MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Chlorhexidine

(GHXZTYHSJHQHIJ-UHFFFAOYSA-N)

Structure

SMILES: NC(=NCCCCCCN=C(/N=C(/Nc1ccc(cc1)Cl)\N)N)/N=C(/Nc1ccc(cc1)Cl)\N
Type(s): Approved; Vet_approved; Withdrawn
ATC code(s): A01AB03; B05CA02; D08AC02; D08AC52; D09AA12; R02AA05; S01AX09; S02AA09; S03AA04
Molecular Formula:: C22H30Cl2N10
Molecular Weight:: 505.447
Log P:: 6.2838
Hydrogen Bond Acceptor:: 10
Hydrogen Bond Donor:: 6
TPSA:: 177.58
CAS Number(s):: 55-56-1; 56-95-1

Synonym(s)

Chlorhexidine

Chlorhexidine Acetate

Chlorhexidine Hydrochloride

MK-412A

Novalsan

Sebidin A

Tubulicid

Acetate, Chlorhexidine

Hydrochloride, Chlorhexidine

10.

MK 412A

11.

MK412A

External Link(s)

MeSH	D002710
PubChem Compound	9552079 88536661 5353524 5360566 2713
BindingDB	50170723 64773 152706 51937
ChEBI	3614
CHEMBL	CHEMBL790
DrugBank	DB00878
DrugCentral	597
KEGG	cpd:C06902 dr:D07668
Therapeutic Target Database	D0V4GY
ZINC	14768621

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Hypotension	FAERS: 8 Canada Vigilance: 4		Canada Vigilance US FAERS
2	Anaphylactic shock	FAERS: 7		SIDER US FAERS
3	Hypersensitivity	FAERS: 7 Canada Vigilance: 2		Canada Vigilance SIDER US FAERS
4	Cardiac Arrest	FAERS: 6 Canada Vigilance: 3		Canada Vigilance US FAERS
5	Abdominal wound dehiscence	FAERS: 5		OFFSIDES US FAERS
6	Pruritus	FAERS: 5 Canada Vigilance: 2		Canada Vigilance US FAERS
7	Shunt infection	FAERS: 5 Canada Vigilance: 5		Canada Vigilance US FAERS
8	Accidental exposure to product	FAERS: 4		US FAERS
9	Headache	FAERS: 4		SIDER US FAERS
10	Pain	FAERS: 4	16512751	CTD OFFSIDES SIDER US FAERS
11	Urticaria	FAERS: 4 Canada Vigilance: 2		Canada Vigilance SIDER US FAERS
12	Arachnoiditis	FAERS: 3		US FAERS
13	Burning sensation	FAERS: 3		SIDER US FAERS
14	Chemical injury	FAERS: 3		US FAERS
15	Documented hypersensitivity to administered product	FAERS: 3		US FAERS
16	Lip swelling	FAERS: 3 Canada Vigilance: 2		Canada Vigilance US FAERS
17	Medication Error	FAERS: 3		US FAERS
18	Rash erythematous	FAERS: 3		US FAERS
19	Syncope	FAERS: 3		US FAERS
20	Wrong drug administered	FAERS: 3		US FAERS
21	Activities of daily living impaired	FAERS: 2		OFFSIDES US FAERS
22	Application site burn	FAERS: 2		US FAERS
23	Application site pruritus	FAERS: 2		US FAERS
24	Cerebrovascular accident	FAERS: 2		US FAERS
25	Diplegia	FAERS: 2		US FAERS
26	Erythema	FAERS: 2 Canada Vigilance: 2		Canada Vigilance OFFSIDES SIDER US FAERS
27	Gangrene	FAERS: 2		OFFSIDES US FAERS
28	Hydrocephalus	FAERS: 2		OFFSIDES US FAERS
29	Hypoxia	FAERS: 2 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
30	Injection site injury	FAERS: 2		US FAERS
31	Occupational exposure to product	FAERS: 2		US FAERS
32	Paraplegia	FAERS: 2		US FAERS
33	Procedural complication	FAERS: 2		US FAERS
34	Restlessness	FAERS: 2		US FAERS
35	Vomiting	FAERS: 2		US FAERS
36	Wheezing	FAERS: 2 Canada Vigilance: 1		Canada Vigilance US FAERS
37	Ageusia	FAERS: 1 Canada Vigilance: 2	711516 11068420	CTD OFFSIDES Canada Vigilance US FAERS
38	Application site inflammation	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
39	Application site reaction	FAERS: 1		OFFSIDES US FAERS
40	Application site vesicles	FAERS: 1		US FAERS
41	Back Pain	FAERS: 1		SIDER US FAERS
42	Chemical burn of gastrointestinal tract	FAERS: 1		US FAERS
43	Contraindicated product administered	FAERS: 1		US FAERS
44	Cyanosis	FAERS: 1	2774629	CTD US FAERS
45	Deafness Neurosensory	FAERS: 1		OFFSIDES US FAERS
46	Discomfort	FAERS: 1		SIDER US FAERS
47	Drooling	FAERS: 1		US FAERS
48	Drug administration error	FAERS: 1		US FAERS
49	Ear discomfort	FAERS: 1		OFFSIDES US FAERS
50	Exposure to toxic agent	FAERS: 1		OFFSIDES US FAERS
51	Feeling abnormal	FAERS: 1		US FAERS
52	Gastrointestinal mucosal exfoliation	FAERS: 1		US FAERS
53	Gingivitis	FAERS: 1 Canada Vigilance: 2		Canada Vigilance US FAERS
54	Incorrect route of product administration	FAERS: 1		US FAERS
55	Injection site pain	FAERS: 1		US FAERS
56	Maternal exposure during delivery	FAERS: 1		US FAERS
57	Mumps	FAERS: 1		US FAERS
58	Musculoskeletal Pain	FAERS: 1		OFFSIDES US FAERS
59	Oropharyngeal pain	FAERS: 1		OFFSIDES US FAERS
60	Oropharyngeal swelling	FAERS: 1 Canada Vigilance: 2		Canada Vigilance US FAERS
61	Ototoxicity	FAERS: 1		US FAERS
62	Peripheral swelling	FAERS: 1		US FAERS
63	Purpura	FAERS: 1		US FAERS
64	Secretion discharge	FAERS: 1		US FAERS
65	Skin Erosion	FAERS: 1		OFFSIDES US FAERS
66	Skin test positive	FAERS: 1		US FAERS
67	Stridor	FAERS: 1 Canada Vigilance: 2		Canada Vigilance US FAERS
68	Swelling	FAERS: 1		SIDER US FAERS
69	Thermal burn	FAERS: 1		US FAERS
70	Vertigo	FAERS: 1		US FAERS
71	Abasia			OFFSIDES
72	Abdominal Pain			OFFSIDES
73	Abdominal discomfort			OFFSIDES
74	Abdominal mass			OFFSIDES
75	Abdominal sepsis			OFFSIDES
76	Abnormal cervical smear			OFFSIDES
77	Abnormal vision			OFFSIDES
78	Abscess			OFFSIDES SIDER
79	Abuse			OFFSIDES
80	Acanthamoeba Keratitis		17592327 19176099	CTD
81	Acanthoma			OFFSIDES
82	Ache			SIDER
83	Acid reflux			OFFSIDES
84	Acidosis			OFFSIDES
85	Actinic keratosis			OFFSIDES
86	Actinomycosis			OFFSIDES
87	Acute graft versus host disease in liver			OFFSIDES
88	Acute left ventricular failure			OFFSIDES
89	Acute otitis media			OFFSIDES
90	Acute psychosis			OFFSIDES
91	Adenocarcinoma			OFFSIDES
92	Adenoma			OFFSIDES
93	Adrenal mass			OFFSIDES
94	Adrenalectomy			OFFSIDES
95	Agraphia			OFFSIDES
96	Albumin globulin ratio decreased			OFFSIDES
97	Alcohol abuse			OFFSIDES
98	Alopecia			OFFSIDES
99	Alveolitis			OFFSIDES
100	Alveoloplasty			OFFSIDES
101	Amaurosis Fugax			OFFSIDES
102	Amnesia			OFFSIDES
103	Amyloidosis			OFFSIDES
104	Anal abscess			OFFSIDES
105	Aneurysm			OFFSIDES
106	Anhedonia			OFFSIDES
107	Anhidrosis			OFFSIDES
108	Animal bite			OFFSIDES
109	Animal scratch			OFFSIDES
110	Anisocytosis			OFFSIDES
111	Ankle Fracture			OFFSIDES
112	Anorexia			OFFSIDES
113	Anosmia			OFFSIDES
114	Anticonvulsant drug level below therapeutic			OFFSIDES
115	Anxiety			OFFSIDES
116	Aortic Aneurysm			OFFSIDES
117	Aortic aneurysm repair			OFFSIDES
118	Apathy			OFFSIDES
119	Aphakia			OFFSIDES
120	Aphthous Stomatitis			OFFSIDES SIDER
121	Apnea			OFFSIDES
122	Appendectomy			OFFSIDES
123	Application site pain	Canada Vigilance: 1		Canada Vigilance
124	Arterial therapeutic procedure			OFFSIDES
125	Arteriosclerosis			OFFSIDES
126	Arteriovenous fistula			OFFSIDES
127	Arthralgia			SIDER
128	Arthritis			OFFSIDES
129	Arthropathy			OFFSIDES SIDER
130	Arthropod bite			OFFSIDES
131	Arthroscopy			OFFSIDES
132	Artificial crown procedure			OFFSIDES
133	Asbestosis			OFFSIDES
134	Ascites infection			OFFSIDES
135	Ascites			OFFSIDES
136	Aspartate aminotransferase decreased			OFFSIDES
137	Asphyxia			OFFSIDES
138	Aspiration Pneumonia			OFFSIDES
139	Asthenia			OFFSIDES
140	Astigmatism			OFFSIDES
141	Ataxia			OFFSIDES
142	Atelectasis			OFFSIDES
143	Atrial tachycardia			OFFSIDES
144	Aura			OFFSIDES
145	Autologous bone marrow transplantation therapy			OFFSIDES
146	Avulsion fracture			OFFSIDES
147	Back disorder			OFFSIDES
148	Basal cell carcinoma			OFFSIDES
149	Bedridden			OFFSIDES
150	Benign Prostatic Hyperplasia			OFFSIDES
151	Beta 2 microglobulin increased			OFFSIDES
152	Biliary dilatation			OFFSIDES
153	Biopsy bone marrow abnormal			OFFSIDES
154	Biopsy breast abnormal			OFFSIDES
155	Biopsy endometrium abnormal			OFFSIDES
156	Biopsy gingival			OFFSIDES
157	Biopsy			OFFSIDES
158	Bipolar Disorder			OFFSIDES
159	Bipolar I disorder			OFFSIDES
160	Bladder Neoplasm			OFFSIDES
161	Blepharitis			OFFSIDES
162	Blepharoptosis			OFFSIDES
163	Blepharospasm			OFFSIDES
164	Blood Glucose			OFFSIDES
165	Blood antidiuretic hormone decreased			OFFSIDES
166	Blood chloride decreased			OFFSIDES
167	Blood cholesterol			OFFSIDES
168	Blood count abnormal			OFFSIDES
169	Blood creatinine decreased			OFFSIDES
170	Blood creatinine increased			OFFSIDES
171	Blood immunoglobulin A increased			OFFSIDES
172	Blood iron increased			OFFSIDES
173	Blood osmolarity decreased			OFFSIDES
174	Blood potassium			OFFSIDES
175	Blood pressure fluctuation			OFFSIDES
176	Blood sodium increased			OFFSIDES
177	Blood sodium			OFFSIDES
178	Blood urea increased			OFFSIDES
179	Blood urine present			OFFSIDES
180	Blurred vision			OFFSIDES
181	Bone abscess			OFFSIDES
182	Bone callus excessive			OFFSIDES
183	Bone density decreased			OFFSIDES
184	Bone erosion			OFFSIDES
185	Bone fistula			OFFSIDES
186	Bone fragmentation			OFFSIDES
187	Bone lesion			OFFSIDES
188	Bone marrow necrosis			OFFSIDES
189	Bone pain			OFFSIDES
190	Bone scan abnormal			OFFSIDES
191	Bone swelling			OFFSIDES
192	Bowel movement irregularity			OFFSIDES
193	Bradycardia		2774629	CTD
194	Breast cancer recurrent			OFFSIDES
195	Breast tenderness			OFFSIDES
196	Bronchial secretion retention			OFFSIDES
197	Bronchiectasis			OFFSIDES
198	Bronchitis			OFFSIDES SIDER
199	Bronchopneumonia			OFFSIDES
200	Bruxism			OFFSIDES
201	Buccal mucosal roughening			OFFSIDES
202	Bulbar palsy			OFFSIDES
203	Burkholderia cepacia Infection			OFFSIDES
204	Burning Mouth Syndrome			OFFSIDES
205	Bursitis			OFFSIDES
206	Capillary Leak Syndrome			OFFSIDES
207	Cardiac ablation			OFFSIDES
208	Cardiac valve abscess			OFFSIDES
209	Carotid bruit			OFFSIDES
210	Cataract operation			OFFSIDES
211	Cataract			OFFSIDES
212	Catheter placement			OFFSIDES
213	Catheter related infection			OFFSIDES
214	Catheter site discharge			OFFSIDES
215	Cauda Equina Syndrome			OFFSIDES
216	Caustic injury			OFFSIDES
217	Cell Death			OFFSIDES
218	Cellulitis			OFFSIDES
219	Central nervous system lesion			OFFSIDES
220	Central venous catheter removal			OFFSIDES
221	Cerebral Arteriosclerosis			OFFSIDES
222	Cerebral aspergillosis			OFFSIDES
223	Cerebral atrophy			OFFSIDES
224	Cerebral cyst			OFFSIDES
225	Cervical cord compression			OFFSIDES
226	Cervical dysplasia			OFFSIDES
227	Cervical laser therapy			OFFSIDES
228	Cervical myelopathy			OFFSIDES
229	Cervical spine flattening			OFFSIDES
230	Cervicobrachial syndrome			OFFSIDES
231	Chest Pain			OFFSIDES
232	Choking sensation			OFFSIDES
233	Cholecystitis infective			OFFSIDES
234	Chondromalacia			OFFSIDES
235	Chronic Fatigue Syndrome			OFFSIDES
236	Chronic Obstructive Airway Disease			OFFSIDES
237	Chronic sinusitis			OFFSIDES
238	Cirrhosis			OFFSIDES
239	Clostridium difficile colitis			OFFSIDES
240	Clostridium difficile toxin test positive			OFFSIDES
241	Colectomy			OFFSIDES
242	Colon adenoma			OFFSIDES
243	Colon cancer recurrent			OFFSIDES
244	Compression fracture			OFFSIDES
245	Confabulation			OFFSIDES
246	Congenital pyelocaliectasis			OFFSIDES
247	Congenital tricuspid valve incompetence			OFFSIDES
248	Conjunctival deposit			OFFSIDES
249	Conjunctivitis	Canada Vigilance: 1		Canada Vigilance
250	Contact Dermatitis			OFFSIDES
251	Corneal epithelium defect			OFFSIDES
252	Coronary angioplasty			OFFSIDES
253	Cryotherapy			OFFSIDES
254	Culture positive			OFFSIDES
255	Culture wound positive			OFFSIDES
256	Cutaneous Candidiasis			OFFSIDES
257	Cystocele			OFFSIDES
258	Cyst			OFFSIDES
259	Cytoreductive Surgery			OFFSIDES
260	Deafness			OFFSIDES SIDER
261	Debridement			OFFSIDES
262	Decreased Libido			OFFSIDES
263	Dehydration			OFFSIDES
264	Demyelination			OFFSIDES
265	Dental Fistula			OFFSIDES
266	Dental Plaque		9763330 27039991	CTD
267	Dental abscess			OFFSIDES
268	Dental alveolar anomaly			OFFSIDES
269	Dental caries		1771376 22030309	CTD OFFSIDES
270	Dentofacial anomaly			OFFSIDES
271	Denture wearer			OFFSIDES
272	Depressed Level of Consciousness			OFFSIDES
273	Depressed mood			OFFSIDES
274	Dermatitis, Allergic Contact		26795242	CTD
275	Dermatitis, Atopic		15218738	CTD
276	Dermatomycoses		19659541	CTD
277	Dermatophytosis			OFFSIDES
278	Device Failure			OFFSIDES
279	Device breakage			OFFSIDES
280	Device malfunction			OFFSIDES
281	Device occlusion			OFFSIDES
282	Device related infection			OFFSIDES
283	Diabetes			OFFSIDES
284	Diarrhea			OFFSIDES
285	Disease Progression			OFFSIDES
286	Disease recurrence			OFFSIDES
287	Diverticulitis			OFFSIDES
288	Diverticulosis			OFFSIDES
289	Diverticulum			OFFSIDES
290	Dizziness			OFFSIDES
291	Documented hypersensitivity to administered drug			OFFSIDES
292	Drowsiness			OFFSIDES
293	Drug addict			OFFSIDES
294	Drug exposure during pregnancy			OFFSIDES
295	Drug toxicity			OFFSIDES
296	Drug withdrawal headache			OFFSIDES
297	Dry skin			OFFSIDES
298	Duodenal fistula			OFFSIDES
299	Dysgeusia		711516 27039991	CTD OFFSIDES SIDER
300	Dyspepsia			OFFSIDES SIDER
301	Dysphemia			OFFSIDES
302	Dysphonia			OFFSIDES
303	Dysthymic Disorder			OFFSIDES
304	Dysuria			OFFSIDES
305	Ear infection staphylococcal			OFFSIDES
306	Economic problem			OFFSIDES
307	Eczema			OFFSIDES
308	Ejection Fraction Decreased			OFFSIDES
309	Ejection fraction abnormal			OFFSIDES
310	Electrocardiogram ST-T segment abnormal			OFFSIDES
311	Emotional distress			OFFSIDES
312	Empyema			OFFSIDES
313	Encephalomalacia			OFFSIDES
314	Endarterectomy			OFFSIDES
315	Endocarditis			OFFSIDES
316	Endodontic procedure			OFFSIDES
317	Endometrial Hyperplasia			OFFSIDES
318	Engraftment syndrome			OFFSIDES
319	Enterobacter pneumonia			OFFSIDES
320	Enterococcal infection			OFFSIDES
321	Enterovesical Fistula			OFFSIDES
322	Enthesopathy			OFFSIDES
323	Eosinophilic myocarditis			OFFSIDES
324	Epididymitis			OFFSIDES
325	Epidural lipomatosis			OFFSIDES
326	Epistaxis			OFFSIDES
327	Erectile dysfunction			OFFSIDES
328	Erysipelas			OFFSIDES
329	Escherichia infection			OFFSIDES
330	Escherichia urinary tract infection			OFFSIDES
331	Esophageal Stenosis			OFFSIDES
332	Essential Hypertension			OFFSIDES
333	Eustachian tube disorder			OFFSIDES
334	Excoriation			OFFSIDES
335	Exfoliative rash			OFFSIDES
336	Eye laser surgery			OFFSIDES
337	Eye pain			OFFSIDES
338	Eyelid margin crusting			OFFSIDES
339	Face Lift			OFFSIDES
340	Failure to Thrive			OFFSIDES
341	Fat necrosis			OFFSIDES
342	Fatigue			OFFSIDES
343	Fatty Liver			OFFSIDES
344	Febrile Neutropenia			OFFSIDES
345	Fibroadenoma of breast			OFFSIDES
346	Fibromyalgia			OFFSIDES
347	Fistula repair			OFFSIDES
348	Flank Pain			OFFSIDES
349	Fluid overload			OFFSIDES
350	Focal glomerulosclerosis			OFFSIDES
351	Formication			OFFSIDES
352	Fracture			SIDER
353	Fungal test positive			OFFSIDES
354	Gambling			OFFSIDES
355	Gamma-Glutamyltransferase Increased			OFFSIDES
356	Gammopathy			OFFSIDES
357	Gastrectomy			OFFSIDES
358	Gastric Bypass			OFFSIDES
359	Gastric ulcer			OFFSIDES
360	Gastroduodenitis			OFFSIDES
361	Gastroenteritis			OFFSIDES
362	Gastrointestinal arteriovenous malformation			OFFSIDES
363	Gastrointestinal inflammation			OFFSIDES
364	Gastrointestinal toxicity			OFFSIDES
365	Gene Mutation			OFFSIDES
366	General physical health deterioration			OFFSIDES
367	Gingival Hyperplasia			OFFSIDES SIDER
368	Gingival erythema			OFFSIDES
369	Gingival graft			OFFSIDES
370	Glaucoma			OFFSIDES
371	Gliosis			OFFSIDES
372	Globulinuria			OFFSIDES
373	Glomerulonephritis			OFFSIDES
374	Glossitis			SIDER
375	Goiter			OFFSIDES
376	Gout			OFFSIDES
377	Granulocytosis			OFFSIDES
378	Granuloma			OFFSIDES
379	Hearing aid user			OFFSIDES
380	Heat Exhaustion			OFFSIDES
381	Hemiparesis			OFFSIDES
382	Heparin-induced thrombocytopenia			OFFSIDES
383	Hepatojugular reflux			OFFSIDES
384	Hiccough			OFFSIDES
385	Hip surgery			OFFSIDES
386	Hyalohyphomycosis		18415842	CTD
387	Hydronephrosis			OFFSIDES
388	Hypercapnia			OFFSIDES
389	Hyperkeratosis			OFFSIDES
390	Hypertrophic Cardiomyopathy			OFFSIDES
391	Hypervigilance			OFFSIDES
392	Hypoaesthesia facial			OFFSIDES
393	Hypogeusia			OFFSIDES
394	Hypokinesia			OFFSIDES
395	Hypophagia			OFFSIDES
396	Hysterectomy			OFFSIDES
397	Impaired driving ability			OFFSIDES
398	Impaired gastric emptying			OFFSIDES
399	Impaired self-care			OFFSIDES
400	Impaired work ability			OFFSIDES
401	Implantable defibrillator insertion			OFFSIDES
402	Incision site erythema			OFFSIDES
403	Incisional hernia			OFFSIDES
404	Incoherent			OFFSIDES
405	Incontinence			OFFSIDES
406	Incorrect route of drug administration			OFFSIDES
407	Increased upper airway secretion			OFFSIDES
408	Infection			OFFSIDES
409	Infectious disease carrier			OFFSIDES
410	Inflammation		9619932 27039991	CTD
411	Influenza-like symptoms			SIDER
412	Infusion site mobility decreased			OFFSIDES
413	Injection Site Reaction	Canada Vigilance: 1		Canada Vigilance
414	Intentional drug misuse			OFFSIDES
415	Intermittent Claudication			OFFSIDES
416	Intervertebral Disc Degeneration			OFFSIDES
417	Intervertebral disc compression			OFFSIDES
418	Intervertebral disc disorder			OFFSIDES
419	Intestinal resection			OFFSIDES
420	Intravenous catheter management			OFFSIDES
421	Iridocyclitis			OFFSIDES
422	Joint injury			OFFSIDES
423	Jugular vein distension			OFFSIDES
424	Keratitis sicca			OFFSIDES
425	Keratomileusis			OFFSIDES
426	Kidney Failure			OFFSIDES
427	Knee Injuries		9619932	CTD
428	Labile blood pressure			OFFSIDES
429	Laceration			OFFSIDES
430	Lactose Intolerance			OFFSIDES
431	Left Ventricular Hypertrophy			OFFSIDES
432	Left atrial dilatation			OFFSIDES
433	Left ventricular end-diastolic pressure increased			OFFSIDES
434	Lesion excision			OFFSIDES
435	Lethargy			OFFSIDES
436	Leukodystrophy			OFFSIDES
437	Leukoencephalopathy			OFFSIDES
438	Leukopenia neonatal			OFFSIDES
439	Life expectancy shortened			OFFSIDES
440	Ligament rupture			OFFSIDES
441	Light chain analysis increased			OFFSIDES
442	Limb discomfort			OFFSIDES
443	Limb injury			OFFSIDES
444	Lithotripsy			OFFSIDES
445	Loose tooth			OFFSIDES
446	Lordosis			OFFSIDES
447	Lumbar radiculopathy			OFFSIDES
448	Lumbar spine flattening			OFFSIDES
449	Lung consolidation			OFFSIDES
450	Lymph node palpable			OFFSIDES
451	Lymphedema			OFFSIDES
452	Lymphocyte count decreased			OFFSIDES
453	Lymphocytic infiltration			OFFSIDES
454	Lymphoma			OFFSIDES
455	Malabsorption			OFFSIDES
456	Malignant neoplasm progression			OFFSIDES
457	Mass excision			OFFSIDES
458	Mastication disorder			OFFSIDES
459	Mastoiditis			OFFSIDES
460	Maxillofacial operation			OFFSIDES
461	Mechanical ventilation			OFFSIDES
462	Mediastinal mass			OFFSIDES
463	Medical device complication			OFFSIDES
464	Medical device implantation			OFFSIDES
465	Medical device removal			OFFSIDES
466	Megacolon			OFFSIDES
467	Mental disorder due to a general medical condition			OFFSIDES
468	Mental impairment			OFFSIDES
469	Mental status changes			OFFSIDES
470	Metastases to thorax			OFFSIDES
471	Metastatic Neoplasm			OFFSIDES
472	Metastatic pain			OFFSIDES
473	Microalbuminuria			OFFSIDES
474	Migraine with Aura			OFFSIDES
475	Mixed Connective Tissue Disease			OFFSIDES
476	Molluscum Contagiosum			OFFSIDES
477	Monoclonal immunoglobulin present			OFFSIDES
478	Mononeuritis			OFFSIDES
479	Mouth irritation			SIDER
480	Multiple Myeloma			OFFSIDES
481	Muscle Weakness			OFFSIDES
482	Muscle necrosis			OFFSIDES
483	Muscle strain			OFFSIDES
484	Muscle tightness			OFFSIDES
485	Musculoskeletal chest pain			OFFSIDES
486	Musculoskeletal discomfort			OFFSIDES SIDER
487	Myalgia			SIDER
488	Myasthenia Gravis			OFFSIDES
489	Myelitis			OFFSIDES
490	Myeloma recurrence			OFFSIDES
491	Narcotic intoxication			OFFSIDES
492	Nausea			OFFSIDES
493	Necrosis		22488977	CTD
494	Nephrolithiasis			OFFSIDES
495	Nerve Block			OFFSIDES
496	Neuralgia			OFFSIDES
497	Neurogenic Bowel			OFFSIDES
498	Neutropenic colitis			OFFSIDES
499	Neutropenic infection			OFFSIDES
500	Neutropenic sepsis			OFFSIDES
501	Nocturia			OFFSIDES
502	Nodule on extremity			OFFSIDES
503	Nodule			OFFSIDES
504	Nutritional condition abnormal			OFFSIDES
505	Occult blood positive			OFFSIDES
506	Onychalgia			OFFSIDES
507	Open reduction of fracture			OFFSIDES
508	Open wound			OFFSIDES
509	Optic Disc Edema			OFFSIDES
510	Oral Cavity Fistula			OFFSIDES
511	Oral infection			OFFSIDES
512	Oral mucosa atrophy			OFFSIDES
513	Oral mucosal erythema			OFFSIDES
514	Oral mucosal exfoliation			SIDER
515	Oral pain			SIDER
516	Oral polypectomy			OFFSIDES
517	Oral torus			OFFSIDES
518	Orchitis			OFFSIDES
519	Oropharyngeal blistering			OFFSIDES
520	Oropharyngeal plaque			OFFSIDES
521	Orthopnea			OFFSIDES
522	Orthosis user			OFFSIDES
523	Osteitis Deformans			OFFSIDES
524	Osteochondritis		9619932	CTD
525	Osteochondrosis			OFFSIDES
526	Osteolysis			OFFSIDES
527	Osteomyelitis			OFFSIDES
528	Osteopenia			OFFSIDES
529	Osteopetrosis			OFFSIDES
530	Osteoporosis			OFFSIDES
531	Osteoradionecrosis			OFFSIDES
532	Osteosclerosis			OFFSIDES
533	Overdose			OFFSIDES
534	Overweight			OFFSIDES
535	Oxygen supplementation			OFFSIDES
536	Pancreatic Cyst			OFFSIDES
537	Papilloma			OFFSIDES
538	Paracentesis			OFFSIDES
539	Paranoia			OFFSIDES
540	Paraparesis			OFFSIDES
541	Partner stress			OFFSIDES
542	Pectus excavatum			OFFSIDES
543	Pericardial effusion			OFFSIDES
544	Periodontal operation			OFFSIDES
545	Periodontitis		12747445	CTD OFFSIDES
546	Peripheral embolism			OFFSIDES
547	Perivascular dermatitis			OFFSIDES
548	Pharyngitis			SIDER
549	Pharyngolaryngeal Pain			OFFSIDES
550	Phlebitis			OFFSIDES
551	Physical disability			OFFSIDES
552	Pilonidal Cyst			OFFSIDES
553	Plasmacytoma			OFFSIDES
554	Plasmacytosis			OFFSIDES
555	Pleurodesis			OFFSIDES
556	Pneumoconiosis			OFFSIDES
557	Pneumothorax			OFFSIDES
558	Poikilocytosis			OFFSIDES
559	Polyneuropathy			OFFSIDES
560	Polyuria			OFFSIDES
561	Poor dental condition			OFFSIDES
562	Poor peripheral circulation			OFFSIDES
563	Poor personal hygiene			OFFSIDES
564	Positron emission tomogram abnormal			OFFSIDES
565	Post procedural fistula			OFFSIDES
566	Posterior Capsulotomy			OFFSIDES
567	Posterior capsule opacification			OFFSIDES
568	Postmenopausal bleeding			OFFSIDES
569	Postoperative fever			OFFSIDES
570	Postoperative ileus			OFFSIDES
571	Presbyopia			OFFSIDES
572	Primary sequestrum			OFFSIDES
573	Product contamination			OFFSIDES
574	Productive Cough			OFFSIDES
575	Propofol Infusion Syndrome			OFFSIDES
576	Prostate examination abnormal			OFFSIDES
577	Prostatectomy			OFFSIDES
578	Prostatic Obstruction			OFFSIDES
579	Protein total increased			OFFSIDES
580	Psychiatric symptom			OFFSIDES
581	Pterygium			OFFSIDES
582	Pulmonary Hypertension			OFFSIDES
583	Pulmonary congestion			OFFSIDES
584	Pulmonary function test decreased			OFFSIDES
585	Pulmonary radiation injury			OFFSIDES
586	Purulence			OFFSIDES
587	Purulent discharge			OFFSIDES
588	Pyelonephritis			OFFSIDES
589	Pyogenic granuloma			OFFSIDES
590	QRS axis abnormal			OFFSIDES
591	Quality of life decreased			OFFSIDES
592	Radiation necrosis			OFFSIDES
593	Rectocele			OFFSIDES
594	Redness			SIDER
595	Renal Colic			OFFSIDES
596	Renal cyst			OFFSIDES
597	Renal tubular acidosis			OFFSIDES
598	Respiratory Failure			OFFSIDES
599	Respiratory tract congestion			OFFSIDES
600	Reticulocyte count increased			OFFSIDES
601	Retinal Vasculitis			OFFSIDES
602	Rhinitis			OFFSIDES SIDER
603	Rhinorrhea			OFFSIDES
604	Rhonchi			OFFSIDES
605	Right atrial dilatation			OFFSIDES
606	Risus sardonicus			OFFSIDES
607	Saliva altered			OFFSIDES
608	Salpingo-oophorectomy			OFFSIDES
609	Sarcoidosis			OFFSIDES
610	Scan lymph nodes			OFFSIDES
611	Sclerosing encapsulating peritonitis			OFFSIDES
612	Scotoma			OFFSIDES
613	Scrotal cyst			OFFSIDES
614	Scrotal erythema			OFFSIDES
615	Scrotal irritation			OFFSIDES
616	Secondary sequestrum			OFFSIDES
617	Sequestrectomy			OFFSIDES
618	Sick Sinus Syndrome			OFFSIDES
619	Sinus bradycardia			OFFSIDES
620	Sinus headache			OFFSIDES
621	Sinus operation			OFFSIDES
622	Sinusitis			OFFSIDES SIDER
623	Sjogren's Syndrome			OFFSIDES
624	Skin laceration			OFFSIDES
625	Skin lesion			OFFSIDES
626	Skin necrosis			OFFSIDES
627	Skin neoplasm excision			OFFSIDES
628	Skin reaction	Canada Vigilance: 1		Canada Vigilance
629	Skin toxicity			OFFSIDES
630	Skull X-ray abnormal			OFFSIDES
631	Snoring			OFFSIDES
632	Soft tissue inflammation			OFFSIDES
633	Specific gravity urine decreased			OFFSIDES
634	Speech rehabilitation			OFFSIDES
635	Spinal column stenosis			OFFSIDES
636	Spinal corpectomy			OFFSIDES
637	Spinal fusion acquired			OFFSIDES
638	Spinal fusion surgery			OFFSIDES
639	Spinal haemangioma			OFFSIDES
640	Spondylitic myelopathy			OFFSIDES
641	Spondylitis			OFFSIDES
642	Spondylolisthesis			OFFSIDES
643	Spondylolysis			OFFSIDES
644	Sputum culture positive			OFFSIDES
645	Stem cell transplant			OFFSIDES
646	Stent occlusion			OFFSIDES
647	Stoma site erythema	Canada Vigilance: 1		Canada Vigilance
648	Stoma site inflammation	Canada Vigilance: 1		Canada Vigilance
649	Stomatitis			SIDER
650	Stress			OFFSIDES
651	Subacute endocarditis			OFFSIDES
652	Subcutaneous Abscess			OFFSIDES
653	Subcutaneous nodule			OFFSIDES
654	Submandibular mass			OFFSIDES
655	Superior Vena Cava Syndrome			OFFSIDES
656	Suture insertion			OFFSIDES
657	Synovial Cyst			OFFSIDES
658	Synovitis		9619932	CTD OFFSIDES
659	Taste Disorders		9763330 16512751	CTD
660	Tendinitis			OFFSIDES
661	Testicular mass			OFFSIDES
662	Therapeutic procedure			OFFSIDES
663	Thoracic cavity drainage			OFFSIDES
664	Thoracotomy			OFFSIDES
665	Thrombophlebitis			OFFSIDES
666	Thyroidectomy			OFFSIDES
667	Thyroiditis			OFFSIDES
668	Tinea cruris			OFFSIDES
669	Tinnitus			OFFSIDES
670	Toe operation			OFFSIDES
671	Tooth Demineralization		17153647	CTD
672	Tooth Extraction			OFFSIDES
673	Tooth Infection			OFFSIDES
674	Tooth Loss			OFFSIDES
675	Tooth Resorption			OFFSIDES
676	Tooth repair			OFFSIDES
677	Toothache			SIDER
678	Transaminases increased			OFFSIDES
679	Transfusion Reaction			OFFSIDES
680	Transmission of an infectious agent via a medicinal product			OFFSIDES
681	Trauma			SIDER
682	Tryptase increased			OFFSIDES
683	Tympanic Membrane Perforation			SIDER
684	Ulcerative stomatitis			SIDER
685	Ulcer			SIDER
686	Umbilical hernia			OFFSIDES
687	Unresponsive to stimuli			OFFSIDES
688	Upper airway obstruction			OFFSIDES
689	Ureteral stent insertion			OFFSIDES
690	Urethral Obstruction			OFFSIDES
691	Urge Incontinence			OFFSIDES
692	Urinary tract infection fungal			OFFSIDES
693	Urine flow decreased			OFFSIDES
694	Uterine Prolapse			OFFSIDES
695	VIIth nerve paralysis			OFFSIDES
696	Vagotomy			OFFSIDES
697	Vena cava filter insertion			OFFSIDES
698	Venous occlusion			OFFSIDES
699	Ventricular Fibrillation		1560587	CTD
700	Ventricular hypokinesia			OFFSIDES
701	Vertebroplasty			OFFSIDES
702	Viral pharyngitis			OFFSIDES
703	Viral upper respiratory tract infection			OFFSIDES
704	Vitamin A Deficiency			OFFSIDES
705	Vitamin B 12 Deficiency			OFFSIDES
706	Walking aid user			OFFSIDES
707	Weight Gain			OFFSIDES
708	Wheelchair user			OFFSIDES
709	Wound Debridement			OFFSIDES
710	Wound Infection			OFFSIDES
711	Wound dehiscence			OFFSIDES
712	Wound infection staphylococcal			OFFSIDES
713	Xerosis			OFFSIDES
714	anaphylaxis		1560587 27039991	CTD
715	colonoscopy			OFFSIDES
716	effusion			OFFSIDES
717	fibroma			OFFSIDES
718	furuncle			OFFSIDES
719	kyphosis			OFFSIDES
720	muscle injury			OFFSIDES
721	pH urine increased			OFFSIDES

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