MetaADEDB 2.0 @ LMMD
Medroxyprogesterone
(FRQMUZJSZHZSGN-HBNHAYAOSA-N)
Structure
SMILES
O=C1CC[C@]2(C(=C1)[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@]2(O)C(=O)C)C)C
Molecular Formula:
C22H32O3
Molecular Weight:
344.488
Log P:
4.0844
Hydrogen Bond Acceptor:
3
Hydrogen Bond Donor:
1
TPSA:
54.37
CAS Number(s):
520-85-4
Synonym(s)
1.
Medroxyprogesterone
2.
Methylhydroxyprogesterone
3.
17 alpha-Hydroxy-6 alpha-Methylprogesterone
4.
Adgyn Medro
5.
17 alpha Hydroxy 6 alpha Methylprogesterone
External Link(s)
MeSHD008525
PubChem Compound10631
ChEBI6715
CHEMBLCHEMBL1390
IUPHAR/BPS Guide to PHARMACOLOGY2879
KEGGcpd:C07119
dr:D08166
Therapeutic Target DatabaseD0I2SD
ZINC5763835
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Pregnancy with injectable contraceptiveFAERS: 12OFFSIDES
US FAERS
2Drug exposure during pregnancyFAERS: 10OFFSIDES
US FAERS
3Drug ineffectiveFAERS: 9US FAERS
4DizzinessFAERS: 7
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
5AlopeciaFAERS: 6SIDER
US FAERS
6HeadacheFAERS: 6
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
7PainFAERS: 6US FAERS
8Pharmaceutical product complaintFAERS: 6US FAERS
9ArthralgiaFAERS: 5SIDER
US FAERS
10Maternal exposure during pregnancyFAERS: 5US FAERS
11MetrorrhagiaFAERS: 5SIDER
US FAERS
12PruritusFAERS: 5
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
13Abdominal PainFAERS: 4SIDER
US FAERS
14FatigueFAERS: 4SIDER
US FAERS
15Injection site painFAERS: 4
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
16MenorrhagiaFAERS: 4SIDER
US FAERS
17NauseaFAERS: 4SIDER
US FAERS
18Pulmonary EmbolismFAERS: 4SIDER
US FAERS
19UrticariaFAERS: 4SIDER
US FAERS
20AngerFAERS: 3US FAERS
21Back PainFAERS: 3SIDER
US FAERS
22Chest PainFAERS: 3SIDER
US FAERS
23Device FailureFAERS: 3US FAERS
24Mood swingsFAERS: 3
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
25MyalgiaFAERS: 3SIDER
US FAERS
26Pregnancy test positiveFAERS: 3US FAERS
27PregnancyFAERS: 3SIDER
US FAERS
28VomitingFAERS: 3SIDER
US FAERS
29Weight decreasedFAERS: 3SIDER
US FAERS
30AcneFAERS: 2SIDER
US FAERS
31Adverse eventFAERS: 2US FAERS
32AnxietyFAERS: 2SIDER
US FAERS
33Breast tendernessFAERS: 2SIDER
US FAERS
34Burning sensationFAERS: 2US FAERS
35CholelithiasisFAERS: 2SIDER
US FAERS
36CryingFAERS: 2US FAERS
37Cytolytic hepatitisFAERS: 2US FAERS
38Deep Vein ThrombosisFAERS: 2SIDER
US FAERS
39Device malfunctionFAERS: 2US FAERS
40EndometritisFAERS: 2US FAERS
41Feeling abnormalFAERS: 2SIDER
US FAERS
42HypersensitivityFAERS: 2SIDER
US FAERS
43Incorrect dose administeredFAERS: 2US FAERS
44MalaiseFAERS: 2SIDER
US FAERS
45Neck PainFAERS: 2US FAERS
46Pregnancy on contraceptiveFAERS: 2US FAERS
47Product use in unapproved indicationFAERS: 2
Canada Vigilance: 2
Canada Vigilance
US FAERS
48ScreamingFAERS: 2US FAERS
49SwellingFAERS: 2SIDER
US FAERS
50TachycardiaFAERS: 2SIDER
US FAERS
51Therapeutic response unexpected with drug substitutionFAERS: 2US FAERS
52ThrombosisFAERS: 2SIDER
US FAERS
53TremorFAERS: 2SIDER
US FAERS
54Abdominal discomfortFAERS: 1SIDER
US FAERS
55AgitationFAERS: 1SIDER
US FAERS
56Alanine Aminotransferase IncreasedFAERS: 1SIDER
US FAERS
57AmnesiaFAERS: 1SIDER
US FAERS
58AnorexiaFAERS: 1SIDER
US FAERS
59AphoniaFAERS: 1US FAERS
60Aspartate Aminotransferase IncreasedFAERS: 1US FAERS
61AstheniaFAERS: 1SIDER
US FAERS
62BlindnessFAERS: 1SIDER
US FAERS
63Blood glucose increasedFAERS: 1US FAERS
64Bone painFAERS: 1US FAERS
65BruxismFAERS: 1US FAERS
66Concomitant disease aggravatedFAERS: 1US FAERS
67ConstipationFAERS: 1SIDER
US FAERS
68Diabetes MellitusFAERS: 1SIDER
US FAERS
69Drug administration errorFAERS: 1US FAERS
70Drug prescribing errorFAERS: 1US FAERS
71Drug withdrawal syndromeFAERS: 1US FAERS
72DysarthriaFAERS: 1SIDER
US FAERS
73DyspepsiaFAERS: 1SIDER
US FAERS
74Educational problemFAERS: 1OFFSIDES
US FAERS
75Emotional disorderFAERS: 1US FAERS
76ErythemaFAERS: 1SIDER
US FAERS
77FlatulenceFAERS: 1SIDER
US FAERS
78Gamma-glutamyltransferase abnormalFAERS: 1US FAERS
79GlaucomaFAERS: 1US FAERS
80HirsutismFAERS: 1SIDER
US FAERS
81HyperandrogenismFAERS: 1US FAERS
82Impaired work abilityFAERS: 1US FAERS
83Inadequate analgesiaFAERS: 1US FAERS
84Inappropriate schedule of drug administrationFAERS: 1US FAERS
85Incorrect product storageFAERS: 1US FAERS
86Incorrect storage of drugFAERS: 1US FAERS
87Initial insomniaFAERS: 1US FAERS
88Injection Site ReactionFAERS: 1SIDER
US FAERS
89Injection site bruisingFAERS: 1US FAERS
90Injection site necrosisFAERS: 1US FAERS
91Joint Range of Motion DecreasedFAERS: 1US FAERS
92Joint swellingFAERS: 1SIDER
US FAERS
93LethargyFAERS: 1US FAERS
94Malignant neoplasm progressionFAERS: 1US FAERS
95Memory impairmentFAERS: 1US FAERS
96MeningiomaFAERS: 1SIDER
US FAERS
97Mental impairmentFAERS: 1US FAERS
98Middle insomniaFAERS: 1US FAERS
99NervousnessFAERS: 1SIDER
US FAERS
100NeuralgiaFAERS: 1US FAERS
101No reaction on previous exposure to drugFAERS: 1US FAERS
102Nonspecific reactionFAERS: 1US FAERS
103Occupational exposure to productFAERS: 1US FAERS
104OsteomalaciaFAERS: 1US FAERS
105OsteoporosisFAERS: 1OFFSIDES
SIDER
US FAERS
106PalpitationsFAERS: 1SIDER
US FAERS
107Placenta AccretaFAERS: 1US FAERS
108Poor quality sleepFAERS: 1US FAERS
109Post procedural complicationFAERS: 1US FAERS
110Product depositFAERS: 1US FAERS
111Product packaging issueFAERS: 1US FAERS
112Product physical issueFAERS: 1US FAERS
113Product preparation issueFAERS: 1US FAERS
114Product storage errorFAERS: 1US FAERS
115Product substitution issueFAERS: 1US FAERS
116Product use complaintFAERS: 1US FAERS
117Product use issueFAERS: 1US FAERS
118PsoriasisFAERS: 1US FAERS
119Purulent dischargeFAERS: 1US FAERS
120Retinal DetachmentFAERS: 1US FAERS
121Retinal Vein OcclusionFAERS: 1SIDER
US FAERS
122Rheumatoid ArthritisFAERS: 1US FAERS
123Skin irritationFAERS: 1US FAERS
124SomnolenceFAERS: 1SIDER
US FAERS
125SunburnFAERS: 1US FAERS
126Suppressed lactationFAERS: 1US FAERS
127SyncopeFAERS: 1SIDER
US FAERS
128Syringe issueFAERS: 1US FAERS
129Thermal burnFAERS: 1US FAERS
130Tumour haemorrhageFAERS: 1US FAERS
131Visual ImpairmentFAERS: 1SIDER
US FAERS
132Visual disturbanceFAERS: 1SIDER
US FAERS
133Abdominal CrampsSIDER
134Abdominal bloatingSIDER
135Abdominal distressSIDER
136Abnormal cervical smearOFFSIDES
137AbscessSIDER
138Acquired diaphragmatic eventrationOFFSIDES
139Acute Coronary SyndromeSIDER
140Acute psychosisOFFSIDES
SIDER
141Adenocarcinoma12549624CTD
OFFSIDES
142AgoraphobiaOFFSIDES
143Alopecia effluviumOFFSIDES
144AmenorrheaOFFSIDES
145Anaphylactic shockSIDER
146Anaphylactoid ReactionSIDER
147AnencephalySIDER
148AngioedemaSIDER
149AngiomyolipomaOFFSIDES
150Angle Closure GlaucomaOFFSIDES
151Ankle brachial index decreasedOFFSIDES
152AnorgasmiaSIDER
153AnosmiaSIDER
154AnovulationSIDER
155Anoxic EncephalopathyOFFSIDES
156Antepartum hemorrhageSIDER
157Anticoagulation drug level above therapeuticOFFSIDES
158Aortic aneurysm repairOFFSIDES
159AppendectomyOFFSIDES
160Application site abscessOFFSIDES
161Arterial thrombosisSIDER
162AsterixisOFFSIDES
163AsthmaSIDER
164AtaxiaSIDER
165Attention Deficit DisorderSIDER
166B-cell lymphoma recurrentOFFSIDES
167Bacteria stool identifiedOFFSIDES
168Basal cell carcinomaOFFSIDES
169BicytopeniaOFFSIDES
170Biopsy bone abnormalOFFSIDES
171Biopsy breast abnormalOFFSIDES
172Biopsy endometrium abnormalOFFSIDES
173Biopsy site unspecified abnormalOFFSIDES
174BiopsyOFFSIDES
175Bipolar DisorderOFFSIDES
176Bladder Exstrophy1873679CTD
177Bladder painSIDER
178BlepharoptosisOFFSIDES
179Blighted ovumSIDER
180Blood alkaline phosphatase increasedSIDER
181Blood and lymphatic system disordersSIDER
182Blood bilirubin unconjugated increasedOFFSIDES
183Blood creatine increasedOFFSIDES
184Blood creatinine increasedSIDER
185Blood follicle stimulating hormone decreasedOFFSIDES
186Blood immunoglobulin MOFFSIDES
187Blood pressure immeasurableOFFSIDES
188Blood testosterone decreasedSIDER
189Body odorSIDER
190Bone density decreasedOFFSIDES
191Bone marrow depressionOFFSIDES
192Bone swellingOFFSIDES
193BradycardiaSIDER
194Breast CystOFFSIDES
195Breast FeedingSIDER
196Breast MicrocalcificationOFFSIDES
197Breast cancer recurrentOFFSIDES
198Breast cancer stage IIIOFFSIDES
199Breast cancer stage IIOFFSIDES
200Breast hyperplasiaOFFSIDES
201Breast necrosisOFFSIDES
202BronchitisSIDER
203Bronchoalveolar lavage abnormalOFFSIDES
204BronchospasmSIDER
205CachexiaSIDER
206Cancer gene carrierOFFSIDES
207Carbohydrate antigen 27.29 increasedOFFSIDES
208Carcinoembryonic antigen increasedOFFSIDES
209Cardiac DeathOFFSIDES
210Cardioactive drug level increasedOFFSIDES
211Cartilage injuryOFFSIDES
212Catheter placementOFFSIDES
213Cerebral ThrombosisSIDER
214Cerebrovascular accidentSIDER
215Cervical dysplasiaOFFSIDES
SIDER
216Cervix carcinomaSIDER
217ChillsSIDER
218ChloasmaSIDER
219CholangitisSIDER
220ChoreaSIDER
221Chronic ulcerative colitisOFFSIDES
222Cleft PalateSIDER
223Cognitive deteriorationOFFSIDES
224Colonic fistulaOFFSIDES
225Complications of maternal exposure to therapeutic drugsOFFSIDES
226Congenital cystic kidney diseaseOFFSIDES
227Congenital diaphragmatic herniaSIDER
228Congenital hypertrichosisOFFSIDES
229Congenital pyelocaliectasisOFFSIDES
230Contralateral breast cancerOFFSIDES
231Corneal degenerationOFFSIDES
232Coronary Thrombosis8172379CTD
233Cramps of lower extremitiesSIDER
234Creatinine renal clearance decreasedOFFSIDES
235Cyst aspirationOFFSIDES
236CystitisSIDER
237CystSIDER
238Cytomegalovirus antibody positiveOFFSIDES
239Decreased LibidoOFFSIDES
240DementiaSIDER
241Dermatitis hemorrhagicSIDER
242DermatitisSIDER
243Dermatologic examination abnormalOFFSIDES
244Diaphragmatic HerniaOFFSIDES
245DiplopiaSIDER
246DiscomfortSIDER
247Disturbance in sexual arousalSIDER
248DrowsinessSIDER
249Drug exposure before pregnancyOFFSIDES
250Drug exposure via breast milkOFFSIDES
251Dry skinSIDER
252Duodenogastric RefluxOFFSIDES
253Dysfunction adrenalSIDER
254DysgeusiaSIDER
255DyspareuniaSIDER
256DysphemiaSIDER
257DysphoniaSIDER
258DystoniaOFFSIDES
259DysuriaSIDER
260Ear and labyrinth disordersSIDER
261Early satietyOFFSIDES
262Ectopic PregnancySIDER
263Ectropion of cervixSIDER
264Electrocardiogram T wave peakedOFFSIDES
265Electrocardiogram changeOFFSIDES
266EmbolismSIDER
267Endocervical curettageOFFSIDES
268Endometrial disorderOFFSIDES
269Endometrial hypertrophyOFFSIDES
270Endoscopy abnormalOFFSIDES
271Eosinophil percentage increasedOFFSIDES
272EpiglottitisOFFSIDES
273EpilepsySIDER
274Epispadias1873679CTD
275EpistaxisSIDER
276Erythema MultiformeSIDER
277Erythema NodosumSIDER
278Ethmoid sinus surgeryOFFSIDES
279Euphoric moodOFFSIDES
SIDER
280Exacerbation of asthmaSIDER
281ExtravasationSIDER
282Eyelid infectionOFFSIDES
283Face LiftOFFSIDES
284Facial paralysisSIDER
285False negative pregnancy testOFFSIDES
286Febrile NeutropeniaOFFSIDES
287Feeling jitteryCanada Vigilance: 1Canada Vigilance
288Fibroadenoma of breastOFFSIDES
SIDER
289FibroadenomaOFFSIDES
290Fibromuscular DysplasiaOFFSIDES
291Fungal peritonitisOFFSIDES
292Fungus culture positiveOFFSIDES
293GalactorrheaOFFSIDES
294Gastrointestinal PainSIDER
295General physical health deteriorationOFFSIDES
296Germ Cell CancerOFFSIDES
297Gestational DiabetesOFFSIDES
298GlycosuriaSIDER
299Grip strengthOFFSIDES
300HaematotoxicityOFFSIDES
301HeartburnSIDER
302Hepatitis COFFSIDES
303HepatitisSIDER
304HepatomegalySIDER
305Hip surgeryOFFSIDES
306HoarsenessSIDER
307Hormone TherapyOFFSIDES
308HydrocephalusSIDER
309Hyperdynamic left ventricleOFFSIDES
310HypermetabolismOFFSIDES
311HyperplasiaSIDER
312HyperpyrexiaSIDER
313HyperthyroidismSIDER
314HypogeusiaOFFSIDES
315HypopituitarismSIDER
316HypotensionSIDER
317HypothyroidismSIDER
318HysteroscopyOFFSIDES
319ImmobileSIDER
320Implant site effusionOFFSIDES
321Inadequate lubricationOFFSIDES
322IncoherentOFFSIDES
323IndurationOFFSIDES
324InfarctionSIDER
325InfectionSIDER
326InfertilityOFFSIDES
327InfestationSIDER
328InfluenzaSIDER
329Injection site atrophyOFFSIDES
SIDER
330Injection site discomfortOFFSIDES
331Injection site inflammationOFFSIDES
332Injection site massOFFSIDES
333Injection site scarOFFSIDES
334Intestinal infarctionSIDER
335IridectomyOFFSIDES
336Lactose IntoleranceOFFSIDES
337LaryngospasmSIDER
338LeukocytosisSIDER
339LeukoencephalopathyOFFSIDES
340LeukorrheaSIDER
341Liver carcinoma rupturedOFFSIDES
342Lumbar puncture abnormalOFFSIDES
343Lung Neoplasms2940397CTD
344Lymph node cancer metastaticOFFSIDES
345LymphedemaOFFSIDES
346Lymphoplasmacytoid lymphoma/immunocytomaOFFSIDES
347MacrognathiaOFFSIDES
348MalariaOFFSIDES
349Malignant ascitesOFFSIDES
350Malignant tumour excisionOFFSIDES
351MalnutritionSIDER
352Mammary Neoplasms, Experimental8389152
12549624
CTD
353MassageOFFSIDES
354MastectomyOFFSIDES
355MediastinitisOFFSIDES
356MediastinoscopyOFFSIDES
357Medical device implantationOFFSIDES
358Medical device removalOFFSIDES
359Memory LossSIDER
360MeningoceleOFFSIDES
361Metabolic acidosisOFFSIDES
362Metastases to abdominal wallOFFSIDES
363Metastases to nasal sinusesOFFSIDES
364Metastases to stomachOFFSIDES
365Metastases to thoraxOFFSIDES
366MicrocephalyOFFSIDES
SIDER
367Mitral valve sclerosisOFFSIDES
368Mononucleosis syndromeOFFSIDES
369Multi-organ disorderOFFSIDES
370Musculoskeletal PainSIDER
371Musculoskeletal discomfortSIDER
372MyelitisOFFSIDES
373Myocardial Infarction8172379
15501350
CTD
SIDER
374MyoclonusSIDER
375MyomectomyOFFSIDES
376NasopharyngitisSIDER
377NecrosisSIDER
378Neoplasm Metastasis2940397CTD
379Neoplasm prophylaxisOFFSIDES
380NephrolithiasisSIDER
381Nephrotic SyndromeSIDER
382NeuritisSIDER
383Neuromyelitis OpticaOFFSIDES
384Neutropenic infectionOFFSIDES
385NoduleOFFSIDES
386Obesity surgeryOFFSIDES
387ObstructionOFFSIDES
388Ocular discomfortSIDER
389Oestrogen lowSIDER
390Open reduction of fractureOFFSIDES
391Optic NeuritisSIDER
392Oral polypectomyOFFSIDES
393Oropharyngeal swellingSIDER
394OsteopeniaOFFSIDES
395Pacemaker complicationOFFSIDES
396PancreatitisSIDER
397ParanoiaSIDER
398ParathyroidectomyOFFSIDES
399Parovarian CystOFFSIDES
400Pelvic PainCanada Vigilance: 7Canada Vigilance
SIDER
401PericarditisSIDER
402Perivascular dermatitisOFFSIDES
403PharyngitisSIDER
404Physical breast examination abnormalOFFSIDES
405Physical disabilityOFFSIDES
406PneumoperitoneumOFFSIDES
407PolydactylySIDER
408PolyhydramniosSIDER
409Porphyria aggravatedSIDER
410Portal HypertensionOFFSIDES
411Post procedural cellulitisOFFSIDES
412Posterior capsule opacificationOFFSIDES
413Postmenopausal bleedingOFFSIDES
414Postoperative wound complicationOFFSIDES
415Premature MenopauseSIDER
416Premenstrual syndromeSIDER
417ProctitisOFFSIDES
418ProctocolitisOFFSIDES
419Progesterone receptor assay negativeOFFSIDES
420Progesterone receptor assayOFFSIDES
421ProgesteroneSIDER
422Protein urine presentSIDER
423ProteinuriaSIDER
424Pruritus VulvaeSIDER
425Pruritus allergicOFFSIDES
426Psychiatric symptomOFFSIDES
427Pulmonary Valve StenosisOFFSIDES
428Pulmonary function test decreasedOFFSIDES
429Pulmonary radiation injuryOFFSIDES
430PurpuraSIDER
431PyeloplastyOFFSIDES
432Radiation PneumonitisOFFSIDES
433Rectal polypectomyOFFSIDES
434Rectal polypOFFSIDES
435Red man syndromeOFFSIDES
436Renal massOFFSIDES
437Renal tubular acidosisOFFSIDES
438Renal tubular disorderOFFSIDES
439Retinal VasculitisOFFSIDES
440Retinal vascular thrombosisSIDER
441Retrograde amnesiaCanada Vigilance: 1Canada Vigilance
OFFSIDES
442Retroperitoneal lymphadenopathyOFFSIDES
443Rift Valley FeverOFFSIDES
444SalpingitisSIDER
445SchizophreniaOFFSIDES
446SclerodermaSIDER
447Secondary sequestrumOFFSIDES
448Seizures18760902CTD
449SepsisSIDER
450Sexually activeSIDER
451ShockSIDER
452Single umbilical arterySIDER
453Sinus antrostomyOFFSIDES
454SinusitisSIDER
455Sjogren's SyndromeOFFSIDES
456Skin IndurationOFFSIDES
457Skin neoplasm excisionOFFSIDES
458Skin tightnessOFFSIDES
459Spina BifidaSIDER
460Splenic InfarctionSIDER
461Squamous cell carcinomaSIDER
462StillbirthSIDER
463StomatitisSIDER
464Subcutaneous noduleOFFSIDES
465Sudden infant death syndromeSIDER
466Supraventricular tachycardiaSIDER
467SweatingSIDER
468SyphilisOFFSIDES
469TalipesSIDER
470TensionSIDER
471Therapeutic procedureOFFSIDES
472Therapeutic product ineffective for unapproved indicationOFFSIDES
473ThirstCanada Vigilance: 1Canada Vigilance
SIDER
474Thoracic vertebral fractureOFFSIDES
475ThoracotomyOFFSIDES
476ThrombocytopeniaSIDER
477ThromboembolismSIDER
478ThrombophlebitisSIDER
479ThyroiditisSIDER
480TinnitusSIDER
481Toe operationOFFSIDES
482Tooth ExtractionOFFSIDES
483Transfusion ReactionOFFSIDES
484Tremor of handsSIDER
485Tricuspid Atresia830309CTD
486Trisomy 21SIDER
487UlcerSIDER
488Ultrasound abdomen abnormalOFFSIDES
489Ultrasound biliary tractOFFSIDES
490Ultrasound breast abnormalOFFSIDES
491Ultrasound scan abnormalOFFSIDES
492Ultrasound thyroid abnormalOFFSIDES
493Unspecified visual lossSIDER
494Upper airway obstructionOFFSIDES
495UreteritisOFFSIDES
496Urinary RetentionSIDER
497Urinary tract infectionSIDER
498Uterine PolypOFFSIDES
499VIIth nerve paralysisSIDER
500Vaginal DischargeSIDER
501Vaginal mucosal blisteringSIDER
502VaginoplastyOFFSIDES
503VasectomyOFFSIDES
504Venous Thrombosis8793518CTD
SIDER
505Ventricular FibrillationOFFSIDES
506Vertebrobasilar InsufficiencyOFFSIDES
507VertigoSIDER
508Victim of homicideOFFSIDES
509Vitamin K DeficiencyOFFSIDES
510Vulvovaginal mycotic infectionSIDER
511Vulvovaginal pruritusSIDER
512Weight Gain4332067CTD
513Wound closureOFFSIDES
514jaundiceSIDER
515nervous system disorderSIDER
516neurofibromaSIDER
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