MetaADEDB 2.0 @ LMMD
Lactulose
(JCQLYHFGKNRPGE-FCVZTGTOSA-N)
Structure
SMILES
OC[C@H]1O[C@]([C@H]([C@@H]1O[C@@H]1O[C@H](CO)[C@@H]([C@@H]([C@H]1O)O)O)O)(O)CO
Type(s)
Approved
ATC code(s)
A06AD11; A06AD61
Molecular Formula:
C12H22O11
Molecular Weight:
342.296
Log P:
-5.3956
Hydrogen Bond Acceptor:
11
Hydrogen Bond Donor:
8
TPSA:
189.53
CAS Number(s):
4618-18-2; 58166-24-8; 58166-25-9
Synonym(s)
1.
Lactulose
2.
Amivalex
3.
Duphalac
4.
Normase
External Link(s)
MeSHD007792
PubChem Compound11333
BindingDB50377984
ChEBI6359
CHEMBLCHEMBL296306
DrugBankDB00581
KEGGcpd:C07064
dr:D00352
ZINC3977952
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 49
Canada Vigilance: 6		Canada Vigilance
US FAERS
2NauseaFAERS: 18
Canada Vigilance: 1		234288CTD
OFFSIDES
SIDER
Canada Vigilance
US FAERS
3VomitingFAERS: 15SIDER
US FAERS
4Ammonia increasedFAERS: 13
Canada Vigilance: 2		Canada Vigilance
OFFSIDES
US FAERS
5ConstipationFAERS: 10
Canada Vigilance: 2		Canada Vigilance
US FAERS
6Blood glucose increasedFAERS: 9US FAERS
7Product quality issueFAERS: 9US FAERS
8HypersensitivityFAERS: 8US FAERS
9MalaiseFAERS: 8US FAERS
10DehydrationFAERS: 7OFFSIDES
SIDER
US FAERS
11FlatulenceFAERS: 7
Canada Vigilance: 2		1531204CTD
OFFSIDES
SIDER
Canada Vigilance
US FAERS
12Abdominal discomfortFAERS: 6SIDER
US FAERS
13Product taste abnormalFAERS: 6US FAERS
14Abdominal PainFAERS: 514991555CTD
OFFSIDES
US FAERS
15AngioedemaFAERS: 5US FAERS
16BronchospasmFAERS: 5US FAERS
17DizzinessFAERS: 5OFFSIDES
US FAERS
18Pharmaceutical product complaintFAERS: 5US FAERS
19Flat affectFAERS: 4US FAERS
20Hepatic EncephalopathyFAERS: 4

View details

234288
1531204
1618465
9145459
19831495
 		CTD
US FAERS
21IleusFAERS: 4US FAERS
22Lip swellingFAERS: 4US FAERS
23PneumoniaFAERS: 4US FAERS
24DysgeusiaFAERS: 3US FAERS
25ErythemaFAERS: 3US FAERS
26Feeling abnormalFAERS: 3US FAERS
27GastroenteritisFAERS: 3US FAERS
28Medication ErrorFAERS: 3US FAERS
29Pneumatosis intestinalisFAERS: 3US FAERS
30Product substitution issueFAERS: 3US FAERS
31Rectal fissureFAERS: 3US FAERS
32RetchingFAERS: 3US FAERS
33TremorFAERS: 3US FAERS
34AmnesiaFAERS: 2US FAERS
35AstheniaFAERS: 2US FAERS
36Burning sensationFAERS: 2US FAERS
37Dental cariesFAERS: 2US FAERS
38Diabetes mellitus inadequate controlFAERS: 2US FAERS
39Drug dispensing errorFAERS: 2US FAERS
40Drug ineffective for unapproved indicationFAERS: 2US FAERS
41EructationFAERS: 2SIDER
US FAERS
42FatigueFAERS: 2US FAERS
43HeadacheFAERS: 2US FAERS
44LethargyFAERS: 2
Canada Vigilance: 2		Canada Vigilance
OFFSIDES
US FAERS
45OverdoseFAERS: 2OFFSIDES
US FAERS
46PainFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
47Product storage errorFAERS: 2US FAERS
48Renal painFAERS: 2US FAERS
49Respiratory FailureFAERS: 2OFFSIDES
US FAERS
50ThrombosisFAERS: 2US FAERS
51Urinary tract infectionFAERS: 2US FAERS
52UrticariaFAERS: 2US FAERS
53treatment failureFAERS: 2US FAERS
54AgitationFAERS: 1US FAERS
55Ammonia decreasedFAERS: 1US FAERS
56AngerFAERS: 1
Canada Vigilance: 2		Canada Vigilance
US FAERS
57AsthmaFAERS: 1US FAERS
58Back PainFAERS: 1US FAERS
59Blood electrolytes decreasedFAERS: 1US FAERS
60Blood glucose fluctuationFAERS: 1US FAERS
61Body temperature fluctuationFAERS: 1US FAERS
62Bowel movement irregularityFAERS: 1US FAERS
63Cardiac ArrestFAERS: 1US FAERS
64CellulitisFAERS: 1OFFSIDES
US FAERS
65CheilitisFAERS: 1OFFSIDES
US FAERS
66Chest PainFAERS: 1OFFSIDES
US FAERS
67CholelithiasisFAERS: 1US FAERS
68Clostridium difficile infectionFAERS: 1US FAERS
69CryingFAERS: 1US FAERS
70Depressed Level of ConsciousnessFAERS: 1OFFSIDES
US FAERS
71Device use errorFAERS: 1US FAERS
72DisabilityFAERS: 1US FAERS
73Drug dose omissionFAERS: 1US FAERS
74Drug prescribing errorFAERS: 1US FAERS
75DyspepsiaFAERS: 1OFFSIDES
US FAERS
76DysphoniaFAERS: 1US FAERS
77DysuriaFAERS: 1US FAERS
78Emotional disorderFAERS: 1US FAERS
79EpistaxisFAERS: 1US FAERS
80Expired drug administeredFAERS: 1US FAERS
81Food AllergyFAERS: 1US FAERS
82Food cravingFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
83Gastric DilatationFAERS: 1US FAERS
84Gastrointestinal carcinomaFAERS: 1US FAERS
85General physical health deteriorationFAERS: 1OFFSIDES
US FAERS
86GlossitisFAERS: 1US FAERS
87Gluten sensitivityFAERS: 1US FAERS
88GoutFAERS: 1US FAERS
89Inappropriate schedule of drug administrationFAERS: 1US FAERS
90Incorrect route of drug administrationFAERS: 1US FAERS
91Intestinal ObstructionFAERS: 1OFFSIDES
US FAERS
92Lactose IntoleranceFAERS: 1US FAERS
93Large intestine perforationFAERS: 1US FAERS
94LymphadenopathyFAERS: 1US FAERS
95Mastication disorderFAERS: 1OFFSIDES
US FAERS
96MegacolonFAERS: 1US FAERS
97Mental status changesFAERS: 1OFFSIDES
US FAERS
98Milk AllergyFAERS: 1US FAERS
99Mood swingsFAERS: 1
Canada Vigilance: 2		Canada Vigilance
US FAERS
100Mouth swellingFAERS: 1US FAERS
101Oral pruritusFAERS: 1US FAERS
102Osmotic demyelination syndromeFAERS: 1US FAERS
103PancreatitisFAERS: 1OFFSIDES
US FAERS
104Pelvic PainFAERS: 1US FAERS
105PneumoperitoneumFAERS: 1OFFSIDES
US FAERS
106Post procedural complicationFAERS: 1US FAERS
107Prerenal failureFAERS: 1
Canada Vigilance: 2		Canada Vigilance
US FAERS
108PresyncopeFAERS: 1US FAERS
109Procedural complicationFAERS: 1US FAERS
110ProctitisFAERS: 1OFFSIDES
US FAERS
111Product administration errorFAERS: 1US FAERS
112Product container issueFAERS: 1US FAERS
113Product contamination microbialFAERS: 1US FAERS
114Product expiration date issueFAERS: 1US FAERS
115Product label confusionFAERS: 1US FAERS
116Product use complaintFAERS: 1US FAERS
117PruritusFAERS: 1US FAERS
118QuadriparesisFAERS: 1US FAERS
119Raoultella ornithinolytica infectionFAERS: 1US FAERS
120RestlessnessFAERS: 1US FAERS
121ShockFAERS: 1US FAERS
122Skin irritationFAERS: 1US FAERS
123SplenomegalyFAERS: 1US FAERS
124StomatitisFAERS: 1US FAERS
125StressFAERS: 1US FAERS
126SyncopeFAERS: 1US FAERS
127Therapeutic response unexpectedFAERS: 1US FAERS
128Therapeutic response unexpected with drug substitutionFAERS: 1US FAERS
129Transcription medication errorFAERS: 1US FAERS
130Visual ImpairmentFAERS: 1US FAERS
131Vulvovaginal painFAERS: 1US FAERS
132Wrong doseFAERS: 1US FAERS
133jaundiceFAERS: 1US FAERS
134Abdominal adhesionsOFFSIDES
135Acute Coronary SyndromeOFFSIDES
136Acute left ventricular failureOFFSIDES
137Acute myocardial infarctionOFFSIDES
138Acute respiratory failureOFFSIDES
139Adrenal massOFFSIDES
140AgnosiaOFFSIDES
141Alanine Aminotransferase IncreasedOFFSIDES
142Altered state of consciousnessOFFSIDES
143AmimiaOFFSIDES
144AmphetaminesOFFSIDES
145AngiodysplasiaOFFSIDES
146Ankylosing spondylitisOFFSIDES
147Anorexia234288CTD
SIDER
148Anticonvulsant drug level above therapeuticOFFSIDES
149Antidepressant drug clearance decreasedOFFSIDES
150Antipsychotic drug level increasedOFFSIDES
151AnuriaOFFSIDES
152AnxietyOFFSIDES
153ApathyOFFSIDES
154Arterial insufficiencyOFFSIDES
155AscitesOFFSIDES
156Aspiration PneumoniaOFFSIDES
157AtaxiaOFFSIDES
158Atrial FlutterOFFSIDES
159Atrial tachycardiaOFFSIDES
160AuraOFFSIDES
161Axonal neuropathyOFFSIDES
162Bacterial test positiveOFFSIDES
163BedriddenOFFSIDES
164BelligerenceCanada Vigilance: 1Canada Vigilance
165Biliary adenomaOFFSIDES
166Bladder cystOFFSIDES
167Bladder prolapseOFFSIDES
168Blood GlucoseOFFSIDES
169Blood albumin decreasedOFFSIDES
170Blood alkaline phosphatase decreasedOFFSIDES
171Blood bicarbonateOFFSIDES
172Blood chloride decreasedOFFSIDES
173Blood creatine increasedOFFSIDES
174Blood pressure inadequately controlledOFFSIDES
175Blood sodium increasedOFFSIDES
176Blood sodiumOFFSIDES
177Blood uric acidOFFSIDES
178Body TemperatureOFFSIDES
179Bone erosionOFFSIDES
180Bone lesionOFFSIDES
181Bone marrow toxicityOFFSIDES
182Bone painOFFSIDES
183BradycardiaOFFSIDES
184Bronchial ObstructionOFFSIDES
185BronchiolitisOFFSIDES
186BronchitisOFFSIDES
187Bronchoalveolar LavageOFFSIDES
188BronchopneumoniaOFFSIDES
189Bulbar palsyOFFSIDES
190Candidiasis of vaginaOFFSIDES
191Capillary Leak SyndromeOFFSIDES
192Cardiac asthmaOFFSIDES
193Cardioactive drug levelOFFSIDES
194Cardiomyopathy acuteOFFSIDES
195Cartilage injuryOFFSIDES
196Catheter sepsisOFFSIDES
197Catheter site infectionOFFSIDES
198Catheter site painOFFSIDES
199Cauda Equina SyndromeOFFSIDES
200Central line infectionOFFSIDES
201Cerebral calcificationOFFSIDES
202Chemical and Drug Induced Liver Injury30450033CTD
203Chemotherapeutic drug level increasedOFFSIDES
204Choking sensationOFFSIDES
205CholangiolitisOFFSIDES
206Chronic Obstructive Airway DiseaseOFFSIDES
207CirrhosisOFFSIDES
208Citrobacter infectionOFFSIDES
209Coagulation factor V level decreasedOFFSIDES
210Colorectal cancer recurrentOFFSIDES
211Complications of maternal exposure to therapeutic drugsOFFSIDES
212Concomitant disease progressionOFFSIDES
213ConfabulationOFFSIDES
214Consciousness fluctuatingOFFSIDES
215Creatinine renal clearance decreasedOFFSIDES
216Culture positiveOFFSIDES
217Cytolytic hepatitisOFFSIDES
218Cytomegalovirus testOFFSIDES
219DeafnessOFFSIDES
220DemyelinationOFFSIDES
221Dental abscessOFFSIDES
222Depressed moodOFFSIDES
223DermatophytosisOFFSIDES
224Diabetic FootOFFSIDES
225Diabetic RetinopathyOFFSIDES
226Diarrhea234288CTD
227Diastolic dysfunctionOFFSIDES
228Diet refusalOFFSIDES
229Disease ProgressionOFFSIDES
230Disease recurrenceOFFSIDES
231DistentionSIDER
232DiverticulosisOFFSIDES
233Dolichocolon acquiredOFFSIDES
234DrowsinessOFFSIDES
235Drug abuserOFFSIDES
236Drug toxicityOFFSIDES
237Duodenal UlcerOFFSIDES
238Ear congestionOFFSIDES
239Economic problemOFFSIDES
240Educational problemCanada Vigilance: 2Canada Vigilance
241EnuresisOFFSIDES
242Epidural lipomatosisOFFSIDES
243EpilepsyOFFSIDES
244ErysipelasOFFSIDES
245Escherichia infectionOFFSIDES
246Fanconi SyndromeOFFSIDES
247Febrile NeutropeniaOFFSIDES
248Fluid lossSIDER
249Fluid overloadOFFSIDES
250Focal glomerulosclerosisOFFSIDES
251Food PoisoningOFFSIDES
252Fracture treatmentOFFSIDES
253Gamma-Glutamyltransferase IncreasedOFFSIDES
254GangreneOFFSIDES
255Gastric BypassOFFSIDES
256Gastric ulcerOFFSIDES
257Gastrointestinal PainSIDER
258Gastrointestinal obstructionOFFSIDES
259GastrostomyOFFSIDES
260General physical conditionOFFSIDES
261GoiterOFFSIDES
262HemiparesisOFFSIDES
263Hepatic Vein ThrombosisOFFSIDES
264Hepatic congestionOFFSIDES
265Hepatitis COFFSIDES
266HepatitisOFFSIDES
267HydrocephalusOFFSIDES
268HydronephrosisOFFSIDES
269Hyperammonemia11430560CTD
270HypercreatininaemiaOFFSIDES
271Hypersplenism acquiredOFFSIDES
272HypersplenismOFFSIDES
273Hypertensive cardiomyopathyOFFSIDES
274HypophagiaOFFSIDES
275HypoxiaOFFSIDES
276Idiopathic urticariaOFFSIDES
277IncoherentOFFSIDES
278IncontinenceOFFSIDES
279Increased thirstSIDER
280Increased upper airway secretionOFFSIDES
281Increased viscosity of bronchial secretionOFFSIDES
282InfectionOFFSIDES
283Infusion site mobility decreasedOFFSIDES
284Intention tremorOFFSIDES
285Intervertebral Disc DegenerationOFFSIDES
286Intervertebral disc disorderOFFSIDES
287Intestinal crampsSIDER
288Jaundice, Obstructive2311978CTD
289Joint Range of Motion DecreasedOFFSIDES
290Joint sprainOFFSIDES
291Kaolin cephalin clotting time abnormalOFFSIDES
292Kidney Diseases9145459CTD
293Kidney FailureOFFSIDES
294Labile blood pressureOFFSIDES
295LaryngomalaciaOFFSIDES
296LeukoencephalopathyOFFSIDES
297Leukopenia neonatalOFFSIDES
298Limb injuryOFFSIDES
299LipaseOFFSIDES
300Lipodystrophy acquiredOFFSIDES
301Liver carcinoma rupturedOFFSIDES
302Long QT SyndromeOFFSIDES
303Lymphocyte count decreasedOFFSIDES
304Malignant neoplasm progressionOFFSIDES
305Mental disorder due to a general medical conditionOFFSIDES
306Metastases to abdominal wallOFFSIDES
307Metastases to adrenalsOFFSIDES
308Metastases to diaphragmOFFSIDES
309MicrocephalyOFFSIDES
310Mixed liver injuryOFFSIDES
311Monoclonal immunoglobulin presentOFFSIDES
312MonocytosisOFFSIDES
313Motor retardationOFFSIDES
314Mucosal erosionOFFSIDES
315Multiple MyelomaOFFSIDES
316Muscular DystrophyOFFSIDES
317Musculoskeletal PainOFFSIDES
318Mycosis FungoidesOFFSIDES
319Nasal mucosal disorderOFFSIDES
320Nephrogenic Fibrosing DermopathyOFFSIDES
321Nephrotic SyndromeOFFSIDES
322NeuralgiaOFFSIDES
323Neurotoxicity Syndromes30450033CTD
324Neutropenic colitisOFFSIDES
325Neutropenic sepsisOFFSIDES
326ObstructionOFFSIDES
327Ocular discomfortOFFSIDES
328OliguriaOFFSIDES
329OrthopneaOFFSIDES
330OsteopeniaOFFSIDES
331PROTHROMBIN TIMEOFFSIDES
332ParaplegiaOFFSIDES
333ParathyroidectomyOFFSIDES
334ParotitisOFFSIDES
335Pelvic venous thrombosisOFFSIDES
336Pericardial effusionOFFSIDES
337PeritonitisOFFSIDES
338Personality ChangeCanada Vigilance: 1Canada Vigilance
339PhlebitisOFFSIDES
340PolyhydramniosOFFSIDES
341PolyneuropathyOFFSIDES
342Poor sucking reflexOFFSIDES
343Portal HypertensionOFFSIDES
344Portal Vein ThrombosisOFFSIDES
345Post procedural painOFFSIDES
346Protein total decreasedOFFSIDES
347Prothrombin level decreasedOFFSIDES
348Prothrombin time ratio decreasedOFFSIDES
349PsoriasisOFFSIDES
350Pulmonary HypertensionOFFSIDES
351Pulmonary arterial hypertensionOFFSIDES
352Pulmonary congestionOFFSIDES
353PurulenceOFFSIDES
354QRS axis abnormalOFFSIDES
355Radiation mucositisOFFSIDES
356RalesOFFSIDES
357RegurgitationOFFSIDES
358Renal tubular necrosisOFFSIDES
359Retinal VasculitisOFFSIDES
360Septic ShockOFFSIDES
361Sick Sinus SyndromeOFFSIDES
362Silent myocardial infarctionOFFSIDES
363Sjogren's SyndromeOFFSIDES
364Sphincter of Oddi DysfunctionOFFSIDES
365Spinal column stenosisOFFSIDES
366Sputum culture positiveOFFSIDES
367Staphylococcal abscessOFFSIDES
368Status EpilepticusOFFSIDES
369Stevens-Johnson SyndromeOFFSIDES
370StridorOFFSIDES
371SubileusOFFSIDES
372Supraventricular tachycardiaOFFSIDES
373Synovial CystOFFSIDES
374ThirstSIDER
375ThrombophlebitisOFFSIDES
376ThyroidectomyOFFSIDES
377Tracheobronchitis viralOFFSIDES
378Troponin increasedOFFSIDES
379Unresponsive to stimuliOFFSIDES
380UrinomaOFFSIDES
381Venous InsufficiencyOFFSIDES
382Visual disturbanceOFFSIDES
383Vitamin B 12 DeficiencyOFFSIDES
384Weight decreasedCanada Vigilance: 2Canada Vigilance
385Wound infection staphylococcalOFFSIDES
386effusionOFFSIDES
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