MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Cefotaxime

(GPRBEKHLDVQUJE-QSWIMTSFSA-N)

Structure

SMILES: CO/N=C(/c1csc(n1)N)\C(=O)N[C@@H]1C(=O)N2[C@@H]1SCC(=C2C(=O)O)COC(=O)C
Type(s): Approved
ATC code(s): J01DD01
Molecular Formula:: C16H17N5O7S2
Molecular Weight:: 455.465
Log P:: 0.2875
Hydrogen Bond Acceptor:: 14
Hydrogen Bond Donor:: 3
TPSA:: 227.05
CAS Number(s):: 60846-21-1; 63527-52-6; 1056874-43-1

Synonym(s)

Cefotaxime

Benaxima

Biosint

Cefotaxim

Cefotaxime Sodium

Cefradil

Cephotaxim

Claforan

Fotexina

10.

HR-756

11.

Kendrick

12.

Klaforan

13.

Primafen

14.

Ru-24756

15.

Taporin

16.

HR 756

17.

HR756

18.

Ru 24756

19.

Ru24756

20.

Sodium, Cefotaxime

External Link(s)

MeSH	D002439
PubChem Compound	5742673
ChEBI	204928
CHEMBL	CHEMBL1730
DrugBank	DB00493
DrugCentral	546
KEGG	cpd:C06885 dr:D07647
ZINC	3830437

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Disorientation	FAERS: 4		US FAERS
2	Anaphylactic shock	FAERS: 3		SIDER US FAERS
3	Aspartate Aminotransferase Increased	FAERS: 3		US FAERS
4	Eosinophilia	FAERS: 3		SIDER US FAERS
5	Hypotension	FAERS: 3		US FAERS
6	Myoclonus	FAERS: 3		US FAERS
7	Neutropenia	FAERS: 3		SIDER US FAERS
8	Status Epilepticus	FAERS: 3	3110537	CTD OFFSIDES US FAERS
9	Agitation	FAERS: 2		US FAERS
10	Altered state of consciousness	FAERS: 2		US FAERS
11	Arthralgia	FAERS: 2		US FAERS
12	Clostridium difficile colitis	FAERS: 2		OFFSIDES US FAERS
13	Cyanosis	FAERS: 2	9915680	CTD US FAERS
14	Depressed Level of Consciousness	FAERS: 2		US FAERS
15	Malaise	FAERS: 2		SIDER US FAERS
16	Respiratory Failure	FAERS: 2		OFFSIDES US FAERS
17	Restlessness	FAERS: 2		US FAERS
18	Shock	FAERS: 2		SIDER US FAERS
19	Skin reaction	FAERS: 2		US FAERS
20	Tachycardia	FAERS: 2		US FAERS
21	Transaminases increased	FAERS: 2		OFFSIDES US FAERS
22	Tremor	FAERS: 2		US FAERS
23	White blood cell count decreased	FAERS: 2		US FAERS
24	nervous system disorder	FAERS: 2		US FAERS
25	Alanine Aminotransferase Increased	FAERS: 1		OFFSIDES US FAERS
26	Amylase increased	FAERS: 1		US FAERS
27	Anxiety	FAERS: 1		US FAERS
28	Atrial Fibrillation	FAERS: 1		US FAERS
29	Blood alkaline phosphatase increased	FAERS: 1		US FAERS
30	Blood creatinine increased	FAERS: 1		OFFSIDES US FAERS
31	Blood lactate dehydrogenase increased	FAERS: 1		OFFSIDES US FAERS
32	Bronchospasm	FAERS: 1		SIDER US FAERS
33	Cheilitis	FAERS: 1		US FAERS
34	Cholestasis	FAERS: 1	17530386 19321684	CTD SIDER US FAERS
35	Electrolyte imbalance	FAERS: 1		US FAERS
36	Erythema	FAERS: 1		OFFSIDES US FAERS
37	Formication	FAERS: 1		US FAERS
38	Hepatic necrosis	FAERS: 1		OFFSIDES US FAERS
39	Kounis Syndrome	FAERS: 1		US FAERS
40	Lymphadenopathy	FAERS: 1		US FAERS
41	Lymphocyte stimulation test positive	FAERS: 1		US FAERS
42	Medical device complication	FAERS: 1		OFFSIDES US FAERS
43	Mental impairment	FAERS: 1		US FAERS
44	Metabolic acidosis	FAERS: 1		OFFSIDES US FAERS
45	Mouth swelling	FAERS: 1		US FAERS
46	Pallor	FAERS: 1		OFFSIDES US FAERS
47	Pancreatitis	FAERS: 1		US FAERS
48	Pneumococcal sepsis	FAERS: 1		OFFSIDES US FAERS
49	Pruritus	FAERS: 1		SIDER US FAERS
50	Rash erythematous	FAERS: 1		US FAERS
51	Sepsis	FAERS: 1	6295339 19321684	CTD US FAERS
52	Septic Shock	FAERS: 1		OFFSIDES US FAERS
53	Somnolence	FAERS: 1		US FAERS
54	Stomatitis	FAERS: 1		US FAERS
55	Suicide attempt	FAERS: 1		US FAERS
56	Supraventricular tachycardia	FAERS: 1		US FAERS
57	Throat irritation	FAERS: 1		US FAERS
58	Toxic Epidermal Necrolysis	FAERS: 1		SIDER US FAERS
59	Urticaria	FAERS: 1	11792017	CTD SIDER US FAERS
60	Vibratory sense increased	FAERS: 1		US FAERS
61	Visual disturbance	FAERS: 1		US FAERS
62	17-hydroxyprogesterone increased			OFFSIDES
63	Abdominal Pain			SIDER
64	Abdominal sepsis			OFFSIDES
65	Abnormalities, Drug-Induced		29596928	CTD
66	Acanthosis			OFFSIDES
67	Acid fast bacilli infection			OFFSIDES
68	Acidosis			OFFSIDES
69	Acute kidney injury		10803769	CTD
70	Acute myocardial infarction			OFFSIDES
71	Acute sinusitis			OFFSIDES
72	Agranulocytosis			SIDER
73	Allergy test positive			OFFSIDES
74	Anemia, Hemolytic		2316002	CTD
75	Angioedema			SIDER
76	Anisocoria			OFFSIDES
77	Anoxic Encephalopathy			OFFSIDES
78	Anticonvulsant drug level decreased			OFFSIDES
79	Anuria			OFFSIDES
80	Aortic valve calcification			OFFSIDES
81	Apallic syndrome			OFFSIDES
82	Apnea			OFFSIDES
83	Arteriovenous fistula thrombosis			OFFSIDES
84	Arthritis		2041948	CTD OFFSIDES
85	Ascites			OFFSIDES
86	Aseptic Meningitis			OFFSIDES
87	Aspiration Pneumonia			OFFSIDES
88	Asthma			OFFSIDES
89	Ataxia		2669668	CTD
90	Atherosclerosis			OFFSIDES
91	Atrioventricular Block			OFFSIDES
92	Automatism			OFFSIDES
93	Bacillus infection			OFFSIDES
94	Bacteremia		3888810 10897142	CTD
95	Bacterial Infections		6089633	CTD
96	Bacterial culture positive			OFFSIDES
97	Bacterial sepsis			OFFSIDES
98	Balanitis			OFFSIDES
99	Bile Duct Stenosis			OFFSIDES
100	Biliary adenoma			OFFSIDES
101	Bladder cyst			OFFSIDES
102	Blood albumin decreased			OFFSIDES
103	Blood alkaline phosphatase decreased			OFFSIDES
104	Blood amylase increased			OFFSIDES
105	Blood corticotrophin abnormal			OFFSIDES
106	Blood fibrinogen			OFFSIDES
107	Blood immunoglobulin E			OFFSIDES
108	Blood pH decreased			OFFSIDES
109	Blood potassium increased			OFFSIDES
110	Blood sodium increased			OFFSIDES
111	Blood sodium			OFFSIDES
112	Blood stem cell transplant failure			OFFSIDES
113	Body Temperature			OFFSIDES
114	Bone marrow depression			OFFSIDES
115	Bradycardia			OFFSIDES
116	Brain Abscess			OFFSIDES
117	Brain Death			OFFSIDES
118	Brain Diseases		12899029	CTD
119	Brain natriuretic peptide increased			OFFSIDES
120	Bullous eruption			SIDER
121	Calcinosis			OFFSIDES
122	Candida sepsis			OFFSIDES
123	Capillary Leak Syndrome			OFFSIDES
124	Cardioactive drug level			OFFSIDES
125	Cardioactive drug level increased			OFFSIDES
126	Catheter sepsis			OFFSIDES
127	Central nervous system lesion			OFFSIDES
128	Cerebellar infarction			OFFSIDES
129	Cholangiolitis			OFFSIDES
130	Chorioamnionitis			OFFSIDES
131	Chronic respiratory failure			OFFSIDES
132	Cirrhosis			OFFSIDES
133	Citrobacter infection			OFFSIDES
134	Clostridium colitis			OFFSIDES
135	Colectomy			OFFSIDES
136	Colitis			SIDER
137	Complex partial seizures			OFFSIDES
138	Confabulation			OFFSIDES
139	Congenital cystic kidney disease			OFFSIDES
140	Cryptosporidiosis			OFFSIDES
141	Culture positive			OFFSIDES
142	Cytolytic hepatitis			OFFSIDES
143	Cytomegalovirus test			OFFSIDES
144	Demyelination			OFFSIDES
145	Dental caries			OFFSIDES
146	Dermatitis, Photoallergic		10971368	CTD
147	Dermatitis			SIDER
148	Diarrhea		2041948 9551246	CTD
149	Discomfort			SIDER
150	Disease recurrence			OFFSIDES
151	Disseminated Intravascular Coagulation		9915680	CTD OFFSIDES
152	Diverticular hernia			OFFSIDES
153	Drug Eruptions		10971368 11792017	CTD
154	Drug resistance			OFFSIDES
155	Drug toxicity			OFFSIDES
156	Dyspnoea exacerbated			OFFSIDES
157	Ear congestion			OFFSIDES
158	Ecchymosis		9915680	CTD
159	Electrocardiogram ST segment abnormal			OFFSIDES
160	Embryo Loss		29596928	CTD
161	Encephalitis			OFFSIDES
162	Enteritis			OFFSIDES
163	Enterococcal infection			OFFSIDES
164	Enterococcal sepsis			OFFSIDES
165	Enterocolitis			SIDER
166	Epilepsies, Partial		3110537	CTD
167	Erythema Multiforme			OFFSIDES SIDER
168	Escherichia infection			OFFSIDES
169	Excoriation			OFFSIDES
170	Extremity necrosis			OFFSIDES
171	Eye Infection			OFFSIDES
172	Fatty Liver			OFFSIDES
173	Feeling abnormal			SIDER
174	Femoral arterial stenosis			OFFSIDES
175	Fluid overload			OFFSIDES
176	Gamma-Glutamyltransferase Increased			OFFSIDES
177	Gastric infection			OFFSIDES
178	Gastroenteritis norovirus			OFFSIDES
179	Gastrointestinal Pain			SIDER
180	Gastrointestinal infection			OFFSIDES
181	Gastrointestinal stoma complication			OFFSIDES
182	General physical condition			OFFSIDES
183	General physical health deterioration			OFFSIDES
184	Globulinuria			OFFSIDES
185	Gonorrhea		6271049	CTD
186	Granulocyte count decreased			OFFSIDES
187	Granulocytosis			OFFSIDES
188	Haemophilus Infections		9755831	CTD
189	Headache			SIDER
190	Hearing Loss, Bilateral		2041948	CTD
191	Hepatitis B positive			OFFSIDES
192	Hepatitis			OFFSIDES SIDER
193	Hepatosplenomegaly			OFFSIDES
194	Histiocytosis haematophagic			OFFSIDES
195	Hydrocephalus			OFFSIDES
196	Hypercapnia			OFFSIDES
197	Hypersensitivity			SIDER
198	Hypocoagulable state			OFFSIDES
199	Hypoxia			OFFSIDES
200	Iatrogenic injury			OFFSIDES
201	Impetigo			OFFSIDES
202	Induration			SIDER
203	Infantile apnoeic attack			OFFSIDES
204	Infection			OFFSIDES
205	Infusion site reaction			OFFSIDES
206	Injection site inflammation			OFFSIDES SIDER
207	Injection site irritation			OFFSIDES
208	Intervertebral Disc Degeneration			OFFSIDES
209	Intestinal Perforation			OFFSIDES
210	Jejunal ulcer			OFFSIDES
211	Kidney Failure			OFFSIDES
212	Lethargy			OFFSIDES
213	Leukoencephalopathy			OFFSIDES
214	Leukopenia neonatal			OFFSIDES
215	Leukopenia			SIDER
216	Lipase			OFFSIDES
217	Listeriosis			OFFSIDES
218	Livedo Reticularis			OFFSIDES
219	Liver Abscess			OFFSIDES
220	Local reaction			SIDER
221	Localised intraabdominal fluid collection			OFFSIDES
222	Localised skin reaction			OFFSIDES
223	Lung consolidation			OFFSIDES
224	Mastication disorder			OFFSIDES
225	Meningeal disorder			OFFSIDES
226	Meningitis, Bacterial		3850855 7625802 9551246	CTD
227	Meningitis, Haemophilus		View details 2649966 2770124 3264562 6094437	CTD
228	Meningitis, Pneumococcal		1495831 1601755	CTD
229	Meningitis		2041948	CTD
230	Monoclonal immunoglobulin present			OFFSIDES
231	Monoparesis			OFFSIDES
232	Morganella infection			OFFSIDES
233	Motor retardation			OFFSIDES
234	Multiple Myeloma			OFFSIDES
235	Muscle necrosis			OFFSIDES
236	Musculoskeletal discomfort			OFFSIDES
237	Nausea			SIDER
238	Neonatal aspiration			OFFSIDES
239	Neonatal hypotension			OFFSIDES
240	Neonatal intestinal obstruction			OFFSIDES
241	Neonatal respiratory acidosis			OFFSIDES
242	Neonatal respiratory failure			OFFSIDES
243	Nephritis, Interstitial		8684569 8856288 10803769	CTD
244	Nephrogenic Diabetes Insipidus			OFFSIDES
245	Neurotoxicity Syndromes		3335815	CTD
246	Oliguria			OFFSIDES
247	Onycholysis			OFFSIDES
248	Osteomyelitis			OFFSIDES
249	Oxygen consumption increased			OFFSIDES
250	PCO2 increased			OFFSIDES
251	Pain			SIDER
252	Pancreatic enzymes increased			OFFSIDES
253	Panniculitis			OFFSIDES
254	Papilloma			OFFSIDES
255	Pathogen resistance			OFFSIDES
256	Pericardial effusion		29596928	CTD
257	Pericarditis		2041948	CTD
258	Peritoneal Dialysis			OFFSIDES
259	Peritonitis		3888810 11280580	CTD OFFSIDES
260	Pneumonia, Bacterial		1601755	CTD
261	Pneumonia		1583528 2041948	CTD
262	Pneumopericardium			OFFSIDES
263	Pneumoperitoneum			OFFSIDES
264	Pneumothorax			OFFSIDES
265	Polyneuropathy			OFFSIDES
266	Polyuria			OFFSIDES
267	Popliteal pulse decreased			OFFSIDES
268	Portal Vein Thrombosis			OFFSIDES
269	Post procedural complication			OFFSIDES
270	Propofol Infusion Syndrome			OFFSIDES
271	Pseudarthrosis			OFFSIDES
272	Psychoses, Substance-Induced		12899029	CTD
273	Pulmonary Hypertension			OFFSIDES
274	Pulmonary congestion			OFFSIDES
275	Pulmonary interstitial emphysema syndrome			OFFSIDES
276	Pustular psoriasis			OFFSIDES
277	Pyelonephritis		2943665 9402409	CTD
278	Pyloric Stenosis			OFFSIDES
279	Rales			OFFSIDES
280	Red blood cell schistocytes present			OFFSIDES
281	Renal Artery Stenosis			OFFSIDES
282	Renal cyst			OFFSIDES
283	Renal failure neonatal			OFFSIDES
284	Renal tubular disorder			OFFSIDES
285	Renal tubular necrosis			OFFSIDES
286	Respiratory syncytial virus bronchiolitis			OFFSIDES
287	Rhabdomyolysis			OFFSIDES
288	Salmonella infections		8807045	CTD
289	Scab			OFFSIDES
290	Seizures		2669668 6094437 17530386	CTD
291	Sick Sinus Syndrome			OFFSIDES
292	Sinus bradycardia			OFFSIDES
293	Skin laceration			OFFSIDES
294	Skin necrosis			OFFSIDES
295	Skin toxicity			OFFSIDES
296	Sphincter of Oddi Dysfunction			OFFSIDES
297	Staphylococcal Infections		3850855 9755831	CTD
298	Stem cell transplant			OFFSIDES
299	Stevens-Johnson Syndrome		25811541	CTD SIDER
300	Streptococcal Infections		9755831	CTD
301	Subdural Effusion		2041948	CTD
302	Superinfection			SIDER
303	Surgical Wound Infection		3892854	CTD
304	Telangiectasis		10971368	CTD
305	Thrombocytopenia			SIDER
306	Thrombophlebitis			OFFSIDES
307	Thrombosis in device			OFFSIDES
308	Traumatic liver injury			SIDER
309	Troponin increased			OFFSIDES
310	Upper respiratory tract inflammation			OFFSIDES
311	Urinary tract infection enterococcal			OFFSIDES
312	Urinary tract infection pseudomonal			OFFSIDES
313	Urine electrolytes abnormal			OFFSIDES
314	Vasculitis		10803769	CTD
315	Venous thrombosis limb			OFFSIDES
316	Ventricular hypokinesia			OFFSIDES
317	Vomiting			SIDER
318	Wound dehiscence			OFFSIDES
319	anaphylaxis		9915680	CTD
320	furuncle			OFFSIDES
321	jaundice			SIDER
322	pseudomembranous colitis			SIDER

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