MetaADEDB 2.0 @ LMMD
Thioguanine
(WYWHKKSPHMUBEB-UHFFFAOYSA-N)
Structure
SMILES
Nc1nc(=S)c2c([nH]1)nc[nH]2
Type(s)
Approved
ATC code(s)
L01BB03
Molecular Formula:
C5H5N5S
Molecular Weight:
167.192
Log P:
1.1789
Hydrogen Bond Acceptor:
4
Hydrogen Bond Donor:
3
TPSA:
115.47
CAS Number(s):
154-42-7; 153981-51-2; 153981-52-3; 154034-61-4; 154034-62-5
Synonym(s)
1.
Thioguanine
2.
6-Thioguanine
3.
2-Amino-6-Purinethiol
4.
Lanvis
5.
Tabloid
6.
Thioguanin-GSK
7.
Thioguanine Anhydrous
8.
Thioguanine Hemihydrate
9.
Thioguanine Monosodium Salt
10.
Thioguanine Tabloid
11.
Tioguanina Wellcome
12.
Tioguanine
13.
2 Amino 6 Purinethiol
14.
6 Thioguanine
15.
Anhydrous, Thioguanine
16.
Thioguanin GSK
17.
ThioguaninGSK
External Link(s)
MeSHD013866
PubChem Compound2723601
BindingDB50200099
ChEBI9555
CHEMBLCHEMBL727
DrugBankDB00352
DrugCentral2632
IUPHAR/BPS Guide to PHARMACOLOGY6845
KEGGcpd:C07648
dr:D08603
Therapeutic Target DatabaseD02ZXM
ZINC6382803
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1ThrombocytopeniaFAERS: 814510948
15503293
20124218		CTD
SIDER
US FAERS
2Alanine Aminotransferase IncreasedFAERS: 6US FAERS
3AscitesFAERS: 61958475CTD
OFFSIDES
SIDER
US FAERS
4HepatotoxicityFAERS: 6OFFSIDES
US FAERS
5Aspartate Aminotransferase IncreasedFAERS: 5US FAERS
6HepatosplenomegalyFAERS: 5OFFSIDES
US FAERS
7Nodular regenerative hyperplasiaFAERS: 5OFFSIDES
SIDER
US FAERS
8PancytopeniaFAERS: 515503293CTD
SIDER
US FAERS
9EpistaxisFAERS: 4US FAERS
10Portal Vein ThrombosisFAERS: 4US FAERS
11SplenomegalyFAERS: 42332518
15503293
17015055		CTD
SIDER
US FAERS
12Venoocclusive diseaseFAERS: 4OFFSIDES
SIDER
US FAERS
13White blood cell count decreasedFAERS: 4US FAERS
14Ammonia increasedFAERS: 3US FAERS
15AnxietyFAERS: 3US FAERS
16Blood albumin decreasedFAERS: 3US FAERS
17Drug exposure during pregnancyFAERS: 3OFFSIDES
US FAERS
18General physical health deteriorationFAERS: 3US FAERS
19Lipase increasedFAERS: 3US FAERS
20PancreatitisFAERS: 3OFFSIDES
US FAERS
21Abdominal PainFAERS: 2US FAERS
22ArthralgiaFAERS: 2US FAERS
23AstheniaFAERS: 2US FAERS
24Blood amylase decreasedFAERS: 2US FAERS
25CholestasisFAERS: 2US FAERS
26Clostridium difficile toxin test positiveFAERS: 2US FAERS
27ClubbingFAERS: 2OFFSIDES
US FAERS
28Electroencephalogram abnormalFAERS: 2US FAERS
29NephrolithiasisFAERS: 2US FAERS
30NeutropeniaFAERS: 2US FAERS
31Portal HypertensionFAERS: 2OFFSIDES
SIDER
US FAERS
32TremorFAERS: 24518764CTD
US FAERS
33treatment failureFAERS: 2US FAERS
34AnorexiaFAERS: 1SIDER
US FAERS
35ArthropathyFAERS: 1US FAERS
36AstrocytomaFAERS: 1US FAERS
37Biopsy liver abnormalFAERS: 1US FAERS
38Blood alkaline phosphatase increasedFAERS: 1US FAERS
39Blood iron increasedFAERS: 1US FAERS
40Blood lactic acid decreasedFAERS: 1US FAERS
41Bone marrow depressionFAERS: 1SIDER
US FAERS
42Congenital skin dimplesFAERS: 1US FAERS
43DehydrationFAERS: 1US FAERS
44Duodenal varicesFAERS: 1US FAERS
45ErythemaFAERS: 1US FAERS
46FatigueFAERS: 1US FAERS
47FibrosisFAERS: 115316320CTD
SIDER
US FAERS
48Focal Nodular HyperplasiaFAERS: 115316320
17894846
17943403		CTD
OFFSIDES
US FAERS
49Gamma-Glutamyltransferase IncreasedFAERS: 1US FAERS
50Hepatitis C positiveFAERS: 1US FAERS
51HidradenitisFAERS: 1US FAERS
52Histiocytosis haematophagicFAERS: 1OFFSIDES
US FAERS
53MalaiseFAERS: 1US FAERS
54MyalgiaFAERS: 1US FAERS
55PainFAERS: 1US FAERS
56Pulmonary HypertensionFAERS: 1US FAERS
57Remission not achievedFAERS: 1US FAERS
58Skin lesionFAERS: 1US FAERS
59Suicide attemptFAERS: 1US FAERS
60T-Cell LymphomaFAERS: 1OFFSIDES
US FAERS
61Transaminases increasedFAERS: 1US FAERS
62Ultrasound Doppler abnormalFAERS: 1US FAERS
63Ultrasound scan abnormalFAERS: 1US FAERS
64Abdominal massOFFSIDES
65Abdominal symptomOFFSIDES
66Acute promyelocytic leukaemia differentiation syndromeOFFSIDES
67AdenocarcinomaOFFSIDES
68Adenoviral hepatitisOFFSIDES
69Alcohol abuseSIDER
70Anemia6608270CTD
71AngioedemaOFFSIDES
72ApathyOFFSIDES
73Bacterial sepsisOFFSIDES
74BlepharospasmOFFSIDES
75Blood growth hormone decreasedOFFSIDES
76Blood homocysteineOFFSIDES
77BronchitisOFFSIDES
78Budd-Chiari Syndrome15316320CTD
79Bulbar palsyOFFSIDES
80Candida pneumoniaOFFSIDES
81Candida sepsisOFFSIDES
82CardiotoxicityOFFSIDES
83Catheter sepsisOFFSIDES
84Central nervous system lesionOFFSIDES
85Cerebellar AtaxiaOFFSIDES
86Cerebellar Diseases3684173CTD
87Chemical and Drug Induced Liver Injury

View details

2332518
8496447
17943403
18521912
 		CTD
88CholecystitisOFFSIDES
89CirrhosisOFFSIDES
90Coagulation factor VII level decreasedOFFSIDES
91Conjunctival depositOFFSIDES
92Crohn Disease15472529
18521912		CTD
93CytopeniaSIDER
94Deafness NeurosensoryOFFSIDES
95Depressed moodOFFSIDES
96Device related infectionOFFSIDES
97Diarrhea3684173CTD
98DyspepsiaOFFSIDES
99Epidermal necrosisOFFSIDES
100Epstein-Barr virus associated lymphoproliferative disorderOFFSIDES
101Esophageal and Gastric Varices2889964
15503293		CTD
102FolliculitisOFFSIDES
103GastroenteritisOFFSIDES
104Gastrointestinal Hemorrhage2889964CTD
105GliomaOFFSIDES
106GlossitisOFFSIDES
107Heart Diseases2727390CTD
108HemiparesisOFFSIDES
109HemothoraxOFFSIDES
110Hepatic InfarctionOFFSIDES
111Hepatic Veno-Occlusive Disease

View details

1068643
6957419
7053705
8496447
10914056
12451396
14510948
15472529
16856155
17015055
20124218
21272804
 		CTD
112Hepatic necrosisSIDER
113HepatomegalySIDER
114High density lipoprotein increasedOFFSIDES
115Hyperplasia2889964
17894846
21272804		CTD
116Inflammatory Bowel Diseases15316320
17894846
17943403		CTD
117Insulin-like growth factor decreasedOFFSIDES
118Intestinal necrosisSIDER
119Intestinal stomaOFFSIDES
120Kidney FailureOFFSIDES
121LethargyOFFSIDES
122LeukoencephalopathyOFFSIDES
123Leukopenia neonatalOFFSIDES
124Lysosomal Storage Diseases28551711CTD
125Malignant GliomaOFFSIDES
126Metastatic NeoplasmOFFSIDES
127Mucoepidermoid CarcinomaOFFSIDES
128MutismOFFSIDES
129MyelosuppressionSIDER
130NauseaSIDER
131Optic NeuritisOFFSIDES
132PallorOFFSIDES
133Peliosis Hepatis3198003CTD
SIDER
134Pneumocystis jiroveci pneumoniaOFFSIDES
135Precocious PubertyOFFSIDES
136Precursor T-Cell Lymphoblastic Leukemia-Lymphoma17015055
20167372		CTD
137Primary hypogonadismOFFSIDES
138Productive CoughOFFSIDES
139Prothrombin level decreasedOFFSIDES
140Psoriasis8496447
12451396		CTD
141Splenic InfarctionOFFSIDES
142Stevens-Johnson SyndromeOFFSIDES
143StomatitisSIDER
144Sudden deathOFFSIDES
145Therapy non-responderOFFSIDES
146Thymus enlargementOFFSIDES
147Treatment related secondary malignancyOFFSIDES
148Ultrasound abdomen abnormalOFFSIDES
149VIIth nerve paralysisOFFSIDES
150Viral upper respiratory tract infectionOFFSIDES
151VomitingSIDER
152Weight GainOFFSIDES
153jaundiceSIDER
154leukemia1068643CTD
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