MetaADEDB 2.0 @ LMMD
Bumetanide
(MAEIEVLCKWDQJH-UHFFFAOYSA-N)
Structure
SMILES
CCCCNc1cc(cc(c1Oc1ccccc1)S(=O)(=O)N)C(=O)O
Type(s)
Approved
ATC code(s)
C03CA02; C03CB02; C03EB02; G01AE10
Molecular Formula:
C17H20N2O5S
Molecular Weight:
364.416
Log P:
4.8906
Hydrogen Bond Acceptor:
7
Hydrogen Bond Donor:
3
TPSA:
127.1
CAS Number(s):
28395-03-1
Synonym(s)
1.
Bumetanide
2.
Bumedyl
3.
Bumethanide
4.
Bumex
5.
Burinex
6.
Drenural
7.
Fordiuran
8.
Miccil
9.
PF-1593
10.
PF 1593
11.
PF1593
External Link(s)
MeSHD002034
PubChem Compound2471
BindingDB25903
ChEBI3213
CHEMBLCHEMBL1072
DrugBankDB00887
DrugCentral427
IUPHAR/BPS Guide to PHARMACOLOGY4837
KEGGdr:D00247
Therapeutic Target DatabaseD0R7HO
ZINC3813061
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1MyalgiaFAERS: 36US FAERS
2Drug ineffectiveFAERS: 15US FAERS
3DizzinessFAERS: 8OFFSIDES
SIDER
US FAERS
4HypotensionFAERS: 7SIDER
US FAERS
5NauseaFAERS: 7OFFSIDES
SIDER
US FAERS
6Acute kidney injuryFAERS: 615662077
20128168		CTD
US FAERS
7AstheniaFAERS: 6OFFSIDES
SIDER
US FAERS
8PolyuriaFAERS: 6OFFSIDES
SIDER
US FAERS
9Pharmaceutical product complaintFAERS: 5US FAERS
10PruritusFAERS: 5SIDER
US FAERS
11UrticariaFAERS: 5SIDER
US FAERS
12Weight decreasedFAERS: 5US FAERS
13Blood creatinine increasedFAERS: 4OFFSIDES
SIDER
US FAERS
14Burning sensationFAERS: 4OFFSIDES
US FAERS
15DeafnessFAERS: 4OFFSIDES
US FAERS
16DehydrationFAERS: 4OFFSIDES
SIDER
US FAERS
17Drug dispensing errorFAERS: 4US FAERS
18PainFAERS: 4786692CTD
OFFSIDES
US FAERS
19Product substitution issueFAERS: 4US FAERS
20Abdominal PainFAERS: 3OFFSIDES
SIDER
US FAERS
21Blood urea increasedFAERS: 3OFFSIDES
US FAERS
22ErythemaFAERS: 3US FAERS
23Fluid overloadFAERS: 3OFFSIDES
US FAERS
24SwellingFAERS: 3US FAERS
25SyncopeFAERS: 3US FAERS
26Abdominal discomfortFAERS: 2OFFSIDES
SIDER
US FAERS
27AngioedemaFAERS: 2OFFSIDES
US FAERS
28ArthralgiaFAERS: 2SIDER
US FAERS
29Blood potassium decreasedFAERS: 2US FAERS
30ChillsFAERS: 2US FAERS
31EpistaxisFAERS: 2OFFSIDES
US FAERS
32FatigueFAERS: 2OFFSIDES
SIDER
US FAERS
33HeadacheFAERS: 2SIDER
US FAERS
34Incorrect dose administeredFAERS: 2OFFSIDES
US FAERS
35Lip swellingFAERS: 2US FAERS
36MalaiseFAERS: 2US FAERS
37Medication ErrorFAERS: 2US FAERS
38Musculoskeletal PainFAERS: 2OFFSIDES
SIDER
US FAERS
39Peripheral swellingFAERS: 2US FAERS
40Skin UlcerFAERS: 2US FAERS
41TinnitusFAERS: 2US FAERS
42Unevaluable eventFAERS: 2US FAERS
43VomitingFAERS: 2SIDER
US FAERS
44Adverse eventFAERS: 1US FAERS
45AlopeciaFAERS: 1US FAERS
46AmnesiaFAERS: 1OFFSIDES
US FAERS
47ArthritisFAERS: 1US FAERS
48Atrial FibrillationFAERS: 1US FAERS
49Back PainFAERS: 1US FAERS
50Benign Prostatic HyperplasiaFAERS: 1OFFSIDES
US FAERS
51Blood chloride decreasedFAERS: 1OFFSIDES
US FAERS
52Blood glucose increasedFAERS: 1US FAERS
53Blood sodium decreasedFAERS: 1US FAERS
54CellulitisFAERS: 1OFFSIDES
US FAERS
55Chest PainFAERS: 1OFFSIDES
SIDER
US FAERS
56Circumstance or information capable of leading to device use errorFAERS: 1US FAERS
57Clostridium difficile infectionFAERS: 1US FAERS
58ColectomyFAERS: 1OFFSIDES
US FAERS
59ColitisFAERS: 1US FAERS
60Device malfunctionFAERS: 1US FAERS
61Device related infectionFAERS: 1US FAERS
62Diabetes MellitusFAERS: 1US FAERS
63Diabetes mellitus inadequate controlFAERS: 1US FAERS
64Drug administration errorFAERS: 1US FAERS
65Drug dose omissionFAERS: 1US FAERS
66DysarthriaFAERS: 1US FAERS
67DysuriaFAERS: 1US FAERS
68ExcoriationFAERS: 1US FAERS
69Expired product administeredFAERS: 1US FAERS
70FlatulenceFAERS: 1US FAERS
71GoutFAERS: 1OFFSIDES
US FAERS
72Hepatic EncephalopathyFAERS: 1US FAERS
73HypersensitivityFAERS: 1US FAERS
74Incorrect drug administration rateFAERS: 1US FAERS
75Injection site irritationFAERS: 1US FAERS
76Intercepted drug dispensing errorFAERS: 1US FAERS
77LacerationFAERS: 1US FAERS
78LethargyFAERS: 1OFFSIDES
US FAERS
79Loss of personal independence in daily activitiesFAERS: 1US FAERS
80Memory impairmentFAERS: 1US FAERS
81Mental status changesFAERS: 1OFFSIDES
US FAERS
82Monocyte count increasedFAERS: 1US FAERS
83Mouth swellingFAERS: 1US FAERS
84Muscle tightnessFAERS: 1US FAERS
85NephrolithiasisFAERS: 1OFFSIDES
US FAERS
86Oral painFAERS: 1US FAERS
87OtotoxicityFAERS: 1US FAERS
88PallorFAERS: 1OFFSIDES
US FAERS
89PalpitationsFAERS: 1US FAERS
90PneumoniaFAERS: 1US FAERS
91Product measured potency issueFAERS: 1US FAERS
92Product physical issueFAERS: 1US FAERS
93Rash erythematousFAERS: 1US FAERS
94Renal tubular necrosisFAERS: 1OFFSIDES
US FAERS
95RetchingFAERS: 1US FAERS
96Rheumatic disorderFAERS: 1US FAERS
97SepsisFAERS: 1US FAERS
98Sinus headacheFAERS: 1US FAERS
99SomnolenceFAERS: 1US FAERS
100Stevens-Johnson SyndromeFAERS: 125811541CTD
SIDER
US FAERS
101StomatitisFAERS: 1US FAERS
102Suicide attemptFAERS: 1US FAERS
103TachycardiaFAERS: 1US FAERS
104ThirstFAERS: 1US FAERS
105ThrombocytopeniaFAERS: 1SIDER
US FAERS
106ThrombosisFAERS: 1US FAERS
107Transcription medication errorFAERS: 1US FAERS
108Urinary IncontinenceFAERS: 1US FAERS
109VertigoFAERS: 1SIDER
US FAERS
110Visual ImpairmentFAERS: 1US FAERS
111WheezingFAERS: 1US FAERS
112Wrong drug administeredFAERS: 1US FAERS
113treatment failureFAERS: 1US FAERS
114Abdominal AbscessOFFSIDES
115Acid refluxOFFSIDES
116Acidosis793779CTD
OFFSIDES
117ActinomycosisOFFSIDES
118Activities of daily living impairedOFFSIDES
119Acute respiratory failureOFFSIDES
120Alanine Aminotransferase IncreasedOFFSIDES
121Alkalosis9824779CTD
122AlveolitisOFFSIDES
123Ammonia increasedOFFSIDES
124AmphetaminesOFFSIDES
125Amylase increasedSIDER
126Anal FissureOFFSIDES
127AnorexiaOFFSIDES
128Anti-platelet antibodyOFFSIDES
129AnuriaOFFSIDES
130Application site excoriationOFFSIDES
131Application site pruritusOFFSIDES
132Application site vesiclesOFFSIDES
133AsterixisSIDER
134AsthmaOFFSIDES
135AtelectasisOFFSIDES
136AtherosclerosisOFFSIDES
137Atrial FlutterOFFSIDES
138Atrioventricular BlockOFFSIDES
139Autoimmune hepatitisOFFSIDES
140Back disorderOFFSIDES
141Beta 2 microglobulin increasedOFFSIDES
142BiopsyOFFSIDES
143BlepharitisOFFSIDES
144Blood 1,25-dihydroxycholecalciferol decreasedOFFSIDES
145Blood GlucoseOFFSIDES
146Blood albumin decreasedOFFSIDES
147Blood creatine phosphokinase increasedOFFSIDES
148Blood glucose decreasedOFFSIDES
149Blood glucose fluctuationOFFSIDES
150Blood immunoglobulin A increasedOFFSIDES
151Blood magnesium decreasedOFFSIDES
152Blood parathyroid hormone increasedOFFSIDES
153Blood phosphorus increasedOFFSIDES
154Blood potassium increasedOFFSIDES
155Blood pressure inadequately controlledOFFSIDES
156Blood sodium increasedOFFSIDES
157Blood sodiumOFFSIDES
158Blood uric acidOFFSIDES
159Blurred visionOFFSIDES
160Body TemperatureOFFSIDES
161Bone erosionOFFSIDES
162Bone fistulaOFFSIDES
163Bone fragmentationOFFSIDES
164Bone painOFFSIDES
165Bone scan abnormalOFFSIDES
166Bradycardia15662077CTD
OFFSIDES
167Brain ConcussionOFFSIDES
168BronchitisOFFSIDES
169BruxismOFFSIDES
170BursitisOFFSIDES
171Cardioactive drug level increasedOFFSIDES
172CataractOFFSIDES
173Catheter related complicationOFFSIDES
174Cerebral PalsyOFFSIDES
175Charles Bonnet SyndromeOFFSIDES
176Chest wall painOFFSIDES
177Choking sensationOFFSIDES
178CholangiolitisOFFSIDES
179CholestasisSIDER
180ChromaturiaOFFSIDES
181Chronic Obstructive Airway DiseaseOFFSIDES
182Circumstance or information capable of leading to medication errorOFFSIDES
183ConfabulationOFFSIDES
184Congenital tricuspid valve incompetenceOFFSIDES
185Deafness NeurosensoryOFFSIDES
186DebridementOFFSIDES
187DemyelinationOFFSIDES
188Dental FistulaOFFSIDES
189Dental cariesOFFSIDES
190Depressed Level of ConsciousnessOFFSIDES
191DermatitisSIDER
192Diabetic RetinopathyOFFSIDES
193Diarrhea15662077CTD
OFFSIDES
194Diastolic dysfunctionOFFSIDES
195DiplopiaOFFSIDES
196Disease ProgressionOFFSIDES
197Disseminated Intravascular CoagulationOFFSIDES
198DiuresisSIDER
199Diverticular perforationOFFSIDES
200DiverticulitisOFFSIDES
201Drug abuserOFFSIDES
202Drug toxicityOFFSIDES
203Drug withdrawal headacheOFFSIDES
204DyspepsiaOFFSIDES
205Dyspnea19843838CTD
206Ear discomfortSIDER
207Edema9824779CTD
208Electrolyte imbalanceSIDER
209Emotional distressOFFSIDES
210EncephalitisOFFSIDES
211Endodontic procedureOFFSIDES
212Enterobacter pneumoniaOFFSIDES
213Enterococcal infectionOFFSIDES
214EpilepsyOFFSIDES
215Erosive gastritisOFFSIDES
216Erythema MultiformeSIDER
217Factor V deficiencyOFFSIDES
218Febrile NeutropeniaOFFSIDES
219Feeling ColdOFFSIDES
220Fistula repairOFFSIDES
221Fluid and electrolyte imbalanceSIDER
222Gallop rhythm presentOFFSIDES
223GamblingOFFSIDES
224Gamma-Glutamyltransferase IncreasedOFFSIDES
225GangreneOFFSIDES
226Gastric pH decreasedOFFSIDES
227GastroenteritisOFFSIDES
228Gastrointestinal PainSIDER
229Glucose urine increasedSIDER
230GlycosuriaSIDER
231GranulocytosisOFFSIDES
232Haptoglobin DecreasedOFFSIDES
233Hearing Loss4088324CTD
234Heart failure6788266
19843838		CTD
235HemiparesisOFFSIDES
236Heparin-induced thrombocytopeniaOFFSIDES
237Hepatic InfarctionOFFSIDES
238Hepatic necrosisOFFSIDES
239Hepatitis COFFSIDES
240HepatitisOFFSIDES
241HostilityOFFSIDES
242Human herpesvirus 8 infectionOFFSIDES
243Hyaluronic acid increasedOFFSIDES
244HydronephrosisOFFSIDES
245Hyperalgesia16709721CTD
246HyperpigmentationOFFSIDES
247Hypertrophic CardiomyopathyOFFSIDES
248HyperventilationSIDER
249Hypokalemia9824779CTD
250Ileal ulcerOFFSIDES
251Immunosuppressant drug levelOFFSIDES
252InfectionOFFSIDES
253Infusion site mobility decreasedOFFSIDES
254Intestinal infarctionOFFSIDES
255Intracranial AneurysmOFFSIDES
256Jugular vein distensionOFFSIDES
257Kidney Diseases9824779CTD
258Kidney FailureOFFSIDES
259LeukoencephalopathyOFFSIDES
260LeukopeniaSIDER
261Limb discomfortOFFSIDES
262LipaseOFFSIDES
263Loose toothOFFSIDES
264LymphocytosisOFFSIDES
265MacroglossiaOFFSIDES
266Mastication disorderOFFSIDES
267Mechanical ventilationOFFSIDES
268Multiple MyelomaOFFSIDES
269Musculoskeletal Diseases3315403CTD
270Myocardial Ischemia3204556CTD
271Nephrogenic Fibrosing DermopathyOFFSIDES
272Nephrotic Syndrome19843838CTD
273Neurogenic Inflammation16709721CTD
274Nipple painSIDER
275Nipple tendernessSIDER
276Nodule on extremityOFFSIDES
277Non-cardiac chest painOFFSIDES
278Occult blood positiveOFFSIDES
279Ocular icterusOFFSIDES
280OnychalgiaOFFSIDES
281Oral infectionOFFSIDES
282Oropharyngeal spasmOFFSIDES
283OsteolysisOFFSIDES
284OsteomyelitisOFFSIDES
285OsteopeniaOFFSIDES
286OsteosclerosisOFFSIDES
287OverdoseOFFSIDES
288PancreatitisSIDER
289PeritonitisOFFSIDES
290PhlebitisOFFSIDES
291Physical disabilityOFFSIDES
292PneumothoraxOFFSIDES
293PolyneuropathyOFFSIDES
294Poor peripheral circulationOFFSIDES
295Portal HypertensionOFFSIDES
296Post procedural complicationOFFSIDES
297Postoperative ileusOFFSIDES
298Premature EjaculationSIDER
299Pulmonary HypertensionOFFSIDES
300Pulmonary arterial pressure increasedOFFSIDES
301PyelonephritisOFFSIDES
302RalesOFFSIDES
303Red blood cell schistocytes presentOFFSIDES
304Refusal of treatment by relativeOFFSIDES
305Respiratory FailureOFFSIDES
306Restrictive pulmonary diseaseOFFSIDES
307Retrograde portal vein flowOFFSIDES
308Septic ShockOFFSIDES
309SequestrectomyOFFSIDES
310Serum Amylase IncreasedSIDER
311Sick Sinus SyndromeOFFSIDES
312Sinus operationOFFSIDES
313SinusitisOFFSIDES
314Skin IndurationOFFSIDES
315Skin hypertrophyOFFSIDES
316Skin necrosisOFFSIDES
317Somatoform DisorderOFFSIDES
318Spinal column stenosisOFFSIDES
319Spinal fusion surgeryOFFSIDES
320Splenic InfectionOFFSIDES
321Stasis dermatitisOFFSIDES
322SweatingSIDER
323Synovial CystOFFSIDES
324Thrombosis in deviceOFFSIDES
325Tinea PedisOFFSIDES
326Tooth ExtractionOFFSIDES
327Toxic Epidermal NecrolysisSIDER
328Transaminases increasedOFFSIDES
329Transferrin saturation increasedOFFSIDES
330UlcerOFFSIDES
331Umbilical herniaOFFSIDES
332Upset stomachSIDER
333Vascular stenosisOFFSIDES
334Vena cava filter insertionOFFSIDES
335Venous InsufficiencyOFFSIDES
336Ventricular FibrillationOFFSIDES
337Weight GainOFFSIDES
338Wound dehiscenceOFFSIDES
339Wound infection bacterialOFFSIDES
340fibromaOFFSIDES
341furuncleOFFSIDES
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