Afatinib
(USNRYVNRPYXCSP-JUGPPOIOSA-N)
Structure
- SMILES
- OC(=O)/C=C\C(=O)O.OC(=O)/C=C\C(=O)O.CN(C/C=C/C(=O)Nc1cc2c(ncnc2cc1O[C@@H]1COCC1)Nc1ccc(c(c1)Cl)F)C
- Molecular Formula:
- C32H33ClFN5O11
- Molecular Weight:
- 718.083
- Log P:
- 3.9595
- Hydrogen Bond Acceptor:
- 15
- Hydrogen Bond Donor:
- 6
- TPSA:
- 237.81
- CAS Number(s):
- 850140-73-7
Synonym(s)
1.
Afatinib
2.
(2E)-N-(4-(3-Chloro-4-fluoroanilino)-7-(((3S)-oxolan-3-yl)oxy)quinoxazolin-6-yl)-4-(dimethylamino)but-2-enamide
3.
Afatinib Dimaleate
4.
Afatinib Maleate
5.
BIBW 2992
6.
BIBW-2992
7.
BIBW-2992-MA2
8.
BIBW-2992MA2
9.
BIBW2992
10.
BIBW2992 MA2
11.
Gilotrif
12.
BIBW 2992 MA2
13.
BIBW 2992MA2
External Link(s)
| MeSH | D000077716 |
| PubChem Compound | 15606394 |
| ChEBI | 76003 |
| CHEMBL | CHEMBL2105712 |
| KEGG | dr:D09733 |
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Malignant neoplasm progression | FAERS: 693 Canada Vigilance: 11 | Canada Vigilance US FAERS | |
| 2 | Stomatitis | FAERS: 171 Canada Vigilance: 10 | Canada Vigilance US FAERS | |
| 3 | Nausea | FAERS: 95 Canada Vigilance: 5 | Canada Vigilance US FAERS | |
| 4 | Dehydration | FAERS: 90 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 5 | Vomiting | FAERS: 89 Canada Vigilance: 10 | Canada Vigilance US FAERS | |
| 6 | Asthenia | FAERS: 61 Canada Vigilance: 6 | Canada Vigilance US FAERS | |
| 7 | Acne | FAERS: 53 Canada Vigilance: 8 | Canada Vigilance US FAERS | |
| 8 | Drug ineffective | FAERS: 53 Canada Vigilance: 25 | Canada Vigilance US FAERS | |
| 9 | Malaise | FAERS: 53 Canada Vigilance: 8 | Canada Vigilance US FAERS | |
| 10 | Pneumonia | FAERS: 52 Canada Vigilance: 5 | Canada Vigilance US FAERS | |
| 11 | Fatigue | FAERS: 47 Canada Vigilance: 6 | Canada Vigilance US FAERS | |
| 12 | Dermatitis acneiform | FAERS: 46 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 13 | Disease Progression | FAERS: 44 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 14 | Pruritus | FAERS: 42 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 15 | Weight decreased | FAERS: 42 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 16 | Dry skin | FAERS: 40 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 17 | Epistaxis | FAERS: 35 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 18 | Acute kidney injury | FAERS: 30 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 19 | Alopecia | FAERS: 30 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 20 | Dizziness | FAERS: 30 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 21 | Respiratory Failure | FAERS: 27 | US FAERS | |
| 22 | Pneumonitis | FAERS: 25 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 23 | General physical health deterioration | FAERS: 24 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 24 | EGFR gene mutation | FAERS: 23 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 25 | Drug resistance | FAERS: 21 | US FAERS | |
| 26 | Toxicity to various agents | FAERS: 21 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 27 | Blood creatinine increased | FAERS: 20 | US FAERS | |
| 28 | Pain | FAERS: 20 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 29 | Abdominal Pain | FAERS: 19 | US FAERS | |
| 30 | Skin toxicity | FAERS: 19 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 31 | Cerebrovascular accident | FAERS: 18 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 32 | Oral pain | FAERS: 18 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 33 | Sepsis | FAERS: 18 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 34 | Headache | FAERS: 17 | US FAERS | |
| 35 | Back Pain | FAERS: 16 | US FAERS | |
| 36 | Gene Mutation | FAERS: 16 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 37 | Conjunctivitis | FAERS: 15 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 38 | Erythema | FAERS: 15 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 39 | Oropharyngeal pain | FAERS: 14 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 40 | Pulmonary Embolism | FAERS: 14 | US FAERS | |
| 41 | Unevaluable event | FAERS: 14 | US FAERS | |
| 42 | Urinary tract infection | FAERS: 14 | US FAERS | |
| 43 | Cerebral Infarction | FAERS: 13 | US FAERS | |
| 44 | Chest Pain | FAERS: 13 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 45 | Nail Infection | FAERS: 13 | US FAERS | |
| 46 | Dysgeusia | FAERS: 12 | US FAERS | |
| 47 | Abdominal discomfort | FAERS: 11 | US FAERS | |
| 48 | Metastasis | FAERS: 11 | US FAERS | |
| 49 | Skin reaction | FAERS: 11 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 50 | Anxiety | FAERS: 10 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 51 | Constipation | FAERS: 10 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 52 | Drug effect incomplete | FAERS: 10 | US FAERS | |
| 53 | Onychoclasis | FAERS: 10 | US FAERS | |
| 54 | Peripheral swelling | FAERS: 10 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 55 | Therapeutic response unexpected | FAERS: 10 | US FAERS | |
| 56 | Cystitis | FAERS: 9 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 57 | Gastrointestinal toxicity | FAERS: 9 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 58 | Glossitis | FAERS: 9 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 59 | Infection | FAERS: 9 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 60 | Ageusia | FAERS: 8 | US FAERS | |
| 61 | Dyspepsia | FAERS: 8 | US FAERS | |
| 62 | Inflammation | FAERS: 8 | US FAERS | |
| 63 | Meningitis | FAERS: 8 | US FAERS | |
| 64 | Skin Ulcer | FAERS: 8 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 65 | Skin lesion | FAERS: 8 | US FAERS | |
| 66 | Syncope | FAERS: 8 | US FAERS | |
| 67 | treatment failure | FAERS: 8 | US FAERS | |
| 68 | Dysphonia | FAERS: 7 | US FAERS | |
| 69 | Feeling abnormal | FAERS: 7 | US FAERS | |
| 70 | Intestinal Perforation | FAERS: 7 | US FAERS | |
| 71 | Lymphadenopathy | FAERS: 7 | US FAERS | |
| 72 | Memory impairment | FAERS: 7 | US FAERS | |
| 73 | Myocardial Infarction | FAERS: 7 | US FAERS | |
| 74 | Nasopharyngitis | FAERS: 7 | US FAERS | |
| 75 | Adverse event | FAERS: 6 | US FAERS | |
| 76 | Ascites | FAERS: 6 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 77 | Blood potassium decreased | FAERS: 6 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 78 | Cheilitis | FAERS: 6 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 79 | Dermatitis | FAERS: 6 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 80 | Electrolyte imbalance | FAERS: 6 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 81 | Epilepsy | FAERS: 6 | US FAERS | |
| 82 | Hepatitis | FAERS: 6 | US FAERS | |
| 83 | Ileus | FAERS: 6 | US FAERS | |
| 84 | Nasal discomfort | FAERS: 6 | US FAERS | |
| 85 | Pain of skin | FAERS: 6 | US FAERS | |
| 86 | Pancytopenia | FAERS: 6 | US FAERS | |
| 87 | Pneumothorax | FAERS: 6 | US FAERS | |
| 88 | Visual Impairment | FAERS: 6 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 89 | Amylase increased | FAERS: 5 | US FAERS | |
| 90 | Arthralgia | FAERS: 5 | US FAERS | |
| 91 | Central nervous system lesion | FAERS: 5 | US FAERS | |
| 92 | Enterocolitis | FAERS: 5 | US FAERS | |
| 93 | Gastric ulcer | FAERS: 5 | US FAERS | |
| 94 | Gastroenteritis | FAERS: 5 | US FAERS | |
| 95 | Hypersensitivity | FAERS: 5 | US FAERS | |
| 96 | Hypophagia | FAERS: 5 | US FAERS | |
| 97 | Hypotension | FAERS: 5 | US FAERS | |
| 98 | Laceration | FAERS: 5 | US FAERS | |
| 99 | Lip swelling | FAERS: 5 | US FAERS | |
| 100 | Pericardial effusion | FAERS: 5 | US FAERS | |
| 101 | Prerenal failure | FAERS: 5 | US FAERS | |
| 102 | Tongue blistering | FAERS: 5 | US FAERS | |
| 103 | Accidental overdose | FAERS: 4 | US FAERS | |
| 104 | Acute myocardial infarction | FAERS: 4 | US FAERS | |
| 105 | Adenocarcinoma | FAERS: 4 | US FAERS | |
| 106 | Altered state of consciousness | FAERS: 4 | US FAERS | |
| 107 | Amnesia | FAERS: 4 | US FAERS | |
| 108 | Angular cheilitis | FAERS: 4 | US FAERS | |
| 109 | Bone pain | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 110 | Cancer Pain | FAERS: 4 | US FAERS | |
| 111 | Cardiotoxicity | FAERS: 4 | US FAERS | |
| 112 | Cataract | FAERS: 4 | US FAERS | |
| 113 | Delirium | FAERS: 4 | US FAERS | |
| 114 | Diplopia | FAERS: 4 | US FAERS | |
| 115 | Eczema | FAERS: 4 | US FAERS | |
| 116 | Eye irritation | FAERS: 4 | US FAERS | |
| 117 | Gastritis | FAERS: 4 | US FAERS | |
| 118 | Inappropriate schedule of product administration | FAERS: 4 | US FAERS | |
| 119 | Neutrophil count decreased | FAERS: 4 | US FAERS | |
| 120 | Pancreatitis | FAERS: 4 | US FAERS | |
| 121 | Pneumatosis intestinalis | FAERS: 4 | US FAERS | |
| 122 | Respiratory distress | FAERS: 4 | US FAERS | |
| 123 | Scab | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 124 | Septic Shock | FAERS: 4 | US FAERS | |
| 125 | Swelling | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 126 | Therapy partial responder | FAERS: 4 | US FAERS | |
| 127 | Transaminases increased | FAERS: 4 | US FAERS | |
| 128 | Tremor | FAERS: 4 | US FAERS | |
| 129 | Acquired gene mutation | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 130 | Anuria | FAERS: 3 | US FAERS | |
| 131 | Aspartate Aminotransferase Increased | FAERS: 3 | US FAERS | |
| 132 | Atrial Fibrillation | FAERS: 3 | US FAERS | |
| 133 | Bronchitis | FAERS: 3 | US FAERS | |
| 134 | Cellulitis | FAERS: 3 | US FAERS | |
| 135 | Cerebral disorder | FAERS: 3 | US FAERS | |
| 136 | Chills | FAERS: 3 | US FAERS | |
| 137 | Chromaturia | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 138 | Clostridium difficile colitis | FAERS: 3 | US FAERS | |
| 139 | Clostridium difficile infection | FAERS: 3 | US FAERS | |
| 140 | Dementia | FAERS: 3 | US FAERS | |
| 141 | Depressed Level of Consciousness | FAERS: 3 | US FAERS | |
| 142 | Device related infection | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 143 | Disease complication | FAERS: 3 | US FAERS | |
| 144 | Disorientation | FAERS: 3 | US FAERS | |
| 145 | Drug Tolerance | FAERS: 3 | US FAERS | |
| 146 | Empyema | FAERS: 3 | US FAERS | |
| 147 | Erosive Duodenitis | FAERS: 3 | US FAERS | |
| 148 | Eyelid margin crusting | FAERS: 3 | US FAERS | |
| 149 | Fracture | FAERS: 3 | US FAERS | |
| 150 | Gastrointestinal perforation | FAERS: 3 | US FAERS | |
| 151 | Hepatotoxicity | FAERS: 3 | US FAERS | |
| 152 | Influenza | FAERS: 3 | US FAERS | |
| 153 | Keratitis | FAERS: 3 | US FAERS | |
| 154 | Lethargy | FAERS: 3 | US FAERS | |
| 155 | Lymphangiosis carcinomatosa | FAERS: 3 | US FAERS | |
| 156 | Lymphoma | FAERS: 3 | US FAERS | |
| 157 | Malignant transformation | FAERS: 3 | US FAERS | |
| 158 | Metabolic acidosis | FAERS: 3 | US FAERS | |
| 159 | Metastatic Neoplasm | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 160 | Musculoskeletal Pain | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 161 | Myalgia | FAERS: 3 | US FAERS | |
| 162 | Nail toxicity | FAERS: 3 | US FAERS | |
| 163 | Nephrolithiasis | FAERS: 3 | US FAERS | |
| 164 | Papule | FAERS: 3 | US FAERS | |
| 165 | Pelvic Pain | FAERS: 3 | US FAERS | |
| 166 | Product quality issue | FAERS: 3 | US FAERS | |
| 167 | Rash erythematous | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 168 | Skin irritation | FAERS: 3 | US FAERS | |
| 169 | Somnolence | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 170 | Squamous cell carcinoma of skin | FAERS: 3 | US FAERS | |
| 171 | Stevens-Johnson Syndrome | FAERS: 3 | US FAERS | |
| 172 | Sudden death | FAERS: 3 | US FAERS | |
| 173 | Superior Vena Cava Syndrome | FAERS: 3 | US FAERS | |
| 174 | Therapy cessation | FAERS: 3 | US FAERS | |
| 175 | Thrombocytopenia | FAERS: 3 | US FAERS | |
| 176 | Urticaria | FAERS: 3 | US FAERS | |
| 177 | Wheezing | FAERS: 3 | US FAERS | |
| 178 | White blood cell count decreased | FAERS: 3 | US FAERS | |
| 179 | jaundice | FAERS: 3 | US FAERS | |
| 180 | Abasia | FAERS: 2 | US FAERS | |
| 181 | Adrenal mass | FAERS: 2 | US FAERS | |
| 182 | Alanine Aminotransferase Increased | FAERS: 2 | US FAERS | |
| 183 | Anal Fissure | FAERS: 2 | US FAERS | |
| 184 | Aphasia | FAERS: 2 | US FAERS | |
| 185 | Aphonia | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 186 | Apparent death | FAERS: 2 | US FAERS | |
| 187 | Appendicitis | FAERS: 2 | US FAERS | |
| 188 | Blood creatine phosphokinase increased | FAERS: 2 | US FAERS | |
| 189 | Blood glucose decreased | FAERS: 2 | US FAERS | |
| 190 | Blood lactate dehydrogenase increased | FAERS: 2 | US FAERS | |
| 191 | Blood potassium increased | FAERS: 2 | US FAERS | |
| 192 | Blood urea increased | FAERS: 2 | US FAERS | |
| 193 | Blood urine present | FAERS: 2 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 194 | Bursitis | FAERS: 2 | US FAERS | |
| 195 | Carcinoembryonic antigen increased | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 196 | Cardiac Arrest | FAERS: 2 | US FAERS | |
| 197 | Chest discomfort | FAERS: 2 | US FAERS | |
| 198 | Colitis | FAERS: 2 | US FAERS | |
| 199 | Critical Illness | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 200 | Crying | FAERS: 2 | US FAERS | |
| 201 | Deafness | FAERS: 2 | US FAERS | |
| 202 | Deep Vein Thrombosis | FAERS: 2 | US FAERS | |
| 203 | Depressed mood | FAERS: 2 | US FAERS | |
| 204 | Disseminated Intravascular Coagulation | FAERS: 2 | US FAERS | |
| 205 | Diverticulitis | FAERS: 2 | US FAERS | |
| 206 | Drug administration error | FAERS: 2 | US FAERS | |
| 207 | Duodenal Ulcer | FAERS: 2 | US FAERS | |
| 208 | Embolic stroke | FAERS: 2 | US FAERS | |
| 209 | Encephalitis | FAERS: 2 | US FAERS | |
| 210 | Extra dose administered | FAERS: 2 | US FAERS | |
| 211 | Flatulence | FAERS: 2 | US FAERS | |
| 212 | Folliculitis | FAERS: 2 | US FAERS | |
| 213 | General symptom | FAERS: 2 | US FAERS | |
| 214 | Gout | FAERS: 2 | US FAERS | |
| 215 | Growth of eyelashes | FAERS: 2 | US FAERS | |
| 216 | Hospice Care | FAERS: 2 | US FAERS | |
| 217 | Hypersomnia | FAERS: 2 | US FAERS | |
| 218 | Hypoxia | FAERS: 2 | US FAERS | |
| 219 | Immune thrombocytopenic purpura | FAERS: 2 | US FAERS | |
| 220 | Incontinence | FAERS: 2 | US FAERS | |
| 221 | Incorrect dose administered | FAERS: 2 | US FAERS | |
| 222 | Infarction | FAERS: 2 | US FAERS | |
| 223 | Infectious pleural effusion | FAERS: 2 | US FAERS | |
| 224 | Intentional product misuse | FAERS: 2 | US FAERS | |
| 225 | Intestinal Obstruction | FAERS: 2 | US FAERS | |
| 226 | Joint swelling | FAERS: 2 | US FAERS | |
| 227 | Laryngitis | FAERS: 2 | US FAERS | |
| 228 | Leukocytosis | FAERS: 2 | US FAERS | |
| 229 | Leukoencephalopathy | FAERS: 2 | US FAERS | |
| 230 | Limb injury | FAERS: 2 | US FAERS | |
| 231 | Lower respiratory tract infection | FAERS: 2 | US FAERS | |
| 232 | Lymph node palpable | FAERS: 2 | US FAERS | |
| 233 | Malignant ascites | FAERS: 2 | US FAERS | |
| 234 | Malnutrition | FAERS: 2 | US FAERS | |
| 235 | Medical device site infection | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 236 | Medication Error | FAERS: 2 | US FAERS | |
| 237 | Megacolon | FAERS: 2 | US FAERS | |
| 238 | Mental status changes | FAERS: 2 | US FAERS | |
| 239 | Metastases to adrenals | FAERS: 2 | US FAERS | |
| 240 | Monoplegia | FAERS: 2 | US FAERS | |
| 241 | Nasal mucosal disorder | FAERS: 2 | US FAERS | |
| 242 | Neutropenia | FAERS: 2 | US FAERS | |
| 243 | Night sweats | FAERS: 2 | US FAERS | |
| 244 | No adverse event | FAERS: 2 | US FAERS | |
| 245 | Nodule | FAERS: 2 | US FAERS | |
| 246 | Onychomycosis | FAERS: 2 | US FAERS | |
| 247 | Oral mucosal eruption | FAERS: 2 | US FAERS | |
| 248 | Oral mucosal erythema | FAERS: 2 | US FAERS | |
| 249 | Overdose | FAERS: 2 | US FAERS | |
| 250 | Performance status decreased | FAERS: 2 | US FAERS | |
| 251 | Photophobia | FAERS: 2 | US FAERS | |
| 252 | Pleural Infection | FAERS: 2 | US FAERS | |
| 253 | Post procedural complication | FAERS: 2 | US FAERS | |
| 254 | Postoperative abscess | FAERS: 2 | US FAERS | |
| 255 | Presyncope | FAERS: 2 | US FAERS | |
| 256 | Product use issue | FAERS: 2 | US FAERS | |
| 257 | Psoriasis | FAERS: 2 | US FAERS | |
| 258 | Pulmonary Fibrosis | FAERS: 2 | US FAERS | |
| 259 | Pulmonary congestion | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 260 | Purpura | FAERS: 2 | US FAERS | |
| 261 | Pyelonephritis | FAERS: 2 | US FAERS | |
| 262 | Quality of life decreased | FAERS: 2 | US FAERS | |
| 263 | Squamous cell carcinoma | FAERS: 2 | US FAERS | |
| 264 | Subcorneal pustular dermatosis | FAERS: 2 | US FAERS | |
| 265 | Subileus | FAERS: 2 | US FAERS | |
| 266 | Therapeutic product effect incomplete | FAERS: 2 | US FAERS | |
| 267 | Therapy change | FAERS: 2 | US FAERS | |
| 268 | Thrombosis | FAERS: 2 | US FAERS | |
| 269 | Tongue erythema | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 270 | Ulcer | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 271 | Urinary Incontinence | FAERS: 2 | US FAERS | |
| 272 | Wrong technique in product usage process | FAERS: 2 | US FAERS | |
| 273 | carbuncle | FAERS: 2 | US FAERS | |
| 274 | Abscess | FAERS: 1 | US FAERS | |
| 275 | Acarodermatitis | FAERS: 1 | US FAERS | |
| 276 | Accidental exposure to product | FAERS: 1 | US FAERS | |
| 277 | Accidental exposure to product by child | FAERS: 1 | US FAERS | |
| 278 | Activities of daily living impaired | FAERS: 1 | US FAERS | |
| 279 | Alanine aminotransferase abnormal | FAERS: 1 | US FAERS | |
| 280 | Alopecia Areata | FAERS: 1 | US FAERS | |
| 281 | Ammonia increased | FAERS: 1 | US FAERS | |
| 282 | Anal abscess | FAERS: 1 | US FAERS | |
| 283 | Angina Pectoris | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 284 | Antibiotic therapy | FAERS: 1 | US FAERS | |
| 285 | Aphagia | FAERS: 1 | US FAERS | |
| 286 | Arthritis | FAERS: 1 | US FAERS | |
| 287 | Arthropathy | FAERS: 1 | US FAERS | |
| 288 | Aspartate aminotransferase abnormal | FAERS: 1 | US FAERS | |
| 289 | Atrioventricular Block | FAERS: 1 | US FAERS | |
| 290 | Atypical pneumonia | FAERS: 1 | US FAERS | |
| 291 | Autonomic nervous system imbalance | FAERS: 1 | US FAERS | |
| 292 | Basal cell carcinoma | FAERS: 1 | US FAERS | |
| 293 | Bedridden | FAERS: 1 | US FAERS | |
| 294 | Biopsy | FAERS: 1 | US FAERS | |
| 295 | Bladder prolapse | FAERS: 1 | US FAERS | |
| 296 | Blepharectomy | FAERS: 1 | US FAERS | |
| 297 | Blepharitis | FAERS: 1 | US FAERS | |
| 298 | Blood alkaline phosphatase abnormal | FAERS: 1 | US FAERS | |
| 299 | Blood bilirubin abnormal | FAERS: 1 | US FAERS | |
| 300 | Blood count abnormal | FAERS: 1 | US FAERS | |
| 301 | Blood creatine increased | FAERS: 1 | US FAERS | |
| 302 | Blood creatine phosphokinase abnormal | FAERS: 1 | US FAERS | |
| 303 | Blood creatinine decreased | FAERS: 1 | US FAERS | |
| 304 | Blood glucose abnormal | FAERS: 1 | US FAERS | |
| 305 | Blood magnesium decreased | FAERS: 1 | US FAERS | |
| 306 | Blood thyroid stimulating hormone increased | FAERS: 1 | US FAERS | |
| 307 | Bone lesion | FAERS: 1 | US FAERS | |
| 308 | Bone swelling | FAERS: 1 | US FAERS | |
| 309 | Bowel movement irregularity | FAERS: 1 | US FAERS | |
| 310 | Breast cancer recurrent | FAERS: 1 | US FAERS | |
| 311 | Bronchopulmonary Aspergillosis | FAERS: 1 | US FAERS | |
| 312 | Bruxism | FAERS: 1 | US FAERS | |
| 313 | Burning feet syndrome | FAERS: 1 | US FAERS | |
| 314 | Burning sensation | FAERS: 1 | US FAERS | |
| 315 | C-reactive protein abnormal | FAERS: 1 | US FAERS | |
| 316 | Cachexia | FAERS: 1 | US FAERS | |
| 317 | Carbohydrate antigen 19-9 increased | FAERS: 1 | US FAERS | |
| 318 | Cardiac Tamponade | FAERS: 1 | US FAERS | |
| 319 | Cell Death | FAERS: 1 | US FAERS | |
| 320 | Cholangitis | FAERS: 1 | US FAERS | |
| 321 | Cholelithiasis | FAERS: 1 | US FAERS | |
| 322 | Cholestasis | FAERS: 1 | US FAERS | |
| 323 | Cold sweat | FAERS: 1 | US FAERS | |
| 324 | Completed Suicide | FAERS: 1 | US FAERS | |
| 325 | Compression fracture | FAERS: 1 | US FAERS | |
| 326 | Corneal erosion | FAERS: 1 | US FAERS | |
| 327 | Corneal lesion | FAERS: 1 | US FAERS | |
| 328 | Coronary Artery Disease | FAERS: 1 | US FAERS | |
| 329 | Croup infectious | FAERS: 1 | US FAERS | |
| 330 | Cytopenia | FAERS: 1 | US FAERS | |
| 331 | Dental caries | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 332 | Diabetes mellitus inadequate control | FAERS: 1 | US FAERS | |
| 333 | Diabetic Ketoacidosis | FAERS: 1 | US FAERS | |
| 334 | Diabetic Retinopathy | FAERS: 1 | US FAERS | |
| 335 | Diffuse alopecia | FAERS: 1 | US FAERS | |
| 336 | Drowning | FAERS: 1 | US FAERS | |
| 337 | Drug level above therapeutic | FAERS: 1 | US FAERS | |
| 338 | Duodenal Obstruction | FAERS: 1 | US FAERS | |
| 339 | Dysentery | FAERS: 1 | US FAERS | |
| 340 | Dysphemia | FAERS: 1 | US FAERS | |
| 341 | Ear discomfort | FAERS: 1 | US FAERS | |
| 342 | Ejection Fraction Decreased | FAERS: 1 | US FAERS | |
| 343 | Ejection fraction abnormal | FAERS: 1 | US FAERS | |
| 344 | Electrocardiogram abnormal | FAERS: 1 | US FAERS | |
| 345 | Embolic cerebral infarction | FAERS: 1 | US FAERS | |
| 346 | Embolism | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 347 | Emotional disorder | FAERS: 1 | US FAERS | |
| 348 | Endocarditis | FAERS: 1 | US FAERS | |
| 349 | Endophthalmitis | FAERS: 1 | US FAERS | |
| 350 | Eosinophilia | FAERS: 1 | US FAERS | |
| 351 | Epidermolysis | FAERS: 1 | US FAERS | |
| 352 | Erysipelas | FAERS: 1 | US FAERS | |
| 353 | Escherichia urinary tract infection | FAERS: 1 | US FAERS | |
| 354 | Extraocular Muscle Paresis | FAERS: 1 | US FAERS | |
| 355 | Eye Burns | FAERS: 1 | US FAERS | |
| 356 | Eye Infection | FAERS: 1 | US FAERS | |
| 357 | Eye pain | FAERS: 1 | US FAERS | |
| 358 | Eyelid Function Disorder | FAERS: 1 | US FAERS | |
| 359 | Facial paralysis | FAERS: 1 | US FAERS | |
| 360 | Failure to Thrive | FAERS: 1 | US FAERS | |
| 361 | Feeling Cold | FAERS: 1 | US FAERS | |
| 362 | Fibrin D dimer increased | FAERS: 1 | US FAERS | |
| 363 | Flank Pain | FAERS: 1 | US FAERS | |
| 364 | Fluid overload | FAERS: 1 | US FAERS | |
| 365 | Food aversion | FAERS: 1 | US FAERS | |
| 366 | Food craving | FAERS: 1 | US FAERS | |
| 367 | Frustration tolerance decreased | FAERS: 1 | US FAERS | |
| 368 | Gastrointestinal Pain | FAERS: 1 | US FAERS | |
| 369 | Gastrointestinal bacterial infection | FAERS: 1 | US FAERS | |
| 370 | Gastrointestinal inflammation | FAERS: 1 | US FAERS | |
| 371 | Gastrointestinal motility disorder | FAERS: 1 | US FAERS | |
| 372 | Gastrointestinal sounds abnormal | FAERS: 1 | US FAERS | |
| 373 | Gastrostomy | FAERS: 1 | US FAERS | |
| 374 | General physical condition abnormal | FAERS: 1 | US FAERS | |
| 375 | Genital rash | FAERS: 1 | US FAERS | |
| 376 | Gingival Recession | FAERS: 1 | US FAERS | |
| 377 | Gingivitis | FAERS: 1 | US FAERS | |
| 378 | Glaucoma | FAERS: 1 | US FAERS | |
| 379 | Haematotoxicity | FAERS: 1 | US FAERS | |
| 380 | Hemiparesis | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 381 | Hemiplegia | FAERS: 1 | US FAERS | |
| 382 | Hepatic Encephalopathy | FAERS: 1 | US FAERS | |
| 383 | Hepatic Infarction | FAERS: 1 | US FAERS | |
| 384 | Hepatic Vein Thrombosis | FAERS: 1 | US FAERS | |
| 385 | Hepatic cancer metastatic | FAERS: 1 | US FAERS | |
| 386 | Hepatorenal Syndrome | FAERS: 1 | US FAERS | |
| 387 | Hepatosplenomegaly | FAERS: 1 | US FAERS | |
| 388 | Homicide | FAERS: 1 | US FAERS | |
| 389 | Human epidermal growth factor receptor negative | FAERS: 1 | US FAERS | |
| 390 | Hydronephrosis | FAERS: 1 | US FAERS | |
| 391 | Hyperpyrexia | FAERS: 1 | US FAERS | |
| 392 | Hypogeusia | FAERS: 1 | US FAERS | |
| 393 | Hypothyroidism | FAERS: 1 | US FAERS | |
| 394 | Hypotrichosis | FAERS: 1 | US FAERS | |
| 395 | Hysterectomy | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 396 | Immobile | FAERS: 1 | US FAERS | |
| 397 | Impetigo | FAERS: 1 | US FAERS | |
| 398 | Inappropriate schedule of drug administration | FAERS: 1 | US FAERS | |
| 399 | Incoherent | FAERS: 1 | US FAERS | |
| 400 | Incorrect route of drug administration | FAERS: 1 | US FAERS | |
| 401 | Intertrigo | FAERS: 1 | US FAERS | |
| 402 | Iritis | FAERS: 1 | US FAERS | |
| 403 | Joint stiffness | FAERS: 1 | US FAERS | |
| 404 | Lactose Intolerance | FAERS: 1 | US FAERS | |
| 405 | Large intestine perforation | FAERS: 1 | US FAERS | |
| 406 | Limb asymmetry | FAERS: 1 | US FAERS | |
| 407 | Lip erythema | FAERS: 1 | US FAERS | |
| 408 | Loss of personal independence in daily activities | FAERS: 1 | US FAERS | |
| 409 | Lower Urinary Tract Symptoms | FAERS: 1 | US FAERS | |
| 410 | Lung Abscess | FAERS: 1 | US FAERS | |
| 411 | Lymphocytic infiltration | FAERS: 1 | US FAERS | |
| 412 | Macular fibrosis | FAERS: 1 | US FAERS | |
| 413 | Medical diet | FAERS: 1 | US FAERS | |
| 414 | Meningioma | FAERS: 1 | US FAERS | |
| 415 | Metastases to muscle | FAERS: 1 | US FAERS | |
| 416 | Monocyte count increased | FAERS: 1 | US FAERS | |
| 417 | Mouth swelling | FAERS: 1 | US FAERS | |
| 418 | Mucocutaneous rash | FAERS: 1 | US FAERS | |
| 419 | Mucosal toxicity | FAERS: 1 | US FAERS | |
| 420 | Multimorbidity | FAERS: 1 | US FAERS | |
| 421 | Multiple Sclerosis | FAERS: 1 | US FAERS | |
| 422 | Musculoskeletal discomfort | FAERS: 1 | US FAERS | |
| 423 | Myositis | FAERS: 1 | US FAERS | |
| 424 | Nail bed infection | FAERS: 1 | US FAERS | |
| 425 | Nasal inflammation | FAERS: 1 | US FAERS | |
| 426 | Nasal mucosal ulcer | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 427 | Neck Pain | FAERS: 1 | US FAERS | |
| 428 | Neurological examination abnormal | FAERS: 1 | US FAERS | |
| 429 | Nocturia | FAERS: 1 | US FAERS | |
| 430 | Nutritional condition abnormal | FAERS: 1 | US FAERS | |
| 431 | Ocular Hypertension | FAERS: 1 | US FAERS | |
| 432 | Ocular Toxicity | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 433 | Ocular discomfort | FAERS: 1 | US FAERS | |
| 434 | Ocular icterus | FAERS: 1 | US FAERS | |
| 435 | Oncologic complication | FAERS: 1 | US FAERS | |
| 436 | Onychalgia | FAERS: 1 | US FAERS | |
| 437 | Onycholysis | FAERS: 1 | US FAERS | |
| 438 | Oral candidiasis | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 439 | Oropharyngeal blistering | FAERS: 1 | US FAERS | |
| 440 | Otitis Externa | FAERS: 1 | US FAERS | |
| 441 | Palliative Care | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 442 | Palpitations | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 443 | Paraplegia | FAERS: 1 | US FAERS | |
| 444 | Paratracheal lymphadenopathy | FAERS: 1 | US FAERS | |
| 445 | Parenteral Nutrition | FAERS: 1 | US FAERS | |
| 446 | Paternal exposure before pregnancy | FAERS: 1 | US FAERS | |
| 447 | Pelvic discomfort | FAERS: 1 | US FAERS | |
| 448 | Peptic Ulcer Perforation | FAERS: 1 | US FAERS | |
| 449 | Peritonitis | FAERS: 1 | US FAERS | |
| 450 | Personality Change | FAERS: 1 | US FAERS | |
| 451 | Pharyngitis | FAERS: 1 | US FAERS | |
| 452 | Pneumococcal sepsis | FAERS: 1 | US FAERS | |
| 453 | Post procedural infection | FAERS: 1 | US FAERS | |
| 454 | Post procedural pulmonary embolism | FAERS: 1 | US FAERS | |
| 455 | Pre-existing condition improved | FAERS: 1 | US FAERS | |
| 456 | Procedural site reaction | FAERS: 1 | US FAERS | |
| 457 | Product counterfeit | FAERS: 1 | US FAERS | |
| 458 | Product preparation error | FAERS: 1 | US FAERS | |
| 459 | Product use complaint | FAERS: 1 | US FAERS | |
| 460 | Pulmonary Infarction | FAERS: 1 | US FAERS | |
| 461 | Pulmonary artery thrombosis | FAERS: 1 | US FAERS | |
| 462 | Pulmonary pain | FAERS: 1 | US FAERS | |
| 463 | Pulmonary sepsis | FAERS: 1 | US FAERS | |
| 464 | Purulence | FAERS: 1 | US FAERS | |
| 465 | Radiation Fibrosis | FAERS: 1 | US FAERS | |
| 466 | Radiation Pneumonitis | FAERS: 1 | US FAERS | |
| 467 | Radiation injury | FAERS: 1 | US FAERS | |
| 468 | Respiratory arrest | FAERS: 1 | US FAERS | |
| 469 | Respiratory tract congestion | FAERS: 1 | US FAERS | |
| 470 | Restlessness | FAERS: 1 | US FAERS | |
| 471 | Retinal Detachment | FAERS: 1 | US FAERS | |
| 472 | Retroperitoneal fibrosis | FAERS: 1 | US FAERS | |
| 473 | Rhabdomyolysis | FAERS: 1 | US FAERS | |
| 474 | Rhinitis | FAERS: 1 | US FAERS | |
| 475 | Rosacea | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 476 | Secretion discharge | FAERS: 1 | US FAERS | |
| 477 | Shock | FAERS: 1 | US FAERS | |
| 478 | Single functional kidney | FAERS: 1 | US FAERS | |
| 479 | Sinusitis | FAERS: 1 | US FAERS | |
| 480 | Skin Induration | FAERS: 1 | US FAERS | |
| 481 | Skin discomfort | FAERS: 1 | US FAERS | |
| 482 | Skin lesion inflammation | FAERS: 1 | US FAERS | |
| 483 | Small cell lung cancer metastatic | FAERS: 1 | US FAERS | |
| 484 | Soft tissue inflammation | FAERS: 1 | US FAERS | |
| 485 | Spinal fusion surgery | FAERS: 1 | US FAERS | |
| 486 | Stress | FAERS: 1 | US FAERS | |
| 487 | Syphilis | FAERS: 1 | US FAERS | |
| 488 | Tachycardia | FAERS: 1 | US FAERS | |
| 489 | Teeth brittle | FAERS: 1 | US FAERS | |
| 490 | Terminal state | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 491 | Therapy non-responder | FAERS: 1 | US FAERS | |
| 492 | Thoracic cavity drainage | FAERS: 1 | US FAERS | |
| 493 | Thoracotomy | FAERS: 1 | US FAERS | |
| 494 | Tooth Extraction | FAERS: 1 | US FAERS | |
| 495 | Tooth Loss | FAERS: 1 | US FAERS | |
| 496 | Trichiasis | FAERS: 1 | US FAERS | |
| 497 | Troponin increased | FAERS: 1 | US FAERS | |
| 498 | Trousseau's syndrome | FAERS: 1 | US FAERS | |
| 499 | Tyrosine kinase mutation | FAERS: 1 | US FAERS | |
| 500 | Upper-airway cough syndrome | FAERS: 1 | US FAERS | |
| 501 | Urinary Retention | FAERS: 1 | US FAERS | |
| 502 | Urinary Tract Pain | FAERS: 1 | US FAERS | |
| 503 | Urinary tract infection fungal | FAERS: 1 | US FAERS | |
| 504 | Urine flow decreased | FAERS: 1 | US FAERS | |
| 505 | Uterine Cancer | FAERS: 1 | US FAERS | |
| 506 | Vaginal Discharge | FAERS: 1 | US FAERS | |
| 507 | Vaginal erosion | FAERS: 1 | US FAERS | |
| 508 | Vascular compression | FAERS: 1 | US FAERS | |
| 509 | Venous Injury | FAERS: 1 | US FAERS | |
| 510 | Vertigo | FAERS: 1 | US FAERS | |
| 511 | Vestibular Neuronitis | FAERS: 1 | US FAERS | |
| 512 | Vulvovaginal inflammation | FAERS: 1 | US FAERS | |
| 513 | Wound dehiscence | FAERS: 1 | US FAERS | |
| 514 | Wrong drug | FAERS: 1 | US FAERS | |
| 515 | Xeroderma | FAERS: 1 | US FAERS | |
| 516 | Xerophthalmia | FAERS: 1 | US FAERS | |
| 517 | Xerosis | FAERS: 1 | US FAERS | |
| 518 | nervous system disorder | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 519 | prostatitis | FAERS: 1 | US FAERS | |
| 520 | Basilar artery occlusion | Canada Vigilance: 1 | Canada Vigilance | |
| 521 | Drooling | Canada Vigilance: 1 | Canada Vigilance | |
| 522 | Eyelid rash | Canada Vigilance: 1 | Canada Vigilance | |
| 523 | Gait inability | Canada Vigilance: 1 | Canada Vigilance | |
| 524 | Intraocular pressure test | Canada Vigilance: 1 | Canada Vigilance | |
| 525 | Oral toxicity | Canada Vigilance: 1 | Canada Vigilance | |
| 526 | Pallor | Canada Vigilance: 1 | Canada Vigilance |
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