FAERS: 3		OFFSIDES US FAERS
19	Abdominal discomfort	FAERS: 2		OFFSIDES US FAERS
20	Arthralgia	FAERS: 2		SIDER US FAERS
21	Bradycardia	FAERS: 2		OFFSIDES US FAERS
22	Chest Pain	FAERS: 2		OFFSIDES SIDER US FAERS
23	Dehydration	FAERS: 2		OFFSIDES US FAERS
24	Dysgeusia	FAERS: 2		SIDER US FAERS
25	Erection increased	FAERS: 2		US FAERS
26	Erythema	FAERS: 2		US FAERS
27	Malaise	FAERS: 2 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
28	Medication Error	FAERS: 2		US FAERS
29	Myalgia	FAERS: 2		SIDER US FAERS
30	Nocturia	FAERS: 2		OFFSIDES US FAERS
31	Presyncope	FAERS: 2		US FAERS
32	Pruritus	FAERS: 2		SIDER US FAERS
33	Skin lesion	FAERS: 2		OFFSIDES US FAERS
34	Therapeutic response unexpected with drug substitution	FAERS: 2		US FAERS
35	Unevaluable event	FAERS: 2		US FAERS
36	Urinary tract infection	FAERS: 2		SIDER US FAERS
37	Accidental overdose	FAERS: 1		US FAERS
38	Adverse event	FAERS: 1		OFFSIDES US FAERS
39	Agitation	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
40	Alanine Aminotransferase Increased	FAERS: 1		US FAERS
41	Angioedema	FAERS: 1		OFFSIDES SIDER US FAERS
42	Atrial Fibrillation	FAERS: 1		SIDER US FAERS
43	Back Pain	FAERS: 1		SIDER US FAERS
44	Benign Prostatic Hyperplasia	FAERS: 1		OFFSIDES US FAERS
45	Blood glucose increased	FAERS: 1		US FAERS
46	Blood pressure inadequately controlled	FAERS: 1 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
47	Blood pressure orthostatic abnormal	FAERS: 1		US FAERS
48	Chest discomfort	FAERS: 1		US FAERS
49	Chills	FAERS: 1		US FAERS
50	Completed Suicide	FAERS: 1		US FAERS
51	Constipation	FAERS: 1		SIDER US FAERS
52	Diabetic Ketoacidosis	FAERS: 1		US FAERS
53	Drug prescribing error	FAERS: 1		US FAERS
54	Flatulence	FAERS: 1		OFFSIDES SIDER US FAERS
55	Flushing	FAERS: 1		US FAERS
56	Gastrostomy	FAERS: 1		US FAERS
57	Genital abscess	FAERS: 1		US FAERS
58	Genital burning sensation	FAERS: 1		US FAERS
59	Grip strength decreased	FAERS: 1		US FAERS
60	HIV-associated neurocognitive disorder	FAERS: 1		US FAERS
61	Hormone level abnormal	FAERS: 1		US FAERS
62	Hypophagia	FAERS: 1		OFFSIDES US FAERS
63	Hyporesponsive to stimuli	FAERS: 1		US FAERS
64	Inappropriate schedule of product administration	FAERS: 1		US FAERS
65	Incorrect dose administered	FAERS: 1		US FAERS
66	Intervertebral Disc Degeneration	FAERS: 1		OFFSIDES US FAERS
67	Iridocele	FAERS: 1		OFFSIDES US FAERS
68	Joint swelling	FAERS: 1		US FAERS
69	Limb discomfort	FAERS: 1		US FAERS
70	Lip swelling	FAERS: 1		US FAERS
71	Myocardial Infarction	FAERS: 1		US FAERS
72	Nervousness	FAERS: 1 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
73	Palpitations	FAERS: 1		SIDER US FAERS
74	Penile swelling	FAERS: 1		OFFSIDES US FAERS
75	Piloerection	FAERS: 1		US FAERS
76	Product compounding quality issue	FAERS: 1		US FAERS
77	Prostatic pain	FAERS: 1		US FAERS
78	Rebound effect	FAERS: 1		US FAERS
79	Renal pain	FAERS: 1		US FAERS
80	Scab	FAERS: 1		US FAERS
81	Somnolence	FAERS: 1		SIDER US FAERS
82	Suicide attempt	FAERS: 1		US FAERS
83	Therapy change	FAERS: 1		US FAERS
84	Therapy non-responder	FAERS: 1		OFFSIDES US FAERS
85	Tongue biting	FAERS: 1		US FAERS
86	Tremor	FAERS: 1		SIDER US FAERS
87	Unresponsive to stimuli	FAERS: 1		OFFSIDES US FAERS
88	Urinary Incontinence	FAERS: 1		SIDER US FAERS
89	Urinary tract inflammation	FAERS: 1		US FAERS
90	Visual disturbance	FAERS: 1		US FAERS
91	Vomiting	FAERS: 1		SIDER US FAERS
92	Wheezing	FAERS: 1		US FAERS
93	White blood cell count abnormal	FAERS: 1		US FAERS
94	Wrong technique in product usage process	FAERS: 1		US FAERS
95	Abdominal Pain			OFFSIDES SIDER
96	Abdominal strangulated hernia			OFFSIDES
97	Abnormal vision			SIDER
98	Acid reflux			OFFSIDES
99	Actinic keratosis			OFFSIDES
100	Actinomycosis			OFFSIDES
101	Acute bronchitis			OFFSIDES
102	Acute glomerulonephritis			OFFSIDES
103	Acute myocardial infarction			OFFSIDES
104	Acute respiratory failure			OFFSIDES
105	Adenocarcinoma			OFFSIDES
106	Adrenal mass			OFFSIDES
107	Allergy to arthropod sting			OFFSIDES
108	Alopecia			OFFSIDES
109	Amblyopia			SIDER
110	Anal Fissure			OFFSIDES
111	Anaphylactic shock			SIDER
112	Anaphylactoid Reaction			SIDER
113	Angina Pectoris			SIDER
114	Anhidrosis			OFFSIDES
115	Ankylosing spondylitis			OFFSIDES
116	Anorexia			SIDER
117	Anuria			OFFSIDES
118	Anxiety	Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER
119	Aortic Aneurysm			OFFSIDES
120	Aortic valve calcification			OFFSIDES
121	Aortic valve sclerosis			OFFSIDES
122	Appendicitis			OFFSIDES
123	Application site pruritus			OFFSIDES
124	Arteriosclerosis			OFFSIDES
125	Arteriovenous fistula thrombosis			OFFSIDES
126	Arthritis			OFFSIDES SIDER
127	Arthropathy			SIDER
128	Aspiration Pneumonia			OFFSIDES
129	Asthenopia			OFFSIDES
130	Asthma			SIDER
131	Atelectasis			OFFSIDES
132	Atrial Flutter			OFFSIDES
133	Aura			OFFSIDES
134	Bacteria tissue specimen identified			OFFSIDES
135	Bacterial test positive			OFFSIDES
136	Balanitis			OFFSIDES
137	Basal cell carcinoma			OFFSIDES
138	Beta 2 microglobulin increased			OFFSIDES
139	Bifascicular block			OFFSIDES
140	Biopsy bone abnormal			OFFSIDES
141	Biopsy mucosa abnormal			OFFSIDES
142	Bipolar Disorder			OFFSIDES
143	Bladder neck obstruction			OFFSIDES
144	Bladder spasm			OFFSIDES
145	Blood Glucose			OFFSIDES
146	Blood cholesterol			OFFSIDES
147	Blood creatinine increased			OFFSIDES
148	Blood folate increased			OFFSIDES
149	Blood glucose decreased			OFFSIDES
150	Blood glucose fluctuation			OFFSIDES
151	Blood homocysteine			OFFSIDES
152	Blood parathyroid hormone increased			OFFSIDES
153	Blood potassium increased			OFFSIDES
154	Blood pressure orthostatic decreased			OFFSIDES
155	Blood testosterone decreased			OFFSIDES
156	Blood triglycerides increased			OFFSIDES
157	Blood urea increased			OFFSIDES
158	Blood urine present			OFFSIDES
159	Bone density decreased			OFFSIDES
160	Bone erosion			OFFSIDES
161	Bone fragmentation			OFFSIDES
162	Bone pain			OFFSIDES
163	Bone scan abnormal			OFFSIDES
164	Bronchitis			SIDER
165	Bronchoalveolar Lavage			OFFSIDES
166	Bronchopneumonia			OFFSIDES
167	Carcinoma, Transitional Cell		15882756	CTD
168	Cardioactive drug level increased			OFFSIDES
169	Carotid bruit			OFFSIDES
170	Cataract operation complication			OFFSIDES
171	Cataract			OFFSIDES
172	Cellulitis			OFFSIDES
173	Central line infection			OFFSIDES
174	Cerebral atrophy			OFFSIDES
175	Cerebrovascular accident			SIDER
176	Chest wall pain			OFFSIDES
177	Choking sensation			OFFSIDES
178	Cholecystitis infective			OFFSIDES
179	Cholecystitis			OFFSIDES
180	Chronic Fatigue Syndrome			OFFSIDES
181	Chronic Obstructive Airway Disease			OFFSIDES
182	Chronic respiratory failure			OFFSIDES
183	Clostridium difficile colitis			OFFSIDES
184	Cold sweat			OFFSIDES
185	Cold symptoms			SIDER
186	Colon adenoma			OFFSIDES
187	Confabulation			OFFSIDES
188	Congenital tricuspid valve incompetence			OFFSIDES
189	Conjunctivitis			SIDER
190	Cyanopsia			OFFSIDES
191	Cyst			OFFSIDES
192	Deafness Neurosensory			OFFSIDES
193	Deafness			OFFSIDES
194	Delayed sleep phase			OFFSIDES
195	Demyelination			OFFSIDES
196	Dental Fistula			OFFSIDES
197	Dermatitis			SIDER
198	Diabetes			OFFSIDES
199	Diabetic Foot			OFFSIDES
200	Diarrhea			OFFSIDES
201	Diastolic dysfunction			OFFSIDES
202	Diplopia			OFFSIDES
203	Discomfort			SIDER
204	Disturbance in sexual arousal			SIDER
205	Diverticulum			OFFSIDES
206	Drowsiness			OFFSIDES
207	Drug abuser			OFFSIDES
208	Drug addict			OFFSIDES
209	Duodenal ulcer perforation			OFFSIDES
210	Duodenitis			OFFSIDES
211	Dyspepsia			SIDER
212	Dysphonia			OFFSIDES
213	Economic problem			OFFSIDES
214	Eczema			OFFSIDES
215	Edema		9160069 17617290	CTD
216	Ejection Fraction Decreased			OFFSIDES
217	Electrocardiogram ST-T change			OFFSIDES
218	Electrocardiogram poor R-wave progression			OFFSIDES
219	Electromechanical dissociation			OFFSIDES
220	Emotional distress			OFFSIDES
221	Encephalomalacia			OFFSIDES
222	Endocarditis			OFFSIDES
223	Endodontic procedure			OFFSIDES
224	Endotracheal intubation complication			OFFSIDES
225	Epistaxis			OFFSIDES SIDER
226	Erectile dysfunction			OFFSIDES SIDER
227	Excoriation			OFFSIDES
228	Exposure to toxic agent			OFFSIDES
229	Factor VIII Deficiency			OFFSIDES
230	Failure to Thrive			OFFSIDES
231	Feeling abnormal			SIDER
232	Flank Pain			OFFSIDES
233	Floppy iris syndrome	Canada Vigilance: 1		Canada Vigilance SIDER
234	Flu symptoms			SIDER
235	Fluid overload			OFFSIDES
236	Formication			OFFSIDES
237	Gastritis			SIDER
238	Gastroenteritis			OFFSIDES
239	Gastrointestinal Pain			SIDER
240	Gastrointestinal disorder postoperative			OFFSIDES
241	Gastrointestinal sounds abnormal			OFFSIDES
242	Genital Herpes			OFFSIDES
243	Gingival graft			OFFSIDES
244	Gout			OFFSIDES SIDER
245	Graft dysfunction			OFFSIDES
246	Grip strength			OFFSIDES
247	Haptoglobin Decreased			OFFSIDES
248	Hemiparesis			OFFSIDES
249	Hepatic Infarction			OFFSIDES
250	Hepatic congestion			OFFSIDES
251	Hernia			OFFSIDES
252	Hoarseness			OFFSIDES
253	Hydronephrosis			OFFSIDES
254	Hyperkeratosis			OFFSIDES
255	Hypotension, Orthostatic		View details 1711689 9643668 10364649 15811171	CTD
256	Hypotensive			SIDER
257	Hypoxia			OFFSIDES
258	Immune reconstitution syndrome			OFFSIDES
259	Impaired work ability			OFFSIDES
260	Incisional hernia			OFFSIDES
261	Incontinence			OFFSIDES
262	Influenza			SIDER
263	Injection site burning			OFFSIDES
264	Intermittent Claudication			OFFSIDES
265	Intestinal infarction			OFFSIDES
266	Intraoperative Complications		7911308	CTD
267	Intraoperative floppy iris syndrome			SIDER
268	Iodine allergy			OFFSIDES
269	Joint Instability			OFFSIDES
270	Kidney Failure			OFFSIDES
271	Labile hypertension			OFFSIDES
272	Laceration			OFFSIDES
273	Laryngospasm			SIDER
274	Lassitude			SIDER
275	Left Ventricular Hypertrophy			OFFSIDES
276	Lethargy			OFFSIDES
277	Leukoencephalopathy			OFFSIDES
278	Limb injury			OFFSIDES
279	Loose associations			OFFSIDES
280	Loose tooth			OFFSIDES
281	Lumbar radiculopathy			OFFSIDES
282	Lung infection pseudomonal			OFFSIDES
283	Lymph node cancer metastatic			OFFSIDES
284	Lymph nodes scan abnormal			OFFSIDES
285	Malignant Hypertension			OFFSIDES
286	Malnutrition			SIDER
287	Mastication disorder			OFFSIDES
288	Menopause			SIDER
289	Mental status changes			OFFSIDES
290	Mesenteric vascular insufficiency			OFFSIDES
291	Metanephrine urine increased			OFFSIDES
292	Micrographic skin surgery			OFFSIDES
293	Micturition frequency decreased			OFFSIDES
294	Migraine with Aura			OFFSIDES
295	Moaning			OFFSIDES
296	Muscle Weakness			OFFSIDES
297	Musculoskeletal Pain			SIDER
298	Musculoskeletal discomfort			OFFSIDES SIDER
299	Myelitis			OFFSIDES
300	Myelodysplasia			OFFSIDES
301	Myocardial rupture			OFFSIDES
302	Nasopharyngitis			OFFSIDES SIDER
303	Neck Pain			SIDER
304	Nephrolithiasis			OFFSIDES
305	Nicotine Dependence			OFFSIDES
306	Nipple pain			OFFSIDES
307	No reaction on previous exposure to drug			OFFSIDES
308	Non-cardiac chest pain			OFFSIDES
309	Ocular icterus			OFFSIDES
310	Oliguria			OFFSIDES
311	Optic Neuropathy			OFFSIDES
312	Optic nerve cupping			OFFSIDES
313	Oral Cavity Fistula			OFFSIDES
314	Oral mucosa atrophy			OFFSIDES
315	Oral torus			OFFSIDES
316	Orchitis			OFFSIDES
317	Oropharyngeal pain			OFFSIDES
318	Oropharyngeal swelling			OFFSIDES
319	Osteolysis			OFFSIDES
320	Osteomyelitis			OFFSIDES
321	Osteopenia			OFFSIDES
322	Osteoradionecrosis			OFFSIDES
323	Pain of skin			OFFSIDES
324	Pain			OFFSIDES SIDER
325	Pallor			OFFSIDES
326	Panic Disorder			OFFSIDES
327	Paranasal sinus hypersecretion			OFFSIDES
328	Paranoid Personality Disorder			OFFSIDES
329	Pedal pulse decreased			OFFSIDES
330	Pemphigus			OFFSIDES
331	Perianal abscess			OFFSIDES
332	Pericardial effusion			OFFSIDES
333	Personality Change			OFFSIDES
334	Pharyngitis			SIDER
335	Phimosis			OFFSIDES
336	Plasmacytosis			OFFSIDES
337	Pneumothorax			OFFSIDES
338	Polyuria			OFFSIDES
339	Positron emission tomogram abnormal			OFFSIDES
340	Post procedural complication			OFFSIDES
341	Postmenopausal bleeding			OFFSIDES
342	Postoperative infection			OFFSIDES
343	Postoperative wound complication			OFFSIDES
344	Precancerous skin lesion			OFFSIDES
345	Pressure of speech			OFFSIDES
346	Procedural complication			OFFSIDES
347	Progressive supranuclear palsy			OFFSIDES
348	Prostatic Hyperplasia		View details 1711689 7528458 8633398 9772873 10332490 10503165 11583366 17617290 21128595 21256572	CTD
349	Prostatic Neoplasms		10969806	CTD
350	Prostatic Obstruction			OFFSIDES
351	Prostatism		8633398 10364649 10503165	CTD OFFSIDES
352	Psychotic disorder due to a general medical condition			OFFSIDES
353	Pulmonary Hypertension			OFFSIDES
354	Pulmonary congestion			OFFSIDES
355	Purulent discharge			OFFSIDES
356	Quality of life decreased			OFFSIDES
357	Rales			OFFSIDES
358	Rectal fissure			OFFSIDES
359	Renal cyst			OFFSIDES
360	Respiratory Failure			OFFSIDES
361	Respiratory tract congestion			OFFSIDES
362	Retinal Artery Occlusion			OFFSIDES
363	Retrograde ejaculation			OFFSIDES
364	Rhabdomyolysis			OFFSIDES
365	Rhinitis			SIDER
366	Rhonchi			OFFSIDES
367	Sebaceous adenoma			OFFSIDES
368	Shock			SIDER
369	Shoulder Pain			SIDER
370	Sick Sinus Syndrome			OFFSIDES
371	Sinusitis			OFFSIDES SIDER
372	Skin Induration			OFFSIDES
373	Skin necrosis			OFFSIDES
374	Skin neoplasm excision			OFFSIDES
375	Skin tightness			OFFSIDES
376	Soft Tissue Infection			OFFSIDES
377	Soft tissue necrosis			OFFSIDES
378	Spinal column stenosis			OFFSIDES
379	Stem cell transplant			OFFSIDES
380	Subcutaneous nodule			OFFSIDES
381	Supraventricular tachycardia			OFFSIDES
382	Sweating			SIDER
383	T-Cell Lymphoma			OFFSIDES
384	Tachycardia			SIDER
385	Tension Headache			OFFSIDES
386	Tension			SIDER
387	Therapy regimen changed			OFFSIDES
388	Thrombocytopenia			SIDER
389	Tinnitus			OFFSIDES SIDER
390	Tooth Extraction			OFFSIDES
391	Tooth Infection			OFFSIDES
392	Tooth Loss			OFFSIDES
393	Tooth repair			OFFSIDES
394	Umbilical hernia			OFFSIDES
395	Urinary Retention		7528458	CTD
396	Urination Disorders		1711689	CTD
397	Urine flow decreased			OFFSIDES
398	Urologic Diseases		20126606	CTD
399	VIIth nerve paralysis			OFFSIDES
400	Vascular calcification			OFFSIDES
401	Vasodilation procedure			SIDER
402	Vasodilation			SIDER
403	Vertigo			SIDER
404	Visual Impairment			SIDER
405	Wound Debridement			OFFSIDES
406	Wound dehiscence			OFFSIDES
407	Wound infection staphylococcal			OFFSIDES
408	colonoscopy			OFFSIDES
409	fibroma			OFFSIDES
410	jaundice			SIDER
411	prostatitis			OFFSIDES

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