MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Nicardipine

(ZBBHBTPTTSWHBA-UHFFFAOYSA-N)

Structure

SMILES: COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C
Type(s): Approved; Investigational
ATC code(s): C08CA04
Molecular Formula:: C26H29N3O6
Molecular Weight:: 479.525
Log P:: 4.5298
Hydrogen Bond Acceptor:: 6
Hydrogen Bond Donor:: 1
TPSA:: 113.69
CAS Number(s):: 55985-32-5

Synonym(s)

Nicardipine

Antagonil

Cardene

Cardene I.V.

Cardene SR

Dagan

Flusemide

Lecibral

Lincil

10.

Loxen

11.

Lucenfal

12.

Nicardipine Hydrochloride

13.

Nicardipine LA

14.

Nicardipino Ratiopharm

15.

Nicardipino Seid

16.

Perdipine

17.

Ridene

18.

Vasonase

19.

Y-93

20.

Hydrochloride, Nicardipine

21.

LA, Nicardipine

22.

Y 93

23.

Y93

External Link(s)

MeSH	D009529
PubChem Compound	4474
BindingDB	50101815 50291816
ChEBI	7550
CHEMBL	CHEMBL1484 CHEMBL3302409
DrugBank	DB00622
DrugCentral	1909
IUPHAR/BPS Guide to PHARMACOLOGY	2559
KEGG	cpd:C07264 dr:D08270
Therapeutic Target Database	D0T0KA

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Cerebral vasoconstriction	FAERS: 9		US FAERS
2	Cerebral Infarction	FAERS: 5		US FAERS
3	Hypotension	FAERS: 5	View details 1615378 1797359 1867428 1920780 2098586 2263931 2301244 2448012 2481182 2742097 2808990 2851455 3349516 3691633 6441544 7924898 8323415 8467312 8534474 8590494 9192235 9305565 10624637 10960392 11004045 11772822 15278512 15983455 16189831 17458638 18848109 19696681 20535586	CTD SIDER US FAERS
4	Maternal exposure during pregnancy	FAERS: 5		US FAERS
5	Bradycardia	FAERS: 3	2481182 11004045 12088942	CTD OFFSIDES US FAERS
6	Blood creatinine increased	FAERS: 2		OFFSIDES US FAERS
7	Hypoxia	FAERS: 2		OFFSIDES US FAERS
8	Respiratory Failure	FAERS: 2		OFFSIDES US FAERS
9	Staphylococcal Scalded Skin Syndrome	FAERS: 2		US FAERS
10	Atrial Fibrillation	FAERS: 1		SIDER US FAERS
11	Bone pain	FAERS: 1		US FAERS
12	Cerebral Arteriosclerosis	FAERS: 1		US FAERS
13	Headache	FAERS: 1	View details 1369704 2285627 2405616 2660993 2688586 6743490	CTD SIDER US FAERS
14	Injection site erythema	FAERS: 1		US FAERS
15	Injection site inflammation	FAERS: 1		US FAERS
16	Low birth weight baby	FAERS: 1		US FAERS
17	Maternal exposure during delivery	FAERS: 1		US FAERS
18	Nausea	FAERS: 1	2660993	CTD SIDER US FAERS
19	Neonatal hypotension	FAERS: 1		OFFSIDES US FAERS
20	Off label use of device	FAERS: 1		US FAERS
21	Transaminases increased	FAERS: 1		OFFSIDES US FAERS
22	Vomiting	FAERS: 1		SIDER US FAERS
23	Abdominal Pain			SIDER
24	Abnormal vision			SIDER
25	Acidosis			OFFSIDES
26	Actinomycosis			OFFSIDES
27	Acute Coronary Syndrome			OFFSIDES SIDER
28	Adrenocortical carcinoma			OFFSIDES
29	Agitation			SIDER
30	Agraphia			OFFSIDES
31	Akinesia			OFFSIDES
32	Alanine Aminotransferase Increased			OFFSIDES
33	Albuminuria		7920453	CTD
34	Angina Pectoris		View details 1369704 2405616 3094355 3154312 3297616 7642851	CTD SIDER
35	Angina pectoris aggravated			SIDER
36	Angioedema		21330681	CTD OFFSIDES
37	Anisocoria			OFFSIDES
38	Anticholinergic Syndrome			OFFSIDES
39	Antidepressant drug level			OFFSIDES
40	Anuria			OFFSIDES
41	Anxiety			SIDER
42	Apallic syndrome			OFFSIDES
43	Apnea			OFFSIDES
44	Apparent death			OFFSIDES
45	Arterial thrombosis			OFFSIDES
46	Arteritis			OFFSIDES
47	Arthralgia			SIDER
48	Asthenia		2660993	CTD SIDER
49	Asthma		2413722	CTD
50	Atherosclerosis		3300238 11002857	CTD
51	Atrial tachycardia			OFFSIDES
52	Atrioventricular Block		1793524	CTD SIDER
53	Basal cell carcinoma			OFFSIDES
54	Blood albumin decreased			OFFSIDES
55	Blood alkaline phosphatase increased			OFFSIDES
56	Blood blister			OFFSIDES
57	Blood creatine phosphokinase MB increased			OFFSIDES
58	Blood creatine phosphokinase increased			OFFSIDES
59	Blood fibrinogen increased			OFFSIDES
60	Blood lactate dehydrogenase increased			OFFSIDES
61	Blood potassium decreased			OFFSIDES
62	Blood pressure inadequately controlled			OFFSIDES
63	Blood sodium			OFFSIDES
64	Blood urea increased			OFFSIDES
65	Blood uric acid			OFFSIDES
66	Body height below normal			OFFSIDES
67	Bone lesion			OFFSIDES
68	Brain Ischemia		1731424 3574682	CTD
69	Bronchopulmonary Dysplasia			OFFSIDES
70	Cardiac Tamponade			OFFSIDES
71	Cardiovascular Diseases		3297616	CTD
72	Cataract operation			OFFSIDES
73	Catatonia			OFFSIDES
74	Catheter related complication			OFFSIDES
75	Cerebral Hemorrhage		19770736	CTD
76	Cerebral disorder			OFFSIDES
77	Chemotherapeutic drug level increased			OFFSIDES
78	Chest Pain		3349516	CTD SIDER
79	Choking sensation			OFFSIDES
80	Cholangiolitis			OFFSIDES
81	Cholecystitis			OFFSIDES
82	Chronic left ventricular failure			OFFSIDES
83	Chronic ulcerative colitis			OFFSIDES
84	Colon adenoma			OFFSIDES
85	Complications of maternal exposure to therapeutic drugs			OFFSIDES
86	Compression fracture			OFFSIDES
87	Conjunctivitis			SIDER
88	Constipation		2660993	CTD SIDER
89	Coronary Artery Disease		View details 1766214 2301244 2808990 4076202	CTD
90	Creatinine renal clearance decreased			OFFSIDES
91	Cubital Tunnel Syndrome			OFFSIDES
92	Cytolytic hepatitis			OFFSIDES
93	Cytomegalovirus antibody positive			OFFSIDES
94	Deep Vein Thrombosis			SIDER
95	Dental Fistula			OFFSIDES
96	Depressed Level of Consciousness			OFFSIDES
97	Dermatitis			SIDER
98	Discomfort			SIDER
99	Disease Progression			SIDER
100	Dizziness		2405616 2660993	CTD SIDER
101	Drug dispensing error			OFFSIDES
102	Drug exposure during pregnancy			OFFSIDES
103	Dyspepsia			SIDER
104	Edema		View details 2285627 2405616 2660993 7508328	CTD
105	Ejection fraction abnormal			OFFSIDES
106	Electrocardiogram abnormal			SIDER
107	Electrocardiogram repolarisation abnormality			OFFSIDES
108	Electromyogram abnormal			OFFSIDES
109	Embolic cerebral infarction			OFFSIDES
110	Endocarditis			OFFSIDES
111	Enterocolitis			OFFSIDES
112	Eosinophilic myocarditis			OFFSIDES
113	Epilepsy			OFFSIDES
114	Epstein-Barr virus associated lymphoproliferative disorder			OFFSIDES
115	Erectile dysfunction			SIDER
116	Erysipelas			OFFSIDES
117	Erythema Multiforme			OFFSIDES
118	Erythromelalgia		2502240 2503135 2504422	CTD
119	Escherichia sepsis			OFFSIDES
120	Escherichia urinary tract infection			OFFSIDES
121	Febrile infection			OFFSIDES
122	Feeling abnormal			SIDER
123	Fixed eruption			OFFSIDES
124	Flushing		View details 2285627 2405616 2660993 6743490	CTD SIDER
125	Gammopathy			OFFSIDES
126	Gastrointestinal Pain			SIDER
127	General physical health deterioration			OFFSIDES
128	Glasgow coma scale			OFFSIDES
129	Graft infection			OFFSIDES
130	Granulocytosis			OFFSIDES
131	HELLP Syndrome			OFFSIDES
132	Heart failure		2808990 9192235	CTD
133	Hemiparesis			OFFSIDES
134	Hemiplegia			OFFSIDES
135	Hepatic congestion			OFFSIDES
136	Hepatic necrosis			OFFSIDES
137	Hydrocephalus			OFFSIDES
138	Hyperkeratosis			OFFSIDES
139	Hyperkinesia			SIDER
140	Hyperplasia		9120663	CTD
141	Hypersensitivity			SIDER
142	Hypertrophic Cardiomyopathy			OFFSIDES
143	Hypertrophy		2053553 7920453 9120663	CTD
144	Hypophagia			OFFSIDES
145	Hysterotomy			OFFSIDES
146	Incontinence			OFFSIDES
147	Increased upper airway secretion			OFFSIDES
148	Infection			SIDER
149	Infusion Site Extravasation			OFFSIDES
150	Infusion site erythema			OFFSIDES
151	Infusion site pain			OFFSIDES
152	Infusion site reaction			OFFSIDES
153	Injection Site Reaction			SIDER
154	Injection site infection			OFFSIDES
155	Injection site pain			SIDER
156	Intestinal infarction			OFFSIDES
157	Intubation			OFFSIDES
158	Iron Overload			OFFSIDES
159	Ischemia		2301244	CTD
160	Joint prosthesis user			OFFSIDES
161	Kidney Failure			OFFSIDES
162	Kidney Neoplasm			OFFSIDES
163	Laceration			OFFSIDES
164	Lack of spontaneous speech			OFFSIDES
165	Left ventricle outflow tract obstruction			OFFSIDES
166	Leukoencephalopathy			OFFSIDES
167	Leukopenia neonatal			OFFSIDES
168	Limb discomfort			OFFSIDES
169	Lipase			OFFSIDES
170	Liver diseases		1766214	CTD
171	Loose tooth			OFFSIDES
172	Lordosis			OFFSIDES
173	Lymphangitis			OFFSIDES
174	Lymphocyte count decreased			OFFSIDES
175	Lymphocytic infiltration			OFFSIDES
176	Macroglossia		21330681	CTD
177	Malaise			SIDER
178	Meconium ileus			OFFSIDES
179	Mitochondrial toxicity			OFFSIDES
180	Motor retardation			OFFSIDES
181	Muscle necrosis			OFFSIDES
182	Musculoskeletal discomfort			SIDER
183	Myalgia			SIDER
184	Myasthenic Syndrome			OFFSIDES
185	Myelocyte count increased			OFFSIDES
186	Myocardial Infarction			SIDER
187	Myocardial Ischemia		2048906 3349516 3812268	CTD
188	Myoglobin blood increased			OFFSIDES
189	Myoglobin urine present			OFFSIDES
190	Myoglobinaemia			OFFSIDES
191	Neck Pain			SIDER
192	Nervousness			SIDER
193	Neuroblastoma recurrent			OFFSIDES
194	Nocturia			SIDER
195	Nutritional condition abnormal			OFFSIDES
196	Obstetric procedure complication			OFFSIDES
197	Occult blood positive			OFFSIDES
198	Ocular Hypertension			OFFSIDES
199	Oculomucocutaneous syndrome			OFFSIDES
200	Oligohydramnios			OFFSIDES
201	Oliguria			OFFSIDES
202	Omphalitis			OFFSIDES
203	Oropharyngeal discomfort			SIDER
204	Oropharyngeal pain			SIDER
205	Orthopnea			OFFSIDES
206	PROTHROMBIN TIME			OFFSIDES
207	Pain			SIDER
208	Palpitations			SIDER
209	Paraplegia			OFFSIDES
210	Pericarditis			SIDER
211	Peripheral embolism			OFFSIDES
212	Personality Disorders		1930612	CTD
213	Phlebitis			OFFSIDES
214	Photodermatosis			OFFSIDES
215	Polyuria			SIDER
216	Post procedural complication			OFFSIDES
217	Pre-Eclampsia			OFFSIDES
218	Primary sequestrum			OFFSIDES
219	Procedural hypertension			OFFSIDES
220	Prothrombin level decreased			OFFSIDES
221	Pulmonary arterial hypertension			OFFSIDES
222	Pulmonary congestion			OFFSIDES
223	Pustular psoriasis			OFFSIDES
224	Quadriparesis			OFFSIDES
225	Rales			OFFSIDES
226	Renal Colic			OFFSIDES
227	Renal embolism			OFFSIDES
228	Renal tubular atrophy			OFFSIDES
229	Renal tubular disorder			OFFSIDES
230	Renal tubular necrosis			OFFSIDES
231	Respiratory Insufficiency		8274062	CTD
232	Rhabdomyolysis			OFFSIDES
233	Rheumatoid factor increased			OFFSIDES
234	Rhinitis			SIDER
235	Rubella antibody positive			OFFSIDES
236	Septic Shock			OFFSIDES
237	Sequestrectomy			OFFSIDES
238	Shock			SIDER
239	Sigmoiditis			OFFSIDES
240	Sinus Arrhythmia			SIDER
241	Sinusitis			SIDER
242	Skin lesion			OFFSIDES
243	Somnolence			SIDER
244	Spinal column stenosis			OFFSIDES
245	Splenic necrosis			OFFSIDES
246	Splenic vein thrombosis			OFFSIDES
247	Status Epilepticus			OFFSIDES
248	Stenotrophomonas infection			OFFSIDES
249	Stevens-Johnson Syndrome			OFFSIDES
250	Subarachnoid Hemorrhage		1615378 20535586	CTD
251	Substance-Related Disorders		1930612	CTD
252	Supraventricular tachycardia			SIDER
253	Surgical vascular shunt			OFFSIDES
254	Sweating			SIDER
255	Syncope			SIDER
256	Tachycardia		View details 1706810 2742097 3349516 3691633 3957469 11004045	CTD SIDER
257	Tension			SIDER
258	Thrombocytopenia			SIDER
259	Tinnitus			SIDER
260	Tooth Loss			OFFSIDES
261	Toxoplasma serology			OFFSIDES
262	Toxoplasmosis			OFFSIDES
263	Tremor			SIDER
264	Troponin increased			OFFSIDES
265	Unresponsive to stimuli			OFFSIDES
266	Urea renal clearance decreased			OFFSIDES
267	Urinary Retention		3682133	CTD
268	Urine output increased			OFFSIDES SIDER
269	Urine potassium decreased			OFFSIDES
270	Urine sodium decreased			OFFSIDES
271	VIIth nerve paralysis			OFFSIDES
272	Vascular resistance systemic decreased			OFFSIDES
273	Vasodilation procedure			SIDER
274	Vasodilation			SIDER
275	Vasoplegia syndrome			OFFSIDES
276	Vasospasm, Intracranial		19057314	CTD
277	Vasospasm			OFFSIDES
278	Ventricular hyperkinesia			OFFSIDES
279	Ventricular hypokinesia			OFFSIDES
280	Ventricular hypoplasia			OFFSIDES
281	Vertigo			SIDER
282	Visual Impairment			SIDER
283	Vitamin K Deficiency			OFFSIDES
284	Wrong drug administered			OFFSIDES
285	muscle injury			OFFSIDES

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