MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

fosamprenavir

(MLBVMOWEQCZNCC-OEMFJLHTSA-N)

Structure

SMILES: CC(CN(S(=O)(=O)c1ccc(cc1)N)C[C@H]([C@H](Cc1ccccc1)NC(=O)O[C@H]1CCOC1)OP(=O)(O)O)C
Type(s): Approved
ATC code(s): J05AE07
Molecular Formula:: C25H36N3O9PS
Molecular Weight:: 585.607
Log P:: 4.5727
Hydrogen Bond Acceptor:: 12
Hydrogen Bond Donor:: 4
TPSA:: 195.91
CAS Number(s):: 226700-79-4; 226700-81-8

Synonym(s)

fosamprenavir

(3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-1-(phenylmethyl)-2-(phosphonooxy)propyl)carbamic acid C-(tetrahydro-3-furanyl) ester

GW 433908

GW 433908G

GW 908

GW-433908

GW-433908G

GW-908

GW433908

10.

GW433908G

11.

GW908 cpd

12.

Lexiva

13.

VX 175

14.

VX-175

15.

VX175 cpd

16.

fos-amprenavir

17.

fosamprenavir calcium

External Link(s)

MeSH	C426859
PubChem Compound	131536
ChEBI	82941
CHEMBL	CHEMBL1664
DrugBank	DB01319
DrugCentral	1240
KEGG	dr:D02497
Therapeutic Target Database	D0F5MT
ZINC	3941829

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Cytolytic hepatitis	FAERS: 3		OFFSIDES US FAERS
2	Transaminases increased	FAERS: 3		OFFSIDES US FAERS
3	Autoimmune thyroiditis	FAERS: 2		OFFSIDES US FAERS
4	Hypothyroidism	FAERS: 2		US FAERS
5	Alanine Aminotransferase Increased	FAERS: 1		SIDER US FAERS
6	Aspartate Aminotransferase Increased	FAERS: 1		SIDER US FAERS
7	Blood creatine phosphokinase increased	FAERS: 1		US FAERS
8	Blood lactate dehydrogenase increased	FAERS: 1		US FAERS
9	Cholestasis	FAERS: 1		US FAERS
10	Drug administration error	FAERS: 1		OFFSIDES US FAERS
11	Hepatitis C	FAERS: 1		US FAERS
12	Lipodystrophy acquired	FAERS: 1		OFFSIDES SIDER US FAERS
13	Malaise	FAERS: 1		US FAERS
14	Orthostatic hypertension	FAERS: 1		US FAERS
15	Pneumonia	FAERS: 1		US FAERS
16	nervous system disorder	FAERS: 1		SIDER US FAERS
17	Abdominal Pain			OFFSIDES SIDER
18	Accidental exposure			OFFSIDES
19	Acidosis			OFFSIDES
20	Acute Coronary Syndrome			SIDER
21	Acute myocardial infarction			OFFSIDES
22	Adenocarcinoma			OFFSIDES
23	Adrenogenital Syndrome			OFFSIDES
24	Albuminuria			OFFSIDES
25	Alcohol poisoning			OFFSIDES
26	Amnesia			OFFSIDES
27	Amphetamines			OFFSIDES
28	Anal Fistula			OFFSIDES
29	Anal fistula infection			OFFSIDES
30	Angioedema			OFFSIDES SIDER
31	Anogenital dysplasia			OFFSIDES
32	Anorectal discomfort			OFFSIDES
33	Anorexia			SIDER
34	Antipsychotic drug level below therapeutic			OFFSIDES
35	Apathy			OFFSIDES
36	Aphthous Stomatitis			OFFSIDES
37	Appendicitis			OFFSIDES
38	Arteritis			OFFSIDES
39	Aspiration Pneumonia			OFFSIDES
40	Asthenia			SIDER
41	Autoimmune thrombocytopenia			OFFSIDES
42	Bacterial culture positive			OFFSIDES
43	Blighted ovum			OFFSIDES
44	Blood cholesterol increased			SIDER
45	Blood cortisol decreased			OFFSIDES
46	Blood osmolarity decreased			OFFSIDES
47	Blood triglycerides increased			SIDER
48	Blood uric acid			OFFSIDES
49	Bone fissure			OFFSIDES
50	Bronchitis			OFFSIDES
51	Bronchopleural Fistula			OFFSIDES
52	Buffalo hump			SIDER
53	Bulimia			OFFSIDES
54	CD4 Lymphocytes Decreased			OFFSIDES
55	Cerebral hygroma			OFFSIDES
56	Cerebral ventricle dilatation			OFFSIDES
57	Cheilitis			OFFSIDES
58	Chest Pain			OFFSIDES
59	Choking sensation			OFFSIDES
60	Circumstance or information capable of leading to medication error			OFFSIDES
61	Congenital cerebral cyst			OFFSIDES
62	Congenital heart disease			OFFSIDES
63	Congenital hydronephrosis			OFFSIDES
64	Congenital hypertrichosis			OFFSIDES
65	Congenital mitochondrial cytopathy			OFFSIDES
66	Congenital tricuspid valve incompetence			OFFSIDES
67	Cortisol free urine decreased			OFFSIDES
68	Cyst			OFFSIDES
69	Cytomegalovirus chorioretinitis			OFFSIDES
70	Cytomegalovirus test			OFFSIDES
71	Dental abscess			OFFSIDES
72	Depressed mood			OFFSIDES
73	Dermatitis			SIDER
74	Diabetes Insipidus			OFFSIDES
75	Diabetes Mellitus			SIDER
76	Diarrhea			OFFSIDES
77	Dizziness			SIDER
78	Drug Tolerance			OFFSIDES
79	Drug resistance			OFFSIDES
80	Drug toxicity			OFFSIDES
81	Drug withdrawal headache			OFFSIDES
82	Eczema			OFFSIDES
83	Erythema Multiforme			OFFSIDES SIDER
84	Excoriation			OFFSIDES
85	Exfoliative rash			OFFSIDES
86	Eye inflammation			OFFSIDES
87	Facial wasting			OFFSIDES
88	Factor VIII Deficiency			OFFSIDES
89	Fat redistribution			SIDER
90	Fatigue			OFFSIDES SIDER
91	Feeling Cold			OFFSIDES
92	Flatulence			SIDER
93	Food aversion			OFFSIDES
94	Gastritis			SIDER
95	Gastroenteritis			OFFSIDES
96	Gastrointestinal Pain			SIDER
97	Gastrointestinal toxicity			OFFSIDES
98	Glaucoma			OFFSIDES
99	Granulocytosis			OFFSIDES
100	Granulomatous liver disease			OFFSIDES
101	HIV Infections		16639341 20660842	CTD
102	Haematotoxicity			OFFSIDES
103	Haptoglobin Decreased			OFFSIDES
104	Headache			SIDER
105	Heat Stroke			OFFSIDES
106	Hepatotoxicity			OFFSIDES
107	Hilar lymphadenopathy			OFFSIDES
108	Hostility			OFFSIDES
109	Hyperkeratosis			OFFSIDES
110	Hypersensitivity			SIDER
111	Hypertrophy of Breast			SIDER
112	Hypoxia			OFFSIDES
113	Hysterectomy			OFFSIDES
114	Iliac artery stenosis			OFFSIDES
115	Inflammation			SIDER
116	Injection site erythema			OFFSIDES
117	Injection site pruritus			OFFSIDES
118	Insulin Resistance			SIDER
119	Intentional misuse			OFFSIDES
120	Intracranial Hypotension			OFFSIDES
121	Jejunal ulcer			OFFSIDES
122	Joint injury			OFFSIDES
123	Leukoencephalopathy			OFFSIDES
124	Lipase increased			SIDER
125	Lipodystrophy			SIDER
126	Lipohypertrophy			SIDER
127	Lymphedema			OFFSIDES
128	Lymphocyte count decreased			OFFSIDES
129	Lymphoma			OFFSIDES
130	Malabsorption from injection site			OFFSIDES
131	Malnutrition			SIDER
132	Mesenteric artery stenosis			OFFSIDES
133	Metabolic acidosis			OFFSIDES
134	Mitochondrial toxicity			OFFSIDES
135	Mononeuritis			OFFSIDES
136	Monoparesis			OFFSIDES
137	Multiple allergies			OFFSIDES
138	Muscle necrosis			OFFSIDES
139	Musculoskeletal discomfort			SIDER
140	Myalgia			SIDER
141	Myelocytosis			OFFSIDES
142	Myocardial Infarction		20660842	CTD SIDER
143	Myositis			SIDER
144	Nausea			OFFSIDES SIDER
145	Nephrogenic Diabetes Insipidus			OFFSIDES
146	Nephrolithiasis			OFFSIDES SIDER
147	Nephrotic Syndrome			OFFSIDES
148	Neuralgia			OFFSIDES
149	Neutropenia			SIDER
150	No adverse effect			OFFSIDES
151	Oligohydramnios			OFFSIDES
152	Optic Neuropathy			OFFSIDES
153	Osteoma			OFFSIDES
154	Pancreatic enzymes increased			OFFSIDES
155	Partner stress			OFFSIDES
156	Perirectal abscess			OFFSIDES
157	Peritoneal Infection			OFFSIDES
158	Photodermatosis			OFFSIDES
159	Plagiocephaly			OFFSIDES
160	Poor peripheral circulation			OFFSIDES
161	Portal Hypertension			OFFSIDES
162	Portal hypertensive gastropathy			OFFSIDES
163	Post procedural complication			OFFSIDES
164	Pre-Eclampsia			OFFSIDES
165	Productive Cough			OFFSIDES
166	Prothrombin level decreased			OFFSIDES
167	Pruritus			SIDER
168	Pulmonary necrosis			OFFSIDES
169	Pus in stool			OFFSIDES
170	Rales			OFFSIDES
171	Reaction gastrointestinal			SIDER
172	Respiratory tract congestion			OFFSIDES
173	Retinal Degeneration			OFFSIDES
174	Retinitis			OFFSIDES
175	Retrograde amnesia			OFFSIDES
176	Rhabdomyolysis			OFFSIDES SIDER
177	Sarcoidosis			OFFSIDES
178	Serratia sepsis			OFFSIDES
179	Sinusitis			OFFSIDES
180	Skin lesion			OFFSIDES
181	Stevens-Johnson Syndrome		25811541	CTD SIDER
182	Subacute combined cord degeneration			OFFSIDES
183	Sudden onset of sleep			OFFSIDES
184	Tachyphrenia			OFFSIDES
185	Talipes			OFFSIDES
186	Transfusion Reaction			OFFSIDES
187	Trisomy 21			OFFSIDES
188	Troponin increased			OFFSIDES
189	Ulcer			OFFSIDES
190	Ultrasound antenatal screen			OFFSIDES
191	Ultrasound scan abnormal			OFFSIDES
192	Umbilical hernia			OFFSIDES
193	Urinary Tract Pain			OFFSIDES
194	Uterine Cancer			OFFSIDES
195	Vaginal lesion			OFFSIDES
196	Visual disturbance			OFFSIDES
197	Vitamin B 12 Deficiency			OFFSIDES
198	Vitreous opacities			OFFSIDES
199	Vomiting			SIDER
200	Vulvitis			OFFSIDES

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