MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Chlorpromazine

(ZPEIMTDSQAKGNT-UHFFFAOYSA-N)

Structure

SMILES: CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C
Type(s): Approved; Investigational; Vet_approved
ATC code(s): N05AA01
Molecular Formula:: C17H19ClN2S
Molecular Weight:: 318.864
Log P:: 4.9594
Hydrogen Bond Acceptor:: 2
Hydrogen Bond Donor:: 0
TPSA:: 31.78
CAS Number(s):: 50-53-3; 69-09-0; 34468-21-8

Synonym(s)

Chlorpromazine

Aminazine

Chlorazine

Chlordelazine

Chlorpromazine Hydrochloride

Contomin

Fenactil

Largactil

Propaphenin

10.

Thorazine

11.

Hydrochloride, Chlorpromazine

External Link(s)

MeSH	D002746
PubChem Compound	2726
BindingDB	50001888
ChEBI	3647
CHEMBL	CHEMBL71
DrugBank	DB00477
DrugCentral	621
IUPHAR/BPS Guide to PHARMACOLOGY	83
KEGG	cpd:C06906 dr:D00270
Therapeutic Target Database	D01ZII
ZINC	44027

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Alanine Aminotransferase Increased	FAERS: 6		OFFSIDES US FAERS
2	Aspartate Aminotransferase Increased	FAERS: 6 Canada Vigilance: 1		Canada Vigilance US FAERS
3	Lethargy	FAERS: 6		OFFSIDES US FAERS
4	Neuroleptic Malignant Syndrome	FAERS: 6	View details 1485575 1674666 6407647 6407706 6661471 6662980 6703834 7387498 8555725 9128030 18494081	CTD OFFSIDES SIDER US FAERS
5	Tremor	FAERS: 6 Canada Vigilance: 75	View details 961932 1147074 4651776 4942959 7540798 10082231 12933958 14172950	CTD SIDER Canada Vigilance US FAERS
6	Blood alkaline phosphatase increased	FAERS: 5 Canada Vigilance: 3		Canada Vigilance OFFSIDES US FAERS
7	Cholestasis	FAERS: 5 Canada Vigilance: 2	View details 110598 416590 572556 1728036 1728037 2628084 3442185 4692711 7202939 8563000 11669021 17335721 26881866 27344345 28188341	CTD Canada Vigilance US FAERS
8	Tachycardia	FAERS: 5 Canada Vigilance: 7		Canada Vigilance SIDER US FAERS
9	Cataract	FAERS: 4		US FAERS
10	Dystonia	FAERS: 4 Canada Vigilance: 15	View details 589060 1119613 2278124 3775927 4566388 4583571 4942959 7111060 7393810 10389620 15266186	CTD OFFSIDES Canada Vigilance US FAERS
11	Glaucoma	FAERS: 4		US FAERS
12	Incorrect dose administered	FAERS: 4		US FAERS
13	Priapism	FAERS: 4	2279216 3573170 14999218	CTD SIDER US FAERS
14	Adverse event	FAERS: 3		US FAERS
15	Headache	FAERS: 3 Canada Vigilance: 6	2948633 9035996 10431323	CTD Canada Vigilance US FAERS
16	Hepatitis	FAERS: 3 Canada Vigilance: 11		Canada Vigilance OFFSIDES US FAERS
17	Hypophagia	FAERS: 3		OFFSIDES US FAERS
18	Hypotension	FAERS: 3 Canada Vigilance: 30	View details 508006 718334 869664 2596658 3567260 3945176 4605009 4610613 4988497 5089398 6030495 6108744 6167651 7032226 7208775 8044746	CTD SIDER Canada Vigilance US FAERS
19	Pharmaceutical product complaint	FAERS: 3		US FAERS
20	Somnolence	FAERS: 3 Canada Vigilance: 107		Canada Vigilance SIDER US FAERS
21	Status Epilepticus	FAERS: 3	4605009	CTD US FAERS
22	Tardive Dyskinesia	FAERS: 3 Canada Vigilance: 3		Canada Vigilance OFFSIDES SIDER US FAERS
23	jaundice	FAERS: 3 Canada Vigilance: 34	3183354 4692711 11669021	CTD SIDER Canada Vigilance US FAERS
24	Accidental overdose	FAERS: 2 Canada Vigilance: 3		Canada Vigilance US FAERS
25	Antiphospholipid Syndrome	FAERS: 2		US FAERS
26	Anxiety	FAERS: 2 Canada Vigilance: 2		Canada Vigilance US FAERS
27	Asthenia	FAERS: 2 Canada Vigilance: 23		Canada Vigilance OFFSIDES US FAERS
28	Ataxia	FAERS: 2 Canada Vigilance: 3	8083816	CTD Canada Vigilance US FAERS
29	Bedridden	FAERS: 2		US FAERS
30	Dizziness	FAERS: 2 Canada Vigilance: 36	3512622	CTD OFFSIDES SIDER Canada Vigilance US FAERS
31	Drug ineffective	FAERS: 2		OFFSIDES US FAERS
32	Drug level increased	FAERS: 2 Canada Vigilance: 1		Canada Vigilance US FAERS
33	Drug toxicity	FAERS: 2		OFFSIDES US FAERS
34	Dysarthria	FAERS: 2 Canada Vigilance: 12	4144147 4247303 7387498	CTD Canada Vigilance US FAERS
35	Dysgraphia	FAERS: 2		US FAERS
36	Floppy iris syndrome	FAERS: 2		US FAERS
37	Medication Error	FAERS: 2 Canada Vigilance: 1		Canada Vigilance US FAERS
38	Mental status changes	FAERS: 2		OFFSIDES US FAERS
39	Thrombocytopenia	FAERS: 2 Canada Vigilance: 1		Canada Vigilance US FAERS
40	Tinnitus	FAERS: 2 Canada Vigilance: 3		Canada Vigilance US FAERS
41	Vanishing bile duct syndrome	FAERS: 2		US FAERS
42	Vomiting	FAERS: 2 Canada Vigilance: 6	2865637 19000276	CTD Canada Vigilance US FAERS
43	Abasia	FAERS: 1		OFFSIDES US FAERS
44	Accidental exposure	FAERS: 1		US FAERS
45	Agitation	FAERS: 1 Canada Vigilance: 8		Canada Vigilance US FAERS
46	Altered state of consciousness	FAERS: 1		OFFSIDES US FAERS
47	Amnesia	FAERS: 1		US FAERS
48	Angle Closure Glaucoma	FAERS: 1		US FAERS
49	Antiphospholipid Antibodies	FAERS: 1		US FAERS
50	Aphagia	FAERS: 1		OFFSIDES US FAERS
51	Atrial Fibrillation	FAERS: 1	5633497	CTD US FAERS
52	Bipolar I disorder	FAERS: 1		OFFSIDES US FAERS
53	Blood creatine increased	FAERS: 1		OFFSIDES US FAERS
54	Blood creatine phosphokinase increased	FAERS: 1		OFFSIDES US FAERS
55	Blood prolactin increased	FAERS: 1		OFFSIDES US FAERS
56	Blood thyroid stimulating hormone decreased	FAERS: 1		US FAERS
57	Bradycardia	FAERS: 1 Canada Vigilance: 1	6030495 22744888	CTD Canada Vigilance US FAERS
58	Burning sensation	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
59	Cellulitis	FAERS: 1 Canada Vigilance: 2	9921085	CTD OFFSIDES Canada Vigilance US FAERS
60	Choking	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
61	Cholelithiasis	FAERS: 1		US FAERS
62	Chromaturia	FAERS: 1		US FAERS
63	Constipation	FAERS: 1 Canada Vigilance: 26	4942959	CTD SIDER Canada Vigilance US FAERS
64	Corneal Opacity	FAERS: 1		US FAERS
65	Deep Vein Thrombosis	FAERS: 1		US FAERS
66	Deposit eye	FAERS: 1		US FAERS
67	Depressed Level of Consciousness	FAERS: 1 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
68	Discomfort	FAERS: 1		US FAERS
69	Disease recurrence	FAERS: 1		OFFSIDES US FAERS
70	Drooling	FAERS: 1		SIDER US FAERS
71	Drug dispensing error	FAERS: 1		OFFSIDES US FAERS
72	Drug withdrawal syndrome	FAERS: 1		US FAERS
73	Dysuria	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
74	Eczema	FAERS: 1		US FAERS
75	Epilepsy	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
76	Erection increased	FAERS: 1		US FAERS
77	Erythema	FAERS: 1 Canada Vigilance: 13		Canada Vigilance OFFSIDES US FAERS
78	Eye pain	FAERS: 1		US FAERS
79	Fatigue	FAERS: 1		OFFSIDES US FAERS
80	Fibrosis	FAERS: 1		US FAERS
81	Frustration	FAERS: 1		US FAERS
82	Gamma-Glutamyltransferase Increased	FAERS: 1		OFFSIDES US FAERS
83	Gastrointestinal motility disorder	FAERS: 1		US FAERS
84	General physical health deterioration	FAERS: 1		OFFSIDES US FAERS
85	Hepatic necrosis	FAERS: 1		US FAERS
86	Heterophoria	FAERS: 1		US FAERS
87	Hyperacusis	FAERS: 1		US FAERS
88	Hypersensitivity	FAERS: 1 Canada Vigilance: 5		Canada Vigilance SIDER US FAERS
89	Hypersomnia	FAERS: 1		US FAERS
90	Hypoventilation	FAERS: 1		US FAERS
91	Impaired driving ability	FAERS: 1		US FAERS
92	Kaolin cephalin clotting time prolonged	FAERS: 1		US FAERS
93	Keratopathy	FAERS: 1		SIDER US FAERS
94	Lagophthalmos	FAERS: 1		US FAERS
95	Lipase increased	FAERS: 1		US FAERS
96	Malaise	FAERS: 1		US FAERS
97	Myocardial Infarction	FAERS: 1		US FAERS
98	Myoclonus	FAERS: 1	2860211	CTD US FAERS
99	Myoglobinuria	FAERS: 1		US FAERS
100	Neck Pain	FAERS: 1		US FAERS
101	Night sweats	FAERS: 1		US FAERS
102	Ocular Toxicity	FAERS: 1		US FAERS
103	Ocular icterus	FAERS: 1		US FAERS
104	Palpitations	FAERS: 1		US FAERS
105	Parophthalmia	FAERS: 1		US FAERS
106	Photodermatosis	FAERS: 1		US FAERS
107	Photophobia	FAERS: 1		US FAERS
108	Pneumonia	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
109	Posterior capsule rupture	FAERS: 1		US FAERS
110	Pruritus	FAERS: 1 Canada Vigilance: 18	4692711 11669021	CTD Canada Vigilance US FAERS
111	Rash erythematous	FAERS: 1 Canada Vigilance: 9		Canada Vigilance US FAERS
112	Russell's viper venom time abnormal	FAERS: 1		US FAERS
113	Schizophrenia	FAERS: 1	View details 284201 709472 1103205 1119614 1485575 2218093 3427786 3512622 4163280 4441459 4583571 4605009 4942959 6110346 6150030 6438683 6665117 6805002 7208775 8055610 9350955 15694263 17542047 25231249	CTD US FAERS
114	Sexual Dysfunction	FAERS: 1		US FAERS
115	Staring	FAERS: 1		US FAERS
116	Stevens-Johnson Syndrome	FAERS: 1		OFFSIDES US FAERS
117	Strabismus	FAERS: 1 Canada Vigilance: 2		Canada Vigilance US FAERS
118	Stress	FAERS: 1		OFFSIDES US FAERS
119	Syncope	FAERS: 1 Canada Vigilance: 16	3530167 4441459	CTD SIDER Canada Vigilance US FAERS
120	Tachyphrenia	FAERS: 1		US FAERS
121	Toxicity to various agents	FAERS: 1		US FAERS
122	Ulcer	FAERS: 1		US FAERS
123	Urticaria	FAERS: 1 Canada Vigilance: 17		Canada Vigilance US FAERS
124	Victim of sexual abuse	FAERS: 1		US FAERS
125	Visual disturbance	FAERS: 1		US FAERS
126	nervous system disorder	FAERS: 1		US FAERS
127	Abdominal Pain	Canada Vigilance: 2		Canada Vigilance
128	Abnormal palmar/plantar creases			OFFSIDES
129	Abscess	Canada Vigilance: 2	9921085	CTD Canada Vigilance
130	Acid reflux			OFFSIDES
131	Actinomycosis			OFFSIDES
132	Acute Coronary Syndrome			OFFSIDES
133	Acute kidney injury		1485575	CTD
134	Ageusia			OFFSIDES
135	Agranulocytosis	Canada Vigilance: 3	2749161	CTD SIDER Canada Vigilance
136	Akathisia, Drug-Induced		1147074 4566388	CTD
137	Akathisia	Canada Vigilance: 41		Canada Vigilance SIDER
138	Akinesia			OFFSIDES
139	Akinetic Mutism		4405372	CTD
140	Amenorrhea			OFFSIDES
141	Anaphylactic shock			SIDER
142	Anaphylactoid Reaction	Canada Vigilance: 1		Canada Vigilance SIDER
143	Anemia, Hemolytic		876939 3925683 7471027	CTD
144	Anger			OFFSIDES
145	Angioedema	Canada Vigilance: 2		Canada Vigilance SIDER
146	Angiogram abnormal			OFFSIDES
147	Anorexia			OFFSIDES
148	Anosmia			OFFSIDES
149	Antisocial Personality Disorder			OFFSIDES
150	Anuria			OFFSIDES
151	Anxiety Disorders		View details 237735 4247303 4816841 6662980	CTD
152	Apathy	Canada Vigilance: 4		Canada Vigilance OFFSIDES
153	Aphasia	Canada Vigilance: 2		Canada Vigilance
154	Apnea		2028629	CTD OFFSIDES
155	Arterial Occlusive Diseases		2228677	CTD
156	Arteriosclerosis			OFFSIDES
157	Arthritis			OFFSIDES
158	Ascites			OFFSIDES
159	Asphyxia			SIDER
160	Aspiration Pneumonia			OFFSIDES
161	Asthma			SIDER
162	Athetosis		20686158	CTD
163	Atrial tachycardia			OFFSIDES
164	Atrioventricular Block		1011369	CTD
165	Aura			OFFSIDES
166	Autoimmune Diseases		3128108	CTD
167	Back Pain	Canada Vigilance: 1		Canada Vigilance
168	Band neutrophil percentage increased			OFFSIDES
169	Basal Ganglia Diseases		View details 889418 1745440 2775969 2865637 3054982 3080413 3323261 4144552 4523436 4759422 5781950 6016862 6438683 7862923 9179395 9350955 11549212 16867246 17542047 17915974 18408624 20580759	CTD
170	Bile Duct Diseases		11669021	CTD
171	Bile duct necrosis			OFFSIDES
172	Biopsy liver abnormal			OFFSIDES
173	Bipolar Disorder		View details 961932 1111885 2616436 4402472 4605009 5077102 8608393 11394195 17414256	CTD OFFSIDES
174	Blepharoptosis			OFFSIDES
175	Blepharospasm			OFFSIDES
176	Blindness		2043180 7663839	CTD
177	Blood Coagulation Disorders		3142154	CTD
178	Blood Glucose			OFFSIDES
179	Blood albumin decreased			OFFSIDES
180	Blood bilirubin abnormal			OFFSIDES
181	Blood bilirubin unconjugated increased			OFFSIDES
182	Blood chloride increased			OFFSIDES
183	Blood cholesterol			OFFSIDES
184	Blood creatine decreased			OFFSIDES
185	Blood creatine phosphokinase MB increased			OFFSIDES
186	Blood creatinine decreased			OFFSIDES
187	Blood creatinine increased			OFFSIDES
188	Blood fibrinogen			OFFSIDES
189	Blood glucose decreased			OFFSIDES
190	Blood immunoglobulin G decreased			OFFSIDES
191	Blood immunoglobulin M decreased			OFFSIDES
192	Blood ketone body present			OFFSIDES
193	Blood lactate dehydrogenase increased			OFFSIDES
194	Blood magnesium decreased			OFFSIDES
195	Blood osmolarity decreased			OFFSIDES
196	Blood potassium decreased			OFFSIDES
197	Blood sodium increased			OFFSIDES
198	Blood sodium			OFFSIDES
199	Blood triglycerides increased			OFFSIDES
200	Blood urea increased			OFFSIDES
201	Blood uric acid decreased			OFFSIDES
202	Body temperature fluctuation			OFFSIDES
203	Bone lesion			OFFSIDES
204	Brain Edema		20324	CTD
205	Breast engorgement			SIDER
206	Bromosulphthalein test abnormal	Canada Vigilance: 1		Canada Vigilance
207	Bronchitis			OFFSIDES
208	Bronchoalveolar lavage abnormal			OFFSIDES
209	Budd-Chiari Syndrome			OFFSIDES
210	Bundle-Branch Block		4441459 5633497 5869867	CTD
211	Cardiac Arrest	Canada Vigilance: 1		Canada Vigilance SIDER
212	Cardiac Tamponade			OFFSIDES
213	Cardiomyopathies		3843588	CTD
214	Carotid Endarterectomy			OFFSIDES
215	Catalepsy		View details 119254 583013 1827527 4058245 5065892 6141998 6152791 7036117 9142555 9335068 15083255 19374163	CTD
216	Cataract operation			OFFSIDES
217	Catatonia		View details 1674666 4856722 5077102 18494081	CTD SIDER
218	Cerebellar Diseases		3054982	CTD
219	Cerebellar infarction			OFFSIDES
220	Cerebral Infarction	Canada Vigilance: 1		Canada Vigilance
221	Cerebral ventricle dilatation			OFFSIDES
222	Ceruloplasmin decreased			OFFSIDES
223	Chemical and Drug Induced Liver Injury		View details 3442185 5327471 8014443 9035996 11461765 15674093 17013467 17335721 19362101 22258563 22331495 23238562 23397584 24085192 25231249 25512232 26477383 26881866 27485346 27765674	CTD
224	Chemotherapeutic drug level increased			OFFSIDES
225	Chest Pain	Canada Vigilance: 1		Canada Vigilance
226	Child Behavior Disorders		10742070	CTD
227	Chills	Canada Vigilance: 2		Canada Vigilance
228	Cholangiolitis			OFFSIDES
229	Cholangitis		5327471	CTD
230	Cholecystitis			OFFSIDES
231	Chorea		20686158	CTD
232	Chronic Obstructive Airway Disease			OFFSIDES
233	Clostridium difficile colitis			OFFSIDES
234	Cogwheel Rigidity	Canada Vigilance: 1		Canada Vigilance SIDER
235	Colitis	Canada Vigilance: 1		Canada Vigilance
236	Completed Suicide	Canada Vigilance: 6		Canada Vigilance OFFSIDES
237	Compression fracture			OFFSIDES
238	Conduct Disorder		15266186	CTD
239	Confabulation			OFFSIDES
240	Confusion		3080413	CTD
241	Congenital Hypothyroidism			OFFSIDES
242	Congenital tricuspid valve incompetence			OFFSIDES
243	Conjunctival abrasion			OFFSIDES
244	Conjunctival deposit			OFFSIDES
245	Craniotabes			OFFSIDES
246	Creatinine renal clearance decreased			OFFSIDES
247	Crying			OFFSIDES
248	Cubital Tunnel Syndrome			OFFSIDES
249	Cyst			OFFSIDES
250	Cytolytic hepatitis			OFFSIDES
251	Deglutition Disorders		4247303	CTD
252	Dehydration			OFFSIDES
253	Delirium		6810714 8561204	CTD
254	Dementia	Canada Vigilance: 1		Canada Vigilance
255	Demyelination			OFFSIDES
256	Dental Fistula			OFFSIDES
257	Dental caries	Canada Vigilance: 1		Canada Vigilance
258	Dependence			OFFSIDES
259	Depressed mood			OFFSIDES
260	Depression suicidal			OFFSIDES
261	Depressive disorder		4610613 6438683 8608393	CTD
262	Dermatitis	Canada Vigilance: 6		Canada Vigilance
263	Diabetes			OFFSIDES
264	Diabetes Mellitus		5634402	CTD
265	Diabetes mellitus inadequate control			OFFSIDES
266	Diabetes with hyperosmolarity			OFFSIDES
267	Diabetic Nephropathy			OFFSIDES
268	Diabetic Retinopathy			OFFSIDES
269	Diarrhea		4247303	CTD
270	Disorders of Excessive Somnolence		View details 2043180 4562464 4851438 6117919 8839521 10742070	CTD
271	Disorientation	Canada Vigilance: 1		Canada Vigilance
272	Disseminated Intravascular Coagulation			OFFSIDES
273	Drowsiness			OFFSIDES SIDER
274	Drug addict			OFFSIDES
275	Drug withdrawal headache			OFFSIDES
276	Duodenitis			OFFSIDES
277	Dysgeusia			OFFSIDES
278	Dyskinesia, Drug-Induced		View details 1147074 1350058 3978350 4414178 4414187 4718286 4816841 4938245 5106314 5781950 6662980 6781005 18193111	CTD
279	Dysphonia	Canada Vigilance: 3		Canada Vigilance
280	Dysthymic Disorder			OFFSIDES
281	Edema		4610613	CTD
282	Ejection Fraction Decreased			OFFSIDES
283	Electrocardiogram abnormal	Canada Vigilance: 3		Canada Vigilance
284	Emotional disorder			OFFSIDES
285	Emotional distress	Canada Vigilance: 1		Canada Vigilance OFFSIDES
286	Enzyme Inhibition			OFFSIDES
287	Enzyme abnormality	Canada Vigilance: 1		Canada Vigilance
288	Eosinophilia	Canada Vigilance: 2		Canada Vigilance SIDER
289	Eosinophilic myocarditis			OFFSIDES
290	Epistaxis			OFFSIDES
291	Erectile dysfunction	Canada Vigilance: 2	5557274 14999218	CTD OFFSIDES SIDER Canada Vigilance
292	Erosive gastritis			OFFSIDES
293	Euphoric mood			OFFSIDES
294	Exanthema		4247303 4610613 7196160	CTD
295	Eye irritation	Canada Vigilance: 3		Canada Vigilance
296	Facial Neuralgia			OFFSIDES
297	Facial paralysis	Canada Vigilance: 1		Canada Vigilance
298	Fatty Liver		2986319	CTD
299	Fecal Incontinence		4247303	CTD
300	Feeding and Eating Disorders		4562464	CTD
301	Feeling abnormal			OFFSIDES
302	Feeling jittery			SIDER
303	Fever		View details 469518 4247303 7387498 9035996 9498910 11669021 18494081	CTD
304	Flatulence			OFFSIDES
305	Flight of ideas			OFFSIDES
306	Flushing	Canada Vigilance: 2		Canada Vigilance
307	Galactorrhea		7196160	CTD OFFSIDES
308	Gastric ulcer			OFFSIDES
309	Gastrointestinal hypomotility			OFFSIDES
310	Gastrointestinal mucosal disorder			OFFSIDES
311	Gaze palsy			OFFSIDES
312	Glioma		20368687	CTD
313	Glycosuria			SIDER
314	Granulocyte count decreased			OFFSIDES
315	Granulocytosis			OFFSIDES
316	Grip strength			OFFSIDES
317	Hallucinations		237735	CTD
318	Haptoglobin Decreased			OFFSIDES
319	Head Banging			OFFSIDES
320	Hepatic vein occlusion			OFFSIDES
321	Hepatitis A			SIDER
322	Hepatitis, Chronic		4692711	CTD
323	Hepatomegaly	Canada Vigilance: 1		Canada Vigilance
324	Hepatosplenomegaly	Canada Vigilance: 1		Canada Vigilance
325	Hepatotoxicity	Canada Vigilance: 1		Canada Vigilance OFFSIDES
326	Hiccough			OFFSIDES
327	Human herpes virus 6 serology positive			OFFSIDES
328	Hypercholesterolemia		11669021	CTD
329	Hyperkeratosis			OFFSIDES
330	Hyperprolactinemia		564936 718334	CTD
331	Hyperpyrexia	Canada Vigilance: 1		Canada Vigilance SIDER
332	Hypokinesia		237735 2880435 12933958	CTD
333	Hypotension, Orthostatic		View details 3530167 3559152 4556089 5042830 10742070 11145175 17700005	CTD
334	Hypotensive			SIDER
335	Incontinence			OFFSIDES
336	Infection			OFFSIDES SIDER
337	Infertility		31369748	CTD
338	Inflammation	Canada Vigilance: 1		Canada Vigilance
339	Influenza			SIDER
340	Injection Site Reaction	Canada Vigilance: 3		Canada Vigilance
341	Injection site abscess	Canada Vigilance: 3		Canada Vigilance
342	Injection site dermatitis			OFFSIDES
343	Injection site inflammation	Canada Vigilance: 1		Canada Vigilance
344	Insulin Resistance		17512020	CTD OFFSIDES
345	Insulin-requiring type 2 diabetes mellitus			OFFSIDES
346	Intention tremor			OFFSIDES
347	Intentional self-injury			OFFSIDES
348	Intermittent Explosive Disorder			OFFSIDES
349	Intestinal Obstruction			OFFSIDES
350	Iritis			OFFSIDES
351	Jaundice, Obstructive		2749161 6057380 14961937	CTD
352	Joint prosthesis user			OFFSIDES
353	Joint stiffness	Canada Vigilance: 1		Canada Vigilance OFFSIDES
354	Kidney Failure			OFFSIDES
355	Laryngospasm	Canada Vigilance: 2		Canada Vigilance
356	Leukocytosis	Canada Vigilance: 1		Canada Vigilance
357	Leukoencephalopathy			OFFSIDES
358	Leukopenia neonatal			OFFSIDES
359	Leukopenia	Canada Vigilance: 7		Canada Vigilance SIDER
360	Lichen Planus			OFFSIDES
361	Liver diseases		1175890 14986274	CTD
362	Liver transplant rejection			OFFSIDES
363	Long QT Syndrome		View details 2218093 7134999 12788816 12866343 15071359 16178046 24052561	CTD
364	Loose tooth			OFFSIDES
365	Lung Injury			OFFSIDES
366	Lupus Erythematosus, Systemic		68769 2245719	CTD
367	Lymphocyte count decreased			OFFSIDES
368	Lymphocyte percentage decreased			OFFSIDES
369	Lymphocyte stimulation test positive			OFFSIDES
370	Lymphocytic infiltration			OFFSIDES
371	Lymphoma			OFFSIDES
372	Lymphopenia	Canada Vigilance: 1		Canada Vigilance
373	Malaria		23129054	CTD
374	Male sexual dysfunction			OFFSIDES
375	Megacolon			SIDER
376	Meige Syndrome		2887231	CTD
377	Menorrhagia			SIDER
378	Mental disorders		View details 1509179 5647155 16856516 17896459	CTD
379	Metabolic acidosis			OFFSIDES
380	Migraine Disorders		20530076	CTD
381	Migraine with Aura			OFFSIDES
382	Morbid thoughts			OFFSIDES
383	Motor restlessness			SIDER
384	Movement Disorders		View details 851793 1971459 4058245 4247303 12010767 17513028	CTD
385	Multiple drug overdose			OFFSIDES
386	Muscle Fatigue			OFFSIDES
387	Muscle Rigidity	Canada Vigilance: 9	View details 4247303 4759422 6577485 7387498 12933958 14172950	CTD Canada Vigilance
388	Muscle Spasticity	Canada Vigilance: 2		Canada Vigilance
389	Musculoskeletal Pain			OFFSIDES
390	Musculoskeletal stiffness	Canada Vigilance: 3		Canada Vigilance OFFSIDES
391	Mutism		4405372	CTD OFFSIDES
392	Mycoplasma Infections		10773494	CTD
393	Mydriasis			SIDER
394	Myoglobin blood increased			OFFSIDES
395	Nausea	Canada Vigilance: 7	25231249	CTD Canada Vigilance
396	Necrosis		3947399	CTD
397	Neonatal Abstinence Syndrome		4275009 7873960	CTD
398	Neoplasms		20368687	CTD
399	Nephritic syndrome			OFFSIDES
400	Nephrolithiasis			OFFSIDES
401	Nervous tension			OFFSIDES
402	Nervousness			SIDER
403	Neurobehavioral Manifestations		469518	CTD
404	Neutropenia	Canada Vigilance: 2		Canada Vigilance
405	Obesity	Canada Vigilance: 2		Canada Vigilance
406	Obsessive-Compulsive Disorder		8890690	CTD
407	Obstipation			SIDER
408	Ocular Hypertension			OFFSIDES
409	Ocular Motility Disorders		4144147 4247303	CTD
410	Oculogyric crisis	Canada Vigilance: 10		Canada Vigilance OFFSIDES
411	Opisthotonus	Canada Vigilance: 1		Canada Vigilance
412	Optic Atrophy		5777357	CTD
413	Optic Disc Edema			OFFSIDES
414	Optic Neuropathy			OFFSIDES
415	Oropharyngeal blistering			OFFSIDES
416	Oropharyngeal discomfort			SIDER
417	Oropharyngeal pain			SIDER
418	Orthopnea			OFFSIDES
419	Osteomyelitis			OFFSIDES
420	Ovarian Diseases		12512871	CTD
421	Overdose	Canada Vigilance: 1		Canada Vigilance
422	Overweight			OFFSIDES
423	PCO2 decreased			OFFSIDES
424	Pain		1566986	CTD OFFSIDES
425	Pallor	Canada Vigilance: 9		Canada Vigilance
426	Pancreatitis			OFFSIDES
427	Pancytopenia	Canada Vigilance: 1	6016859	CTD SIDER Canada Vigilance
428	Paranoia			OFFSIDES
429	Paraplegia			OFFSIDES
430	Paresis		9921085	CTD
431	Parkinsonian Disorders		View details 996201 1631189 4734007 5077102 10389620	CTD
432	Parkinsonian rest tremor			SIDER
433	Paroxysmal perceptual alteration			OFFSIDES
434	Pericardial effusion			OFFSIDES
435	Peripheral Nervous System Diseases		223082	CTD
436	Personality Disorders		6781005 7800667	CTD
437	Pharyngeal swelling	Canada Vigilance: 1		Canada Vigilance
438	Phonophobia			OFFSIDES
439	Photosensitivity Disorders		709472 6810714	CTD
440	Pituitary Apoplexy		718334	CTD
441	Pneumothorax			OFFSIDES
442	Polymyositis			OFFSIDES
443	Polyuria	Canada Vigilance: 1		Canada Vigilance
444	Portal Vein Thrombosis			OFFSIDES
445	Post procedural complication			OFFSIDES
446	Postural Orthostatic Tachycardia Syndrome			OFFSIDES
447	Pregnancy Complications		11669021	CTD
448	Pregnancy test false positive			SIDER
449	Prenatal Exposure Delayed Effects		3988167 7254089	CTD
450	Presbyopia			OFFSIDES
451	Primary sequestrum			OFFSIDES
452	Productive Cough			OFFSIDES
453	Prolonged menses			SIDER
454	Protein total decreased			OFFSIDES
455	Prothrombin level decreased			OFFSIDES
456	Pseudoparkinsonism			SIDER
457	Psoriasis			OFFSIDES
458	Psychiatric symptom			OFFSIDES
459	Psychomotor Agitation		View details 2279216 4942959 7387498 8890690 18494081	CTD
460	Psychomotor Disorders		7914050	CTD
461	Psychomotor skills impaired	Canada Vigilance: 1		Canada Vigilance
462	Psychoses, Substance-Induced		View details 316351 4163280 4834427 5574054 17414256 18794663	CTD
463	Psychotic Disorders		View details 996201 3559152 4556089 4566388 5042825 7663839 9179395 14961937 15071359 20368687	CTD
464	Puerperal Disorders		3559152	CTD
465	Pulmonary Embolism		12520151	CTD
466	Pulmonary Valve Stenosis			OFFSIDES
467	Pulmonary arterial pressure increased			OFFSIDES
468	Pulmonary artery stenosis			OFFSIDES
469	Purpura	Canada Vigilance: 1		Canada Vigilance
470	Reduced facial expression	Canada Vigilance: 1		Canada Vigilance
471	Reflex, Abnormal		7471027	CTD
472	Renal tubular necrosis			OFFSIDES
473	Respiratory Depression	Canada Vigilance: 1		Canada Vigilance
474	Respiratory Failure			OFFSIDES
475	Respiratory Insufficiency		283080	CTD
476	Respiratory Therapy			OFFSIDES
477	Restlessness	Canada Vigilance: 1		Canada Vigilance
478	Retinal Diseases		7663839 16117689	CTD
479	Rhabdomyolysis			OFFSIDES
480	Rhabdomyosarcoma			OFFSIDES
481	Rhinitis	Canada Vigilance: 2		Canada Vigilance OFFSIDES
482	Right Ventricular Dysfunction			OFFSIDES
483	Right Ventricular Hypertrophy			OFFSIDES
484	Scab			OFFSIDES
485	Schizoaffective Disorder			OFFSIDES
486	Schizophrenia, Catatonic		5777357	CTD
487	Scleritis	Canada Vigilance: 1		Canada Vigilance
488	Scotoma			OFFSIDES
489	Seizures		View details 1803 65671 810000 1660160 4115818 5020345 6175290 8055610 8645877 12623218 16962289	CTD
490	Senile dementia			OFFSIDES
491	Septic Shock			OFFSIDES
492	Sequestrectomy			OFFSIDES
493	Serotonin Syndrome		8862337	CTD
494	Shock	Canada Vigilance: 3		Canada Vigilance SIDER
495	Sialorrhea		3978350 7387498	CTD
496	Sinus Tachycardia	Canada Vigilance: 2		Canada Vigilance
497	Sinusitis			OFFSIDES
498	Skin lesion			OFFSIDES
499	Skin necrosis			OFFSIDES
500	Skin reaction	Canada Vigilance: 1		Canada Vigilance
501	Skin test positive			OFFSIDES
502	Sleep Initiation and Maintenance Disorders		8555725 18494081	CTD
503	Smoker			OFFSIDES
504	Sneezing	Canada Vigilance: 1		Canada Vigilance
505	Somnambulism		453369 3093469	CTD
506	Spasm		4144147 5430219	CTD
507	Sputum culture positive			OFFSIDES
508	Stem cell transplant			OFFSIDES
509	Stomatitis	Canada Vigilance: 1		Canada Vigilance
510	Stress ulcer			OFFSIDES
511	Stupor	Canada Vigilance: 2	1674666 2860211 4247303	CTD Canada Vigilance
512	Stuttering		6110346	CTD
513	Substance Withdrawal Syndrome		View details 284201 961932 1147074 1473547 5781950 6150030	CTD
514	Substance-Related Disorders		8083816	CTD
515	Sudden death			SIDER
516	Supraventricular tachycardia			OFFSIDES
517	Tachycardia, Paroxysmal		5633497	CTD
518	Tachycardia, Ventricular		2218093 4441459 7134999	CTD
519	Tendinitis			OFFSIDES
520	Testicular Diseases		8207755	CTD
521	Thrombocytopenic purpura			SIDER
522	Thromboembolism		12520151	CTD
523	Tobacco user			OFFSIDES
524	Tobacco withdrawal symptoms			OFFSIDES
525	Tongue spasm	Canada Vigilance: 1		Canada Vigilance
526	Tooth Extraction			OFFSIDES
527	Tooth Loss			OFFSIDES
528	Torsades de Pointes		View details 2218093 7134999 11444585 12788816 15071359 16178046	CTD
529	Torticollis	Canada Vigilance: 5	1677550	CTD Canada Vigilance
530	Trismus	Canada Vigilance: 2		Canada Vigilance
531	Troponin I increased			OFFSIDES
532	Urethral Stenosis			OFFSIDES
533	Urinary Incontinence		4247303	CTD
534	Urinary Retention	Canada Vigilance: 1		Canada Vigilance SIDER
535	Urine ketone body present			OFFSIDES
536	Uterine Diseases		12512871	CTD
537	Vascular resistance systemic increased			OFFSIDES
538	Venous Thrombosis		6665117 15298663	CTD
539	Ventricular Dysfunction		6167651	CTD
540	Ventricular Fibrillation		501931 2616436	CTD
541	Vertigo	Canada Vigilance: 6		Canada Vigilance
542	Violence-related symptom			OFFSIDES
543	Visual Impairment	Canada Vigilance: 1		Canada Vigilance SIDER
544	Weight Gain		17512020	CTD OFFSIDES
545	Weight decreased	Canada Vigilance: 1		Canada Vigilance
546	Wheelchair user			OFFSIDES
547	Xerostomia		3512622 4942959	CTD
548	furuncle			OFFSIDES

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