MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Ifosfamide

(HOMGKSMUEGBAAB-UHFFFAOYSA-N)

Structure

SMILES: ClCCNP1(=O)OCCCN1CCCl
Type(s): Approved
ATC code(s): L01AA06
Molecular Formula:: C7H15Cl2N2O2P
Molecular Weight:: 261.086
Log P:: 2.2128
Hydrogen Bond Acceptor:: 4
Hydrogen Bond Donor:: 1
TPSA:: 51.38
CAS Number(s):: 3778-73-2

Synonym(s)

Ifosfamide

Isofosfamide

Isophosphamide

Asta Z 4942

Holoxan

Iphosphamide

Iso-Endoxan

NSC-109,724

NSC-109724

10.

Iso Endoxan

11.

NSC 109,724

12.

NSC 109724

13.

NSC109,724

14.

NSC109724

External Link(s)

MeSH	D007069
PubChem Compound	3690
BindingDB	189358
ChEBI	5864
CHEMBL	CHEMBL1024
DrugBank	DB01181
DrugCentral	1421
IUPHAR/BPS Guide to PHARMACOLOGY	7201
KEGG	cpd:C07047 dr:D00343
Therapeutic Target Database	D02TLO

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Myoclonus	FAERS: 15	12084448	CTD US FAERS
2	Somnolence	FAERS: 14		SIDER US FAERS
3	Disorientation	FAERS: 13		SIDER US FAERS
4	Tremor	FAERS: 13		US FAERS
5	Urinary Incontinence	FAERS: 10	16174228	CTD SIDER US FAERS
6	Mental status changes	FAERS: 9		OFFSIDES US FAERS
7	Agitation	FAERS: 8 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
8	Osteomalacia	FAERS: 8	7663031 11219485 15975640	CTD SIDER US FAERS
9	Lethargy	FAERS: 7	3098318	CTD OFFSIDES US FAERS
10	Renal tubular disorder	FAERS: 7		OFFSIDES SIDER US FAERS
11	Unresponsive to stimuli	FAERS: 7		US FAERS
12	Metabolic acidosis	FAERS: 5		OFFSIDES SIDER US FAERS
13	Nausea	FAERS: 5 Canada Vigilance: 1	View details 206339 1100226 1899352 3114435 3132591 3815719 3924401 8453695 8526193	CTD SIDER Canada Vigilance US FAERS
14	Aphasia	FAERS: 4	16174228	CTD US FAERS
15	Asterixis	FAERS: 4		OFFSIDES SIDER US FAERS
16	Electroencephalogram abnormal	FAERS: 4		US FAERS
17	Mental impairment	FAERS: 4		OFFSIDES US FAERS
18	Renal tubular acidosis	FAERS: 4		SIDER US FAERS
19	Sopor	FAERS: 4		US FAERS
20	Status Epilepticus	FAERS: 4	View details 8215972 8672829 12035842 14727169 16449538 24209900	CTD OFFSIDES SIDER US FAERS
21	Toxicity to various agents	FAERS: 4		US FAERS
22	Delirium	FAERS: 3 Canada Vigilance: 1	1743553	CTD SIDER Canada Vigilance US FAERS
23	Depressed Level of Consciousness	FAERS: 3		SIDER US FAERS
24	Drug toxicity	FAERS: 3		US FAERS
25	Fanconi Syndrome	FAERS: 3	View details 1396897 1574040 1649270 1720453 1993970 2029077 2166154 2566853 2567921 2910509 3234441 7663031 7761316 7990759 8018491 8183542 8232077 8270973 8431714 8486147 8570867 8648909 8666724 8774570 8950339 9641191 9851889 10063969 10064184 10401022 10450020 10619376 15738605 15975640 17265418 17481685 23213347	CTD OFFSIDES SIDER US FAERS
26	Febrile Neutropenia	FAERS: 3		OFFSIDES SIDER US FAERS
27	Hydronephrosis	FAERS: 3		US FAERS
28	Malignant neoplasm progression	FAERS: 3		US FAERS
29	Nephrogenic Diabetes Insipidus	FAERS: 3		SIDER US FAERS
30	Vomiting	FAERS: 3	View details 206339 1100226 1659980 3114435 3132591 3815719 3924401 6086264 7865862 8453695 8526193	CTD SIDER US FAERS
31	nervous system disorder	FAERS: 3		SIDER US FAERS
32	Accidental exposure	FAERS: 2		OFFSIDES US FAERS
33	Altered state of consciousness	FAERS: 2		OFFSIDES US FAERS
34	Amnesia	FAERS: 2		SIDER US FAERS
35	Anxiety	FAERS: 2		US FAERS
36	Asthenia	FAERS: 2		SIDER US FAERS
37	Electrolyte imbalance	FAERS: 2		US FAERS
38	Failure to Thrive	FAERS: 2		US FAERS
39	Flat affect	FAERS: 2		US FAERS
40	Growth retardation	FAERS: 2		SIDER US FAERS
41	Incoherent	FAERS: 2		US FAERS
42	Incontinence	FAERS: 2		OFFSIDES SIDER US FAERS
43	Incorrect product storage	FAERS: 2		US FAERS
44	Mantle cell lymphoma	FAERS: 2		OFFSIDES US FAERS
45	Medication Error	FAERS: 2		US FAERS
46	Pancytopenia	FAERS: 2		SIDER US FAERS
47	Restlessness	FAERS: 2		US FAERS
48	Screaming	FAERS: 2		OFFSIDES US FAERS
49	Thrombocytopenia	FAERS: 2	View details 3114435 7541449 15150579 16246977 16273254 20087171	CTD SIDER US FAERS
50	Abdominal Pain	FAERS: 1		SIDER US FAERS
51	Acidosis	FAERS: 1	3924401	CTD OFFSIDES SIDER US FAERS
52	Acute Coronary Syndrome	FAERS: 1		SIDER US FAERS
53	Acute myocardial infarction	FAERS: 1		US FAERS
54	Alopecia	FAERS: 1	View details 3089596 3924401 6176753 8453695 11290867	CTD SIDER US FAERS
55	Amnestic Disorder	FAERS: 1		US FAERS
56	Blood creatinine increased	FAERS: 1		OFFSIDES SIDER US FAERS
57	Blood magnesium decreased	FAERS: 1		US FAERS
58	Blood phosphorus decreased	FAERS: 1		US FAERS
59	Bone Sarcoma	FAERS: 1		OFFSIDES US FAERS
60	Bradyphrenia	FAERS: 1		SIDER US FAERS
61	Catatonia	FAERS: 1		SIDER US FAERS
62	Cerebellar Ataxia	FAERS: 1		US FAERS
63	Chills	FAERS: 1		SIDER US FAERS
64	Circumstance or information capable of leading to medication error	FAERS: 1		US FAERS
65	Conversion disorder	FAERS: 1		OFFSIDES US FAERS
66	Discomfort	FAERS: 1		SIDER US FAERS
67	Disease Progression	FAERS: 1		US FAERS
68	Dizziness	FAERS: 1		SIDER US FAERS
69	Dysarthria	FAERS: 1		SIDER US FAERS
70	Dysgeusia	FAERS: 1		US FAERS
71	Dysuria	FAERS: 1		OFFSIDES SIDER US FAERS
72	Echolalia	FAERS: 1		SIDER US FAERS
73	Encephalitis	FAERS: 1		SIDER US FAERS
74	Fatigue	FAERS: 1		SIDER US FAERS
75	Febrile bone marrow aplasia	FAERS: 1		OFFSIDES SIDER US FAERS
76	Feeling abnormal	FAERS: 1		SIDER US FAERS
77	Flight of ideas	FAERS: 1		US FAERS
78	Gaze palsy	FAERS: 1		US FAERS
79	General physical condition abnormal	FAERS: 1		US FAERS
80	Glycosuria	FAERS: 1	View details 2567921 8666724 10194544 16958212 19826134	CTD US FAERS
81	Headache	FAERS: 1		US FAERS
82	Hydrocephalus	FAERS: 1		US FAERS
83	Hypertensive Encephalopathy	FAERS: 1		US FAERS
84	Hypertensive crisis	FAERS: 1		US FAERS
85	Hypomania	FAERS: 1		US FAERS
86	Hypophagia	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
87	Memory impairment	FAERS: 1		US FAERS
88	Moaning	FAERS: 1		US FAERS
89	Mutism	FAERS: 1	3098318 12035842	CTD SIDER US FAERS
90	Neutropenia	FAERS: 1	View details 206339 3114435 7541449 8453695 9007130 11290867 11855871 15150579 15503294 16246977 16273254 20087171	CTD US FAERS
91	No reaction on previous exposure to drug	FAERS: 1		US FAERS
92	Pancreatitis	FAERS: 1		SIDER US FAERS
93	Pericarditis	FAERS: 1		SIDER US FAERS
94	Perseveration	FAERS: 1		SIDER US FAERS
95	Pneumonitis	FAERS: 1		US FAERS
96	Posterior reversible encephalopathy syndrome	FAERS: 1		SIDER US FAERS
97	Product measured potency issue	FAERS: 1		US FAERS
98	Product substitution issue	FAERS: 1		US FAERS
99	Psychomotor skills impaired	FAERS: 1		US FAERS
100	Pulmonary Embolism	FAERS: 1		SIDER US FAERS
101	Recall phenomenon	FAERS: 1		OFFSIDES SIDER US FAERS
102	Renal tubular necrosis	FAERS: 1		OFFSIDES SIDER US FAERS
103	Respiratory Failure	FAERS: 1		SIDER US FAERS
104	Retching	FAERS: 1		US FAERS
105	Rhabdomyolysis	FAERS: 1		SIDER US FAERS
106	Rhabdomyosarcoma	FAERS: 1	View details 1574040 3114437 7978043 8950339 9374361 9569955 11846301 15354722 19826134	CTD US FAERS
107	Sarcoma	FAERS: 1	View details 1846407 2106162 2858016 3102088 3114435 3924401 7541449 7978043 8453693 8453695 8453697 8625085 9180836 10473106 11254426 11568902 15049014 15625365 17710206 18313854 18840018 19588140 19826134	CTD SIDER US FAERS
108	Septic Shock	FAERS: 1		SIDER US FAERS
109	Sinus Tachycardia	FAERS: 1		US FAERS
110	Soliloquy	FAERS: 1		US FAERS
111	Staring	FAERS: 1		US FAERS
112	Stupor	FAERS: 1		SIDER US FAERS
113	Supraventricular tachycardia	FAERS: 1		US FAERS
114	T-Cell Lymphoma	FAERS: 1		US FAERS
115	Tachycardia	FAERS: 1	8416155	CTD US FAERS
116	Tinnitus	FAERS: 1		SIDER US FAERS
117	Tonic clonic movements	FAERS: 1		US FAERS
118	Treatment related secondary malignancy	FAERS: 1		OFFSIDES US FAERS
119	Unresponsive to verbal stimuli	FAERS: 1		OFFSIDES US FAERS
120	Urinary tract infection	FAERS: 1		US FAERS
121	Weight decreased	FAERS: 1		US FAERS
122	Wrong drug administered	FAERS: 1		US FAERS
123	liposarcoma	FAERS: 1		OFFSIDES US FAERS
124	Abdominal mass			OFFSIDES
125	Accidental overdose			OFFSIDES
126	Acute graft versus host disease in liver			OFFSIDES
127	Acute kidney injury		View details 2170045 2495864 8486146 8874474 12180108 15738605 18037123	CTD
128	Adenocarcinoma		3133435	CTD
129	Agnosia		16174228	CTD
130	Agranulocytosis		2156418	CTD SIDER
131	Agraphia			OFFSIDES
132	Albuminuria		1718222	CTD
133	Alcoholic Intoxication			OFFSIDES
134	Aminoaciduria			SIDER
135	Amphetamines			OFFSIDES
136	Anal Fissure			OFFSIDES
137	Anaphylactic shock			SIDER
138	Anemia		15150579 16273254	CTD
139	Angina Pectoris			SIDER
140	Angioedema			SIDER
141	Anorexia		6176753	CTD SIDER
142	Anticholinergic Syndrome			OFFSIDES
143	Anuria		2320800	CTD OFFSIDES
144	Anxiety Disorders		2156418	CTD
145	Apnea			OFFSIDES
146	Appendicitis			OFFSIDES
147	Arthralgia			SIDER
148	Ataxia		16174228	CTD OFFSIDES
149	Atrial Fibrillation			SIDER
150	Atrial Flutter			SIDER
151	Atrial tachycardia			OFFSIDES
152	Aura			OFFSIDES
153	Automatism			OFFSIDES
154	Azoospermia			OFFSIDES SIDER
155	BK virus infection			OFFSIDES
156	Back Pain	Canada Vigilance: 1		Canada Vigilance
157	Bacteria blood identified			OFFSIDES
158	Bacterial Infections		12180108	CTD
159	Ballismus			OFFSIDES
160	Band neutrophil percentage decreased			OFFSIDES
161	Basal Ganglia Diseases		2049756	CTD
162	Basophil percentage increased			OFFSIDES
163	Beta 2 microglobulin increased			OFFSIDES
164	Bipolar Disorder		10766557	CTD
165	Blood and lymphatic system disorders			SIDER
166	Blood follicle stimulating hormone increased			OFFSIDES
167	Blood gonadotrophin increased			SIDER
168	Blood immunoglobulin M decreased			OFFSIDES
169	Blood pH decreased			OFFSIDES
170	Blood parathyroid hormone increased			OFFSIDES
171	Blood potassium decreased			OFFSIDES
172	Blood sodium increased			OFFSIDES
173	Blood sodium			OFFSIDES
174	Blood testosterone decreased			OFFSIDES
175	Blood uric acid			OFFSIDES
176	Blood urine present			OFFSIDES
177	Bone Marrow Diseases		1732425	CTD
178	Bone erosion			OFFSIDES
179	Bone marrow depression			OFFSIDES
180	Bone marrow toxicity			OFFSIDES
181	Bone neoplasms		8452388 8453693 15503294	CTD
182	Bone trimming			OFFSIDES
183	Bradycardia			SIDER
184	Brain Diseases		View details 1481635 2261371 2460709 2600992 2806353 2840485 2857462 2858016 2874408 2880199 2967486 3095121 3114437 3132998 7549123 7700329 8255482 8384523 8803513 8879383 8925751 9815837 10216884 10921521 11799423 12084448 12425514 14555540 15923801 15948552 16364615 17389531 17953463 18840018 19953647	CTD
185	Brain Ischemia		16174228	CTD
186	Brain Neoplasms		9760072	CTD
187	Bronchospasm			SIDER
188	Budd-Chiari Syndrome			OFFSIDES
189	Burkitt Lymphoma		9186541 18782177	CTD
190	CNS toxicity			SIDER
191	Candida sepsis			OFFSIDES
192	Candida serology positive			OFFSIDES
193	Candiduria			OFFSIDES
194	Capillary Leak Syndrome			SIDER
195	Carcinoma, Ehrlich Tumor		10619376	CTD
196	Carcinoma, Large Cell		206339	CTD
197	Carcinoma, Small Cell		206339 2156418 6307164	CTD
198	Carcinoma, Transitional Cell		12425514	CTD
199	Carcinoma		1846407 8416155	CTD
200	Cardiac Arrest			SIDER
201	Cardiac Flutter			OFFSIDES
202	Cardiotoxicity			OFFSIDES SIDER
203	Catheter related infection			OFFSIDES
204	Catheter site infection			OFFSIDES
205	Catheter site inflammation			OFFSIDES
206	Cauda Equina Syndrome			OFFSIDES
207	Cellulitis			OFFSIDES
208	Cerebellar Diseases		3090210	CTD
209	Cerebral Arteriosclerosis			SIDER
210	Cerebral Infarction		20087171	CTD
211	Cheilitis			OFFSIDES
212	Chest Pain			SIDER
213	Cholestasis			SIDER
214	Chondrosarcoma			OFFSIDES
215	Clostridium difficile colitis			OFFSIDES
216	Colitis			SIDER
217	Colonic Neoplasms		16096652	CTD
218	Confabulation			OFFSIDES
219	Confusion		View details 1899352 2156418 2806353 2882385 3132591 3815719 7240342 9007130 11218192 15923801	CTD
220	Congenital osteodystrophy			OFFSIDES
221	Conjunctivitis			SIDER
222	Constipation			SIDER
223	Contracture			OFFSIDES
224	Cystitis		View details 119317 206339 475846 1100226 1743553 3089596 3090314 3132591 3688893 3924401 4833912 6495457 6792207 6792599 7281389 7668875 7794006 8158849 8452388 8677458 14586140 14633084 15022166 16174228 16708234 16947012 17133240 17638016 17980069 19738981 23949582 24550594	CTD
225	Cyst			SIDER
226	Cytolytic hepatitis			OFFSIDES SIDER
227	Cytomegalovirus enterocolitis			OFFSIDES
228	Deafness			SIDER
229	Deep Vein Thrombosis			SIDER
230	Demyelination			OFFSIDES
231	Dental abscess			OFFSIDES
232	Dental prosthesis placement			OFFSIDES
233	Dermatitis			SIDER
234	Desmoplastic Small Round Cell Tumor		10555010	CTD
235	Diffuse large B-cell lymphoma recurrent			OFFSIDES
236	Disorders of Excessive Somnolence		9571977	CTD
237	Disseminated Intravascular Coagulation			SIDER
238	Drowsiness			OFFSIDES
239	Drug administration error			OFFSIDES
240	Drug exposure during pregnancy			OFFSIDES
241	Drug ineffective			OFFSIDES
242	Dyspnea		8416155	CTD
243	Dystrophic calcification			OFFSIDES
244	Ear and labyrinth disorders			SIDER
245	Edema		View details 6792207 7308258 9090445 17980069 24550594	CTD
246	Ejection Fraction Decreased			SIDER
247	Electrocardiogram ST segment abnormal			SIDER
248	Endometrial Neoplasms		2857462	CTD
249	Enteral Nutrition			OFFSIDES
250	Enterocolitis			SIDER
251	Enuresis			SIDER
252	Eosinophil percentage increased			OFFSIDES
253	Epilepsy		15354722	CTD OFFSIDES
254	Epistaxis			OFFSIDES
255	Erectile dysfunction			OFFSIDES
256	Erythema Multiforme			SIDER
257	Erythema			SIDER
258	Escherichia sepsis			OFFSIDES
259	Ethmoid sinus surgery			OFFSIDES
260	Exophthalmos			OFFSIDES
261	Extravasation of Diagnostic and Therapeutic Materials		7308258	CTD
262	Extravasation			SIDER
263	Eye irritation			SIDER
264	Feeling of residual urine			SIDER
265	Fever of Unknown Origin			SIDER
266	Fever		3114435 15503294	CTD
267	Flank Pain	Canada Vigilance: 1		Canada Vigilance OFFSIDES
268	Flatulence			OFFSIDES
269	Flushing			SIDER
270	Folliculitis			OFFSIDES
271	Frank hematuria			SIDER
272	Ganglioneuroma			OFFSIDES
273	Gastric mucosal lesion			OFFSIDES
274	Gastrointestinal Diseases		11161394	CTD
275	Gastrointestinal Pain			SIDER
276	Gastrointestinal mucosal disorder			OFFSIDES
277	General physical condition			OFFSIDES
278	Genital Neoplasms, Female		3133435	CTD
279	Glasgow coma scale			OFFSIDES
280	Glioma			OFFSIDES
281	Globulinuria			OFFSIDES
282	Growth Disorders		2029077 16755549	CTD
283	Haematotoxicity			SIDER
284	Hallucinations		View details 2156418 7240342 8111719 9180836 11218192	CTD
285	Hearing Loss		8095647	CTD
286	Heart failure		8416155 14586140	CTD
287	Hematologic Neoplasms		24550594	CTD
288	Hematuria		View details 1277203 1428725 1899352 2509063 2914270 3090314 3106585 3815719 6106781 6307164 6836328 7163814 8158849 9007130 17133240	CTD
289	Hemorrhage		View details 119317 206339 475846 3090314 3132591 3688893 3924401 6495457 7281389 7308258 7668875 7794006 8158849 8452388 8677458 14586140 14633084 15022166 16708234 16947012 17638016 17980069 19738981 23949582 24550594	CTD
290	Hepatic Vein Thrombosis			OFFSIDES
291	Hepatic congestion			OFFSIDES
292	Hepatic necrosis			OFFSIDES
293	Hepatitis			SIDER
294	Hepatosplenomegaly			OFFSIDES
295	Hepatotoxicity			SIDER
296	Hiccough			OFFSIDES
297	Hodgkin Disease		6816479 16135485	CTD
298	Hungry bone syndrome			OFFSIDES
299	Hyperphosphaturia			OFFSIDES
300	Hyperpigmentation		6176753	CTD
301	Hyperreflexia			OFFSIDES
302	Hypersensitivity			SIDER
303	Hypokalemia		View details 2567921 2806353 2896952 16174228	CTD
304	Hyponatremia		2261371 16174228 19542534	CTD
305	Hypophosphatemia		View details 2386379 2504390 2567921 8508598 8774570 8950339 9261752 11605785 16628552	CTD
306	Hyporeflexia			OFFSIDES
307	Hypotension		9829858	CTD SIDER
308	Hypoxia			SIDER
309	Idiopathic pneumonia syndrome			OFFSIDES
310	Ileus			SIDER
311	Infection			OFFSIDES SIDER
312	Infertility			SIDER
313	Infestation			SIDER
314	Inflammation		7849337	CTD SIDER
315	Inguinal mass			OFFSIDES
316	Injection site phlebitis			OFFSIDES
317	Intention tremor			OFFSIDES
318	Intertrigo			OFFSIDES
319	JC virus infection			OFFSIDES
320	Kidney Diseases		View details 1419294 1428725 1487409 1571213 1718222 1720453 1732425 2320800 2386379 2510931 2567844 2567921 2879626 2914270 3089596 6423391 6437825 6816479 7505048 7532742 7540421 7957353 7978043 7990759 8259103 8270973 8318805 8413339 8614393 8625085 8699991 8774570 9261752 9374361 9381703 9523738 9815837 9829858 10064184 10194544 10234592 11523744 11605785 12868187 14966836 15049014 15503294 15614250 16221203 16246977 16628552 16755549 16885387 17035713 17922055 18278066 19017849 19826134 20405516	CTD
321	Kidney Failure, Chronic		View details 7983965 8625132 8874474 8950339 9569955 15503294	CTD
322	Leukoencephalopathy			OFFSIDES SIDER
323	Leukopenia neonatal			OFFSIDES
324	Leukopenia		View details 1100226 1899352 2507474 3089596 3133435 6307164 8453695 8931677 11290867 17593098	CTD SIDER
325	Life expectancy shortened			OFFSIDES
326	Lung Neoplasms		View details 206339 1846407 2156418 2170045 2880199 3090314 6307164 7163814 7863185 15214333 16453328	CTD
327	Lymph node abscess			OFFSIDES
328	Lymphohistiocytosis			OFFSIDES
329	Lymphoma transformation			OFFSIDES
330	Lymphoma, Follicular		11571709	CTD
331	Lymphoma, Non-Hodgkin		3132591 6816479 7849337	CTD
332	Lymphoma		2914270 8416155 12180108	CTD SIDER
333	MYELODYSPLASTIC SYNDROME			SIDER
334	Malaise			SIDER
335	Malignant mesenchymal tumor		7505048	CTD
336	Malnutrition			SIDER
337	Mechanical ventilation			OFFSIDES
338	Megakaryocytes decreased			OFFSIDES
339	Meningioma			OFFSIDES
340	Metaplasia			OFFSIDES
341	Metastases to muscle			OFFSIDES
342	Microscopic hematuria			SIDER
343	Microsporum infection			OFFSIDES
344	Mitochondrial Diseases		10401022	CTD
345	Mononeuritis			OFFSIDES
346	Mood Disorders		16261598	CTD
347	Motor retardation			OFFSIDES
348	Musculoskeletal discomfort			SIDER
349	Myalgia			SIDER
350	Myelodysplasia			OFFSIDES
351	Myelosuppression			SIDER
352	Myocardial Infarction			SIDER
353	Myocardial fibrosis			OFFSIDES
354	Myocarditis		4833912	CTD SIDER
355	Myoclonic Epilepsy			OFFSIDES
356	Myoglobin blood increased			OFFSIDES
357	Necrosis		11332993	CTD SIDER
358	Neoplasm Metastasis		15214333 16453328	CTD
359	Neoplasms, Experimental		10619376 17878523	CTD
360	Neoplasms, Germ Cell and Embryonal		1846407 17593098 18643784	CTD
361	Neoplasms, Second Primary		7596151	CTD
362	Neoplasms		View details 1277203 1525342 1659980 2386379 2879626 3090210 3095121 6816479 7540421 7957353 8270973 8318805 8774570 9090445 9261752 9381703 9523738 9815837 10234592 10646879 15150579 16282887 16755549 20087171 24209900	CTD
363	Nephritis, Interstitial		9569955 10968388	CTD
364	Nephrogenic Fibrosing Dermopathy			OFFSIDES
365	Nerve Degeneration		10921521	CTD
366	Neuralgia			OFFSIDES SIDER
367	Neurilemmoma		2567921	CTD
368	Neuroblastoma		2910509 3688893 3819813	CTD OFFSIDES
369	Neurocognitive Disorders		7240342	CTD
370	Neurological decompensation	Canada Vigilance: 1		Canada Vigilance
371	Neurotoxicity Syndromes		11855871	CTD
372	Neutropenic infection			OFFSIDES
373	Neutropenic sepsis			OFFSIDES
374	Obstruction			SIDER
375	Oligospermia			SIDER
376	Oliguria			OFFSIDES
377	Optic Disc Edema			OFFSIDES
378	Oral Cavity Fistula			OFFSIDES
379	Oral infection			OFFSIDES
380	Osteodystrophy			OFFSIDES
381	Osteolysis			OFFSIDES
382	Osteosarcoma		View details 7660382 7663031 9761357 9851889 10194544 10766557 10774566 14760101 14767549 15043115 15503294 16246977 16453328 16912244 17389531 19826134 20347613	CTD
383	Ototoxicity			OFFSIDES
384	Ovarian failure			SIDER
385	Ovulation disorder			SIDER
386	Pain			SIDER
387	Palpitations			SIDER
388	Panniculitis			OFFSIDES
389	Paranoia			OFFSIDES SIDER
390	Paraplegia			OFFSIDES
391	Paresthesia		11568902	CTD
392	Parophthalmia			OFFSIDES
393	Perianal abscess			OFFSIDES
394	Pericardial effusion			SIDER
395	Peripheral Nervous System Diseases		8158686 11568902	CTD
396	Perirectal abscess			OFFSIDES
397	Petechiae			SIDER
398	Phlebitis		8931677	CTD SIDER
399	Pneumonia			SIDER
400	Pneumothorax			OFFSIDES
401	Polydipsia			SIDER
402	Polyneuropathy			SIDER
403	Polyomavirus-associated nephropathy			OFFSIDES
404	Polyuria			SIDER
405	Poor sucking reflex			OFFSIDES
406	Portal Vein Thrombosis			OFFSIDES SIDER
407	Post procedural nausea			OFFSIDES
408	Premature Menopause			SIDER
409	Prostatic Neoplasms		8950339	CTD
410	Protein urine present			SIDER
411	Proteinuria		View details 2510931 8666724 9261752 9523738 11605785 16628552 16958212 19826134	CTD SIDER
412	Pruritus			SIDER
413	Psychoses, Substance-Induced		2882385 17166068	CTD
414	Pulmonary Edema		1487409 8416155	CTD
415	Pulmonary Fibrosis			SIDER
416	Pulmonary Hypertension			SIDER
417	Pulmonary congestion			OFFSIDES
418	Pulmonary toxicity			SIDER
419	Puncture site infection			OFFSIDES
420	QRS axis abnormal			OFFSIDES
421	Radiation Pneumonitis			OFFSIDES
422	Renal Cell Carcinoma			SIDER
423	Renal Insufficiency		1846407 7540421 11161394	CTD
424	Renal lipomatosis			OFFSIDES
425	Renal mass			OFFSIDES
426	Renal rickets			SIDER
427	Retinal pigmentation			OFFSIDES
428	Rickets		View details 1574040 2029077 2166154 2386379 2504390 2567921 7761316 8183542 8508598 8774570 8950339 11219485 12806945	CTD OFFSIDES SIDER
429	Risus sardonicus			OFFSIDES
430	Sarcoma of skin			OFFSIDES
431	Seizures		View details 2882385 3090210 11218192 16174228 24209900	CTD
432	Sepsis		3114435	CTD SIDER
433	Septic embolus			OFFSIDES
434	Serum amyloid A protein increased			OFFSIDES
435	Sinus antrostomy			OFFSIDES
436	Sinus operation			OFFSIDES
437	Sinusitis			OFFSIDES
438	Skin Erosion			OFFSIDES
439	Skin Induration			OFFSIDES
440	Skin necrosis			SIDER
441	Skin toxicity			OFFSIDES
442	Soft Tissue Neoplasms		View details 3102088 3924401 8452388 8453693 8453695 8453697 9180836 15625365 19826134	CTD
443	Sputum culture positive			OFFSIDES
444	Stem cell transplant			OFFSIDES
445	Stevens-Johnson Syndrome		25811541	CTD SIDER
446	Stomatitis			SIDER
447	Subcutaneous nodule			OFFSIDES
448	Subdural Effusion			OFFSIDES
449	Sudden Cardiac Death			OFFSIDES
450	Sudden death			OFFSIDES
451	Swelling			SIDER
452	Tachycardia, Ectopic Atrial		15205092	CTD
453	Testicular Neoplasms		6176753 6495457 17593098	CTD
454	Tetany			OFFSIDES
455	Therapy non-responder			OFFSIDES
456	Thrombophlebitis			SIDER
457	Tooth Extraction			OFFSIDES
458	Tooth Infection			OFFSIDES
459	Toxic Epidermal Necrolysis			SIDER
460	Ultrasound scan abnormal			OFFSIDES
461	Urinary Bladder Diseases		View details 2121633 2724678 6402369 6816479 16947012	CTD
462	Urinary Retention			SIDER
463	Urination Disorders		1909700	CTD
464	Urine leukocyte esterase			OFFSIDES
465	Urine output increased			SIDER
466	Urine phosphorus increased			SIDER
467	Urologic Diseases		View details 2156418 2507474 2727395 9090445	CTD
468	Urticaria			SIDER
469	Uterine Cancer			OFFSIDES
470	Vaginal obstruction			OFFSIDES
471	Vasculitis			SIDER
472	Ventricular Fibrillation			SIDER
473	Ventricular arrhythmia			SIDER
474	Vertigo			SIDER
475	Viral upper respiratory tract infection			OFFSIDES
476	Vision Disorders		3690810	CTD
477	Visual Impairment			SIDER
478	Vulvovaginal adhesion			OFFSIDES
479	Weaning failure			OFFSIDES
480	Xerosis			OFFSIDES
481	anaphylaxis		3132591	CTD
482	leiomyosarcoma		15878560	CTD
483	leukemia		7596151	CTD
484	synovial sarcoma			OFFSIDES

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