MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Phenobarbital

(DDBREPKUVSBGFI-UHFFFAOYSA-N)

Structure

SMILES: CCC1(C(=O)NC(=O)NC1=O)c1ccccc1
Type(s): Approved; Investigational
ATC code(s): N03AA02; N05CB01
Molecular Formula:: C12H12N2O3
Molecular Weight:: 232.235
Log P:: 1.3580
Hydrogen Bond Acceptor:: 5
Hydrogen Bond Donor:: 2
TPSA:: 75.27
CAS Number(s):: 50-06-6; 11097-06-6; 18420

Synonym(s)

Phenobarbital

Phenemal

Phenobarbitone

Phenylbarbital

Gardenal

Hysteps

Luminal

Phenobarbital Sodium

Phenobarbital, Monosodium Salt

10.

Phenylethylbarbituric Acid

11.

Acid, Phenylethylbarbituric

12.

Monosodium Salt Phenobarbital

13.

Sodium, Phenobarbital

External Link(s)

MeSH	D010634
PubChem Compound	4763
BindingDB	50021437
ChEBI	8069
CHEMBL	CHEMBL40
DrugBank	DB01174
DrugCentral	2134
IUPHAR/BPS Guide to PHARMACOLOGY	2804
KEGG	cpd:C07434 dr:D00506
Therapeutic Target Database	D0Y7RW
ZINC	95588079

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Stevens-Johnson Syndrome	FAERS: 6	4541299 12554048	CTD OFFSIDES SIDER US FAERS
2	Drug ineffective	FAERS: 5 Canada Vigilance: 4		Canada Vigilance US FAERS
3	Product quality issue	FAERS: 5		US FAERS
4	Lethargy	FAERS: 3 Canada Vigilance: 1	4734509 5282879 6693586	CTD OFFSIDES SIDER Canada Vigilance US FAERS
5	Pharmaceutical product complaint	FAERS: 3		US FAERS
6	Product substitution issue	FAERS: 3 Canada Vigilance: 2		Canada Vigilance US FAERS
7	Altered state of consciousness	FAERS: 2		US FAERS
8	Completed Suicide	FAERS: 2 Canada Vigilance: 17		Canada Vigilance OFFSIDES US FAERS
9	Dehydration	FAERS: 2 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
10	Drug exposure during pregnancy	FAERS: 2		OFFSIDES US FAERS
11	Epilepsy	FAERS: 2	View details 188784 413897 1246508 1486836 1811369 1893664 2220307 2716074 3110642 3142761 3579660 4128012 4162951 4235182 4734509 5598703 6264351 8652013 8816215 9433424 10691121 12352223 14642999 15143958 17128563 17574447 18760938 20163200 20417680 25745819	CTD OFFSIDES US FAERS
12	Growth retardation	FAERS: 2		US FAERS
13	Incorrect dose administered	FAERS: 2		US FAERS
14	Myocarditis	FAERS: 2		US FAERS
15	Somnolence	FAERS: 2 Canada Vigilance: 8		Canada Vigilance SIDER US FAERS
16	Vomiting	FAERS: 2 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
17	Acute kidney injury	FAERS: 1	1485575	CTD US FAERS
18	Alanine Aminotransferase Increased	FAERS: 1		US FAERS
19	Amnesia	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
20	Anticonvulsant drug level abnormal	FAERS: 1		OFFSIDES US FAERS
21	Anticonvulsant drug level above therapeutic	FAERS: 1 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
22	Anticonvulsant drug level below therapeutic	FAERS: 1 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
23	Anticonvulsant drug level increased	FAERS: 1		OFFSIDES US FAERS
24	Aspartate Aminotransferase Increased	FAERS: 1		US FAERS
25	Asthenia	FAERS: 1 Canada Vigilance: 2		Canada Vigilance OFFSIDES US FAERS
26	Circumstance or information capable of leading to medication error	FAERS: 1		OFFSIDES US FAERS
27	Corneal erosion	FAERS: 1		US FAERS
28	Depressed mood	FAERS: 1		US FAERS
29	Diffuse alopecia	FAERS: 1		US FAERS
30	Discomfort	FAERS: 1		US FAERS
31	Dizziness	FAERS: 1 Canada Vigilance: 2	11051127	CTD SIDER Canada Vigilance US FAERS
32	Drug dispensing error	FAERS: 1		OFFSIDES US FAERS
33	Drug dose omission	FAERS: 1		US FAERS
34	Drug toxicity	FAERS: 1		OFFSIDES US FAERS
35	Drug withdrawal syndrome	FAERS: 1		US FAERS
36	Electroencephalogram abnormal	FAERS: 1		US FAERS
37	Encephalitis	FAERS: 1		US FAERS
38	Eosinophilia	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
39	Epileptic aura	FAERS: 1		US FAERS
40	Erythema	FAERS: 1 Canada Vigilance: 5		Canada Vigilance SIDER US FAERS
41	Euphoric mood	FAERS: 1		US FAERS
42	Euthanasia	FAERS: 1		US FAERS
43	Feeling abnormal	FAERS: 1		SIDER US FAERS
44	Fixed eruption	FAERS: 1		US FAERS
45	Hemiparesis	FAERS: 1		OFFSIDES US FAERS
46	Hepatic Encephalopathy	FAERS: 1	347920 12175977	CTD US FAERS
47	Hepatitis A	FAERS: 1		OFFSIDES US FAERS
48	Hypersomnia	FAERS: 1		US FAERS
49	Hypotension	FAERS: 1	4973764	CTD SIDER US FAERS
50	Infusion site rash	FAERS: 1		US FAERS
51	Intercepted drug dispensing error	FAERS: 1		US FAERS
52	Intercepted product administration error	FAERS: 1		US FAERS
53	Leukocytosis	FAERS: 1		US FAERS
54	Liquid product physical issue	FAERS: 1		US FAERS
55	Lung neoplasm surgery	FAERS: 1		US FAERS
56	Lymphadenopathy	FAERS: 1		US FAERS
57	Lymphocytosis	FAERS: 1		US FAERS
58	Lymphoma	FAERS: 1		US FAERS
59	Myalgia	FAERS: 1		SIDER US FAERS
60	Nephrolithiasis	FAERS: 1		US FAERS
61	Overdose	FAERS: 1 Canada Vigilance: 2		Canada Vigilance OFFSIDES US FAERS
62	Patent ductus arteriosus	FAERS: 1		US FAERS
63	Pneumonia	FAERS: 1		US FAERS
64	Product contamination	FAERS: 1		US FAERS
65	Product deposit	FAERS: 1		US FAERS
66	Product dispensing error	FAERS: 1		US FAERS
67	Product dosage form issue	FAERS: 1		US FAERS
68	Product measured potency issue	FAERS: 1		US FAERS
69	Respiratory Depression	FAERS: 1		SIDER US FAERS
70	Rickets	FAERS: 1		US FAERS
71	Screaming	FAERS: 1		US FAERS
72	Sjogren's Syndrome	FAERS: 1		US FAERS
73	Squamous cell carcinoma of lung	FAERS: 1		US FAERS
74	Tachycardia	FAERS: 1		US FAERS
75	Throat irritation	FAERS: 1		US FAERS
76	Toxic Epidermal Necrolysis	FAERS: 1		SIDER US FAERS
77	Toxicity to various agents	FAERS: 1		US FAERS
78	Transcription medication error	FAERS: 1		US FAERS
79	Unevaluable event	FAERS: 1		US FAERS
80	Urinary tract infection	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
81	Vertigo	FAERS: 1		SIDER US FAERS
82	Vitamin D Deficiency	FAERS: 1		US FAERS
83	Wheezing	FAERS: 1		US FAERS
84	Wrong technique in drug usage process	FAERS: 1		US FAERS
85	jaundice	FAERS: 1 Canada Vigilance: 1	17923349	CTD Canada Vigilance US FAERS
86	17-hydroxyprogesterone increased			OFFSIDES
87	Abdominal Pain			OFFSIDES
88	Abdominal discomfort	Canada Vigilance: 1		Canada Vigilance
89	Abnormalities, Drug-Induced		View details 424928 1893664 2055617 4441320 6195326 6462788 15123016 15644835 17584909	CTD
90	Abruptio Placentae		19047607	CTD
91	Abuse			OFFSIDES
92	Accidental overdose	Canada Vigilance: 3		Canada Vigilance
93	Adenocarcinoma		7586145	CTD OFFSIDES
94	Adenoma		View details 2387015 3180032 6850638 7923571 21424122 23531792	CTD
95	Adrenogenital Syndrome			OFFSIDES
96	Adverse event			OFFSIDES
97	Agitation	Canada Vigilance: 1		Canada Vigilance SIDER
98	Alcohol Withdrawal Seizures		3746988	CTD
99	Alopecia		6782217	CTD
100	Ammonia increased			OFFSIDES
101	Anal Fissure			OFFSIDES
102	Anal Fistula			OFFSIDES
103	Anemia, Hemolytic		9855327	CTD
104	Anemia, Megaloblastic		4627864	CTD
105	Aneuploidy		8093813	CTD
106	Angioedema	Canada Vigilance: 1		Canada Vigilance SIDER
107	Anhidrosis			OFFSIDES
108	Anisocytosis			OFFSIDES
109	Anticonvulsant drug level decreased			OFFSIDES
110	Anxiety			SIDER
111	Apathy			OFFSIDES
112	Apnea		12593465 15306828	CTD OFFSIDES
113	Arteriosclerosis			OFFSIDES
114	Arteriovenous fistula site complication			OFFSIDES
115	Arthralgia			SIDER
116	Arthritis			OFFSIDES
117	Aspergillosis			OFFSIDES
118	Aspiration Pneumonia			OFFSIDES
119	Asthma		208429	CTD SIDER
120	Ataxia	Canada Vigilance: 2	View details 188784 1242663 2721568 4479423 4734509 5282879	CTD OFFSIDES SIDER Canada Vigilance
121	Athetosis		835515	CTD
122	Automatism			OFFSIDES
123	Autonomic neuropathy			OFFSIDES
124	Bacteria stool identified			OFFSIDES
125	Balanitis			OFFSIDES
126	Band neutrophil percentage increased			OFFSIDES
127	Basal cell carcinoma			OFFSIDES
128	Bedridden			OFFSIDES
129	Biopsy bone marrow abnormal			OFFSIDES
130	Bladder discomfort			OFFSIDES
131	Blood Coagulation Disorders		17923349	CTD
132	Blood albumin decreased			OFFSIDES
133	Blood alkaline phosphatase increased	Canada Vigilance: 1		Canada Vigilance
134	Blood brain barrier defect			OFFSIDES
135	Blood chloride increased			OFFSIDES
136	Blood corticotrophin			OFFSIDES
137	Blood cortisol decreased			OFFSIDES
138	Blood electrolytes abnormal			OFFSIDES
139	Blood fibrinogen increased			OFFSIDES
140	Blood iron increased			OFFSIDES
141	Blood lactate dehydrogenase increased			OFFSIDES
142	Blood lactic acid decreased			OFFSIDES
143	Blood magnesium increased			OFFSIDES
144	Blood pH decreased			OFFSIDES
145	Blood potassium increased			OFFSIDES
146	Blood pressure fluctuation			OFFSIDES
147	Blood pressure immeasurable			OFFSIDES
148	Blood sodium increased			OFFSIDES
149	Blood sodium			OFFSIDES
150	Blood testosterone decreased			OFFSIDES
151	Blood urea abnormal			OFFSIDES
152	Blood urea increased			OFFSIDES
153	Body Temperature			OFFSIDES
154	Bone Diseases		946392	CTD
155	Bone lesion			OFFSIDES
156	Bone marrow depression			OFFSIDES
157	Bradycardia			SIDER
158	Brain Abscess			OFFSIDES
159	Brain Death			OFFSIDES
160	Brain Diseases		17456340	CTD
161	Brain Injuries		3607518	CTD
162	Breast tenderness			OFFSIDES
163	Breath Holding			OFFSIDES
164	Bronchopulmonary Dysplasia			OFFSIDES
165	Bulbar palsy			OFFSIDES
166	Carcinoma, Transitional Cell		3779637	CTD
167	Carcinoma		3856057	CTD
168	Cardiac Flutter	Canada Vigilance: 1		Canada Vigilance OFFSIDES
169	Cardioactive drug level			OFFSIDES
170	Cardiovascular insufficiency			OFFSIDES
171	Carotid artery occlusion			OFFSIDES
172	Cataract operation			OFFSIDES
173	Cataract			OFFSIDES
174	Catheter sepsis			OFFSIDES
175	Cellulitis			OFFSIDES
176	Cerebellar Ataxia			OFFSIDES
177	Cerebral Hemorrhage		3588144	CTD
178	Cerebral Palsy			OFFSIDES
179	Cerebral artery occlusion			OFFSIDES
180	Cerebral artery stenosis			OFFSIDES
181	Cerebral atrophy			OFFSIDES
182	Cerebrosclerosis			OFFSIDES
183	Chemical and Drug Induced Liver Injury		View details 616978 839448 1530819 3105904 7377592 7699230 8563032 10817630 16815962 17574447 18336983 19433268 19797861 22331495 25242409 28058446 28495587 31270302	CTD
184	Chest discomfort	Canada Vigilance: 1		Canada Vigilance
185	Child Behavior Disorders		662511 8252516	CTD
186	Cholangiocarcinoma		12597444	CTD
187	Cholangiolitis			OFFSIDES
188	Cholangitis		17574447	CTD
189	Cholestasis		1283232 3105904 3740671	CTD
190	Chromosome Breakage		8093813	CTD
191	Chronic ulcerative colitis			OFFSIDES
192	Cleft Palate		2492459	CTD
193	Clumsiness	Canada Vigilance: 1		Canada Vigilance
194	Cognition Disorders		View details 381616 2492459 4836373 8652013 18760938 19398681 19507301 20667451	CTD
195	Colitis			OFFSIDES
196	Complex partial seizures			OFFSIDES
197	Confusion		6693586	CTD
198	Congenital pulmonary hypertension			OFFSIDES
199	Constipation			SIDER
200	Continuous Positive Airway Pressure			OFFSIDES
201	Craniofacial Abnormalities		15644835	CTD
202	Cyanosis	Canada Vigilance: 1		Canada Vigilance OFFSIDES
203	Cytolytic hepatitis			OFFSIDES
204	Deafness			OFFSIDES
205	Delirium			SIDER
206	Demyelination			OFFSIDES
207	Dental caries			OFFSIDES
208	Depressed Level of Consciousness	Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER
209	Depressive disorder		2339032 17987732	CTD
210	Dermatitis	Canada Vigilance: 6		Canada Vigilance SIDER
211	Diabetes			OFFSIDES
212	Diplopia	Canada Vigilance: 1		Canada Vigilance OFFSIDES
213	Disease Progression			OFFSIDES
214	Disorders of Excessive Somnolence		2912718	CTD
215	Diverticulosis			OFFSIDES
216	Double Outlet Right Ventricle		16732768	CTD
217	Drowning	Canada Vigilance: 1		Canada Vigilance
218	Drowsiness			OFFSIDES SIDER
219	Drug Eruptions		11431905 11434197 12926190	CTD
220	Drug administration error			OFFSIDES
221	Drug level changed			OFFSIDES
222	Drug level increased	Canada Vigilance: 1		Canada Vigilance
223	Duodenal Ulcer		7352543	CTD
224	Dyskinesia, Drug-Induced		View details 1011032 3383911 6504332 6811702	CTD
225	Dysphonia	Canada Vigilance: 1		Canada Vigilance
226	Dystonia		1851702 5331863	CTD
227	Dysuria			OFFSIDES
228	Economic problem			OFFSIDES
229	Edema		17923349	CTD
230	Emotional disorder			SIDER
231	End Stage Liver Disease		11144963	CTD
232	Enuresis			OFFSIDES
233	Epilepsies, Partial		3922381 4627864 11558140	CTD
234	Epilepsy, Complex Partial		View details 3107333 6806087 7750514 8347908	CTD
235	Epilepsy, Generalized		20001779	CTD
236	Epilepsy, Temporal Lobe		4032590	CTD
237	Erythema Multiforme	Canada Vigilance: 1	3740671	CTD SIDER Canada Vigilance
238	Essential Hypertension			OFFSIDES
239	Exanthema		5282879	CTD
240	Excoriation			OFFSIDES
241	Extravasation			SIDER
242	Eye pain			OFFSIDES
243	Failure to Thrive			OFFSIDES
244	Fatigue			OFFSIDES
245	Fatty Liver		844254 3769139 25786523	CTD OFFSIDES
246	Febrile infection			OFFSIDES
247	Feeling of body temperature change			OFFSIDES
248	Fetal Death		3086173 19047607	CTD
249	Fetal Growth Retardation		1893664 3086173 19047607	CTD
250	Fever		4258879	CTD
251	Fibromyalgia		7673010	CTD
252	Fibrosis		25242409	CTD
253	Flushing	Canada Vigilance: 1		Canada Vigilance
254	Folic Acid Deficiency		4627864	CTD
255	Food aversion			OFFSIDES
256	Gamma-Glutamyltransferase Increased			OFFSIDES
257	Gastroenteritis			OFFSIDES
258	Gastrooesophageal sphincter insufficiency			OFFSIDES
259	Gaze palsy			OFFSIDES
260	General physical health deterioration			OFFSIDES
261	General symptom			OFFSIDES
262	Genital Neoplasms, Male		7586145	CTD
263	Gingival Hypertrophy			OFFSIDES
264	Glycosuria		6782217	CTD
265	Graft infection			OFFSIDES
266	Headache	Canada Vigilance: 2		Canada Vigilance SIDER
267	Heart failure		11038904	CTD
268	Hepatitis C			OFFSIDES
269	Hepatitis		3740671 7875406	CTD SIDER
270	Hepatoblastoma		View details 2472233 7817132 11560253 11714029	CTD
271	Hepatomegaly	Canada Vigilance: 1	View details 3856057 4258879 5158462 5490893 7248170 7958203 9720140 11298494 16109766 17557908 17923349 19920070 19952500 20403969 20735435 22008526 22008536 22467018 22584684 23531792 23665940 23681119 23721867 24025784 24090815 24418717 25182419 28108177 28218408 28245158 28495587 28520973 29425889 31270302	CTD Canada Vigilance
272	Hernia			OFFSIDES
273	Histiocytosis haematophagic			OFFSIDES
274	Hydrocephalus			OFFSIDES
275	Hyperalgesia		9239313 11262592	CTD
276	Hyperammonemia		6420866	CTD
277	Hypercapnia			OFFSIDES
278	Hyperkinesia	Canada Vigilance: 1		Canada Vigilance SIDER
279	Hyperlipasaemia			OFFSIDES
280	Hyperpigmentation			OFFSIDES
281	Hyperplasia		View details 117197 2711390 9720140 11121869 23291559	CTD
282	Hypersensitivity	Canada Vigilance: 2		Canada Vigilance SIDER
283	Hypertensive cardiomyopathy			OFFSIDES
284	Hypertrophy		View details 3698194 9121950 9268606 9720140 16542693 22037397 23091169 28495587 28520973	CTD
285	Hypervitaminosis A		946392	CTD
286	Hypocalcemia		849004	CTD
287	Hypospadias		1893664	CTD
288	Hypothalamo-pituitary disorder			OFFSIDES
289	Hypoventilation			SIDER
290	Hypoxia		3421495	CTD OFFSIDES SIDER
291	Iatrogenic injury			OFFSIDES
292	Implantable defibrillator insertion			OFFSIDES
293	Inappropriate schedule of product administration	Canada Vigilance: 1		Canada Vigilance
294	Incision site infection			OFFSIDES
295	Incontinence			OFFSIDES
296	Incorrect route of drug administration			OFFSIDES
297	Increased bronchial secretion			OFFSIDES
298	Induration			OFFSIDES
299	Infant, Premature, Diseases		4096759	CTD
300	Injection Site Reaction			SIDER
301	Intellectual Disability	Canada Vigilance: 1	4702089	CTD Canada Vigilance
302	Intestinal Neoplasms		28245158	CTD
303	Joint Range of Motion Decreased			OFFSIDES
304	Joint sprain			OFFSIDES
305	Kidney Diseases		View details 982456 1239223 2734806 4416261 6782217 7059030 11594702 17006072	CTD
306	Kidney Failure			OFFSIDES
307	Language Development Disorders		6504639	CTD
308	Laryngospasm			SIDER
309	Leukoencephalopathy			OFFSIDES
310	Leukopenia neonatal			OFFSIDES
311	Limb Deformities, Congenital		2492459 15644835	CTD
312	Lip erosion			OFFSIDES
313	Liver Cirrhosis, Experimental		2007767 17342914	CTD
314	Liver Cirrhosis		View details 2025881 6301521 7248170 8187048 9927535 11014614 11144963 21047994	CTD
315	Liver Failure, Acute		17923349 18336983	CTD
316	Liver Neoplasms, Experimental		View details 21565 117197 119661 688193 838519 1308624 1361160 1399818 1444806 1638702 1672562 1691053 1902451 1971196 2179966 2322997 2379175 2482284 2515178 2563599 2766464 2857671 2863007 2865001 2867966 2890430 3137195 3180032 3359418 3365836 3472502 3691396 3779898 3787112 3856057 3948311 3957177 3971486 6131863 6149819 6150874 6151563 6499117 6697434 6825212 6849796 6850638 6872148 7274642 7526561 7586145 7779714 7817118 7817132 7834623 7923591 8001232 8019987 8093813 8106178 8167465 8187048 8242871 8242872 8565130 9037862 9140468 9210259 9744545 9863012 10425313 10466434 10965525 11016633 11121869 11526486 11753661 12528547 12792738 15082532 15112340 15684501 16188247 16433035 16734725 17172636 17399847 17636249 17658503 18308698 19123478 20091025 20843149 21035526 21424122 22436021 22659510	CTD
317	Liver diseases		View details 3689669 6149821 9268606 9879813 19363144 22037397	CTD
318	Liver neoplasms		View details 280716 1364405 1370768 2055368 2431762 3133336 3621148 3698194 3865012 3966244 3993736 6126160 6194333 6498799 7586158 7852184 8092930 8532726 8742319 12384525 12543062 12963118 15975961 19073162 19482888 19812893 21047994 23091169 24418717 24449422 25058030 25374375 28108177 28245158 28414157 28899750	CTD
319	Lower respiratory tract inflammation			OFFSIDES
320	Lung Neoplasms		3194660 8019987	CTD
321	Lymphatic Diseases		4258879	CTD
322	Lymphedema			OFFSIDES
323	Lymphocyte count decreased			OFFSIDES
324	Lymphocyte percentage decreased			OFFSIDES
325	Markedly reduced dietary intake			OFFSIDES
326	Massive Hepatic Necrosis		17962186	CTD
327	Mastectomy			OFFSIDES
328	Mastication disorder			OFFSIDES
329	Memory Disorders		View details 381616 8080250 8652013 15521558	CTD
330	Mental Retardation			OFFSIDES
331	Mental disorders		1509179 3142761	CTD
332	Mental status changes			OFFSIDES
333	Metabolic Diseases		19797861	CTD
334	Metabolic acidosis			OFFSIDES
335	Metastatic Neoplasm			OFFSIDES
336	Microcephaly		15123016	CTD
337	Micrognathism		2492459	CTD
338	Micrographic skin surgery			OFFSIDES
339	Micronuclei, Chromosome-Defective		3764927	CTD
340	Mononucleosis syndrome			OFFSIDES
341	Mood swings			SIDER
342	Motor retardation			OFFSIDES
343	Movement Disorders		19760798 22107891	CTD
344	Multicystic Dysplastic Kidney		17310358	CTD
345	Multiple Sclerosis			OFFSIDES
346	Multiple drug overdose intentional			OFFSIDES
347	Muscle necrosis			OFFSIDES
348	Musculoskeletal Deformity			OFFSIDES
349	Musculoskeletal discomfort			SIDER
350	Mutism			OFFSIDES
351	Myocardial fibrosis			OFFSIDES
352	Myoclonic Epilepsies, Progressive		17484760	CTD
353	Myoclonic Epilepsy			OFFSIDES
354	Nails, Malformed		2055617	CTD
355	Nausea	Canada Vigilance: 3		Canada Vigilance SIDER
356	Necrosis		View details 347920 616978 839448 2006506 2734806 7377592 10817630 21763762	CTD SIDER
357	Neonatal Abstinence Syndrome		3348657 14689334	CTD
358	Neoplasms, Experimental		View details 508562 3133336 3779637 6883313 28245158	CTD
359	Neoplasms		1719565	CTD
360	Nephritis, Interstitial		1530819	CTD
361	Nephrogenic Diabetes Insipidus			OFFSIDES
362	Nerve Block			OFFSIDES
363	Nerve Degeneration		4041913	CTD
364	Nervousness			SIDER
365	Neural Tube Defects		3086173	CTD
366	Neurobehavioral Manifestations		1431827	CTD
367	Neuroblastoma			OFFSIDES
368	Neuroleptic Malignant Syndrome		1485575	CTD
369	Neurotoxicity Syndromes		6681871	CTD
370	Neutropenia		9524640 9855327	CTD
371	Nocturia			OFFSIDES
372	Nystagmus			OFFSIDES SIDER
373	Ocular Motility Disorders		6504331	CTD
374	Oculocephalogyric reflex absent			OFFSIDES
375	Oculogyric crisis	Canada Vigilance: 1		Canada Vigilance
376	Oculomucocutaneous syndrome			OFFSIDES
377	Opisthorchiasis			OFFSIDES
378	Oral Ulcer		4258879	CTD
379	Oral mucosal erythema			OFFSIDES
380	Organophosphate poisoning		7059232	CTD
381	Orthosis user			OFFSIDES
382	Osteomalacia		188784 4148461 17016548	CTD SIDER
383	Osteoporosis			OFFSIDES
384	Ovarian Infection			OFFSIDES
385	PO2 decreased			OFFSIDES
386	Pain of skin			OFFSIDES
387	Pain		11262592	CTD SIDER
388	Palpable purpura			OFFSIDES
389	Pancreatic enlargement			OFFSIDES
390	Pancreatic enzymes increased			OFFSIDES
391	Paraparesis			OFFSIDES
392	Pathogen resistance			OFFSIDES
393	Perianal abscess			OFFSIDES
394	Peripheral Nervous System Diseases		1320594	CTD
395	Peritonitis			OFFSIDES
396	Personality Disorders		4836373 9169974	CTD
397	Petechiae	Canada Vigilance: 1		Canada Vigilance
398	Pharyngeal candidiasis			OFFSIDES
399	Pneumopericardium			OFFSIDES
400	Pneumothorax	Canada Vigilance: 1		Canada Vigilance OFFSIDES
401	Poisoning		2993847	CTD
402	Polyuria		1239223	CTD
403	Poor quality drug administered			OFFSIDES
404	Pre-Eclampsia		19047607	CTD
405	Precancerous Conditions		View details 117197 280716 1691053 1902451 1973356 2055368 2427192 2431769 2563599 2862719 2875809 3137195 3365836 3401844 3780814 6126160 6142138 6144610 6288500 7274635 7576107 7910516 8175925 8242853 8593453 8640942 8706241 10506011 11526486 11749691 17243116 26838046 27914986	CTD
406	Pregnancy on oral contraceptive			OFFSIDES
407	Premenstrual syndrome		8270591	CTD
408	Prenatal Exposure Delayed Effects		View details 849004 1893664 2505945 3925485 4041913 4080065 7474220 10783737 16732768 17310358 19398681 19507301	CTD
409	Primary sequestrum			OFFSIDES
410	Proctitis			OFFSIDES
411	Product lot number issue	Canada Vigilance: 1		Canada Vigilance
412	Propofol Infusion Syndrome			OFFSIDES
413	Prostate examination abnormal			OFFSIDES
414	Proteinuria		6782217	CTD
415	Pruritus	Canada Vigilance: 13		Canada Vigilance
416	Pseudolymphoma		12752131	CTD
417	Psychomotor Disorders		4836373	CTD
418	Psychomotor skills impaired			OFFSIDES
419	Pulmonary Hypertension			OFFSIDES
420	Pulmonary arterial hypertension			OFFSIDES
421	Pulmonary congestion			OFFSIDES
422	Pulmonary function test decreased			SIDER
423	Puncture site infection			OFFSIDES
424	Purpura	Canada Vigilance: 2		Canada Vigilance
425	Purulence			OFFSIDES
426	Pyelonephritis			OFFSIDES
427	Quadriplegia		3632327	CTD
428	Rash erythematous	Canada Vigilance: 4		Canada Vigilance
429	Recurrence		8814099	CTD
430	Reflex Sympathetic Dystrophy		View details 2464337 2578677 3003874 3146789 3671844 4136241 4162951 6857200 8156963 8962978 9471167 9608219 10442276 11392062 16986675 17722788	CTD
431	Reflex, Abnormal		2600817 8437130	CTD
432	Renal cyst			OFFSIDES
433	Respiratory Failure			OFFSIDES SIDER
434	Respiratory Insufficiency		4973764	CTD
435	Respiratory syncytial virus test positive			OFFSIDES
436	Rhinitis	Canada Vigilance: 1		Canada Vigilance
437	Right ventricle outflow tract obstruction			OFFSIDES
438	Risus sardonicus			OFFSIDES
439	Schizoaffective Disorder			OFFSIDES
440	Schizophrenia		1485575	CTD
441	Seizures		View details 1803 81379 519576 565846 743650 817891 817892 841172 976216 1242663 1322322 1326092 1334454 1348065 1509179 1563341 1639237 1847729 1933276 2325832 2436354 2474871 2622091 2721568 2734334 2831068 2905779 2978064 3137016 3177989 3228330 3607518 3632327 3707597 3723646 3815249 3994321 4039156 4414729 4512319 4719784 4740029 5355257 5451364 6069279 6353625 6442397 6504331 6504332 6681871 6681872 6693586 6807671 7057304 7813146 7875556 8058587 8112511 8274150 8432072 8480078 8645877 9030893 9339868 9524640 9662735 10225597 10728915 10874349 11197575 11442880 11738929 12352283 12376152 12423383 12667892 14636342 14704477 15266951 15306828 15461671 15740777 16876388 17145735 17499921 18028184 19553180 20162077 20573177 22107891 23091169 26910900	CTD
442	Self Mutilation			OFFSIDES
443	Septic Shock			OFFSIDES
444	Shock			SIDER
445	Sinus polyp			OFFSIDES
446	Sinusitis			OFFSIDES
447	Skin Induration			OFFSIDES
448	Skin hypertrophy			OFFSIDES
449	Skin laceration			OFFSIDES
450	Skin lesion			OFFSIDES
451	Sleep Apnea, Obstructive		11022396	CTD
452	Sleep Wake Disorders		381616	CTD
453	Sleep study abnormal			OFFSIDES
454	Soft Tissue Infection			OFFSIDES
455	Speech Disorders		2492459	CTD
456	Spondylolisthesis			OFFSIDES
457	Staring			OFFSIDES
458	Starvation			OFFSIDES
459	Status Epilepticus		View details 976216 2806362 3582562 6050800 8080250 8814099 12200221 19671890 20453796 25715797	CTD OFFSIDES
460	Stridor			OFFSIDES
461	Stupor	Canada Vigilance: 1		Canada Vigilance
462	Sturge-Weber Syndrome		19671890	CTD
463	Substance Withdrawal Syndrome		View details 2560590 2721568 3395463 3426170 3665395 16471094 18676160	CTD
464	Suicide attempt	Canada Vigilance: 1		Canada Vigilance
465	Superficial Thrombophlebitis			OFFSIDES
466	Sweat gland infection			OFFSIDES
467	Syncope	Canada Vigilance: 1		Canada Vigilance SIDER
468	Tension			SIDER
469	Tetany		849004	CTD
470	Therapeutic product effect incomplete	Canada Vigilance: 1		Canada Vigilance
471	Thrombocytopenia	Canada Vigilance: 1	9855327	CTD Canada Vigilance
472	Thyroid Diseases		19797861 22037397	CTD
473	Thyroid cancer, follicular		2910521	CTD
474	Tonsillitis			OFFSIDES
475	Tooth Extraction			OFFSIDES
476	Tooth Loss			OFFSIDES
477	Torticollis		1563202	CTD
478	Tracheal Stenosis			OFFSIDES
479	Transaminases increased			OFFSIDES
480	Transposition of Great Vessels		16732768	CTD
481	Tremor		30590068	CTD
482	Ulcer			OFFSIDES
483	Urinary Bladder Diseases		3966972	CTD
484	Urinary Retention		606178	CTD
485	Urinary tract infection pseudomonal			OFFSIDES
486	Urinary tract infection staphylococcal			OFFSIDES
487	Urination Disorders		982456	CTD
488	Urticaria	Canada Vigilance: 9		Canada Vigilance SIDER
489	Vascular insufficiency			OFFSIDES
490	Vitamin B 12 Deficiency		188784 4627864	CTD
491	Vitamin K Deficiency			SIDER
492	Walking aid user			OFFSIDES
493	Weight Gain		19797861	CTD
494	colonoscopy			OFFSIDES
495	diagnostic procedure			OFFSIDES

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