MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Trimetazidine

(UHWVSEOVJBQKBE-UHFFFAOYSA-N)

Structure

SMILES: COc1c(ccc(c1OC)OC)CN1CCNCC1
Type(s): Approved; Investigational
ATC code(s): C01EB15
Molecular Formula:: C14H22N2O3
Molecular Weight:: 266.336
Log P:: 1.3843
Hydrogen Bond Acceptor:: 5
Hydrogen Bond Donor:: 1
TPSA:: 42.96
CAS Number(s):: 5011-34-7; 13171-25-0

Synonym(s)

Trimetazidine

Centrophène

Idaptan

Trimetazidine Dihydrochloride

Trimétazidine Irex

Vasartel

Vastarel

Dihydrochloride, Trimetazidine

External Link(s)

MeSH	D014292
PubChem Compound	21109
BindingDB	80613 50403036
ChEBI	94789
CHEMBL	CHEMBL203266
DrugBank	DB09069
DrugCentral	2750
KEGG	dr:D01606 dr:D08642
Therapeutic Target Database	D0Q4YI
ZINC	19358638

Adverse Drug Event(s)

	Name	Reference(s)	Data Source
1	Acidosis		OFFSIDES
2	Acute Coronary Syndrome		OFFSIDES
3	Acute bronchitis		OFFSIDES
4	Acute kidney injury	20063365	CTD
5	Acute myocardial infarction		OFFSIDES
6	Acute respiratory failure		OFFSIDES
7	Agraphia		OFFSIDES
8	Alanine Aminotransferase Increased		OFFSIDES
9	Alcoholic Intoxication		OFFSIDES
10	Amnestic Disorder		OFFSIDES
11	Amphetamines		OFFSIDES
12	Angina Pectoris	12439634	CTD
13	Angioplasty		OFFSIDES
14	Angle Closure Glaucoma		OFFSIDES
15	Ankylosing spondylitis		OFFSIDES
16	Anuria		OFFSIDES
17	Apathy		OFFSIDES
18	Apparent death		OFFSIDES
19	Arterial thrombosis		OFFSIDES
20	Arteriogram coronary abnormal		OFFSIDES
21	Aspiration Pneumonia		OFFSIDES
22	Atrial tachycardia		OFFSIDES
23	Atrioventricular Block		OFFSIDES
24	Aura		OFFSIDES
25	Beta 2 microglobulin increased		OFFSIDES
26	Biliary adenoma		OFFSIDES
27	Blood bicarbonate abnormal		OFFSIDES
28	Blood creatine phosphokinase MB increased		OFFSIDES
29	Blood creatinine increased		OFFSIDES
30	Blood immunoglobulin E		OFFSIDES
31	Blood iron increased		OFFSIDES
32	Blood sodium		OFFSIDES
33	Blood urea increased		OFFSIDES
34	Body Temperature		OFFSIDES
35	Bradycardia		OFFSIDES
36	Brain scan abnormal		OFFSIDES
37	Calcinosis		OFFSIDES
38	Capillary Leak Syndrome		OFFSIDES
39	Causalgia		OFFSIDES
40	Cerebral atrophy		OFFSIDES
41	Chemotherapeutic drug level increased		OFFSIDES
42	Choking sensation		OFFSIDES
43	Cholangiolitis		OFFSIDES
44	Chromaturia		OFFSIDES
45	Chronic left ventricular failure		OFFSIDES
46	Confabulation		OFFSIDES
47	Conversion disorder		OFFSIDES
48	Creatinine renal clearance decreased		OFFSIDES
49	Cytolytic hepatitis		OFFSIDES
50	Dehydration		OFFSIDES
51	Device ineffective		OFFSIDES
52	Diarrhea		OFFSIDES
53	Diverticulitis		OFFSIDES
54	Drowsiness		OFFSIDES
55	Duodenitis		OFFSIDES
56	Dysphonia		OFFSIDES
57	Edema	16155371	CTD
58	Ejection Fraction Decreased		OFFSIDES
59	Electrocardiogram repolarisation abnormality		OFFSIDES
60	Enterovesical Fistula		OFFSIDES
61	Erysipelas		OFFSIDES
62	Eschar		OFFSIDES
63	Flatulence		OFFSIDES
64	Fluid intake restriction		OFFSIDES
65	Folliculitis		OFFSIDES
66	Gamma-Glutamyltransferase Increased		OFFSIDES
67	Gammopathy		OFFSIDES
68	Gastric ulcer		OFFSIDES
69	Gaze palsy		OFFSIDES
70	General physical health deterioration		OFFSIDES
71	Globulinuria		OFFSIDES
72	Glomerulonephritis		OFFSIDES
73	Glossitis		OFFSIDES
74	Granulomatous liver disease		OFFSIDES
75	Haptoglobin Decreased		OFFSIDES
76	Heart failure	19838493	CTD
77	Hemiplegia		OFFSIDES
78	Hepatitis		OFFSIDES
79	Hiccough		OFFSIDES
80	Hyaluronic acid increased		OFFSIDES
81	Hydrothorax		OFFSIDES
82	Hypercapnia		OFFSIDES
83	Hyperreflexia		OFFSIDES
84	Hypoxia		OFFSIDES
85	Incoherent		OFFSIDES
86	Intra-aortic balloon placement		OFFSIDES
87	Iridocyclitis		OFFSIDES
88	Joint fluid drainage		OFFSIDES
89	Kidney Diseases	10551656 17065180	CTD
90	Kidney Failure		OFFSIDES
91	Leukoencephalopathy		OFFSIDES
92	Lipase		OFFSIDES
93	Macrocytosis		OFFSIDES
94	Meningoradiculitis		OFFSIDES
95	Metabolic acidosis		OFFSIDES
96	Microlithiasis		OFFSIDES
97	Morganella infection		OFFSIDES
98	Motor retardation		OFFSIDES
99	Multiple Myeloma		OFFSIDES
100	Muscle necrosis		OFFSIDES
101	Myasthenia Gravis		OFFSIDES
102	Myocardial Ischemia	9781975	CTD
103	Myoglobin blood increased		OFFSIDES
104	Neutrophil count abnormal		OFFSIDES
105	Obesity surgery		OFFSIDES
106	Optic Disc Edema		OFFSIDES
107	Oral mucosal exfoliation		OFFSIDES
108	Pain	16155371	CTD
109	Pallor		OFFSIDES
110	Pancreatic Cyst		OFFSIDES
111	Pancreatic Neoplasm		OFFSIDES
112	Pancreatic enzymes increased		OFFSIDES
113	Pemphigus		OFFSIDES
114	Pericarditis		OFFSIDES
115	Photodermatosis		OFFSIDES
116	Plasmacytosis		OFFSIDES
117	Pleurisy		OFFSIDES
118	Polymyositis		OFFSIDES
119	Polyneuropathy		OFFSIDES
120	Polyuria		OFFSIDES
121	Primary hypogonadism		OFFSIDES
122	Progressive supranuclear palsy		OFFSIDES
123	Prostatic calcification		OFFSIDES
124	Prothrombin level decreased		OFFSIDES
125	Psychomotor skills impaired		OFFSIDES
126	Rales		OFFSIDES
127	Renal Artery Stenosis		OFFSIDES
128	Renal tubular disorder		OFFSIDES
129	Renal tubular necrosis		OFFSIDES
130	Reticulocyte count abnormal		OFFSIDES
131	Retinal Vein Occlusion		OFFSIDES
132	Retrocollis		OFFSIDES
133	Rhabdomyolysis		OFFSIDES
134	Rhabdomyosarcoma		OFFSIDES
135	Septic Shock		OFFSIDES
136	Sigmoiditis		OFFSIDES
137	Sinus bradycardia		OFFSIDES
138	Sinus rhythm		OFFSIDES
139	Skin lesion		OFFSIDES
140	Staphylococcal abscess		OFFSIDES
141	Status Epilepticus		OFFSIDES
142	Stevens-Johnson Syndrome		OFFSIDES
143	Subcutaneous Emphysema		OFFSIDES
144	Subileus		OFFSIDES
145	Sudden Visual Loss		OFFSIDES
146	Sudden onset of sleep		OFFSIDES
147	Thoracic vertebral fracture		OFFSIDES
148	Thrombophlebitis		OFFSIDES
149	Transaminases increased		OFFSIDES
150	Transferrin saturation increased		OFFSIDES
151	Troponin T		OFFSIDES
152	Troponin increased		OFFSIDES
153	Vascular calcification		OFFSIDES
154	Vasospasm		OFFSIDES
155	Venous Injury		OFFSIDES
156	Venous Insufficiency		OFFSIDES
157	Venous occlusion		OFFSIDES
158	Ventricular Dysfunction, Left	9781975 19838493	CTD
159	Vocal Cord Paralysis		OFFSIDES
160	Vocal cord cyst		OFFSIDES
161	angiogram		OFFSIDES

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