MetaADEDB 2.0 @ LMMD
Dextromethorphan
(MKXZASYAUGDDCJ-NJAFHUGGSA-N)
Structure
SMILES
COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C
Type(s)
Approved
ATC code(s)
N07XX59; R05DA09
Molecular Formula:
C18H25NO
Molecular Weight:
271.397
Log P:
3.3213
Hydrogen Bond Acceptor:
2
Hydrogen Bond Donor:
0
TPSA:
12.47
CAS Number(s):
125-71-3
Synonym(s)
1.
Dextromethorphan
2.
d-Methorphan
3.
Delsym
4.
Dextromethorphan Hydrobromide
5.
Dextromethorphan Hydrobromide, (+-)-Isomer
6.
Dextromethorphan Hydrobromide, Monohydrate
7.
Dextromethorphan Hydrochloride
8.
Dextromethorphan, (+-)-Isomer
9.
Levomethorphan
10.
Racemethorphan
11.
l-Methorphan
12.
Hydrobromide, Dextromethorphan
13.
Hydrochloride, Dextromethorphan
External Link(s)
MeSHD003915
PubChem Compound5360696
BindingDB50366613
ChEBI4470
92579
CHEMBLCHEMBL52440
DrugBankDB00514
DrugCentral842
IUPHAR/BPS Guide to PHARMACOLOGY6953
KEGGcpd:C06947
dr:D03742
Therapeutic Target DatabaseD09OBB
ZINC3201907
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Toxicity to various agentsFAERS: 9US FAERS
2MydriasisFAERS: 7US FAERS
3SomnolenceFAERS: 7
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
4OverdoseFAERS: 6
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
5Wrong drug administeredFAERS: 6OFFSIDES
US FAERS
6AgitationFAERS: 4SIDER
US FAERS
7AtaxiaFAERS: 410195488
16801672		CTD
OFFSIDES
US FAERS
8Mental impairmentFAERS: 4US FAERS
9TremorFAERS: 41557278
21228393		CTD
US FAERS
10DizzinessFAERS: 36375709
14982566		CTD
SIDER
US FAERS
11Drug abuseFAERS: 3US FAERS
12Euphoric moodFAERS: 3OFFSIDES
US FAERS
13Incorrect dose administeredFAERS: 3OFFSIDES
US FAERS
14Intentional drug misuseFAERS: 3OFFSIDES
US FAERS
15LethargyFAERS: 31557278
16089243		CTD
OFFSIDES
US FAERS
16NystagmusFAERS: 3OFFSIDES
US FAERS
17TachycardiaFAERS: 3US FAERS
18Abdominal PainFAERS: 2SIDER
US FAERS
19Accidental drug intake by childFAERS: 2OFFSIDES
US FAERS
20Depressed Level of ConsciousnessFAERS: 2OFFSIDES
US FAERS
21DisorientationFAERS: 2US FAERS
22Drug screen positiveFAERS: 2OFFSIDES
US FAERS
23Drug toxicityFAERS: 2OFFSIDES
US FAERS
24DysphemiaFAERS: 2US FAERS
25FatigueFAERS: 2SIDER
US FAERS
26HyperreflexiaFAERS: 2OFFSIDES
US FAERS
27HypotensionFAERS: 2US FAERS
28Mental status changesFAERS: 2US FAERS
29NauseaFAERS: 2
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
30Serotonin SyndromeFAERS: 212456895CTD
SIDER
US FAERS
31VertigoFAERS: 2US FAERS
32Abdominal tendernessFAERS: 1OFFSIDES
US FAERS
33Accidental exposureFAERS: 1US FAERS
34Accidental overdoseFAERS: 1OFFSIDES
US FAERS
35Acute kidney injuryFAERS: 1US FAERS
36AnxietyFAERS: 1US FAERS
37ArthralgiaFAERS: 1US FAERS
38AstheniaFAERS: 1SIDER
US FAERS
39AtelectasisFAERS: 1US FAERS
40Biopsy colon abnormalFAERS: 1US FAERS
41Bipolar DisorderFAERS: 18600498CTD
US FAERS
42BronchopneumoniaFAERS: 1OFFSIDES
US FAERS
43Burning sensationFAERS: 1US FAERS
44Completed SuicideFAERS: 1OFFSIDES
US FAERS
45CyanosisFAERS: 1US FAERS
46Death of childFAERS: 1US FAERS
47Depressed moodFAERS: 1US FAERS
48Dissociative disorderFAERS: 1US FAERS
49Drug DependenceFAERS: 1US FAERS
50Drug ToleranceFAERS: 1US FAERS
51Drug abuserFAERS: 1OFFSIDES
US FAERS
52Drug ineffectiveFAERS: 1US FAERS
53Drug withdrawal syndromeFAERS: 1US FAERS
54Feeling abnormalFAERS: 1
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
SIDER
US FAERS
55Gastrointestinal mucosal necrosisFAERS: 1US FAERS
56Gastrointestinal sounds abnormalFAERS: 1US FAERS
57Gastrointestinal wall thickeningFAERS: 1US FAERS
58Hilar lymphadenopathyFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
59HypersensitivityFAERS: 1SIDER
US FAERS
60HyperventilationFAERS: 1US FAERS
61Hyporesponsive to stimuliFAERS: 1US FAERS
62HypoxiaFAERS: 1OFFSIDES
US FAERS
63Intentional self-injuryFAERS: 1US FAERS
64Intestinal mucosal atrophyFAERS: 1US FAERS
65LeukocytosisFAERS: 1US FAERS
66LymphadenopathyFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
67MalaiseFAERS: 1US FAERS
68Muscle RigidityFAERS: 1US FAERS
69Myoglobin blood increasedFAERS: 1US FAERS
70PalpitationsFAERS: 1US FAERS
71Pericardial effusionFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
72Pressure of speechFAERS: 1US FAERS
73PruritusFAERS: 1US FAERS
74Pulmonary congestionFAERS: 1
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
75Pupillary light reflex tests abnormalFAERS: 1US FAERS
76Respiratory FailureFAERS: 1
Canada Vigilance: 2		Canada Vigilance
OFFSIDES
US FAERS
77RestlessnessFAERS: 1US FAERS
78RhabdomyolysisFAERS: 1US FAERS
79SplenomegalyFAERS: 1US FAERS
80Suicide attemptFAERS: 1US FAERS
81SyncopeFAERS: 1US FAERS
82UrticariaFAERS: 1
Canada Vigilance: 2		Canada Vigilance
US FAERS
83VomitingFAERS: 11557278
6375709		CTD
SIDER
US FAERS
84WheezingFAERS: 1US FAERS
85Abdominal discomfortSIDER
86AbuseOFFSIDES
87Accidental deathOFFSIDES
88Acute respiratory failureOFFSIDES
89Alcohol consumptionOFFSIDES
90Alcohol poisoningOFFSIDES
91Altered state of consciousnessOFFSIDES
92Amnestic DisorderOFFSIDES
93Amphetamine-Related Disorders16865411CTD
94AnalgesiaOFFSIDES
95AnorexiaOFFSIDES
96Anoxic EncephalopathyOFFSIDES
97Anticholinergic SyndromeOFFSIDES
98Antiviral drug level above therapeuticOFFSIDES
99AscitesOFFSIDES
100AspergillosisOFFSIDES
101AsphyxiaOFFSIDES
102Asthma6375709CTD
OFFSIDES
103Atherosclerosis19189960CTD
104Atrial FlutterOFFSIDES
105AuraOFFSIDES
106Bacteria sputum identifiedOFFSIDES
107BlepharospasmOFFSIDES
108Blood beta-D-glucan increasedOFFSIDES
109Blood fibrinogen increasedOFFSIDES
110Blood glucose decreasedOFFSIDES
111Blood lactate dehydrogenase increasedOFFSIDES
112Blood potassium increasedOFFSIDES
113Blood sodium increasedOFFSIDES
114Blurred visionOFFSIDES
115Body TemperatureOFFSIDES
116Bradycardia20737414CTD
117Brain ContusionOFFSIDES
118BronchiectasisOFFSIDES
119Candida pneumoniaOFFSIDES
120Cardiac HypertrophyOFFSIDES
121Catalepsy1685312
17877148		CTD
122Catheter related infectionOFFSIDES
123Caustic injuryOFFSIDES
124CheilitisOFFSIDES
125Chemical and Drug Induced Liver Injury10592673
30822415		CTD
126Child Behavior Disorders17175572CTD
127ChillsCanada Vigilance: 1Canada Vigilance
128Cholestasis10592673CTD
129ChoreaCanada Vigilance: 1Canada Vigilance
130Circumstance or information capable of leading to medication errorOFFSIDES
131ClonusOFFSIDES
132Cognition Disorders7803371CTD
133ConfabulationOFFSIDES
134Confusion16089243CTD
135Conjunctival ulcerOFFSIDES
136ConstipationSIDER
137Conversion disorderOFFSIDES
138Craniofacial Abnormalities20737414CTD
139Delirium16089243CTD
140Device connection issueOFFSIDES
141Diabetic Neuropathies11981142CTD
142Diarrhea6375709CTD
143Diffuse alveolar damageOFFSIDES
144Disorders of Excessive Somnolence16089243CTD
145Disseminated Intravascular CoagulationOFFSIDES
146DrowsinessOFFSIDES
SIDER
147Drug administered at inappropriate siteOFFSIDES
148Dyskinesia, Drug-Induced9674803
12001656
18281903		CTD
149DyspepsiaSIDER
150Dysthymic DisorderOFFSIDES
151Dystonia8667476
9007349		CTD
152DysuriaOFFSIDES
153Ear dischargeOFFSIDES
154Embryo Loss20737414CTD
155EmpyemaOFFSIDES
156EnterocolitisOFFSIDES
157Enzyme InhibitionOFFSIDES
158Eosinophilic PneumoniaOFFSIDES
159Eosinophilic myocarditisOFFSIDES
160Extremity necrosisOFFSIDES
161Eye irritationCanada Vigilance: 1Canada Vigilance
162FibromyalgiaOFFSIDES
163Flat affectOFFSIDES
164Foaming at mouthOFFSIDES
165Folic Acid Deficiency17488670CTD
166Gastric Antral Vascular EctasiaOFFSIDES
167Gastric ulcerOFFSIDES
168Gastrointestinal PainSIDER
169Gastrointestinal inflammationOFFSIDES
170Gastrointestinal mucosal disorderOFFSIDES
171Hallucinations1530079
3447673
16318953		CTD
172Head BangingOFFSIDES
173Headache6375709CTD
174HepatitisOFFSIDES
175HepatotoxicityOFFSIDES
176Hyperalgesia9540144
17225166
18221780		CTD
177Hypertensive heart diseaseOFFSIDES
178HypervigilanceOFFSIDES
179Immune reconstitution syndromeOFFSIDES
180Infantile spitting upOFFSIDES
181Intention tremorOFFSIDES
182Large intestine perforationOFFSIDES
183LeukoencephalopathyOFFSIDES
184Long QT SyndromeOFFSIDES
185Lordosis20737414CTD
186Lung consolidationOFFSIDES
187Lymphangiosis carcinomatosaOFFSIDES
188Lymphocyte count decreasedOFFSIDES
189Mallory-Weiss SyndromeOFFSIDES
190MediastinitisOFFSIDES
191Mental disorders16122622
16801672		CTD
192Monocyte percentage decreasedOFFSIDES
193MonoplegiaOFFSIDES
194Mood Disorders16634036CTD
195Multiple Sclerosis16634036
19745644		CTD
196Multiple drug overdoseOFFSIDES
197Multiple drug overdose intentionalOFFSIDES
198Musculoskeletal Diseases10985875CTD
199Myoclonus21228393CTD
200MyopiaOFFSIDES
201Narcotic intoxicationOFFSIDES
202NasopharyngitisOFFSIDES
203Neisseria infectionOFFSIDES
204NervousnessSIDER
205Neurobehavioral Manifestations19745644CTD
206Neurotic Disorders28916251CTD
207Ocular icterusOFFSIDES
208PO2 decreasedOFFSIDES
209Pain, Postoperative20935616CTD
210Pain

View details

7562497
11981142
14982566
17461892
 		CTD
211PancreatitisOFFSIDES
212ParanoiaOFFSIDES
213Pelvic abscessOFFSIDES
214Pneumocystis jiroveci pneumoniaOFFSIDES
215PneumoniaCanada Vigilance: 1Canada Vigilance
216PneumothoraxOFFSIDES
217Poisoning8058587CTD
218Polysubstance abuseOFFSIDES
219Postoperative Nausea and Vomiting20935616CTD
220PresbyopiaOFFSIDES
221Psychoses, Substance-Induced10195488
16318953		CTD
222Psychotic Disorders28916251CTD
223Pulmonary function test decreasedSIDER
224PyelonephritisOFFSIDES
225Renal tubular necrosisOFFSIDES
226Reperfusion Injury17102908CTD
227Respiratory DepressionSIDER
228Respiratory Distress Syndrome, Adult17102908CTD
229Restless Legs Syndrome10985875CTD
230ScreamingOFFSIDES
231Secretion dischargeOFFSIDES
232Seizures

View details

2079649
8058587
9187330
10064839
10211593
15723099
28916251
 		CTD
233Sleep Initiation and Maintenance Disorders15231978CTD
234Sleep Wake Disorders6375709CTD
235Speech Disorders21228393CTD
236SplenectomyOFFSIDES
237Sputum retentionOFFSIDES
238Substance Withdrawal Syndrome10448923
16318953		CTD
239Substance-Related Disorders16122622
16318953
16801672		CTD
240Sudden infant death syndromeOFFSIDES
241Supraventricular tachycardiaOFFSIDES
242TensionSIDER
243Thirst decreasedOFFSIDES
244Unresponsive to stimuliOFFSIDES
245Upper respiratory tract inflammationOFFSIDES
246Upset stomachSIDER
247Victim of homicideOFFSIDES
248Vision Disorders6375709CTD
249Vitamin B 12 Deficiency17488670CTD
250Weaning failureOFFSIDES
251Wrong patient received productCanada Vigilance: 1Canada Vigilance
252nervous system disorderSIDER
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