MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

spironolactone, althiazide drug combination

(USEWNOGBXUWCFH-FXFKJASFSA-N)

Structure

SMILES: CC(=O)S[C@@H]1CC2=CC(=O)CC[C@@]2([C@@H]2[C@@H]1[C@@H]1CC[C@]3([C@]1(CC2)C)CCC(=O)O3)C.C=CCSCC1Nc2cc(Cl)c(cc2S(=O)(=O)N1)S(=O)(=O)N
Molecular Formula:: C35H46ClN3O8S4
Molecular Weight:: 800.468
Log P:: 9.1175
Hydrogen Bond Acceptor:: 13
Hydrogen Bond Donor:: 3
TPSA:: 246.16
CAS Number(s):: 76270-06-9

Synonym(s)

spironolactone, althiazide drug combination

Aldactacine

aldactazine

practazin

prinactizide

spiroctazine

External Link(s)

MeSH	C026063
PubChem Compound	86277930

Adverse Drug Event(s)

	Name	Data Source
1	Abasia	OFFSIDES
2	Acidosis	OFFSIDES
3	Agraphia	OFFSIDES
4	Amphetamines	OFFSIDES
5	Angiomyolipoma	OFFSIDES
6	Anorexia	OFFSIDES
7	Anti-neutrophil cytoplasmic antibody positive vasculitis	OFFSIDES
8	Apathy	OFFSIDES
9	Arthritis	OFFSIDES
10	Asphyxia	OFFSIDES
11	Asthenia	OFFSIDES
12	Ataxia	OFFSIDES
13	Atelectasis	OFFSIDES
14	Atrial tachycardia	OFFSIDES
15	Atrioventricular Block	OFFSIDES
16	Aura	OFFSIDES
17	Autoimmune hepatitis	OFFSIDES
18	Automatism	OFFSIDES
19	Benign Prostatic Hyperplasia	OFFSIDES
20	Blepharoptosis	OFFSIDES
21	Blood chloride decreased	OFFSIDES
22	Blood cortisol increased	OFFSIDES
23	Blood creatinine increased	OFFSIDES
24	Blood fibrinogen increased	OFFSIDES
25	Blood iron decreased	OFFSIDES
26	Blood osmolarity decreased	OFFSIDES
27	Blood sodium increased	OFFSIDES
28	Blood sodium	OFFSIDES
29	Body Temperature	OFFSIDES
30	Bone density decreased	OFFSIDES
31	Bone erosion	OFFSIDES
32	Bronchitis	OFFSIDES
33	Bronchopneumonia	OFFSIDES
34	Cardioactive drug level increased	OFFSIDES
35	Cataract	OFFSIDES
36	Cerebral atrophy	OFFSIDES
37	Cheilitis	OFFSIDES
38	Chemotherapeutic drug level increased	OFFSIDES
39	Chronic Obstructive Airway Disease	OFFSIDES
40	Chronic active hepatitis	OFFSIDES
41	Clostridium colitis	OFFSIDES
42	Confabulation	OFFSIDES
43	Creatinine renal clearance decreased	OFFSIDES
44	Cytolytic hepatitis	OFFSIDES
45	Deafness	OFFSIDES
46	Dehydration	OFFSIDES
47	Depressed Level of Consciousness	OFFSIDES
48	Diabetes mellitus inadequate control	OFFSIDES
49	Diaphragmatic Hernia	OFFSIDES
50	Diarrhea	OFFSIDES
51	Drowsiness	OFFSIDES
52	Drug dispensing error	OFFSIDES
53	Duodenal Ulcer	OFFSIDES
54	Duodenal ulcer perforation	OFFSIDES
55	Duodenitis	OFFSIDES
56	Dysgeusia	OFFSIDES
57	Eczema	OFFSIDES
58	Emotional distress	OFFSIDES
59	Empyema	OFFSIDES
60	Endocarditis	OFFSIDES
61	Enterococcal infection	OFFSIDES
62	Epilepsy	OFFSIDES
63	Erectile dysfunction	OFFSIDES
64	Erysipelas	OFFSIDES
65	Escherichia urinary tract infection	OFFSIDES
66	Eye pain	OFFSIDES
67	Gamma-Glutamyltransferase Increased	OFFSIDES
68	General physical health deterioration	OFFSIDES
69	Granulocytosis	OFFSIDES
70	Granuloma	OFFSIDES
71	Hepatitis	OFFSIDES
72	Hyperventilation	OFFSIDES
73	Hypophagia	OFFSIDES
74	Intention tremor	OFFSIDES
75	Kidney Failure	OFFSIDES
76	Leukoencephalopathy	OFFSIDES
77	Lichen Planus	OFFSIDES
78	Life expectancy shortened	OFFSIDES
79	Metabolic acidosis	OFFSIDES
80	Motor retardation	OFFSIDES
81	Muscle Weakness	OFFSIDES
82	Musculoskeletal Pain	OFFSIDES
83	Neutropenic colitis	OFFSIDES
84	Occult blood positive	OFFSIDES
85	Oropharyngeal pain	OFFSIDES
86	Osteoporosis	OFFSIDES
87	Overdose	OFFSIDES
88	Polymyalgia Rheumatica	OFFSIDES
89	Polyneuropathy	OFFSIDES
90	Post procedural complication	OFFSIDES
91	Protein total increased	OFFSIDES
92	Pustular psoriasis	OFFSIDES
93	Radiation interaction	OFFSIDES
94	Radiation skin injury	OFFSIDES
95	Rectal polyp	OFFSIDES
96	Rhinorrhea	OFFSIDES
97	Scleroderma	OFFSIDES
98	Septic Shock	OFFSIDES
99	Sinoatrial Block	OFFSIDES
100	Sinus bradycardia	OFFSIDES
101	Sinusitis	OFFSIDES
102	Skin lesion	OFFSIDES
103	Tardive Dyskinesia	OFFSIDES
104	Tooth Extraction	OFFSIDES
105	Transaminases increased	OFFSIDES

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